Melike Eren

NEW: Technical Specialist @sangerinstitute.bsky.social

Perform large-scale phenotypic CRISPR screens on human iPSC-derived microglia to identify modifiers of immune dysfunction relating to neurodegeneration 🧬

Apply by 11 January: sanger.wd103.myworkdayjobs.com/en-US/Wellco...

#ScienceJobs

High-quality mouse reference genomes reveal the structural complexity of the murine protein-coding landscape Helmy et al. provide a collection of high-quality mouse reference genomes. They were able to resolve some of the most complex regions among mouse genomes that are involved in immune defense. These fin...

High-quality mouse reference genomes [PacBio Long Read genomes of 17 strains] reveal the structural complexity of the murine protein-coding landscape, Cell Genomics. www.cell.com/cell-genomic... Genomes and annotations here: projects.ensembl.org/mouse_genomes/

Measles vaccinations begin in rebel-held Congo almost a year after deadly outbreak Congo has reported over 36,000 suspected cases and 565 deaths across nearly all of its 26 provinces this year as of July.

#Measles vaccines have reached Kachehembe, #DRC, nearly a year after the outbreak began, despite healthcare disruptions caused by M23.

MSF has treated over 1,000 children for measles this year in the area.

Read the story in the @thestar.com: www.thestar.com/news/world/a...

Alexandra Elbakyan on X: "A whitepaper describing the background, purpose and tokenomics of the Sci-Hub token (SCI) is now available on the website: https://t.co/agxEc1AyOT The primary goal is to accelerate transition of science towards Open Access, by rewarding knowledge sharing. Sci-Hub token https://t.co/pBWVa9eKCR" / X A whitepaper describing the background, purpose and tokenomics of the Sci-Hub token (SCI) is now available on the website: https://t.co/agxEc1AyOT The primary goal is to accelerate transition of science towards Open Access, by rewarding knowledge sharing. Sci-Hub token https://t.co/pBWVa9eKCR

x.com/ringo_ring/s...

Aleksandra Elbakyan: There is a new platform, Sci-Net (sci-net.xyz) where researchers can help each other by providing paywalled papers. The platform builds upon Sci-Hub meme token $scihub to reward active members.
x.com/ringo_ring/s...

Spatial and single-cell transcriptomics reveal the reorganization of cerebellar microglia with aging Tsai et al. show that cerebellar microglia undergo distinct molecular and spatial changes during aging. Integrated single-nucleus and spatial transcriptomics identify a neuron-associated microglial st...

Spatial and single-cell transcriptomics reveal the reorganization of cerebellar microglia with aging

www.cell.com/cell-reports...

Microglia modulate Aβ-dependent astrocyte reactivity in Alzheimer’s disease | Nature Neuroscience Experimental evidence suggests that activated microglia induce astrocyte reactivity in neurodegenerative disorders, such as Alzheimer’s disease (AD). In this study, we investigated the association between microglial activation and amyloid-β (Aβ) with reactive astrogliosis in individuals across the AD spectrum. We examined 101 individuals using positron emission tomography radiotracers to assess Aβ deposition ([18F]AZD4694), tau aggregation ([18F]MK-6240) and microglial activation ([11C]PBR28), along with plasma biomarkers for astrocyte reactivity (GFAP) and tau phosphorylation (p-tau217). We further evaluated 251 individuals with cerebrospinal fluid levels of the microglial marker sTREM2. We found that Aβ pathology was associated with astrocyte reactivity across cortical brain regions only in the presence of microglial activation. The microglia-dependent effects of Aβ on astrocyte reactivity were further related to cognitive impairment through tau phosphorylation and aggregation. Our r

101 individuals with AD were studied using PET radiotracers: [18F]AZD4694 for Aβ and [18F]MK-6240 for tau. Microglia impact astrocyte reactivity. PMID:41198899, Nat Neurosci 2025, @NatureNeuro https://doi.org/10.1038/s41593-025-02103-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Happy to be in Liverpool for #BSI25 this week. On Wednesday I’ll be speaking about how microbiome–microglia communication influences brainstem development and contributes to diffuse midline glioma in the Neuroimmunolgy across the body session (Part2).

Science is Like Magic, Just Real Physicists from the groups of Scott Waitukaitis and Carl Goodrich at the Institute of Science and Technology Austria (ISTA) have developed a method to acoustically levitate objects while keeping them ...

Who hasn't dreamed of overcoming gravity and getting objects to hover above ground?

Physicists from the groups of Scott Waitukaitis and Carl Goodrich have developed a method to acoustically levitate objects while keeping them physically separated using charge.

Read more: ista.ac.at/en/news/scie...

