Melike Eren

The intersection of #circadian rhythms and the blood-brain barrier with drug efficacy and delivery in #neurological disorders
www.sciencedirect.com/science/arti...

A bold, patriotic-themed flyer for “31 Days of Action” by Stand Up for Science. The top half features red diagonal banners with white text reading “31 Days of Action” and the Stand Up for Science logo beneath it. The background includes blue ink splatters, red and white stars, and distressed textures evoking protest art. The right side prominently displays the Statue of Liberty in grayscale, holding her torch high. At the bottom, there is a red QR code and a blue banner with the URL: “standupforscience.net/31-DAYS-OF-ACTION”. The overall design conveys urgency, activism, and American iconography.

📣 ANNOUNCEMENT: 31 Days of Action – All August!

Funding cuts. Banned words. Fired public servants.

Trump & his cronies are dismantling America’s greatest experiment - our democracy - & with it, science.

Between now & Sept 30th we decide: Are we a democracy… or an oligarchy?

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G-protein-coupled receptor ADGRG1 drives a protective microglial state in Alzheimer's disease through MYC activation Microglial ADGRG1 drives a protective state in Alzheimer’s disease by activating the transcription factor MYC, which upregulates genes associated with homeostasis, phagocytosis, and lysosomal function...

G-protein-coupled receptor ADGRG1 drives a protective microglial state in Alzheimer's disease through MYC activation: @cp-neuron.bsky.social www.cell.com/neuron/fullt...

Sensory modality-specific wiring of thalamocortical circuits - Nature Reviews Neuroscience The use of transcriptomic technologies has led to advances in our understanding of thalamocortical targeting during development. In this Review, Guillamón-Vivancos et al. discuss these advances in the...

Sensory modality-specific wiring of thalamocortical circuits — a Review by Teresa Guillamón-Vivancos, Mar Aníbal-Martínez, Lorenzo Puche-Aroca, Francisco J. Martini & Guillermina López-Bendito

@guillelbendito.bsky.social @glb-lab.bsky.social

#neuroscience

www.nature.com/articles/s41...

Most comprehensive review of DBS in epilepsy to date (124 studies, 1,210 patients, and 20 anatomical targets) 😱
www.medrxiv.org/content/10.1...

The Alzheimer's-Associated SORL1 p.Y1816C Variant Impairs APP Sorting, Axonal Trafficking, and Neuronal Activity in iPSC-Derived Brain Models #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.1101/2025.07.28.667160v1

Large-scale plasma proteomics uncovers preclinical molecular signatures of Parkinson disease and overlap with other neurodegenerative disorders #NeuroDegeneration 🧪🧠
http://medrxiv.org/cgi/content/short/2025.07.30.25332433v1

Comparative neuroscientist Dr. Andrew Iwaniuk revels in unlocking the what, how and why of bird behaviour | UNews

If you are interested in bird behaviour or animal brains, our book has you covered. Available next week, you can order direct from @mitpress.bsky.social (mitpress.mit.edu/978026255273...) or wherever books are sold.
#birds #neuroskyence 🪶🧠🧪🇨🇦

See more on it here:
www.ulethbridge.ca/unews/articl...

Behavioral Sciences, Vol. 15, Pages 939: Revisiting Public Trust and Media Influence During COVID-19 Post-Vaccination Era—Waning of Anxiety and Depression Levels Among Skilled Workers and Students in Serbia Infectious disease outbreaks amplify the influence of stressors on psychological conditions. The purpose of this study was to analyze the disturbing influence of COVID-19 outbreak-related information and the influence of trust on the Serbian healthcare system and COVID-19 preventive measures on anxiety and depression. An anonymous online questionnaire assessing the demographic information, disturbance level and causes, and levels of anxiety and depression has been distributed to the participants, divided into student and non-student groups. The non-student group was further divided into healthcare, military, and education workers. Anxiety and depression levels, as well as the level of decreased trust in COVID-19-related preventive measures, were higher among students compared to non-students (p = 0.011). Higher anxiety and depression levels, and higher influence of the COVID-19 outbreak on those levels, were observed in education and healthcare workers, compared to military personnel. Medical doctors reported a higher level of trust in the healthcare system compared to nurses (p = 0.023). Trust in the healthcare system increased more frequently compared to the pre-vaccination period among medical doctors, compared to nurses (p = 0.040). Higher anxiety and depression and lower public trust levels in students and workers in education and the healthcare sector indicate a need to focus on these important society members during public health emergencies.

