Marc Duque Ramirez

Check it out!

3/3 We haven't tested in fish yet, but I wonder if there would be a significant difference in the glial calcium effect between DXM alone and DXM + bup. Thanks again for bringing this up!

2/3 I also wondered if this could explain the observed synergy between NMDAR antagonism and NE reuptake inhibition, such as with DXM and bupropion, although I'm sure there's many different mechanisms at play.

1/3 That is fascinating thanks so much for sharing! Looking forward to what you see in terms of non-responders for prazosin and other alpha-1 antagonists.

Astrocytes release ATP/ADP and glutamate in flashes via vesicular exocytosis - Molecular Psychiatry Molecular Psychiatry - Astrocytes release ATP/ADP and glutamate in flashes via vesicular exocytosis

www.nature.com/articles/s41...
Very exciting paper - still need to go through all of it, but already liked the use of cOpn5 to stimulate astrocytes. Potentially interesting if ATP and glutamate are released through independent mechanisms

Your reminder that many of the muscles, nerves and bones you use to hear and talk with correspond to gill structures in fish. 🧪 #evolution #paleontology