Lisa Situ

RAF-independent MEK1-mutant Histiocytoses Respond to ERK Inhibition Major Finding: RAF-independent MEK activation promotes histiocytic neoplasms that are sensitive to ERK inhibition.Concept: MEK1E102_I103del drives myelomonocytic expansion, hepatosplenomegaly, and an ...

RAF-independent MEK1-mutant Histiocytoses Respond to ERK Inhibition
A #ResearchWatch summary of a recent study by
Eli L. Diamond, Omar Abdel-Wahab, Benjamin H. Durham and colleagues @mskcancercenter.bsky.social

@yalecancer.bsky.social @petermaccc.bsky.social #GuangdongProvincialPeoplesHospital

Molecular Residual Disease Precedes Disease-Free Survival Events by Months Major Finding: Molecular residual disease (MRD) preceded death or clinical recurrence in the ADAURA trial by nearly 5 months. Concept: Longitudinal MRD monitoring may stratify risk for patients with E...

Out today: Molecular Residual Disease Precedes Disease-Free Survival Events by Months, a #ResearchWatch summary of an impactful exploratory post hoc analysis of the ADAURA trial by Dr. Roy Herbst, Dr. Thomas John, Dr. Yi-Long Wu, and colleagues

aacrjournals.org/cdnews/news/...

Very interesting findings, congratulations once more on the study! 🎉

Ascites-derived Lipid Uptake Drives NK Cell Dysfunction in Ovarian Cancer Major Finding: Lipids derived from ascites are taken up by NK cells and drive NK cell dysfunction in ovarian cancer. Concept: Polar lipids such as phosphatidylcholine disrupt NK plasma membrane order ...

ICYMI: Ascites-derived Lipid Uptake Drives NK Cell Dysfunction in Ovarian Cancer, a #ResearchWatch summary of a new study by @karen--s.bsky.social, @lydialynch.bsky.social, and colleagues at @ludwigcancer.bsky.social @princetonmolbio.bsky.social

aacrjournals.org/cdnews/news/...

SSRIs Elevate Intratumoral Serotonin and Enhance Antitumor Immunity Major Finding: Serotonin transporter depletes intratumoral serotonin which dampens CD8+ T-cell antitumor immunity.Concept: Serotonin transporter inhibition with SSRIs drives T-cell antitumor immunity ...

ICYMI: SSRIs Elevate Intratumoral Serotonin and Enhance Antitumor Immunity, a #ResearchWatch summary of a new study by Dr. Bo Li, @liliyanglab.bsky.social, and colleagues at @dgsomucla.bsky.social @uclastemcell.bsky.social

aacrjournals.org/cdnews/news/...

Cholesterol Metabolism Dictates Secondary Organ Colonization in Pancreatic Cancer Major Finding: PCSK9 regulates cholesterol uptake and controls the trajectory of metastasis to secondary organs in pancreatic ductal adenocarcinoma (PDAC). Concept: Cholesterol uptake supports mTORC1-...

Out today: Cholesterol Metabolism Dictates Secondary Organ Colonization in Pancreatic Cancer, a #ResearchWatch summary of a new study by Dr. Gilles Rademaker, @rushika-perera.bsky.social, and colleagues at @ucsanfrancisco.bsky.social 🧬
aacrjournals.org/cdnews/news/...

Patient-Specific Hematologic Setpoints Inform Diagnosis and Prognosis Main Findings: Complete blood count indices are patient-specific and stable over decades in healthy adults.Concept: These hematologic setpoints are deep physiological phenotypes associated with variat...

ICYMI: "Patient-Specific Hematologic Setpoints Inform Diagnosis and Prognosis" - a #ResearchWatch summary of a study by Brody Foy, John M. Higgins, and colleagues @uwdeptmedicine.bsky.social @harvardmed.bsky.social #MassGeneralBrigham

doi.org/10.1158/2159...

Digoxin Reduces Circulating Tumor Cell Cluster Size in Breast Cancer Major Finding: Digoxin treatment reduces circulating tumor cell cluster size in patients with metastatic breast cancer.Concept: Genes involved in cell–cell adhesion and cell cycle pathways are suppres...

Cancer Discovery #ResearchWatch: Digoxin Reduces Circulating Tumor Cell Cluster Size in #BreastCancer, a summary of the study by Christian Kurzeder, Bich Doan Nguyen-Sträuli, Ilona Krol, Alexander Ring, Marcus Vetter, Nicola Aceto, et al @ethzurich.bsky.social @unibas.ch

doi.org/10.1158/2159...

