Blanca González (@blancagonzalez) — Bluesky Profile

4 months ago

Staff discontent with leadership continues to grow at Ohio State’s Wexner Center for the Arts – Matter News In late August, 13 employees at the Wexner Center signed on to a letter sent to university officials in which they expressed a vote of no confidence in the leadership of executive director Gaëtane Ver...

matternews.org/community/st...

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7 months ago

Figure 1 Cumulative incidence of invasive Candida infections overall (A), by solid organ transplant type (B), site of infection (C-E; candidemia, intra-abdominal, other), and Candida spp. (F-G; C.albicans, non-albicans Candida spp.). Abbreviations: CE, competing event; C, censored.

This figure shows highest incidence among kidney/pancreas > lung >= liver > heart > kidney. Rates of intra-abdominal candidiasis are higher than those of candidemia

Figure 2 One-year cumulative incidence of invasive Candida infections by transplant period from 2008 until 2020 overall (A) and by solid organ transplant (SOT) type (B). Abbreviations: CE, competing event; C, censored. For the period 2017-2020, no events were observed in pancreas/pancreas-kidney transplant recipients.

This figure shows that cumulative incidence of IC over the first year post transplant has decreased over successive periods from 2008-2012, 2013-2016, 2017-2020. This was statistically significant for all SOTs but not for subgroups

Invasive Candida infections in solid organ transplant recipients between 2008 and 2020

From the Swiss Transport Cohort Study

High rates of IC, predominately intra-abdominal, with decreasing incidence during the study period. Mortality remains high

www.amjtransplant.org/article/S160... #TxID

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7 months ago

115. The Yeasts: PCP/Pneumocytis jirovecii - ID:IOTS - Infectious Disease Insight Of Two Specialists Listen to this Pretty Comprehensive Pod on PCP. Alyssa and Callum cover:EpidemiologyTaxonomy (PCP vs PJP?)Diagnosis TreatmentNote this pod episode also includes some Positively Jolly Puns on...

call it PCP - you might come across as a relic

call it PJP - you may seem cleverish

either way, don't call it PCP-pneumonia or PJP-pneumonia - you will come across as redundant redundant

this @idiots-pod.bsky.social is a great review of the clinical aspects of pneumocystis infections.

#idsky

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7 months ago

Narrative review on fungal diagnostics @cmijournal.bsky.social

doi.org/10.1016/j.cm...

#IDSky

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7 months ago

Oral washes and tongue swabs for Xpert MTB/RIF Ultra-based tuberculosis diagnosis in people with and without the ability to make sputum Oral samples show promise for tuberculosis (TB) diagnosis, but data from different sample types and sputum-scarce individuals remain limited.

Oral washes and tongue swabs for Xpert MTB/RIF Ultra-based tuberculosis diagnosis in people with and without the ability to make sputum

✅ Just Accepted
⭐ Editor's Choice
#IDSky

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7 months ago

Implementation of Diagnostic Stewardship to Improve Urinary Tract Infection Antibiotic Use Across Three Medical Centers Overdiagnosis of urinary tract infections (UTIs) and unnecessary antibiotics are common. This is particularly true in older adult populations such as Veterans. Diagnostic stewardship can decrease overdiagnosis and overtreatment, but optimal implementation of such interventions has not been fully studied.MethodsThis was a multicenter hybrid type two effectiveness-implementation study of UTI diagnostic stewardship interventions at three participating VA hospitals. Each hospital implemented one intervention at either the ordering, processing (conditional reflex urine culturing) or reporting stage. The primary outcome was inpatient UTI antibiotic days of therapy (DOTs) per admission evaluated using generalized estimating equations. Secondary outcomes included rates of urine cultures ordered and performed and, a safety measure of secondary bacteremia from a uropathogen.Results37,085 hospital admissions occurred in the pre-intervention phase and 17,221 in the post-intervention phase. Of these, 6,914 (12.7%) included UTI antibiotics. Hospital 3, which implemented conditional reflex urine culturing had a 39.5% reduction in UTI DOT (95% confidence interval (CI), 13.9%, 57.5%) in the year following the intervention. Additionally, hospital 3 noted fewer urine cultures ordered (22.8% immediate and 35.7% slope reduction) and performed (38.9% immediate and 38.8% slope reduction). No change in UTI DOT was observed for ordering or results reporting interventions at other hospitals. There was no difference in the safety measure of uropathogen bacteremia.ConclusionsConditional reflex urine culturing had a large decrease on UTI antibiotic DOTs and urine cultures performed. Health-systems or medical centers starting urine culture diagnostic stewardship should implement conditional reflex urine culturing first.

In a study of 54,306 admissions, conditional reflex urine culturing reduced UTI antibiotic days by 39.5% (6,914 had UTI antibiotics). No safety issues noted. 🚫💊📉

#idsky

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7 months ago

Outbreak of Salmonella Typhimurium Infections Linked ... This report describes a Salmonella outbreak linked to ...

