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Marc Duque Ramirez

@marcduque.bsky.social

NeuroPhD candidate @Engert Lab. Interested in new neuromodulation techniques and molecular approaches to understand how the brain works.

93 Followers  |  53 Following  |  5 Posts  |  Joined: 12.11.2024  |  1.7771

Latest posts by marcduque.bsky.social on Bluesky

Check it out!

17.04.2025 16:52 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

3/3 We haven't tested in fish yet, but I wonder if there would be a significant difference in the glial calcium effect between DXM alone and DXM + bup. Thanks again for bringing this up!

22.12.2024 11:57 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

2/3 I also wondered if this could explain the observed synergy between NMDAR antagonism and NE reuptake inhibition, such as with DXM and bupropion, although I'm sure there's many different mechanisms at play.

22.12.2024 11:57 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 2    ๐Ÿ“Œ 0

1/3 That is fascinating thanks so much for sharing! Looking forward to what you see in terms of non-responders for prazosin and other alpha-1 antagonists.

22.12.2024 11:57 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
Preview
Astrocytes release ATP/ADP and glutamate in flashes via vesicular exocytosis - Molecular Psychiatry Molecular Psychiatry - Astrocytes release ATP/ADP and glutamate in flashes via vesicular exocytosis

www.nature.com/articles/s41...
Very exciting paper - still need to go through all of it, but already liked the use of cOpn5 to stimulate astrocytes. Potentially interesting if ATP and glutamate are released through independent mechanisms

25.11.2024 15:40 โ€” ๐Ÿ‘ 4    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Your reminder that many of the muscles, nerves and bones you use to hear and talk with correspond to gill structures in fish. ๐Ÿงช #evolution #paleontology

24.11.2024 20:30 โ€” ๐Ÿ‘ 1787    ๐Ÿ” 383    ๐Ÿ’ฌ 56    ๐Ÿ“Œ 37

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