GDF-15 Blockade Overcomes Resistance to Immune Checkpoint Inhibition Main Findings: Visugromab, a GDF-15 blocking antibody, is tolerable and elicits clinical responses in combination with nivolumab.Concept: GDF-15 may represent a mechanism of anti-PD-1 resistance that ...

ICYMI: "Neutralizing GDF-15 can overcome anti-PD-1 and anti-PD-L1 resistance in solid tumours" - a #ResearchWatch summary of a study by Ignacio Melero, Eugen Leo, and colleagues #ClinicaNavarra #CIMA_unav #visugromab #CatalYm

doi.org/10.1158/2159...

The Immune Evasin Nef Augments Allogeneic CAR T Function and Survival Major Finding: HIV Nef expression reduces allorecognition and apoptotic cell death of CAR T cells.Concept: Controlled Nef expression reduces HLA-I levels and protects CAR T cells from CD8+ T cell– and...

🧪Read this week's Cancer Discovery #ResearchWatch: The Immune Evasin Nef Augments Allogeneic #CART Function and Survival, a summary of the study by Karlo Perica, Michel Sadelain, and colleagues @mskcancercenter.bsky.social @mskdeptofmed.bsky.social

doi.org/10.1158/2159...

A Pediatric Pan-Cancer Cohort Enables the Study of Systemic Antitumor Immunity Major Finding: An analysis of immune responses in children with cancer reveals the effects of age and tumor type. Concept: Pediatric tumors have varied mutational burden which correlates with immune c...

🧪Read today's #ResearchWatch: A Pediatric Pan-Cancer Cohort Enables the Study of Systemic Antitumor Immunity, a summary of a 📃by Qi Chen, Binbin Zhao, Ziyang Tan, Linda Ljungblad, @petterbrodin.bsky.social, et al @imperialcollegeldn.bsky.social @ki.se aacrjournals.org/cdnews/news/...

BrainChild-03 Trial Supports Safety of B7-H3 CAR T-cell Therapy for DIPG Main Finding: A phase I trial supported the safety and feasibility of repeated intracranial infusions of B7-H3 CAR T cells for DIPG.Concept: B7-H3 is an immunoregulatory protein expressed on the surfa...

Honored to have our recently published first-in-human phase 1 clinical trial of repeatedly dosed intracerebroventrocular B7-H3 #CARTcells for children with #DIPG highlighted in @theaacr.bsky.social and #CancerDiscovery Research Watch ❤️🔬

Cancer Cells Induce T-Cell Dysfunction Through Mitochondrial Transfer Major Finding: Cancer cells transfer mitophagy-resistant mitochondria to tumor-infiltrating lymphocytes (TIL) that impair antitumor activity. Concept: Deubiquitinase USP30 protects cancer cell-derived...

Read this week's Cancer Discovery #ResearchWatch: Cancer Cells Induce T-Cell Dysfunction Through Mitochondrial Transfer, a summary of the study by Hideki Ikeda, Yosuke Togashi, and colleagues at Okayama University

doi.org/10.1158/2159...

Loss–Translocation–Amplification Chromothripsis Drives Osteosarcoma Evolution Main Finding: High-grade osteosarcomas frequently exhibit a loss–translocation–amplification (LTA) pattern of chromothripsis that inactivates TP53 and amplifies oncogenes.Concept: Ongoing chromothrips...

🧬 #ResearchWatch: Loss–Translocation–Amplification #Chromothripsis Drives #Osteosarcoma Evolution, a summary of the study by @jevalleinclan.bsky.social, Solange De Noon, Adrienne Flanagan, Isidro Cortes-Ciriano, and colleagues @ucl.ac.uk @ebi.embl.org @uclnews.bsky.social

doi.org/10.1158/2159...

High-risk ER+ Breast Cancers Genomically Resemble HER2+ Tumors Main Finding: HER2+ breast tumors and high-risk ER+ breast tumors share genomic features that reflect similar mechanisms of tumor evolution.Concept: The genomic architecture of breast cancer is constr...

Cancer Discovery #ResearchWatch: High-risk ER+ #BreastCancers Genomically Resemble HER2+ Tumors, a summary of the study by @khoulahan.bsky.social, @lisemangiante.bsky.social, @crissotomayor.bsky.social, @alvinahere.bsky.social, @cncurtis.bsky.social + colleagues @ Stanford

doi.org/10.1158/2159...

