Cientounero

First-Trimester COVID-19 Vaccination Not Associated With Congenital Risks | Vaccination | JAMA | JAMA Network

https://jamanetwork.com/journals/jama/fullarticle/2841011

SARS-CoV-2 reinfection is associated with impaired TCR diversity and distinct clonal expansion patterns, underscoring the role of T cell immunity in reinfection susceptibility. healthy convalescent-enriched TCR clusters may represent protective memory responses, whereas primary SARS-CoV-2 […]

COVID-19 mRNA vaccines can trigger the immune system to recognize and kill cancer, research finds The researchers found that mRNA-based COVID-19 vaccines could potentially help patients whose tumors don’t respond well to traditional immunotherapy.

COVID-19 mRNA vaccines can trigger the immune system to recognize and kill cancer, research finds | Live Science

https://www.livescience.com/health/cancer/covid-19-mrna-vaccines-can-trigger-the-immune-system-to-recognize-and-kill-cancer-research-finds

Open-source protein structure AI aims to match AlphaFold

The system, called OpenFold3. OpenFold3 uses proteins’ amino acid sequences to map their 3D structures and model how they interact with other molecules, such as drugs or DNA.

The tool still doesn’t have the same functionality as […]

Another reason to not get Covid

COVID Linked to Eye Issues, Vaccine Offers Protection

Patients with COVID had a higher risk of developing diplopia and cranial nerve VI palsy than those with influenza. Compared with unvaccinated patients, recipients of mRNA vaccines against SARS-CoV-2 had more […]

The entire Western Pacific has been verified free of measles and rubella. The WHO has verified the elimination of both diseases in all Pacific Island countries, alongside rubella elimination in Japan. The achievement follows two decades of coordinated immunisation campaigns, regional […]

Dressing up in a frog costume has to be the brightest stroke of genius I've seen to combat fascism on the ground. When you're dressed in black with a gas mask on, and shouting angry slogans, the perception is you're an enemy combatant thus making the use of force more palpable. When you use […]

Whopper of the Week: RFK Jr. is Dead Wrong Babies Won't Get Hepatitis B | Defend Public Health RFK Jr does not want the CDC to recommend newborns be vaccinated against the Hepatitis B virus (HBV). HBV infection early in life, especially as a baby, puts a person at a high risk of developing a chronic lifelong liver infection, which in a quarter of cases can lead to fatal liver failure or cancer. The hepatitis B vaccine for newborns is safe and effective; and it gives durable lifelong protection against a serious infection that children can encounter during birth, and throughout their lifetime in their families and communities.

The #RFKJr Whopper of the Week: He's dead wrong about #HepatitisB #vaccines. https://www.defendpublichealth.org/opinion/whopper-week-rfk-jr-dead-wrong-babies-wont-get-hepatitis-b

Nobel Prize in Physiology or Medicine 2025 The Nobel Prize in Physiology or Medicine 2025 was awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

Nobel Prize in Physiology or Medicine 2025 - Popular information - NobelPrize.org

https://www.nobelprize.org/prizes/medicine/2025/popular-information/

FYI, the best place to check and see what that cool fireball you saw in the sky was, is this website: https://fireball.amsmeteors.org/members/imo_view/browse_events

You can even report your sightings! This helps scientists to find meteorites, though I think a lot of the sightings now are […]

KI entwickelt erstmals Viren – und sie können bereits Bakterien töten | heise online
https://heise.de/-10663089 #KI #Virus #Viren #Genom

Highway filled with cars

Wide urban arterial filled with cars

Wide one-way street in a downtown filled with cars

Highway filled with cars

Bike-lanes don’t cause traffic congestion.

Car dependency, foolish land-use sprawl, too many (& bigger) cars driving too much taking up too much space, highly subsidized driving costs, and not enough choices in how to get around, ALL cause traffic congestion.

Think about it. THAT’S common sense.

Antibody titers declined more rapidly postvaccination than post-mpox, with most vaccinated recipients, particularly PWH, losing seropositivity at 2 years.

