Devika S Manickam

What's $40k+ a year in unexpected publishing costs in these turbulent times! 😆😭

Super-grateful to @NIH_NINDS, our awesome team and wonderful collaborators! 🙏🏽🙏🏽 @SrutiShiva @LD_McCullough #Venu Venna @UTHealthHouston Looking forward to further refining the engineering of mitochondria-enriched EVs!

This is a fantastic manuscript! Hope all goes well with the review :) Thank you @blacoste.bsky.social for collaborating with us!

Purinergic receptor activation rectifies autism-associated endothelial dysfunction Early cerebrovascular alterations affect brain maturation by impacting trophic support and energy supply. Recent evidence in a 16p11.2 deletion mouse model of autism spectrum disorder (ASD) revealed b...

Happy to share the current version of our latest story, currently under peer review. Cool collab with @dablab.bsky.social @manickam-lab.bsky.social and others. We are not only understanding endothelial deficits in an #autism model, but now also capable of rescuing them! #16p11.2 #treatment #P2Y2

🚨 I’m hiring a postdoc for Fall 2025 with experience in microbial ‘omics data analysis and phylogenetics/genomics. Projects will be centered around ancient microbial ecology & evolution. Click here for more information: bpb-us-e1.wpmucdn.com/wp.txstate.e...

Please share, thank you 🙏🏻

50d free: authors.elsevier.com/a/1l8cjcI2-9...

Congrats Luis on your 1st author paper!

We identified a potent mast cell-activating peptide (MP12W) that, when combined with CpG, forms a nanoparticle intranasal vaccine providing broad protection against H1 influenza.

@dpmp-unc.bsky.social

Neuro-Metabolic and Vascular Dysfunction as an Early Diagnostic for Alzheimer's Disease and Related Dementias. Background Alzheimer's disease (AD), the most common neurodegenerative condition, is characterized by significant cognitive decline. To detect these changes, diagnostic imaging approaches rely primari...

Neuro-Metabolic and Vascular Dysfunction as an Early Diagnostic for Alzheimer's Disease and Related Dementias.

www.biorxiv.org/content/10.1...

Congratulations!

We were awarded a TrailBlazer R21 from NIBIB to design chaperone-mimetic polymers for ribonucleoprotein delivery. Excited to work with coIs Gerard Madlambayan and Serveh Kamrava.

Meme of the week!

WashU is accepting applications for Postdoctoral Fellowship in Diabetes & Related Metabolic Diseases (T32 DK007120). If you are eligible for T32 support (need to be a US citizen or permanent resident) and are interested in working with stem cell-derived islets, please contact me!

Ionic liquid-coated lipid nanoparticles promote enhanced red blood cell hitchhiking Lipid nanoparticles (LNPs) have transformed the delivery of nucleic acid therapeutics; however, their natural tropism favors the liver resulting in clearance by the reticuloendothelial system, with le...

Happy to share our new preprint on ionic liquid coated LNPs! Purva Khare led this work in collaboration with Christine Hamadani, PhD Sara Edgecomb and Eden E. L. Tanner

www.biorxiv.org/content/10.1...

a cartoon of a penguin wearing a red hat and holding a megaphone ALT: a cartoon of a penguin wearing a red hat and holding a megaphone

@Glaivy Batsuli (Stanford) & I are track chairs for the Basic Science (& possibly translational/laboratory) sessions for @THSNA 2026 www.thsna.org/web/

Know trainees or under-represented voices (including yourself!) we should consider?
#thsna2026 #thrombosis #hemostasis
DM or comment below!🙏

Sleep loss is a metabolic disorder Sleep deprivation shifts metabolic resources and deprioritizes processes that support cognition.

Sleep loss is a metabolic disorder

www.science.org/doi/10.1126/...

We shouldn’t ask kids what they want to be when they grow up. It encourages them to define themselves in terms of work.

Who we become is not a question of career—it’s a matter of character.

The highest aspiration is to be a person of generosity, integrity, humility, curiosity, and wisdom.

This week's meme of the week!

This week's meme of the week! #sciencememe

An Open Letter to Canadians: Let's Ensure Canada's Research Reflects All Canadians 🚨 Canada needs research that works for everyone! 🚨 Science shapes the policies that impact our daily lives—from healthcare to climate action to economic growth. But if our research doesn’t include di...

Sign the petition! Canadians: An Open Letter to Canadians: Let's Ensure Canada's Research Reflects All Canadians

YouTube video by Controlled Release Society CRS CRS 2025 Annual Meeting & Exposition: Meet Our Director of Abstract Judging, Juliane Nguyen, PhD!

Who would've thought you could play Bingo with posters? Introducing #PosterBingo for the Controlled Release Society Annual Meeting! Inspired by an idea #AssafZinger and his students had!

See you in Philly!

youtu.be/xMpxLsW-2QA?...

New publication out in Digestive Diseases and Sciences in collaboration with @julienguyenlab.bsky.social
“Engineered Probiotic Saccharomyces boulardii Reduces Colitis-Associated Colorectal Cancer Burden in Mice”
🔗 link.springer.com/article/10.1...

Fueling sleep: UK researchers show key metabolic link to restful nights Scientists have long recognized the brain’s need for energy, but groundbreaking research from the University of Kentucky’s Sanders-Brown Center on Aging has now illuminated how the brain’s energy uti...

A great write up on our recent work in PNAS attempting to understand metabolic drivers of sleep, led by @ncons95.bsky.social !

uknow.uky.edu/research/fue...

Important diabetes news. Unfortunately, while VX264 (Vertex's encapsulated stem cell derived islet product) has been safe in patients, the company has discontinued the trial due to insufficient function of the cells. investors.vrtx.com/news-release...

Official now! Congratulations to Dr. Purva Khare on a stellar defense earlier today! We are very proud of you and will keep rooting for your continued successes at Merck!

One more for the Science 🧪 feed!

🤯🤩 #ElectronMicroscopy #Mitochondria

love this!!! looking forward to reading this paper!

Many thanks for the kind invitation, hosting and all the fantastic discussions I had with faculty at the University of Ottawa! It was wonderful finally meeting the phenomenal @blacoste.bsky.social #Julie Ouellette after years of Zoom call discussions ;) more wins and power to collaborative science!

Next #EVClub is with Tamás Visnovitz and @editbuzas.bsky.social: A ‘torn bag mechanism’ of small extracellular vesicle release via limiting membrane rupture of en bloc released amphisomes (amphiectosomes)
Apr 2, 11 AM EDT/17.00 CEST
Need the login? Sign up: surveymonkey.com/r/EVClubISEV
@isev.org