YouTube video by Unlearning Economics Live The Care Economy is the Everything Economy - with Emma Holten

youtu.be/6yl6JpVZTdM?...

Incretin-based therapeutics for the treatment of neurodegenerative diseases - Nature Metabolism This Review summarizes preclinical and clinical evidence highlighting the potential of incretin-based drugs as treatments of neurodegenerative diseases, such as Alzheimer’s disease or Parkinson’s disease.

#Throwback 🧪

REVIEW | Incretin-based therapeutics for the treatment of neurodegenerative diseases

@clemmensenc.bsky.social‬ et al‬‬

It’s been a week since I finally climbed out of my reading slump, and I honestly owe it all to The Lord of the Rings. For about the seven hundredth time😅, I returned to that world, and once again, it was the one that gently pulled me back into reading😊

On the Spot: Patricia Fara

‘Who is the most underrated person in history? Tupaia, the Tahitian navigator and translator who enabled #JamesCook to reach Australia and New Zealand’

🎯 Patricia Fara answers some quickfire questions

buff.ly/ZQFqvYG

Targeting formyl peptide receptor 1 reduces brain inflammation and neurodegeneration Multiple sclerosis (MS) progresses through brain region–specific inflammation and degeneration, with poorly defined mechanisms. In individuals with MS, we identified increased expression of formyl pep...

New in Science!: Microglial FPR1 is a CNS-specific driver of demyelination. Deletion in MG or CNS macrophages protects against myelin loss, while peripheral deletion helps only partly. CNS-penetrant FPR1 antagonist (T0080) reduces ROS, inflammation & disease severity www.science.org/doi/10.1126/...

A myeloid trisomy 21-associated gene variant is protective from Alzheimer’s disease - Nature Neuroscience Engineering human microglia with a Down-syndrome-linked myeloid gene variant resists tau-induced dysfunction and protects neurons in chimeric brains, offering proof of concept for transformative micro...

New study from Jiang group gives clues to Down syndrome patients' resilience to AD: a DS-linked myeloid mutation (CSF2RB A455D) protects engrafted human microglia against tau by suppressing harmful IFN signaling, boosting phagocytosis, & reducing microglial senescence www.nature.com/articles/s41...

What’s it like for our staff to return to #Gaza City?

Zaher and Sami, MSF nurses, were forced to flee during an Israeli offensive. Now, they’re back and recount their return to a city reduced to rubble.

Despite everything, they’ve resumed their work in two health facilities.

#Sudan: MSF fears many remain stranded, held for ransom and unable to escape.

Watch Mouna Hanebali, MSF medical team leader in #Tawila, and survivors who fled El Fasher share the dire reality of the situation.

You are wellcome😊, it's a very impressive article. It's not being discussed as much as I expected yet, but it has a paradigm-shifting content(I think). It will start to be discussed more in a few days. Direct open source full text sharing is very good

Wow 👌🏻

Hey my first #microglia paper was featured by ASCB! This was a wild result that I first saw as a grad student and couldn’t get out of my head. Im proud of my team for getting this out into the world.

Neuroinflammation: An astrocyte perspective The diverse roles of astrocytes and their cell-cell interactions in neurologic diseases offer opportunities for their therapeutic targeting.

A 2023 Review in #ScienceTranslationalMedicine looks at the complex connections between astrocytes and other types of cells in the nervous system, including neurons, oligodendrocytes, and microglia.

Learn more: https://scim.ag/48bOKbZ #ScienceMagArchives

Left: Lentivirus-mediated overexpression of full-length APP (holo-APP), sAPPα, or AICD in the cerebellar cortex of App−/− mice. Representative images showing co-expression of APP fragments/mCherry (red) and the PC marker calbindin (green) from coronal sections of the cerebellum. Scale bars: 100 µm (main); 40 µm (insets). Right: APP governs cerebellar motor function via Nav1.6 in Purkinje cells. APP deficiency impairs the surface distribution of Nav1.6 in Purkinje cells, leading to aberrant firing patterns, disrupted inhibitory output to the deep cerebellar nuclei, and culminating in motor coordination deficits.

The presence of aberrant forms of APP is linked to #AlzheimersDisease, but its loss leads to motor deficits. This study shows that #APP supports motor coordination by regulating Na+ channels in #PurkinjeCells, expanding our understanding of APP's role in the brain @plosbiology.org 🧪 plos.io/3M1WMwL

The logo for Neurorehabilitation and Neural Repair appears on top. The Text below reads, "The NNR Early Career Editorial Program is accepting applications! Deadline: Dec 1, 2025". The logo for ASNR appears at the bottom.

