Laura Cantini

Laura Cantini

@cantinilab.bsky.social

PI of the machine learning for Integrative genomics lab @pasteur.fr and @CNRS.bsky.social #NewPI #DiversityEqualityInclusion Single-cell, multi-omics, machine learning

913 Followers 235 Following 22 Posts Joined Nov 2024
2 days ago
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Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis Gene expression patterns underlie development, but their systematic detection in whole embryos has remained elusive. We introduce a whole-embryo imaging platform using multiplexed error-robust fluores...

Very happy to see this out. 👏 @yinanwan.bsky.social
Bogdan Bintu and team.
Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis | free link Science www.science.org/eprint/5MHTM...

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5 days ago
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Kicking off the AI for Life Sciences course at @institutpasteur.bsky.social today! 🧬🤖

Special thanks to @bonomimax.bsky.social and Ernest Mordret for the co-organization, to the @pasteuredu.bsky.social and all the trainers.

Excited to dive into how algorithms can help us understand life!

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1 month ago
Portail Emploi CNRS - Offre d'emploi - PhD (M/F) in development of machine learning methods for single-cell omics data integration Assurez-vous que votre profil candidat soit correctement renseigné avant de postuler

PhD position in my team at @pasteur.fr ! The selected canddiate will work on the development of new methods combining biophysicial and machine learning modelling for single-cell multi-omics spatiotemporal data.

emploi.cnrs.fr/Offres/Docto...

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1 month ago

New preprint from my team! led by @remitrimbour.bsky.social in collaboration with the @saezlab.bsky.social, we developped ReCoN a new method to model multicellular coordination and its underlying molecular mechanisms.

📜 Paper: lnkd.in/eJ8SfFNH
💻 Code: lnkd.in/e-qx2iNp

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1 month ago
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Did you miss us? Join us this summer at @netsciconf.bsky.social, where our excellent group of thinkers will explore the role of #NetworkMedicine across different scales!🧬🔁🏥

Submit your contribution by March 3rd: shorturl.at/WC6U3

#NetSci2026 #NetBioMed2026

netbiomed-symposium.github.io

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1 month ago
Portail Emploi CNRS - Offre d'emploi - Two Postdoctoral (M/F) Positions in the Development of Machine Learning Methods for Single-Cell Multi-Omics Spatiotemporal Data Assurez-vous que votre profil candidat soit correctement renseigné avant de postuler

Two postdoc positions opened in my team @pasteur.fr in Paris on the development of machine learning methods for single-cell multi-omics spatiotemporal data.

See the announcement for all details emploi.cnrs.fr/Offres/CDD/U...

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2 months ago

New preprint from my team!

Led by @jkobject.com "scPRINT-2: Towards the next-generation of cell foundation models and benchmarks"

We perform an additive benchmark of single-cell Foundation Models (scFMs) and we present scPRINT-2 pre-trained on 350 million cells

📝 www.biorxiv.org/content/10.6...

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2 months ago

🧑‍🎄🎄 Christmas Foundation Model Release: scPRINT-2

**One-liner:** a **20M-active-param** single-cell foundation model trained on **350M cells / 16 species / 300 tissues / 500 cell types**.
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3 months ago

#ResultatScientifique🔎| Une nouvelle méthode permet de prédire comment les cellules évoluent et se différencient dans le temps et l’espace. 💻
✍️ @cantinilab.bsky.social et @gabrielpeyre.bsky.social
📕 @naturemethods | buff.ly/XJlsK5P

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3 months ago
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Creation of new junior research groups at the Institut Pasteur - Call for applications 2026 - Research The Institut Pasteur is launching an international call to recruit new junior research group leaders leveraging cutting-edge transdisciplinary approaches to exploring infectious diseases, host-microbe...

🔬 Call to create junior research groups at the Institut Pasteur

Focus: Infectious diseases, host-microbe interactions, vaccines
Special interest: AI methodologies

📅 Deadline: Feb 9, 2026
👥 2-12 years post-PhD

Apply now 📝 research.pasteur.fr/en/call/crea...

#JobOpportunity #Research

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3 months ago
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Mid-career Group Leader position in AI in genomics at Institut Pasteur, Paris - Research Institut Pasteur and the CNRS are launching a call for a mid-career group leader position in AI in genomics. We are looking for an experienced researcher (typically with > 8 years of research experien...

There a is a joint call between @pasteur.fr and @cnrsbiologie.bsky.social for a mid career group leader position in AI and genomics (or molecular biology). Don't hesistate to spread the word if you know anyone relevant.

research.pasteur.fr/en/call/mid-...

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3 months ago
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INCEPTION Symposium 2025 - Research INCEPTION symposium 2025 - Focus on GWAS: paving the way for the future of genetics.

The INCEPTION is organizing its Annual Symposium. This year is about GWAS & beyond! We're happy to have @bpasaniuc.bsky.social, @caina89.bsky.social, Iuliana Ionita-Laza , Sriram Sankararaman, and others, who will talk about tools for understanding the genetic determinants of complex diseases

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4 months ago
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STORIES: learning cell fate landscapes from spatial transcriptomics using optimal transport - Nature Methods By learning a differentiation potential using an optimal transport-based approach, STORIES models and infers cell fate trajectories using spatiotemporal omics data.

By learning a differentiation potential using an optimal transport-based approach, STORIES models and infers cell fate trajectories using spatiotemporal omics data. @gabrielpeyre.bsky.social @cantinilab.bsky.social

www.nature.com/articles/s41...

