Marcus Böhme

Fecal exfoliome sequencing captures immune dynamics of the healthy and inflamed gut - Nature Biotechnology Profiling host RNA shed in feces reveals disease states in the gut.

Introducing Foli-seq in @natbiotech.nature.com today. Foli-seq can be used to measure gut-derived RNA from fecal matter (signals of immune, secretory & epithelial cells). We used this to map gut inflammation, drug response, and host-microbe interactions. 💩🧬💊🦠
www.nature.com/articles/s41...

Skyline of Madison, WI

🚨I am looking for a POSTDOC, LAB MANAGER/TECH and GRAD STUDENTS to join my new lab in beautiful Madison, WI.
We study how our brains perceive and represent the physical world around us using behavioral, computational, and neuroimaging methods.
paulunlab.psych.wisc.edu
#VisionScience #NeuroSkyence

Analyzing human gut microbiome data from global populations: challenges and resources Research on the human gut microbiome is expanding rapidly; yet, most published studies focus on populations from high-income regions such as North America and Europe. Underrepresentation of population...

Another review from my lab out this week, on analyzing gut microbiome data from global populations -- tackling computational challenges and providing practical frameworks and resources for the field

With Sabrina Arif, @richabdill.com, @samanthagraham.bsky.social

www.cell.com/trends/micro...

Metabolic ecology of microbiomes: Nutrient competition, host benefits, and community engineering

Review by Erik Bakkeren, Vit Piskovsky, and Kevin R. Foster
www.cell.com/cell-host-mi...

a green circle with white text

📈With obesity and overweight expected to affect 50% of the global population by 2035, the need for change has never been clearer. Join experts on 5 June at #EUParliament for an in-depth discussion on tackling this growing health crisis. Register now: https://bit.ly/3EIlu1H

Inflammasome signaling in astrocytes modulates hippocampal plasticity The function of immune pathways in homeostatic neurobiology remains underexplored. Zengeler et al. find that the inflammasome complex, typically associated with immune responses, is involved in memory...

Excited to share our new work demonstrating a role for astrocytic inflammasome signaling in modulating hippocampal plasticity. @cp-immunity.bsky.social
All credit to Kristine Zengeler, who was the brains🧠 and muscle💪 behind this project and is a wonderful collaborator. www.cell.com/immunity/ful...

Interoceptive processing in the nucleus of the solitary tract The interoceptive nervous system continuously monitors the status of visceral organs to synthesize internal perceptions and regulate behavioral and ph…

Lots of recent papers discuss the nucleus of the solitary tract in interoception. In this review, we take a sensory processing perspective on how interoceptive signals are encoded in the NTS:
www.sciencedirect.com/science/arti...

Stress dynamically modulates neuronal autophagy to gate depression onset - Nature Acute stress activates autophagy in the lateral habenula, whereas chronic stress suppresses it, with this autophagy having a causal role in maintaining emotional homeostasis against stress, and its re...

www.nature.com/articles/s41...

Querying stool for dietary information - Nature Metabolism Accurately determining food intake remains a substantial challenge in nutrition research. This issue of Nature Metabolism introduces a methodology for assessing dietary intake, using stool metagenomic data to detect food DNA from a broad range of foods.

NEWS&VIEWS | LO Dragsted, @hroager.bsky.social , @catalinacuparencu.bsky.social (U Copenhagen):

A methodology for assessing dietary intake using stool metagenomes to detect food DNA🧬💩

https://bit.ly/4lfJ1aK ?utm_source=bluesky&utm_medium=social&utm_campaign=natmetab

A map of neural signals and circuits traces the logic of brain computation A large consortium of scientists adds functional data to neuronal wiring maps, seeking to crack the computational circuitry of the mouse brain.

A map of neural signals and circuits traces the logic of brain computation www.nature.com/articles/d41...

Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety: @cellpress.bsky.social www.cell.com/cell/fulltex...

In people with diabetes, GLP-1 and SGLT2i drugs were associated with less Alzheimer's disease and related dementias
jamanetwork.com/journals/jam...

The impact of ingestion of Bifidobacterium longum NCC3001 on perinatal anxiety and depressive symptoms: a randomized controlled trial - Scientific Reports Scientific Reports - The impact of ingestion of Bifidobacterium longum NCC3001 on perinatal anxiety and depressive symptoms: a randomized controlled trial

I am excited to share our latest publication where we investigated the impact of a #Bifidobacterium longum strain on #perinatal anxiety and depressive symptoms

#mood #stress #postpartum #gutbrainaxis

www.nature.com/articles/s41...

