Camp Lab

We are searching for computational PhDs and Postdocs to join our group in collaboration with Barbara Treutlein's Lab. We have exciting single-cell technology projects that incorporate bioengineering, computation, biology, translation. Send CV to deco_ihb@roche.com

Apply for our Master of Science in Physics of Life – training in cutting-edge research at the interface of physics, mathematics, engineering and life sciences. Scholarships available. Application deadline: 30 November. More: www.biozentrum.unibas.ch/education/de...
@biozentrum.unibas.ch @unibas.ch

Poster with QR code linking to the position

I'm very excited to announce that UNC Biology has 6 faculty positions open this year! The first is for an Asst Professor who studies organismal resilience using an integrative approach 1/n
unc.peopleadmin.com/postings/307...

We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.

Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.

Apply now ➡️ www.crick.ac.uk/careers-stud...

Molecular mechanisms of host-microbiome interactions:

We teamed up w/ @cp-cellchembiol.bsky.social for a Collection of articles uncovering mechanisms by which microbes communicate w/their hosts, shedding light on various conditions & offering therapeutic avenues.Enjoy!
www.cell.com/cp/collectio...

YouTube video by BiozentrumBasel Working at the Biozentrum Basel | World-Class Science & Life in Switzerland

We’re proud of our global research community at the Biozentrum @unibas.ch!
Our scientists from 40+ countries bring their passion & diverse cultures to every discovery.
🔬Join us: www.youtube.com/watch?v=p_Cg...

🚨 We're hiring, please share! The FMI seeks a tenure-track Group Leader (Assistant Prof) in Structural Biology 🔬
Innovative scientists in genome regulation, RNA metabolism, or protein homeostasis—especially using cutting-edge approaches—apply now at www.fmi.ch/education-ca...

Call for Applications / Ausschreibung

Springboard for an international scientific career! 🧬🧪🔭⚛️🧠🌱 Call for #MaxPlanckResearchGroups launched; applications are possible until October 14, 2025 www.mpg.de/max-planck-r... #ScienceCareer

Species-specific Rates of Fatty Acid Metabolism Set the Scale of Temporal Patterning of Corticogenesis through Protein Acetylation Dynamics Developmental processes display temporal differences across species, leading to divergence in organ size and composition. In the cerebral cortex, neurons of diverse identities are generated sequential...

New from the lab: Fatty Acid Metabolism Sets the Species-specific Tempo of Cortical Development through Protein Acetylation Dynamics. Led by amazing trio: @ryo2iwata.bsky.social , Isabel Gallego, @emirerkol.bsky.social, together with @steinaerts.bsky.social , @fendtlab.bsky.social

Call for 20 Assistant Professor positions Karolinska Institutet is a world-leading medical university with a long and proud history of ground-breaking research. We are now recruiting outstanding early-career researchers with particularly exce...

Karolinska is looking for 20 (!!) assistant professors and offering 6 year appointments with ~1M USD startup packages.

ki.se/en/about-ki/...

Final version @science.org "Recent evolution of the developing human intestine affects metabolic and barrier functions". Evolutionary preparation for microbiota, diet, and pathogen exposure is fascinating! Thank you @erc.europa.eu for supporting our vision!
www.science.org/doi/10.1126/...

At their annual retreat, fellows of the
@ethz.ch & #pRED #teamIHB #Roche | #NextGenBioeng programme showcased how organoids, CRISPR screens & spatial omics are reshaping translational #bioengineering. A hub of ideas, data & new collaborations🚀 > u.ethz.ch/1gMXI

We’re looking for curious, innovative science leaders at EMBL Heidelberg! 🔬🧬🦠

Join a vibrant, interdisciplinary community where collaboration and innovation are nurtured at all levels.

