Integrative CSF profiling identifies disease-specific immune responses in leptomeningeal disease
@cp-cellrepmed.bsky.social
www.cell.com/cell-reports...
Its definitely a cool story and has come a long way since the CSHL meeting. Decided against GRC in the end, would have loved to go, but with new students and postdocs starting wanted to make sure I was on hand for them. Major FOMO but hopefully will be back in a couple of years with an entourage 😁
Congrats Julie and Sophia! Looks great and the TNF data are particularly interesting! 🤩
![graphical schematic of the meninges on top depicting the three layers [dura, arachnoid and pia] and other immune and vascular cell types. Inset shows Claudin-11 junction proteins connecting two sides of arachnoid barrier cells
bottom schematic is the same but in inflammation with bacteria, junctions breakdown, depiction of cytokine release by vascular, meningeal and immune cells - at side of graphic is summary of defects we observe in infection: 'increased barrier permeability' 'mislocalization of Cldn11+ tight junction' 'BAM activation' and "increased inflammatory response'](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:ghkjazitflwyaczzoo6mwmld/bafkreig7atwvlrm776nsb46y2ctlhldvpkornt4kfr33iptb7eaidm32hm)
🚨 New preprint from our lab led by Sophia Kim w/ @kellydoran.bsky.social group @cuanschutz.bsky.social -- using neonatal 🐭 model of bacterial meningitis ➡️ arachnoid barrier is leaky, Cldn11 junctions are disrupted & cytokines are part of the problem. Lots of 🤩🧠🦠🔬 & compelling data, check it out! 1/5
Amyloidosis of bridging veins is a pathologic feature of #Alzheimers disease, from @leonsmyth.bsky.social, Rupal Mehta, @jonykipnis.bsky.social et al. rupress.org/jem/article/...
📘 In our #Lymphatics collection: rupress.org/jem/collecti...
How does inflammation kill neurons, and what can we do about it? Check out our latest paper where we consider this question: rdcu.be/e4nfP.
The Da Mesquita lab at Mayo Clinic (www.mayo.edu/research/lab...) is looking for a postdoctoral researcher to work on projects investigating the role(s) of the meningeal lymphatic vasculature in models of neurodegenerative diseases. Please spread the word and contact me in case you are interested! 😃
Base barrier cells provide compartmentalization of choroid plexus, brain and CSF | Nature Neuroscience
www.nature.com/articles/s41...
Review @natrevdrugdiscov.nature.com
Therapeutic targeting of neuroimmune mechanisms in neurodegeneration
www.nature.com/articles/s41...
First proof-of-concept for engineered T cells as a potential treatment for Alzheimer's disease
pnas.org/doi/10.1073/...
Yeah the morphology surely governing a lot of this, and perhaps the more limited set of junctional proteins that they express. Would be super cool to know more about the function!
Very interesting, the junction structure looks different too - lots of buttons… 🤔
ZO1 in the pia? 😮
Cell is hiring!
Do you have a background in #neuroscience or #immunology? Better still, #neuroimmunology? Cell has an opening for a full-time scientific editor. Role will be based out of any one of our offices in Medford, MA, UK, Spain, Netherlands, China tinyurl.com/4ma236xn @cp-cell.bsky.social
🙏🙏 to entire team esp co-lead Tim Bartels. So proud of @seppedeschepper.bsky.social brilliant first postdoc who now leads his own at VIB. 🙏🙏🙏to @chanzuckerberg.bsky.social for supporting the project from early pilot phase. Contact us if u want to explore next steps in PD gut/brain neuroimmunology!
Clonal CD8+ T cells populate the leptomeninges and coordinate with immune cells in human degenerative brain diseases
www.nature.com/articles/s41...
Congrats Ben and team! Beautiful work 🤩
We’re delighted to see this out today! Latest work from the lab reveals insights into the evolution of brain immunity and the developmental and evolutionary plasticity of lymphatic endothelial cells.
www.nature.com/articles/s41...
Fibroblastic reticular cells direct the initiation of T cell responses via CD44 @nature.com @the-de-lab.bsky.social
www.nature.com/articles/s41...
Diversity and immune dynamics of choroid plexus macrophages are shaped by distinct developmental origins @natneuro.nature.com Brioschi & Colonna
www.nature.com/articles/s41...
Preprint: Type I IFN activates border-associated macrophages to drive MHC-I–dependent immune surveillance after stroke
www.researchsquare.com/article/rs-8...
Macrophage immunosenescence prolongs intraocular inflammation in aged mice via impaired induction of regulatory T cells https://www.biorxiv.org/content/10.64898/2026.01.15.697975v1
Very common story from a follower👇
Even if you can avoid ARC’s ludicrously long time-scales & recruit via another country’s much more efficient system, you hit Australia’s immigration system.
Barrier after barrier. It’s YEARS between idea & starting the research in Australia.
The slooow country.
Congrats Caroline and all the authors! 🤩🤩🤩
3 papers in Cell @cellpress.bsky.social today exploring the mechanistic connection between Epstein-Barr virus and multiple sclerosis #MultipleSclerosis
cell.com/cell/fulltex...
cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
A genetically encoded reporter reveals interferon responses in multiple cell lineages https://www.biorxiv.org/content/10.64898/2026.01.08.698513v1
Review @cp-trendsimmuno.bsky.social
Decoding brain border immunity to enable future therapeutic avenues
www.cell.com/trends/immun...
Beautiful preprint by Maria Lehtinen's group on the impact of aging and Alzheimer's disease on the choroid plexus.
www.biorxiv.org/content/10.6...
Thrilled to share our new paper on reactive microglial plasticity! Using long-term fate mapping and epigenetic profiling, we uncover the remarkable plasticity of reactive microglia across the lifespan and the enhancers and associated TFs that govern state transitions.
