Eurico Morais-de-Sá

Cartoon with principle of Flash-away and images of cells

FLASH-AWAY: Intrabody-Directed Targeting of Optogenetic Tools for Protein Degradation: pubs.acs.org/doi/10.1021/...

It’s time to talk about epithelial geometry and cancer. How can the architecture of an epithelium affect how tumors will grow and spread? In this thread, @jorgealmagro.bsky.social

Job Alert! The Institute for Neuro- and Behavioural Biology at the Faculty of Biology @uni-muenster.de invites applications for a Full Professorship (W3) in “Systems Neuroscience” - Highly attractive research environment at the Multiscale Imaging Center. Apply by January 5th. See shorturl.at/VczFp

🚨Our collaboration with @centriolelab.bsky.social & @gautamdey.bsky.social is out today in @cp-cell.bsky.social
We show that #Expansion #Microscopy is a broad-spectrum modality for Euks, enabling 3D phenotypic maps rooted to phylogeny.
#ProtistsOnSky #SciComm #SciSky

www.cell.com/cell/fulltex...

Polo kinase inhibits protein phosphatase 1 to promote the spindle assembly checkpoint and prevent aneuploidy Protein phosphatase 1 (PP1) is essential for spindle assembly checkpoint (SAC) silencing and mitotic exit, but its regulation during mitosis remains i…

Our latest research in collaboration with @nilssonlab.bsky.social, @andrea-musacchio.bsky.social and Mathieu Bollen reveals a new regulatory strategy employed by cells to control PP1 in mitosis. Check it out in @currentbiology.bsky.social

www.sciencedirect.com/science/arti...

Interested in cell migration and developmental biology-check out this PhD opportunity!

www.findaphd.com/phds/project...

So: can a cell hold hands with itself…and do we care? YES and YES! Read on to learn WHY, HOW, and what this has to do with…PARIS (and tree-hugging)? Swansong of Dr. Anamika; Hannah Kim on drums; and fantastic undergrads (Margaret/Lauren) ! 1/n
advanced.onlinelibrary.wiley.com/doi/10.1002/...

See this? This = implanting mouse embryo. Usually this happens inside its mother and is invisible to us, but we can actually watch implantation ex vivo with the hope of understanding why implantation goes awry in embryos of older women. A 🧵...

🧵1/14 Preprint thread! Can we predict a cell’s fate based on its dynamics? 🔮 Our new study unveils a framework for watching development unfold in real-time, revealing how a cell's shape and movement encode info about its future fate. 🔬📄 Preprint: tinyurl.com/4shf8v4x

How can we use cell shapes and geometry to study mechanics of tissues?

I'm @juliaeckert.bsky.social, and with this thread, I would like to show you the secrets of cells and tissues. Let’s connect biology with a little bit of physics. Don't be scared and get inspired 😀. #EpithelialMechanics

Our new collection offers cell biologists practical, expert-driven guidance and best practices in the design, execution, and analysis of experiments, and the subsequent communication of their results to their peers. 👉 rupress.org/jcb/collecti...

#Reproducibility

Advancing cancer research via comparative oncology Nature Reviews Cancer - Comparative oncology combines evolutionary biology, ecology, veterinary medicine and clinical oncology to better understand cancer, for example, by identifying the molecular...

Happy to share a new publication: an introduction to comparative oncology in @natrevcancer.nature.com‬. Thanks to the leaders in the field for welcoming me as an invertebrate researcher.
rdcu.be/etKdN

Epithelial morphogenesis is all about how epithelial tissues develop unique shapes and structures! I'm @nehaghosh.bsky.social and will share some research in this area.

A Drosophila single-cell 3D spatiotemporal multi-omics atlas unveils panoramic key regulators of cell-type differentiation This work introduces Flysta3D-v2, a 3D spatiotemporal multi-omics database that spans Drosophila development from embryogenesis to metamorphosis. Through the integration of multimodal data, we detail ...

A Drosophila single-cell 3D spatiotemporal multi-omics atlas unveils panoramic key regulators of cell-type differentiation: Cell
1/2

www.cell.com/cell/abstrac...

FINALLY out in #Science Advances! 🎉
3 years of hard work, a fantastic team — and I’m proud to be first and co-corresponding author!

It's about Plexin signaling driving collective cell migration & organ sculpting. Check out the videos 😀

www.science.org/doi/10.1126/...

