Luisi-Lab

Iodonitrene-Mediated Nitrogen Transfer to Alkenes for the Direct Synthesis of NH-Aziridines This work presents a novel and efficient method for the direct synthesis of NH-aziridines from a broad range of alkenes under mild conditions. The developed method uses aqueous ammonia and (diacetoxyiodo)benzene (PIDA) at 0 °C, offering a straightforward and atom-economical approach. Notably, this approach addresses the common challenge of chemoselectivity, effectively preventing the overoxidation of aziridines to nitriles. Mechanistic studies support the involvement of an in situ-generated iodonitrene as the key nitrogen-transfer intermediate. Overall, this method represents a significant advancement in aziridine synthesis, combining simplicity and selectivity, and complements the existing procedures for the direct NH insertion into alkenes.

Iodonitrene-Mediated Nitrogen Transfer to Alkenes for the Direct Synthesis of NH-Aziridines | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/...

We’re building the future of pharmaceuticals: connected, intelligent, sustainable. The challenge isn’t to make drugs greener — it’s to redesign the way we make them.
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What happens when design meets catalysis? SusPharma explores additive manufacturing to enable tailor-made, greener reactions.
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For SusPharma, sustainability is not a single task — it’s the foundation of every process, reaction and solution across the project.
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Horizon Europe gave us a challenge: make pharma sustainable by design, not as an afterthought.
Sustainability isn’t a feature. It’s the blueprint.
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Automation isn’t just about efficiency — it’s about safer, smarter, scalable processes.
Robotics is one of SusPharma’s keys to sustainable manufacturing.
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Ten partners, ten expertise areas, one shared goal: redesigning pharmaceutical manufacturing for a sustainable future. Each partner leads a critical piece of SusPharma, bringing science, technology and vision together.
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The pharmaceutical industry must cut its carbon footprint without compromising innovation. SusPharma is piloting technologies to make that shift possible.
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YouTube video by SusPharma SusPharma: shaping a sustainable future for pharmaceuticals

Uniting 10 partners, 30+ researchers, 2 patents & 35+ publications, #SusPharma drives greener & more efficient pharma.
Backed by #HorizonEurope, it links top universities, research centres & companies for a sustainable industry.
🎥 www.youtube.com/watch?v=6ddY...

In SusPharma, continuous crystallization is more than a technique — it’s a way to make greener processes industrially viable. Scalable, consistent, and sustainable by design.
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Generation and Use of Cyclopropenyllithium under Continuous Flow Conditions The cyclopropene scaffold has emerged as a valuable platform in modern synthesis. Here, we present a streamlined flow-based approach for the generation of cyclopropenyllithium and its functionalizatio...

Generation and Use of Cyclopropenyllithium under Continuous Flow Conditions | Organic Letters pubs.acs.org/doi/10.1021/...

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