The gut microbiome's link with multiple sclerosis www.cell.com/cell-reports...

Congrats!

Bifidobacteria support optimal infant vaccine responses - Nature Neonatal antibiotic use is shown to reduce immune response to infant vaccines, accompanied by reduced abundance of Bifidobacteria in the gut microbiota, with experiments in mice indicating that probio...

Delighted our study (7+ years in the making) is out today in Nature. In a nutshell, 48 hours of antibiotics in week 1 led to impaired vaccine responses up to 15 months later in infants. We show (in-vivo) a probiotic can fix it #microbiome #science #immunology
www.nature.com/articles/s41...

The impact of ingestion of Bifidobacterium longum NCC3001 on perinatal anxiety and depressive symptoms: a randomized controlled trial - Scientific Reports Scientific Reports - The impact of ingestion of Bifidobacterium longum NCC3001 on perinatal anxiety and depressive symptoms: a randomized controlled trial

Singapore study of 184 women found that daily probiotic Bifidobacterium longum NCC3001 during late pregnancy and postpartum did not ease anxiety or depression symptoms.

Results varied widely, suggesting more research is needed.

www.nature.com/articles/s41...

The human gut microbiome and sleep across adulthood: associations and therapeutic potential Abstract. Sleep is an essential homeostatic process that undergoes dynamic changes throughout the lifespan, with distinct life stages predisposed to specif

Curious about the gut microbiome & its impacts on sleep throughout the adult lifespan? 🦠😴

You're in luck! @isbscience.org PhD student Jacob Cavon led a review of this topic for the @amiposts.bsky.social journal Letters in Applied Microbiology (just accepted): academic.oup.com/lambio/advan...

I received a heartbreaking email today: A paper in a special issue I’m editing is being retracted because one of its authors is afraid of losing their job and their legal status in the U.S. if they publish a scientific study on evolution. Yes, on evolution, nature's engine of diversity.

In this week’s @nature.com, we publish a group effort to outline a framework for studies with neural #organoids, #assembloids and transplantation. More details below 1/n

No worries. Thank you so much

Prohormone cleavage prediction uncovers a non-incretin anti-obesity peptide

www.nature.com/articles/s41...

This administration is destroying US science.

"Foreign scientists hired under Title 42 have even more reason to worry... their visas require they leave the country within 60 days unless they obtain a new position. Many have put down roots, bought houses & have children in school."

What is your pace of aging? A new @nature.com feature on molecular clocks by gets into the issues surrounding these tests (can is really can't) nature.com/articles/d41... by @heidiledford.bsky.social

Come together, right now The chaos, conflicting information, firings, and hurtful rhetoric of the Trump administration’s approach to science over the past month are causing anxiety, grief, and concern for the scientific commu...

Great minds… within 24 hrs both us at @nature.com and @science.org make similar appeals to the research community. And @holdenthorp.bsky.social and I didn’t even exchange notes about it ;-)
🧪

www.nature.com/articles/d41...

www.science.org/doi/10.1126/...

Revealed: NIH research grants still frozen despite lawsuits challenging Trump order The Trump administration is exploiting a loophole to keep a funding freeze in place, leaving researchers in limbo.

Almost all grant-review meetings under Trump 2.0 remain suspended at the US National Institutes of Health (NIH), preventing the world’s largest public funder of biomedical research from spending much of its US$47 billion annual budget.


https://go.nature.com/4gM6oW4

Congratulations Ben, Jatin and team!

My brother is a wild-land forest fire fighter.

He wasn’t fired, but he says that the degraded workforce will struggle to function in the next fire season.

These are the heroes who risk everything to save lives and homes.

Interested in doing a PhD in Austria focused on understanding how to engineer the composition of the gut microbiota?

Want to work with a brilliant computational biologist and microbiome researcher?

See below!

Querying stool for dietary information - Nature Metabolism Accurately determining food intake remains a substantial challenge in nutrition research. This issue of Nature Metabolism introduces a methodology for assessing dietary intake, using stool metagenomic...

A new way to measure your food intake, from your 💩
www.nature.com/articles/s42...
www.nature.com/articles/s42...
"proof-of-concept for detailed tracking of
individual-specific, health-relevant dietary patterns without the need for questionnaires."