Congratulations on these exciting results, Nick and team! We were very happy to feature the work! #ResearchWatch

I love this!! Heading to my first workshop now 🤗 but I’m definitely on the hunt to find this mascot!

San Diego morning fog forced a flight diversion to Vegas… but finally made it! Very excited to be here at #ASH24!

Congratulations on the publication of this important work! @ejvillablanca.bsky.social @martinaparigi.bsky.social

The Liver X Receptor Axis Balances Intestinal Regeneration and Tumorigenesis Major Finding: The liver X receptor (LXR) pathway drives intestinal regeneration and limits tumorigenesis.Concept: Transcriptomic and pharmacologic studies define a CYP27A1–LXR–TLS signaling axis in i...

How do barrier tissues promote repair and regeneration without tipping the ⚖️ toward malignant transformation?

Find out in today's #ResearchWatch summary of a recent 📜 by Srustidhar Das, S. Martina Parigi, Xinxin Luo, Eduardo J. Villablanca, and colleagues.

aacrjournals.org/cdnews/news/...

That is awesome! I'm excited to learn about germline variants in pediatric AML from @laurenmharmon.bsky.social -- hope to see you at your poster Monday night! Safe travels to you and the whole team 🤗

Oncolytic Virotherapy Plus Nivolumab Is Safe in Muscle-Invasive Bladder Cancer Major Finding: A phase 1b trial demonstrated the safety of cretostimogene grenadenorepvec plus nivolumab in muscle-invasive bladder cancer (MIBC).Concept: Boosting immune checkpoint inhibition with on...

Out today: Oncolytic Virotherapy Plus Nivolumab Is Safe in Muscle-Invasive #BladderCancer, a #ResearchWatch summary of recent clinical findings by Roger Li, James J. Mulé, Jose R. Conejo-Garcia, and colleagues.

aacrjournals.org/cdnews/news/...

Countdown to #ASH24! Are you heading to San Diego this weekend? If so, I'd love to connect! If you're presenting, please let me know - I want to hear about your work!

GD2-CAR T-cell Therapy is Safe in H3K27M+ Diffuse Midline Glioma Main Finding: A phase I clinical trial demonstrates the safety of GD2-targeted CAR T-cell therapy in H3K27M+ diffuse midline glioma.Concept: H3K27M+ diffuse midline gliomas express high levels of GD2,...

Last week in Cancer Discovery News: GD2-CAR T-cell Therapy is Safe in H3K27M+ Diffuse Midline Glioma, a #ResearchWatch summary of promising clinical findings by Michelle Monje, Sneha Ramakrishna, Crystal Mackall, and colleagues.

doi.org/10.1158/2159...

APOBEC3-Mediated Mutations Promote CCND1 ecDNA Biogenesis in Bladder Cancer Major Finding: APOBEC3-associated mutagenesis and ecDNA formation coordinately drive urothelial cancer evolution.Concept: ecDNA events enable adaptive resistance to chemotherapy.Impact: This study del...

ICYMI: "APOBEC3-Mediated Mutations Promote CCND1 ecDNA Biogenesis in Bladder Cancer," a #ResearchWatch summary of recent findings by Duy D. Nguyen, William F. Hooper, Weisi Liu, Olivier Elemento, @nicorobine.bsky.social, Bishoy M. Faltas, and colleagues.

doi.org/10.1158/2159...

Epigenetic Regulation of T-Cell Differentiation Mediates Immunotherapy Response Major Finding: ASXL1 regulates T-cell terminal differentiation and exhaustion during chronic antigen exposure.Concept: Disruption of ASXL1 alters histone ubiquitination to promote a stem-like effector...

ICYMI: "Epigenetic Regulation of T-Cell Differentiation Mediates Immunotherapy Response," a #ResearchWatch summary of recent findings from Tae Gun Kang, Ben Youngblood, Caitlin Zebley, and colleagues.
doi.org/10.1158/2159...

Hello, hello! Very happy to see so many familiar faces over yonder. I’m excited to continue connecting and to receive my daily dose of excellent science! 🤗🔬🧬

Follow Cancer Discovery News for breaking updates and Research Watch summaries! Visit the homepage aacrjournals.org/cdnews and sign up for email alerts aacrjournals.org/pages/alerts!