Etienne Becht

Your yearly reminder to acknowledge the core facilities you use and their staff scientists in your papers. These scientists are a crucial part of the scientific ecosystem and to continue to exist they need tangible credit for their work. Plus their associated expertise adds credibility to your work.

🧪💻 We're hiring ! Post-doctoral position open for a data scientist

👉 Come work with us on high-throughput single cell protein expression data : drive.google.com/file/d/1w8Zv...

Unbelievable news.

Pancreatic is one of the deadliest cancers.

New paper shows personalized mRNA vaccines can induce durable T cells that attack pancreatic cancer, with 75% of patients cancer free at three years—far, far better than standard of care.

www.nature.com/articles/s41...

6. found just enough strength to relay dread while being funny

That is no tiny victory.

I hope you find support until you are strong enough to support those who need it !

LCK–co-receptor association ensures T cell lineage fidelity and maximizes epitope-specific TCR diversity LCK-mutant mice help define the role of LCK–co-receptor association in T cell development and immune responses.

Our paper is out!
LCK–co-receptor association ensures T cell lineage fidelity and maximizes epitope-specific TCR diversity | Science Immunology www.science.org/doi/10.1126/...

CytoNorm 2.0: A flexible normalization framework for cytometry data without requiring dedicated controls Cytometry is a single cell, high-dimensional, high-throughput technique that is being applied across a range of disciplines. However, many elements alongside the data acquisition process might give r...

Flow cytometry batch effect correction without requiring normalization controls 🤩
onlinelibrary.wiley.com/doi/full/10....

Mapping the nanoscale organization of the human cell surface proteome reveals new functional associations and surface antigen clusters The cell surface is a dynamic interface that controls cell-cell communication and signal transduction relevant to organ development, homeostasis and repair, immune reactivity, and pathologies driven b...

Excited to share this new work led by postdoc Brendan Floyd, deep mapping of cell-surface protein interactomes of T and B cells reveals maverick mitochondrial proteins and immune modulatory complexes.

www.biorxiv.org/content/10.1...

Thanks to those who politely pointed out we initially made a list of Metastasis Researchers... we've now made a starter pack! ☺️

go.bsky.app/KasKkhK

Drop us a message or reply here to be added.

More to follow over the coming days.

🦋

tagtango: an application to compare single-cell annotations AbstractSummary. In this article, we present tagtango, an innovative R package and web application designed for robust and intuitive comparison of single-c

Our collaborators @rgottardo.bsky.social and Ken Stuart (+ others) describe tagtango, an application to compare #single-cell annotations.
#bioinformatics
academic.oup.com/bioinformati...

GZMK-expressing CD8+ T cells promote recurrent airway inflammatory diseases - Nature Comparing T cells in nasal polyps from repeated surgeries shows that effector memory-like persistent clones colonize the mucosal tissue during disease recurrence and promote inflammation by producing ...

So THAT'S what Granzyme K does-- cleave complement and promote inflammation in the airway. Fascinating!
#ImmunoSky #AsthmaSky
#InflammationSky
www.nature.com/articles/s41...

La FHU* MOSAIC² relabellisée pour 5 ans !

Félicitations à la Pr Valérie Paradis et ses équipes qui portent ce FHU, illustrant l’engagement de l'Institut du Cancer en faveur de la recherche !

Plus d'informations sur le projet prochainement.

@hopitalbeaujon.bsky.social @ap-hp.bsky.social

Luo et al. developed ATLAS-seq (Aptamer-based T-Lymphocyte Activity Screening and Sequencing), a microfluidic-based high-throughput platform for isolating and profiling antigen-reactive T cells. bit.ly/4fThnwo

Mutations disrupting the kinase domain of IKKα lead to immunodeficiency and immune dysregulation in humans
@jem.org‪
@quentinriller.bsky.social @frl-lab.bsky.social
doi.org/10.1084/jem....

Isabelle Cremer on LinkedIn: Poste MCU immunologie-bioinformatique Un poste de maître de conférences en immunologie-bioinformatique est ouvert au concours à Sorbonne Université, au sein de la Faculté des Sciences et…

Permanent position (research and teaching) for a bioinformatician immunologist available in a great lab and institute, in a beautiful campus in the center of Paris

www.linkedin.com/posts/isabel...

Evaluating data requirements for high-quality haplotype-resolved genomes for creating robust pangenome references - Genome Biology Background Long-read technologies from Pacific Biosciences (PacBio) and Oxford Nanopore Technologies (ONT) have transformed genomics research by providing diverse data types like HiFi, Duplex, and ult...

Evaluating data requirements for high-quality haplotype-resolved genomes for creating robust pangenome references. #GenomeAssembly #HaplotypeResolved #Pangenomes #Genomics #GenomeBiology 🧬 🖥️
genomebiology.biomedcentral.com/articles/10....

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

🌟 Calling all computational biology enthusiasts! 🌟 The awesome @remynicolle.bsky.social & friends created this Discord community to connect, collaborate, and share insights in this rapidly evolving field.

👉 Click here to join : discord.gg/2PzSE4dC

#Bioinformatics #ComputationalBiology

I’ve tried to put together a starter pack of immunologists/scientists exploring B Cell Repertoires and Antibody Affinities.

Please feel free to share/join!

go.bsky.app/4P64DmM

High content of nuclei-free low-quality cells in reference single-cell atlases: a call for more stringent quality control using nuclear fraction - BMC Genomics The advent of droplet-based single-cell RNA-sequencing (scRNA-seq) has dramatically increased data throughput, enabling the release of a diverse array of tissue cell atlases to the public. However, we...

Not checking nuclear markers like MALAT1 or intronic reads in your scRNA-seq data?🚨
We show their power to flag low-quality cells—even in top public datasets. It’s time to prioritize better QC for cleaner, more reliable genomics research!
Read more: bmcgenomics.biomedcentral.com/articles/10....
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I made a starter pack for single cell and spatial people on BlueSky! 🧬🧪🥳

I’m certain it’s very incomplete, so please just let me know if you’d like to be included 😊

go.bsky.app/U57Mar8

Thanks @tsanglab.bsky.social for putting this together! #immunology #datascience

go.bsky.app/PjH2Fuj

Ok, I tried to create my own list of people working on developing statistical or machine learning models applied to omics data. I am sure I missed a lot of cool people. If you'd like to be added, let me know. #Stats #ML #Omics
go.bsky.app/73rcuJn