Behavioral Sciences, Vol. 15, Pages 939: Revisiting Public Trust and Media Influence During COVID-19 Post-Vaccination Era—Waning of Anxiety and Depression Levels Among Skilled Workers and Students in Serbia BehSciMDPI

A hypothalamic circuit that modulates feeding and parenting behaviours - Nature Single-cell transcriptomic analysis of mouse hypothalamus and behavioural experiments show that specific hypothalamic networks regulate conflicting feeding versus parenting behaviours of female mice.

How do animals decide if they should forage for food or stay home to take care of newborn offspring? Whose needs come first? For my PhD work now out in Nature, we examined how hunger and parenting neurons interact and are reshaped postpartum in mice 🧵⬇️ www.nature.com/articles/s41...

Dialogues Across Time? Conceptualising the Temporal Relationships of Palimpsests in the Upper Palaeolithic Cave Art of El Castillo (Cantabria, Spain) - Journal of Archaeological Method and Theory Cave sites were frequently reused throughout the Upper Palaeolithic, with many sites within south-western Europe having deep chronologies of activity. The repeated engagement with the same caves, or s...

Why did Palaeolithic artists decide to produce art on the same walls that someone else had decorated? Do rock art palimpsests reflect dialogues that occurred across tens-of-thousands of years? My new OA paper develops a conceptual framework to explore these dimensions! 👇🏺

doi.org/10.1007/s108...

Stomach–brain coupling indexes a dimensional signature of mental health - Nature Mental Health Using a relatively large and diverse sample of mostly young adults, this study by Banellis, Rebollo and colleagues examines associations between regional stomach–brain coupling and mental health and i...

I’m elated to share our latest publication - out now in @natmentalhealth.nature.com! www.nature.com/articles/s44... - tour de force by @leahbanellis.bsky.social @brainandstomach.bsky.social and the rest of the VMP team!

A neural manifold view of the brain - Nature Neuroscience Recent advances in neuroscience have revealed how neural population activity underlying behavior can be well described by topological objects called neural manifolds. Understanding how nature, nurture...

Check out our new review/perspective (w/ @juangallego.bsky.social & Devika Narain) on neural manifolds in the brain! It was a lot of fun to think through these ideas over the past couple of years, and I'm excited it's finally out in the world!

🔗: www.nature.com/articles/s41...
📄: rdcu.be/ex8hW

Preclinical science is changing- and about time 🧪

Our latest blog reviews “Navigating the Paradigm Shift of Sex-Inclusive Preclinical Research”, a crucial read on why accounting for sex in lab research isn’t optional- it’s essential.

www.womeninneuroscienceuk.org/post/bridgin...

#SABV #Science

Spatial proteomics of Alzheimer’s disease-specific human microglial states - Nature Immunology In this Resource paper, the authors use MIBI spatial proteomics to map microglial cell states in brains from cognitively normal humans and those with Alzheimer’s disease.

Spatial proteomics of Alzheimer’s disease-specific human microglial states

www.nature.com/articles/s41...

Conservation and divergence of metabolic phenotypes between patient tumours and matched xenografts - Nature Metabolism Rao and Cai et al. perform a detailed metabolic comparison between primary tumours from patients and their matching xenografts, which identify conserved as well as divergent metabolic patterns.

1/Patient-derived xenografts (PDXs) are used in preclinical testing of cancer therapies, including metabolic therapies. We determined which metabolic properties are retained, and which are lost, when melanomas from patients are implanted and passaged as PDXs in mice.
www.nature.com/articles/s42...

Top: Optogenetic activation of anterior but not posterior D2R-neurons impaired WM under low cognitive load. Top left: Schematic illustrating virus injection and optic fiber implantation in DMS of Adora2a-Cre (+) mice. Top middle: Representative images showing ChR2 (red) and DAPI (blue) expression in DMS. Top right: Photo-stimulation of ChR2 led to notable c-Fos induction in DMS (green). Scale bar, 100 μm. Bottom: Optogenetic inhibition of D1R-neurons selectively improved WM maintenance and retrieval under higher cognitive loads. Bottom left: Schematic illustrating virus injection and optic fiber implantation in DMS of Drd1-Cre (+) mice, plus a representative images showing ArchT expression (green), DAPI staining (blue) in DMS, and its projections to the GPi and SNR. Bottom right: Photoinhibition of ArchT resulted in c-Fos induction in DMS (red). Scale bar, 100 μm

Untangling the role of the two types of striatal #dopamine neurons in #WorkingMemory has been challenging. This study shows that D2R neurons primarily govern WM under low cognitive load, while D1R neurons take over when cognitive load increases @plosbiology.org 🧪 plos.io/4mfgx0s

Neural anticipation of virtual infection triggers an immune response - Nature Neuroscience Serino et al. show that seeing an infectious avatar approach the body in virtual reality triggers an immune response, indicating that the brain prepares the body to fight infections even for perceived...

