I built my company to fund this kind of research. This milestone belongs to the scientists, the team & to everyone who believed #fungi could help change the trajectory of #humanhealth
π Thank you for your support on this long but epic journey.
Please read the study & please share the science.
5/5
For years, conventional medicine has asked for placebo-controlled randomized clinical trials.
π― This is it.
We now have two clinical studies showing reproducibility. This is another scientific success from our team and a powerful step forward in validating #fungi through rigorous science.
4/5
To our knowledge, this is the 1st placebo-controlled human clinical trial demonstrating a fungal adjunct enhancing vaccine response.
#Immunogenicity increased. #Reactogenicity decreased.
πFungal #mycelium, ancient organisms w/ deep evolutionary intelligence, may offer a scalable, affordable...
3/5
... that was published in BMC Immunology today and highlighted by @ucsandiego.bsky.social, which found that a combination of #Agarikon + Turkey Tail #mycelium used alongside mRNA #COVID-19 #vaccination was safe, reduced vaccine side effects, and did not compromise antibody response.
2/5
π£ In a continuation of our 30 years of research, persistence & millions invested into natural products science, we have another announcement to share.
π° today.ucsd.edu/story/study-...
π link.springer.com/article/10.1...
We supplied this double-blind, placebo-controlled clinical trial...
1/5
... up as #mushrooms surge in popularity. What does the evidence show?
We looked at the efficacy of #mycofermented rice vs rice placebo & data from 2 recent randomized, controlled studies. The takeaway is that #immunesupport is not about overstimulation, but balance.
Thanks to all who joined!
2/2
Hey Folks!
On Feb. 19th, I presented a the Integrative Healthcare Symposium in NYC. I am grateful to have spent time w/ an inspiring community of clinicians & #integrative #health practitioners.
In my talk on #mushroom #mycelium & enhancing immunity, we explored a question that keeps coming...
1/2
*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
TM & Β© 2026 GDP
2/2
A legendary collab just dropped. ππ Grateful Dead Gummiesβ’βa legendary collaboration between Grateful Dead, mayself & Host Defense!
3 groovy organic mushroom mycelium-powered formulas, three distinct vibes, one far-out way to support your wellness.*
Learn more: hostdefense.com/pages/gratef...
1/2
π Hi #Myconauts
We did a lot of π foraging this year, from edible and choice species, to poisonous, and more! Thanks to all of you for coming along for the ride.
Canβt wait to see what fungi we find in 2026 !
#Mycelium #FungiSky #FungiFriends #MushroomSky
... #Mushrooms are complex organisms, and oversimplifying them leads to poor outcomes.
These results track with 2 recent double blinded clinical studies using mushroom #mycelium fermented rice - compared to a rice placebo, post ingestion.
Disclosure: I own Host Defense. The science is solid.
3/3
... The #mycelium extract supported a balanced, adaptable immune response. Under certain conditions, the fruiting body extract increased pro-inflammatory signaling.
As functional #mushrooms move into the mainstream, rigorous science, proper extraction & ingredient standardization are essential.
2/3
π£ New research: Lions Mane #Mycelium out performs Lions Mane Fruitbody.
A new article from Fungi Perfecti and Host Defense compared lionβs mane mycelium and fruiting body extracts, and the #immune responses were notably different.
Link to article: www.supplysidesj.com/immune-healt...
1/3
This work deepens our understanding of how #psilocybin may support mental #health by reshaping large-scale #brain connectivity.
π½οΈ Watch the video by Chris Hughes to learn more: www.youtube.com/watch?v=lZ3_...
3/3
.... effectively rewiring #neuralnetworks.
π As seen in this @cp-cellrepphyssci.bsky.social article: www.cell.com/cell/fulltex...
These changes were network-specific, strengthening pathways tied to perception and the brainβs default mode network, while quieting repetitive #cortical loops.
