Lizzie Dellar

Great talk by Beatrix from the group on targeted long-read sequencing of the C9orf72 HRE at the ARUK Thames Valley Network Research Day in Oxford today #ALS #FTD

Extracellular vesicles in TDP-43 proteinopathies: pathogenesis and biomarker potential - Molecular Neurodegeneration Extracellular vesicles (EVs) are membrane-enclosed nanoparticles released by most cell types, and from multiple sub-cellular compartments. They carry a range of cargo biomolecules, including protein a...

#ExtracellularVesicles in #TDP43 proteinopathies: pathogenesis and #biomarker potential

Elizabeth R. Dellar @lizziedellar.bsky.social Lara Nikel, Stephanie Fowler...Alexander G. Thompson #exosome #ALS #FTD

molecularneurodegeneration.biomedcentral.com/articles/10....

Extracellular vesicles in TDP-43 proteinopathies: pathogenesis and biomarker potential - Molecular Neurodegeneration Extracellular vesicles (EVs) are membrane-enclosed nanoparticles released by most cell types, and from multiple sub-cellular compartments. They carry a range of cargo biomolecules, including protein a...

Very pleased to share our review in @molneurodegen.bsky.social, assessing evidence for #ExtracellularVesicle associated #TDP43. We highlight knowledge gaps relating to its biomarker usage and possible involvement in seeding of templated aggregation in #ALS, #FTD and #LATE.
doi.org/10.1186/s130...

😱 I’m with you on the Oreos but not custard creams!

En route for #ISEV2025! If you want to chat EV enrichment from #brain #blood and #CSF for biomarker discovery in neurodegenerative diseases, then come and find me later this week 🫧

Dr Yvonne Couch - Blog – Writing Your First Fellowship Dr Yvonne Couch shares wisdom (and warnings) on writing your first fellowship application — from timing and ideas to funding and salary tips.

“The time to write a fellowship is when it feels right for you.” Great advice from @dryvonnecouch.bsky.social’s new guest blog on writing your first fellowship.

www.dementiaresearcher.nihr.ac.uk/blog-writing...

Also contributing were Beatrix with her poster on long-read sequencing of #C9orf72 HRE and @lizziedellar.bsky.social with her poster on #ExtracellularVesicle -based biomarker discovery in CSF.

The @mndoxford.bsky.social team enjoyed the day at the Oxford #MDUK Neuromuscular Centre meeting yesterday. In the #ALS/#MND session Alex spoke on our
studies of at-risk pre-symptomatic populations, and Kevin on the path from pre-clinical models to experimental medicine.

Excellent talk by Lizzie @lizziedellar.bsky.social from the group on discovery and validation of early biomarkers in #ALS at the Oxford Neuroscience Symposium this week.

Come and work with me! Research position open to work on isolation of #extracellular #vesicles for biomarker discovery in #ALS #MND. See link for more details, and reach out if you have questions. my.corehr.com/pls/uoxrecru...

Come and join us! Research assistant position open at @mndoxford.bsky.social @ndcnoxford.bsky.social, working on collecting neuroimaging data in #ALS and #FTD. Previous research experience with humans is essential. This post would suit a #Psychology or #Neuroscience graduate. See link below for info

Thankyou!

We also have several group members giving platform talks as well as a plenary lecture! We would be delighted to see you there - see below for our presenters and talks #MND #ALS @mndassoc.bsky.social #alsmndsymp

We are excited to be here in Montreal for @mndassoc.bsky.social #alsmndsymp! We would be delighted to see you at our posters - see below for our presenters and poster numbers #MND #ALS

@mndoxford.bsky.social is now also here on Bluesky. Give it a follow to hear research updates from the whole Oxford MND Centre!

Tau filaments are tethered within brain extracellular vesicles in Alzheimer’s disease - Nature Neuroscience Using cryo-electron tomography (cryo-ET) and proteomics, this study identifies the tethering of pathological tau filaments within defined brain extracellular vesicles in Alzheimer’s disease, shining l...

Congrats to Steph Fowler and team for their excellent work showing the presence of tau filaments in #extracellularvesicles derived from brain tissue in Alzheimer's disease, out in @NatureNeuro today. www.nature.com/articles/s41... Excited to see more on this!

Dr Yvonne Couch - Is Leadership Important In Science? Dr Yvonne Couch talks about leadership in research, exploring different styles and approaches and how you might apply them.

Here's number 2:
(hopefully by now you have figured out where to find them and can head over and browse at your leisure!)
www.dementiaresearcher.nihr.ac.uk/guest-blog-i...

This week’s Science Without Anguish post is out: the slippery slope to imposter syndrome in research and how to escape it.

Please tell your colleagues on or off social media. 🧪

www.sciencewithoutanguish.com/blog/we-are-...

EV people unite! 😁

PXD051859 🚨

Elevated cerebrospinal fluid ubiquitin carboxyl-terminal hydrolase isozyme L1 levels in asymptomatic C9orf72 hexanucleotide repeat expansion carriers.

🚨 New dataset alert! 🚨

(3/3) We have much more work to do on this! Critically, we need to assess whether there is a longitudinal change in UCHL1 levels, and how this relates to timing of symptomatic disease.

(2/3) This could reflect an earlier phase of disease pathogenesis than that marked by elevation of NFL, but we do not know if it is part of a pathogenic or compensatory process.

Elevated Cerebrospinal Fluid Ubiquitin Carboxyl‐Terminal Hydrolase Isozyme L1 in Asymptomatic C9orf72 Hexanucleotide Repeat Expansion Carriers Objective To identify biochemical changes in individuals at higher risk of developing amyotrophic lateral sclerosis (ALS) or frontotemporal dementia (FTD) via C9orf72 hexanucleotide repeat expansion...

(1/3) Happy to share our new work assessing protein changes in CSF of 48 asymptomatic C9orf72 variant carriers at higher risk of #ALS and #FTD.

We find an elevation in levels of UCHL1 protein, even in the absence of elevation in #neurofilament (NFL).

onlinelibrary.wiley.com/doi/full/10....

Please add, thanks!