Avatars who appear to be sick entering the peripersonal space in virtual reality are anticipated by multisensory–motor areas, activate the salience network, and trigger activation of innate lymphoid cells, mirroring responses seen in actual infections

www.nature.com/articles/s41...

Noradrenergic activation of the basolateral amygdala facilitates memory specificity for similar events experienced close in time - Nature Neuroscience Atucha et al. provide evidence that noradrenergic activation of the basolateral amygdala facilitates the formation of discrete memories of similar events experienced close in time via a miR-134-regula...

Noradrenergic activation of the BLA promotes the formation of discrete memories of similar events that were experienced close in time, via a miR-134-regulated consolidation process within the dentate gyrus of the hippocampus

www.nature.com/articles/s41...

Brain Surfaces of 70 primate species

1
To predict the behaviour of a primate, would you rather base your guess on a closely related species or one with a similar brain shape? We looked at brains & behaviours of 70 species, you’ll be surprised!

🧵Thread on our new preprint with @r3rt0.bsky.social , doi.org/10.1101/2025...

Illustration of a scientist holding her child's hand while talking to colleagues. Text says: Making myself visible as a grad student parent

"Despite my discomfort and the potential for backlash, I need to make myself visible as a single parent and to advocate for change."

On #NationalParentsDay, read about how this researcher has advocated for more support for grad student parents. scim.ag/3UpZSLJ

#Gaza: Joanne Perry, a Canadian Doctors Without Borders physician works in Al-Helou hospital, where newborn babies are fighting for their lives and medical teams lack essential equipment to keep them alive.

Read about her experience: ow.ly/alrK50WuWt3

Biology-driven material design for ischaemic stroke repair - Nature Reviews Bioengineering Rehabilitation after ischaemic stroke can promote only limited recovery for many patients with stroke. This Review discusses how the distinctly reparative environment of the subacute time window after stroke can inform the design of biology-driven biomaterial-based stroke therapies.

Ischaemic stroke remains a leading cause of disability. This article discusses the design of biomaterials that can engage and modulate pro-repair mechanisms in the brain to improve repair after ischaemic stroke:

What time do you collect Microglia from preclinical models for downstream analyses? Microglia undergo transcriptional, proteomic and functional adaptations to the wake and sleep phases🧵 shorturl.at/LpEQk

#Medsky🧪 #publichealth
Not all diets are the same & #sexdifferences in the #ketogenicdiet have been a topic of research. Multiple studies have shown considerable variability in the efficacy of KD dietary interventions due to individual variables, adherence, metabolism, & sex-specific factors.

How does the human brain coordinate hierarchical cortical development? Our work in Nature Neuroscience identifies a role for thalamocortical structural connectivity in the expression of hierarchical periods of cortical plasticity & environmental receptivity in youth 🧵 www.nature.com/articles/s41...

Honeymooning in New Zealand when I got the notice that the final version of my thesis paper is out! Huge thank you to the @elife.bsky.social editors and reviewers for making this the smoothest review process I’ve ever had. Give it a read! #microglia #AGS 🤓🧠

elifesciences.org/reviewed-pre...

Rethinking microglia from a circadian perspective in neuroimmunology: New insights - PubMed Rethinking microglia from a circadian perspective in neuroimmunology: New insights

Microglia don’t act the same around the clock! Their transcriptional/proteomic/functional programs shift across sleep/wake phases - yet most studies ignore time-of-day. This perspective calls for a circadian rethink in neuroimmunology!
pubmed.ncbi.nlm.nih.gov/40618264/

Research Associate: Senescence, Microglia and Alzheimer’s Research Associate at Imperial College London: Join Prof. Gil’s team to study senescence in iPSC-derived microglia and identify Alzheimer’s drug targets.

Research Associate (MRC-funded) at Imperial College London: Join Prof. Gil’s team to study senescence in iPSC-derived microglia and identify Alzheimer’s drug targets. Closing date: 17th August

www.dementiaresearcher.nihr.ac.uk/job/research...

Response of spatially defined microglia states with distinct chromatin accessibility in a mouse model of Alzheimer’s disease
www.nature.com/articles/s41...