📢 Reminder! Just a few days left to apply for the #Neurorehabilitation and Neural Repair (NNR) Early Career Editorial Program! Applications are due December 1st!

More information and details on how to apply here: www.asnr.com/files/Call_f...

#rehabilitation #careerdevelopment #neuroscience

Building the First In Vivo Model of Human Neuron–Microglia Interactions at University of Leeds on FindAPhD.com PhD Project - Building the First In Vivo Model of Human Neuron–Microglia Interactions at University of Leeds, listed on FindAPhD.com

A PhD project co-supervised by Dr. Jamie Johnston is available in my lab.

This project offers a unique opportunity to pioneer the world’s first in vivo model of human neuron–microglia interactions.

To know more and apply: www.findaphd.com/phds/project...

Deadline: 07.01.2026, 5pm (UK time)

Up to $25k in funding is available for established #neuroscience internship programs for underrepresented undergraduates in the US & Canada - covering stipends, supplies & more

Apply by 10 Jan 2026:
https://ibro.org/grant/fund-for-undergraduate-research-internship-programs/

#IBROinUSCanada

The metabolic engine of cognition: microglia–neuron interactions in health, ageing and disease - Nature Metabolism This Review highlights how metabolic interactions between microglia and neurons shape brain health, and how their disruption in ageing and disease contributes to cognitive decline.

⚠️ Just out in @natmetabolism.nature.com ⚠️

Our latest review with @pluchinolab.bsky.social & @biancasilvalab.bsky.social explores how #microglia and #neuron #metabolism shapes #brain health and cognition! 🧠

Our Evridiki Asimakidou did a wonderful job leading this! 👏

www.nature.com/articles/s42...

The Alzheimer’s therapeutic Lecanemab attenuates Aβ pathology by inducing an amyloid-clearing program in microglia - Nature Neuroscience Lecanemab, a leading therapy for Alzheimer’s disease, induces an Fc-mediated transcriptional program in human microglia, linked to osteopontin and enhanced plaque phagocytosis, suggesting alternative ...

The #Alzheimer’s therapeutic Lecanemab attenuates Aβ pathology by inducing an amyloid-clearing program in #microglia www.nature.com/articles/s41...

Incretin-based therapeutics for the treatment of neurodegenerative diseases - Nature Metabolism This Review summarizes preclinical and clinical evidence highlighting the potential of incretin-based drugs as treatments of neurodegenerative diseases, such as Alzheimer’s disease or Parkinson’s dise...

Our latest review, led by @anikavear.bsky.social with Michael Heneka, explores the emerging role of incretin-based therapies in neurodegenerative disease treatment www.nature.com/articles/s42...

NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression How NLRP3 impacts Alzheimer’s disease (AD) is unclear. McManus et al. find that NLRP3 is located at mitochondria where it regulates microglial metabolism. Depletion or chronic pharmacological inhibiti...

🎉 Huge congratulations to @roisinmcmanus.bsky.social and Michael Heneka on this exciting study uncovering a novel role for NLRP3 in regulating microglial metabolism and phagocytosis to promote Alzheimer’s disease progression www.cell.com/immunity/abs...

Neonatal hypoxic–ischaemic encephalopathy (HIE) remains a leading cause of infant morbidity and mortality worldwide, with therapeutic hypothermia being the only clinically approved treatment. Cortical subplate neurons have transient secretory function during development and one of the protein they secrete in mouse and human is neuroserpin encoded by the serpini1 gene (https://doi.org/10.3389/fnins.2015.00100; https://doi.org/10.1111/joa.12931). We proposed that subplate might influence cortical circuit formation through a transient secretory function. We have previously demonstrated that exogeneous neuroserpin is protective agains ER stress and hypoxia/ischaemia in adult (DOI: 10.4103/NRR.NRR-D-24-00044). Recent work from Onoda et al. suggests that the brain specific neuroserpin is also a sensitive indicator for abnormal brain development in mild fetal growth restriction DOI: 10.1016/j.isci.2025.113237). In the recent Special Issue of Cells on Perinatal Brain Injury—from Pathophysiology to Therapy we show that endogenous neuroserpin alone is insufficient for neuroprotection against hypoxia ischaemia induced damage, but exogenous neuroserpin shows promise as a pharmacological intervention for mild neonatal HIE (https://doi.org/10.3390/cells14231840).

Neonatal hypoxic–ischaemic encephalopathy (HIE) is a leading cause of infant morbidity and mortality. Cortical subplate neurons transiently secrete a brain specific protein, neuroserpin.
We now show that exogenous neuroserpin is protective agains mild neonatal HIE (doi.org/10.3390/cell...).