2/3
π£ A remarkable new study shows that a single high-equivalent dose of #psilocybin in mice can rapidly increase neuroplasticity by repairing and creating new neural connections in the #brain.
Researchers observed structural remodeling of #dendritic spines in the medial #frontalcortex...
1/3
You donβt get to assume #bioactivity from a species name. You test the actual preparation.
www.preprints.org/manuscript/2...
Important #disclaimer so nobody gets weird: this is a preprint and still under peer review. But the direction is clear enough to be interesting, and it reinforces something Iβve been saying for years:
6/7
Also notable: the #mycelium showed stronger #antioxidant and iron-chelating activity than the fruiting-body extract in this setup.
5/7
...extract. Under the same challenge, the fruiting-body extract nearly doubled IL-1Ξ², while the #mycelium drove it down. Same species, different material, different immune outcome. Thatβs a big deal for anyone who thinks βLionβs Mane is Lionβs Mane.β
4/7
... #mycelium prep consistently reduced classic stress cytokines like IL-1Ξ², TNF-Ξ±, and IL-8, while keeping baseline #cytokines low. In other words: modulate, donβt light the place on fire.
2) Tissue type matters. A lot.
They compared the mycelium to a Ξ²-glucan-enriched fruiting-body...
3/7
... and how it behaves in human immune cells under stress. Not a mouse, not a marketing deck. Actual PBMCs, transcriptomics, and cytokine readouts.
Two things jumped out at me:
1) Calm under challenge.
When immune cells were hit with an inflammatory LPS challenge, the Lionβs Mane ...
2/7
Hi Folks! Interesting reading comparing mushroom #mycelium vs mushroom fruit body extracts. π
Repost from Elan Sudberg:
The team behind Alkemist Labs long time friend and client, Paul Stamets / #HostDefense just posted a mechanistic paper on #LionβsMane ( #Hericiumerinaceus ) mycelium...
1/7
ππ The power of mushrooms ππ
Join @mayimbialik.bsky.social & I as we dive deep into the astonishing power of #fungi, #mycelium, and #psychedelic mushrooms to transform not just our #health, but our #consciousness, society & #planet
www.youtube.com/watch?v=XwCA...
#BialikBreakdown #bialikbreakdown
I adore a Clitocybe odora, the Anise #Mushroom
The smell of anise washed over & w/in us on a trail in a beautiful second conifer growth forest. It is edible but should be used sparingly because the flavor is so pronounced.
I wonder what would happen if you combined w/ fennel?
πΉ by Betsy Bullman
Speaking at the United Nations General Assemblyβs AUDACITY 100 Disruptors Summit was a powerful reminder of how interconnected we all are.
Fungal mycelium can help heal ecosystems & strengthen both food systems & our health. Mycelium supports our collective immunity.
π½οΈ webtv.un.org/en/asset/k15...
...specifically those in the Amanita muscaria and Amanita pantherina complexes.
**Please note: This survey does not include experiences w/ deadly poisonous Amanitas such as Amanita phalloides, Amanita ocreata, Amanita bisporigera, Amanita verna, and Amanita virosa.
Check out the survey in the link below & please help spread the word by sharing w/ your communities. The more responses, the better the data! tinyurl.com/53uj5cz4
The study aims to better understand the effects people experience from moderate to high doses of psychoactive Amanita mushrooms,...
2/3
π£A new IRB-approved #Amanita experiences survey has launched, led by researchers at the Uni. of British Columbia, @ischool.uw.edu & Uni. of Ottawa.
If youβve had an experience w/ these π (also known as Fly Agaric, Panther Cap, or Royal Fly Agaric), this is your chance to contribute to science!
1/3
π£ My newest interview w/ @joerogantop.bsky.social is now out!
π‘π Discover a mind-expanding conversation, exploring my new book, #AI, viral #pandemics (from bees to humans) + how #mushrooms & #mycelium tie us all together.
ποΈ Tune in wherever you get your podcasts.
www.youtube.com/watch?v=hwRD...