#DevBio #CellBio #Microscopy

Intestinal permeability significantly increased 30 days prior to death in AKR/J females

Fat mass decreases significantly in the last month of life

body temperature drops significantly in the last month of life

extremely happy to present the final version of our "smurf mice" paper www.biorxiv.org/content/10.1..., led by Céline Cansell when she was a postdoc in my group (now an independent @inrae-france.bsky.social researcher).
Disclaimer: no blue mice here alas BUT clearly a biphasic ageing process

Cartoon showing a woman looking in to a microscope saying "Whoaah!!!" The caption states "The best part of Science is knowing, for a moment, something that nobody else in the world knows"

A reminder in these hard times. #sciencestrong

Interphase cell morphology defines the mode, symmetry, and outcome of mitosis During tissue formation, dynamic cell shape changes drive morphogenesis while asymmetric divisions create cellular diversity. We found that the shifts in cell morphology that shape tissues could conco...

My first post on Bluesky! Very excited to share our work just published in @science.org. We find that “Interphase cell morphology defines the mode, symmetry, and outcome of mitosis” - in angiogenesis and other tissues! www.science.org/doi/abs/10.1... www.science.org/doi/abs/10.1...

#EDRC2025 👇🏻👇🏻👇🏻👇🏻

Program and application instructions for the 2025 Mechanobiology of tissue morphogenesis and disease workshop in Baeza, Spain, October 21-23. Apply at https://www.unia.es/estudios-y-acceso/oferta-academica/formacion-continua/workshop-mechanobiology-of-tissue-morphogenesis-and-disease

Interested in Developmental Mechanics??? We are organizing a mechanobiology workshop in Baeza, Spain, October 21-23, 2025. Come join us (and please help us spread the word)!!!

#CellMigration 𝐢𝐧 𝐯𝐢𝐯𝐨!
Excited to share this video on #FluorescenceFriday 🌈
Today as a GIF to circumvent video compression 😅!

Migratory Nascent Myotubes on #Drosophila Testes. Marker: Lifeact-eGFP. Scope: 980 Airyscan (@zeiss-microscopy.bsky.social)

#cellbio #sciart #devbio #science #microscopy

Poster for the meeting including speaker list and location

Cell and developmental biologists: as you start looking at conferences in 2025, consider joining us at the 2025 Cell Contact & Adhesion GRC. We've assembled a strong and diverse program of speakers at the cutting-edge of science in our field 1/n Please repost
www.grc.org/cell-contact...

1/14 “Epithelial” & “Mesenchymal” aren’t binary categories—they form a spectrum, or better yet, a multidimensional space. This becomes especially clear in collective cell migration, which often depends on a finely tuned degree of “mesenchymal-ness”.

#cellbio #devbio #cellmigration

Muitos Parabéns Jorge! Isso tem que ser celebrado🍾

Proximity-based activation of AURORA A by MPS1 potentiates error correction Faithful cell division relies on mitotic chromosomes becoming bioriented with each pair of sister kinetochores bound to microtubules oriented toward o…

I'm happy to share our study “Proximity-based activation of AURORA A by MPS1 potentiates error correction” now published at @currentbiology.bsky.social

www.sciencedirect.com/science/arti...

It describes a new way kinetochores and centrosomes communicate to ensure accurate chromosome segregation.

If using Bloomigton #Drosophila Stock Center stocks, pls. acknowledge them & their NIH funding (P40 OD018537). Papers listing this no. are being harvested as evidence. We massively depend on the @bdsc.bsky.social & they need our support in these dire times! @flybase.bsky.social @fly-eds.bsky.social

Same for ZFIN! @zfinmod.bsky.social put them in your papers' acknowledgements and cite them (Bradford et al. 2022 academic.oup.com/genetics/art...)

We’re excited to share our work where we investigated the mechanisms of chromosome motion by tracking all #chromosomes, mapping their interactions, and live cell karyotyping, using #AI based denoising, segmentation and registration, published in Nature Cell Biology.
www.nature.com/articles/s41...

Genetically encoded reporters of actin filament organization in living cells and tissues Tailoring genetic fusions of widely used actin localization reporters by constraining the mobility of the fluorescent proteins allows measurements of actin filament organization in living cells and ti...

Genetically encoded reporters of actin filament organization in living cells and tissues: Cell www.cell.com/cell/fulltex...

Great team effort from our SGR group “REGnetREG” . Find out more by downloading this review 👇🏻👇🏻👇🏻