The CDC describes this salmonella outbreak as “one of the largest foodborne outbreaks linked to raw milk in recent U.S. history.” Out of the 171 people who got sick, 70% were children. The median age was 7 years old. Even worse, 18 children had to be hospitalized. Please do not consume raw milk.

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7 months ago

Fungal meningitis in U.S. Patients who Received Epidural Anesthesia in Matamoros, Mexico Fungal meningitis outbreaks are rare and entail high mortality rates. Beginning May 2023, we investigated fungal meningitis caused by Fusarium solani species complex occurring in U.S. patients who received epidural anesthesia in Matamoros, Mexico.MethodsEarly epidemiological information suggested U.S. patients with suspected fungal meningitis had undergone mostly cosmetic procedures under epidural anesthesia performed in two Matamoros clinics. U.S. patients known to have received surgery at these clinics during January 1–May 13, 2023, (clinic closures date) were identified and notified by public health officials. Epidemiological and clinical data were used to update diagnostic and clinical guidance for outbreak response, including use of the experimental antifungal fosmanogepix. Whole genome sequencing was conducted on outbreak isolates.ResultsU.S. public health officials attempted to contact 233 potentially exposed U.S. residents who underwent surgeries, mostly cosmetic, in Mexico, reaching 170 (73%). Of those, 104 (61%) reported receiving epidural anesthesia and were therefore considered potentially at risk for fungal meningitis. At least 30/104 (29%) at-risk patients received a diagnostic lumbar puncture; 24 (23 women, 17 Hispanic or Latino) were diagnosed with fungal meningitis, and six were not. Twelve (50%) with fungal meningitis died. All cases involved epidural anesthesia administered by the same anesthesiologist in Mexico. Whole genome sequencing showed that patient isolates of Fusarium from the two implicated clinics in Matamoros, Mexico, were genetically closely related.ConclusionsClinicians should maintain suspicion for fungal meningitis in patients with negative bacterial culture, viral culture and molecular testing with a history of epidural anesthesia for any reason.

🦠 Fungal meningitis outbreak in U.S. from May 2023 linked to 233 patients in Mexico; 170 contacted (73%). 104 (61%) at risk, 24 diagnosed, 12 (50%) died. All cases from same anesthesiologist.

#idsky

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7 months ago

Characteristics and outcomes of ICU patients with sepsis transmitted by cats and dogs: the PETSEPSIS multicentre retrospective observational cohort study - Critical Care Millions of households have cats or dogs as pets, and infections due to bites or scratches are increasing, with the most common pathogens being Pasteurella spp., Bartonella spp., Capnocytophaga spp, a...

“PETSEPSIS” out today which evaluated ICU admissions for 🇫🇷 pts w/ 🐕 🐈 bites

10 yrs, 46 ICUs
174 pts, median age: 64

Micro:
1) Pasteurella spp. (70%)
2) Capnocytophaga spp. (16%)

24% in hospital 🏥 mortality

Rare infections, ⬆️ mortality

#IDSky

ccforum.biomedcentral.com/articles/10....

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7 months ago

Please share!

Amazing opportunity at @mcgill.ca

We are looking to recruit an internationally recognized, interdisciplinary scientist with a strong track record in innovation and research to direct a new program in climate, environment, and health

mcgill.wd3.myworkdayjobs.com/en-US/McGill...

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9 months ago

Happy Friday! A new episode is now available. Want to learn more about aztreonam-avibactam? Check out this episode. Link in comments.

#microbiology

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10 months ago

Texas measles total tops 700 cases amid rises in other states

Also, health departments in Illinois, North Dakota, and Missouri reported more measles cases.

www.cidrap.umn.edu/m...

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10 months ago

We don’t need to de-escalate antibiotic therapy.
We need to optimize antibiotic therapy.
#IDSky #MedSky

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10 months ago

2025 CDC HIV postexposure prophylaxis regimens
✅BIC/TAF/FTC
✅DTG + TAF (or TDF) + FTC (or 3TC)
www.cdc.gov/mmwr/volumes...
#IDSky #MedSky #HIVSky

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10 months ago

#idboardreview A pt presents w/Fever & finger tip ulcer where she pricked herself 1 wk earlier with ‘goathead’ plant while weeding in her garden. Recently went hunting & skinned rabbits 2 wks ago. Blood culture with faint gram negative coccobacilli. #meded #idmeded #IDsky

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10 months ago

As a nontenured clinician with an academic appointment, is becoming a full professor an ego thing or something one should aspire to ?