Antibody Responses are Sustained 2 Years Post-Mpox Infection but not Following Modified Vaccinia Ankara–Bavarian Nordic Vaccination […]

The multi-kingdom cancer microbiome. Review | Nature Microbiology

"the use of deep sequencing technologies and computational pipelines has led to reports of multi-kingdom microbial communities in a growing list of cancer types. This has prompted discussions on the role and scope of microbial […]

Management of Staphylococcus aureus Bacteremia: A Review | Infectious Diseases

"Empirical antibiotic treatment should include vancomycin or daptomycin, which are active against MRSA. Once S aureus
susceptibilities are known, MSSA should be treated with cefazolin or an antistaphylococcal […]

Accuracy of leukocyte esterase and nitrite tests for diagnosing bacteriuria in older adults: A systematic review and meta-analysis. - CMI

"A positive dipstick result is inconclusive and does not confirm bacteriuria or UTI in symptomatic older adults. Due to high asymptomatic bacteriuria […]

Europe’s largest paper mill? 1,500 research articles linked to Ukrainian network A group of companies has flooded 380 journals with hundreds of suspect papers since 2017.

Europe’s largest paper mill? 1,500 research articles linked to Ukrainian network.

A group of companies has flooded 380 journals with hundreds of suspect papers since 2017.

https://www.nature.com/articles/d41586-025-02809-y

"In this review, we explore the utility of oral β-lactams for the treatment of systemic gram-negative infections through 3 hypothetical case scenarios common to clinical practice and the decision processes used to select or avoid these agents."

Navigating the Muddled Middle: A Case-Based […]

Repeated heatwaves can age you as much as smoking or drinking.

Long-term study suggests that the more heatwaves people are exposed to, the more it accelerates body ageing.

This is the latest study to show that extreme heat can have invisible effects on the human body and accelerate the […]

Repeated heatwaves can age you as much as smoking or drinking.

Long-term study suggests that the more heatwaves people are exposed to, the more it accelerates body ageing.

This is the latest study to show that extreme heat can have invisible effects on the human body and accelerate the […]

Previous H1N1-2009 infection may be protecting against severe H5N1 infection | JAMA | JAMA Network

https://jamanetwork.com/journals/jama/fullarticle/2838096

If maternal measles antibodies are still present, the vaccine is less likely to produce an immune response.

Research has also shown a measles vaccine given at less than 8.5 months of age can result in an antibody response which declines more quickly. This might be due to interference with […]

Revisiting diagnostics: discarding the urine dipstick is way overdue - Clinical Microbiology and Infection

"Preliminary experience after complete removal of #urinedipsticks from emergency departments of all hospitals providing acute care in North Denmark Region showed an approximate 20% […]

Evidence for Selection of Doxycycline Resistance in Staphylococcus aureus in Doxycycline Preexposure Prophylaxis Study

"We conclude that the data from these 2 studies are compatible with doxyPEP/PrEP selecting for antimicrobial resistance in S. aureus at both individual and population levels" […]

Harvard PhD Graduates To Propel Scientific Discovery at a Pivotal Moment

https://hms.harvard.edu/news/harvard-phd-graduates-propel-scientific-discovery-pivotal-moment

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Highlights from the penicillin study:

Penicillin was noninferior to flucloxacillin in 90-day mortality (13.8% vs 21.5%, respectively) — and might have been superior with a larger sample size.
Significantly lower rates of acute kidney injury with penicillin.
If your lab is conducting […]

SNAP Trial Helps Resolve Long-Running Controversies Over Management of Staph Bacteremia -

Highlights from the cefazolin study:

Cefazolin was noninferior to flucloxacillin for 90-day mortality in MSSA bacteremia — 15.0% and 17.0%, respectively.
Acute kidney injury rates were lower in the […]

"Antimicrobial use in end-of-life settings can have adverse effects, which range from allergic reactions, mental status changes, gastrointestinal issues, drug–drug interactions, and Clostridioides difficile infection to end-organ dysfunction."