Take a look at these four open positions 👇

Altogether, we identify the developing human intestinal epithelium as a rapidly evolving system, and show that great ape #organoids provide insight into human biology. 🙏Thanks 🙏 to all authors! Especially co-first authors: @CY_Qianhui_YU @KlkUmut @stefanosecchia 11/11

We identify and functionally evaluate 2 human accelerated regions (HARs) at the IGFBP2 locus. Provocatively, these data indicate that the IGF pathway contributed to evolutionary change in the developing human intestine, potentially augmenting small intestine length. 10/11

Organoid KO/Reporter assays confirm a bona fide Lactase expression enhancer within an MCM6 intron. Deep learning predicts that a selected SNP associated with lactase persistence removes a transcriptional repressor binding site, a potential mechanism for hypolactasia. 9/11

We used a composite annotation to identify intestinal gene regulatory regions that have strong signatures of function and evolutionary change in humans. Willow plots aesthetically showcase the diverse gene ontologies affected by regulatory changes. 8/10

We identified conservation and divergence between human and chimpanzee intestinal epithelial gene regulation associated with metabolic and barrier functions. 7/10

Truly incredible chimpanzee intestinal tissues can be generated from chimpanzee pluripotent stem cells, providing a very exciting inroad into comparative species analysis! Builds on extraordinary work from @JimWellsLab @TheSpenceLab #organoids #evodevo 6/10

Pluripotent stem cells can generate intestinal organoid tissues that have remarkable similarity to primary tissue counterparts. We performed a multiplexed reporter assay to assess putative enhancers for activity in intestinal organoids. 5/10

We explored the evolution of cell types and gene regulation by comparing tissue and #organoids from humans, chimps, and mice. Many genes and reg. regions active in enterocytes and associated with barrier function and metabolism have signatures of recent change. 4/10

At birth, the human GI tract becomes exposed to the outside world. Prior to birth, gene regulatory networks must orchestrate intestinal development to prepare for dynamic diet and microbiota exposures, which change over lifespan. 3/10

Recent genetic change affects gut function, including variants involved in Crohn’s disease (CD), inflammatory bowel disease (IBD), and hypolactasia. An evolutionary perspective on the developing intestine has human health relevance and can shed light on modern GI disorders. 2/10

Diet/microbes place the gut epithelium as a nexus for evolutionary change. With Jason Spence and Craig Lowe labs we use #organoids to explore how evolution prepared the developing human intestine for exposure to the environment. @science.org #evodevo www.science.org/doi/10.1126/... 1/11

A male-essential miRNA is key for avian sex chromosome dosage compensation - Nature Birds have evolved a unique sex chromosome dosage compensation mechanism involving the male-biased microRNA (miR-2954), which is essential for male survival by regulating the expression of dosage-sens...

Our study on a male-essential microRNA and the evolution of other dosage compensation mechanisms in birds is now out in Nature! www.nature.com/articles/s41...

My postdoc work at Treutlein lab and @graycamplab.bsky.social with @jasperjanssens.bsky.social is out in @science.org ! We screen for neuron subtypes using pro-neural TFs + morphogen combinations + scRNA-seq and profiled over 700,000 cells in 480 conditions. www.science.org/doi/10.1126/...

Neuron programming! Pro-neural TFs + 480 morphogen conditions + scRNA-seq --> Diverse iN subtypes of forebrain, midbrain, hindbrain, spinal cord, and PNS. @hsiuchuanlin.bsky.social‬ @jasperjanssens.bsky.social‬ and Treutlein Lab! @science.org www.science.org/doi/10.1126/... #NGN2 #ASCL1

A major KI initiative to recruit new assistant professors with outstanding proposals in all areas of medicine, biomedicine and public health. We offer an amazing research environment, great colleagues and generous startup packages. Check it out and get working on your applications! (repost please!)

BaCell 3D | Organoid conference BaCell 3D is the essential meeting point for researchers and industry professionals dedicated to transforming developmental and biomedical science through cutting-edge in-vitro multicellular systems.

OK, who will be attending the @bacell3d.bsky.social 2025 meeting on Monday? Let's connect there - looking forward!
#organoidconference #bacell3d #organoids
www.bacell3d.com

On my way to Basel for #BaCell3D. Looking forward to a few days of great science and connecting with colleagues. If you're at the meeting, please do come chat to me about any of @biologists.bsky.social journals, community sites and charitable activities.