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4 months ago
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STORIES: learning cell fate landscapes from spatial transcriptomics using optimal transport - Nature Methods By learning a differentiation potential using an optimal transport-based approach, STORIES models and infers cell fate trajectories using spatiotemporal omics data.

Happy to share STORIES out now on Nature Methods

STORIES learns cell fate landscapes from spatial tramscripromics data profiled at several time points, thus allowing prediction of future cell states.

Led by Geert-Jan Huizing and Jules Samaran

www.nature.com/articles/s41...

@pasteur.fr

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4 months ago

Don't miss the upcoming DBC seminar by @juliosaezrod.bsky.social, head of Research at EMBL-EBI's! (on Friday 24 october at 2pm in Auditorium Jules Bordet for those at Pasteur). Julio will present works on knowledge-based machine learning to extract disease mechanisms from spatial multi-omics data.

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5 months ago

CIRCE out on biorxiv, give it a try for inferring peak co-accessibility networks from large single-cell data!

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5 months ago
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Very happy to introduce jsPCA, a fast and interpretable computational framework for spatial transcriptomics that simultaneously identifies spatial domains and variable genes across multi-slice and multi-sample data.

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6 months ago
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We (with @nicolasdray.bsky.social @zenlabpasteur.bsky.social) are happy to release officially FishFeats, our #napari plugin to streamline 3D smFish/RNA quantification! 🎊
Available here: github.com/gletort/Fish... user documentation: gletort.github.io/FishFeats/

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7 months ago
Brain Surfaces of 70 primate species

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To predict the behaviour of a primate, would you rather base your guess on a closely related species or one with a similar brain shape? We looked at brains & behaviours of 70 species, you’ll be surprised!

🧵Thread on our new preprint with @r3rt0.bsky.social , doi.org/10.1101/2025...

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7 months ago
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SPONGE: simple prior omics network GEnerator AbstractSummary. Gene regulatory networks modelled from experimental data can be improved through the use of prior biological knowledge, e.g. transcription

GRN inference algorithms often build on prior knowledge of e.g. TF binding. Build up-to-date priors with our new tool SPONGE, now out in Bioinformatics: academic.oup.com/bioinformati...

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7 months ago

MOTL is finally out in Genome Biology! Work led by David Hirst and @anaisbaudot.bsky.social

If you are interested in multi-omics matrix factorization when few samples are available (e.g. rare diseases), have a look at it!

#multiomics #machinelearning #transferlearning

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7 months ago

Going back to Paris after four days of awesome science! Really happy to have contributed to #ISMBECCB2025 with a keynote talk in the @netbio.bsky.social.

Thanks again @anaisbaudot.bsky.social and all #NetBio commitee for the invitation!

@institutpasteur.bsky.social #singlecell #AI #netbio

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7 months ago
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Group Leader (282908) | University of Oslo Job title: Group Leader (282908), Employer: University of Oslo, Deadline: Monday, September 8, 2025

🚨 We're hiring! NCMBM @ncmbm.bsky.social is looking for 2 new group leaders to join our vibrant research community. Ready to build your own group with strong support and a solid startup package?

Interested and attending #ISMBECCB2025? Let’s connect!

🔗 www.jobbnorge.no/en/available...

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7 months ago
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🚨 Excited to announce our first keynote for #NetBio 2025: Laura Cantini (@cantinilab.bsky.social)!

She is sharing cutting-edge work on multi-modal learning for single-cell data integration, tackling how to combine diverse omics and spatial data to unlock new insights into cellular heterogeneity.

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7 months ago
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scConfluence: single-cell diagonal integration with regularized Inverse Optimal Transport on weakly connected features - Nature Communications The abundance of unpaired multimodal single-cell data drives the need for improved integration methods. Here, authors introduce scConfluence, a method combining uncoupled autoencoders with regularized...

For more infos on the presented works
scPRINT: www.nature.com/articles/s41...
scConfluence: www.nature.com/articles/s41...
STORIES: www.biorxiv.org/content/10.1...

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7 months ago

Flying to Liverpool for #ISMBECCB2025 @iscb.bsky.social. This year the lab is well represented with @jkobject.com presenting scPRINT in #MLCSB, Jules presenting two posters at #MLCSB: scConfluence and STORIES. I will finally, give a keynote at #NETBIO. Come to see us at the conference!

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8 months ago

Fantastic opportunity to launch your research group following the @embl.org model in a great environment with a solid startup package and access to state-of-the-art resources.

Join us at the @ncmbm.bsky.social, part of the @nordicembl.bsky.social, at @uio.no

Feel free to reach out if you have Qs.

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8 months ago
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Leveraging data as a patient–scientist: frustrations and opportunities Nature Reviews Nephrology, Published online: 19 June 2025; doi:10.1038/s41581-025-00968-9The transition from data scientist to patient–scientist has given me new perspectives into clinical research and strengthened my commitment to open science. Although limitations on data availability have led to frustration, collaboration bodes well for a future in which patients will have access to more personalized information.
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9 months ago
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Two weeks ago, I had the pleasure to discuss the research activity of my team @institutpasteur.bsky.social in the panel discussion "How is AI and data-driven innovation reshaping oncology" at @parissaclay.bsky.social SPRING 2025 in @ecolepolytechnique.bsky.social

#ParisSaclaySPRING #SPRING25

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9 months ago
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Kicking off our afternoon session, @cantinilab.bsky.social discusses her dual approach to capture both multi-modal dimensionality reduction and molecular network inference. She gave a very nice overview of her work!

#NetBioMed2025 #NetSci2025 @verapancaldi.bsky.social

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