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10 months ago

Plasma Microbial Cell-free DNA Metagenomic Sequencing for Diagnosis of Invasive Fungal Diseases Among High-risk Outpatient and Inpatient Immuno New and minimally invasive tools to aid the diagnosis of invasive fungal diseases (IFD) are urgently needed as the immunocompromised population at highest risk increases. Advancements in molecular technology have rendered new diagnostics more readily available for clinical use.

Plasma Microbial Cell-free DNA Metagenomic Sequencing for Diagnosis of Invasive Fungal Diseases Among High-risk Outpatient and Inpatient Immunocompromised Hosts

#IDSky

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10 months ago

Since 2000, 2.2 billion malaria cases and 12.7 million deaths have been averted.

It’s #WorldMalariaDay
The good news: 2.2 billion #malaria cases and 12.7 million deaths have been averted since 2000.
The bad news: after years of steady declines, progress has stalled.
bit.ly/MalariaDay2025

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10 months ago

Patient Age and Antibiotic Formulation Administration in the Pediatric Emergency Department - PubMed We identified age-related differences in antibiotic formulations in a pediatric ED. These findings can inform prescribing practices to optimize medication adherence and treatment effectiveness through...

What age do you prescribe tab/caps instead of suspension for antibitotics? In my practice, I usually see around 7-8 yo (except amox/clav due to formulation issues). This study showed it was much older. 50% Rx tab/cap median 10-14 yo. pubmed.ncbi.nlm.nih.gov/40223565/ #PedsIDsky #Rxsky #IDsky

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11 months ago

Severe Parvovirus B19 associated myocarditis in children in the post COVID-19 era: a multicentre observational cohort study AbstractThis study describes a cluster of severe Parvovirus B19 associated myocarditis in children across England in the context of an increase in circulating virus. Cases were identified across three large children’s centres. Eight cases presented during 1/1/19–31/12/23 compared with 19 during 1/1/24–31/08/24. Almost all (n=25, 93%) required intensive care and 24 (88%) received inotropes and 4 (15%) ECMO. Myocarditis appears to be temporally associated and a late sequalae of Parvovirus B19 resulting in high rates of ICU admission. Testing (using serology and blood PCR) should be part of syndromic screen for all children with severe myocarditis.

🩺 Study found 8 severe myocarditis cases (1/19-12/23) vs. 19 (1/24-8/24) in kids. 93% needed ICU, 88% inotropes, 15% ECMO. Testing for Parvovirus B19 is crucial.

#idsky

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11 months ago

Ceftazidime/avibactam for the treatment of bloodstream infection due to carbapenemase-producing Enterobacterales in onco-haematologic neutropenic patients (the TARZAN study) AbstractObjectives. To assess the clinical features, antibiotic therapy and outcomes of carbapenemase-producing Enterobacterales bloodstream infection (CPE

Ceftazidime/avibactam for the treatment of bloodstream infection due to carbapenemase-producing Enterobacterales in onco-haematologic neutropenic patients (the TARZAN study)
Enric Sastre-Escolà, et al.
Journal of Antimicrobial Chemotherapy, dkaf120, doi.org/10.1093/jac/...

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11 months ago

Fosmanogepix for the Treatment of Invasive Mold Diseases Caused by Aspergillus Species and Rare Molds: A Phase 2, Open-Label Study (AEGIS)

academic.oup.com/cid/advance-...

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1 year ago

Social Media Savvy, It's More Than Just the #Hashtags: How the Use of Social Media in Transplant Infectious Diseases Can Impact the Field and Patients

‼️Our new paper on social media in #TxID is officially out in @thetxidjournal.bsky.social

We summarize findings from our #TxIDChat @txidfellows.bsky.social

We discuss recs for trainees, career advancement, & future directions in this changing landscape. Check it out!

dx.doi.org/10.1111/tid....

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1 year ago

Post-discharge prescriptions should be a key focus for #AMSsky!

In her fantastic talk at #ESCMIDglobal, @valerievaughnmd.bsky.social showed how >90% of antibiotic duration excess occurs post-discharge!

The ROADhome framework can be helpful for this task 👉🏻 academic.oup.com/cid/article/... #IDSky

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1 year ago

www.thelancet.com/journals/lan...

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1 year ago

Predictors of Cryptococcus gattii clinical presentation and outcome: An international study AbstractBackground. Infection by Cryptococcus gattii can lead to pulmonary or central nervous system (CNS) disease, or both. Whether site of infection and

academic.oup.com/cid/advance-...

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1 year ago

Not for those of us who were wronged by Jimmy Carter and his foreign policy . 26 years of dictatorship, death and sorrow in Venezuela will are not easily forgotten or forgiven .

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1 year ago

Celebrating with our adult and peds fellows last night

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1 year ago

I just paid 3000 dollars between several societies and MOC 😭😭

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1 year ago

8 of lowest 9 are pediatric (geriatrics hanging out with us) #PedSky #PedsID

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