Daniel Fazakerley

For ~century, we’ve asked: why do proliferating cells ferment glucose even when O2 is around? I’m thrilled to share our latest work @natmetabolism.nature.com, led by @thebiokimist.bsky.social. By leveraging conditional essentiality in HPLM, we propose a provocative new answer to this classic Q. 🧵

Human Plasma-Like Medium Promotes Maturation of Human Pluripotent Stem Cell-Derived Cardiomyocytes Maturing human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) in vitro is critical for advancing drug discovery and cardiotoxicity screening applications of these cells. However, the metaboli...

🚨 pleased to share a new preprint made possible through a fantastic collaboration with the Skala & Palecek labs! can medium composition impact the behavior of hPSC-derived cardiomyocytes? Andy & Aaron co-led efforts to tackle this question w/HPLM! tinyurl.com/ux2arjw8

A set of four hand-drawn anatomical illustrations, each framed in a square with different background colors. The top left shows the pancreas with surrounding blood vessels and the gallbladder. The top right features the thyroid gland and larynx. The bottom left illustrates the kidneys, adrenal glands, and major blood vessels. The bottom right displays a cross-section of the human brain with detailed internal structures.

A conference programme listing sessions, speakers, and topics related to endocrinology, metabolism, and medical innovation. The schedule includes a keynote on incretins, sessions on clinical translation, fundamental science, and innovation, with discussions on genes, metabolic monitoring, parental plasticity, diabetes management, and obesity drug development. The day concludes with prizes and closing remarks.

I'm delighted to be hosting the Cambridge University Endocrinology Society's annual conference this Friday, entitled: 'From Bench to Bedside (and back again)'.

We're really fortunate to have such an exciting line up of speakers, integrating across a wide range of career stages and fields.

Thanks Jens!

Seeing the world through the eyes of cultured cells The metabolic environment experienced by cultured cells often differs from physiological conditions. Here, we highlight the effects that the microenvironment can have on cultured cell behavior and advocate for researchers to re-evaluate culture practices…

Online now: Seeing the world through the eyes of cultured cells

We have a postdoc position available in our team to undertake a UKRI-funded project to develop a new cultured skeletal muscle model for studying glc metabolism and insulin action. www.jobs.cam.ac.uk/job/50597/ @ims-mrl.bsky.social Please RT. Please email if interested.

Pleased to share our @cp-cellmetabolism.bsky.social forum on why we think standard cell culture practices deserve more consideration. How we culture cells has implications for cell metabolism & beyond! With
@jasonrcantor.bsky.social @joycelyntan.bsky.social
authors.elsevier.com/a/1klN65WXUl...

Anyone interested in working with me at Institute of Metabolic Science - Metabolic Research Laboratories, University of Cambridge, on how AMGEN's new obesity drug MariTide works? I have a 3 year postdoc position available! Deadline March 31st! please share www.jobs.cam.ac.uk/job/50529/

excited to share a new preprint from our lab! led by the outstanding (& newly minted PhD) @thebiokimist.bsky.social we first uncover a basis for conditional HK2 essentiality in HPLM - leveraging this dependence then leads us to distinct rationale underlying why the Warburg Effect is beneficial!

Don’t miss this unique meeting bringing together leading Swedish researchers and practitioners in diabetes to share the latest advancements in diabetes research
👉 lnkd.in/dbbh6vcd
Hope to see you in Umeå!

Pleased to announce a BBSRC-funded research associate position in my lab to study resolution of inflammation here in Sheffield. Closing date=13/2, pls get in touch for more info and pls share! www.jobs.ac.uk/job/DLQ588/r... #Drosophila #macrophages #CellBiology @fohsheffield.bsky.social