Amanda Sierra

Building Immunocompetent Cerebral Organoids From a Developmental Perspective Conventional cerebral organoids do not contain microglia, which must be added. We propose recommendations to assess microglial immunocompetence using quantitative approaches and stringent statist...

Are you interested in human brain #organoids to study #microglia but don't know where to start?🧠🧪
#neuroskyence

Here's our piece of advice on "Building Immunocompetent Cerebral Organoids From a Developmental Perspective"

onlinelibrary.wiley.com/doi/10.1002/...

The @sierralab.bsky.social lab is hiring!

Postdoctoral position in #microglial development (#IKUR)

www.achucarro.org/job/postdoct...

Reaching Marseille was quite an odissey because of the wildfires, but the #Euroglia meeting was quite a success! Tons of science, friends and fun!

¿Y si pudiéramos evitar la menopausia? | El Correo Se están desarrollando terapias para rejuvenecer los ovarios y evitar los efectos negativos sobre la salud

@sierralab.bsky.social reflexiona sobre si se puede parar la #menopausia

www.elcorreo.com/vivir/salud/...

Pero cámbiate el handle que no sabía que eras tú!

Congrats dear Alberto! You rock!

This sounds sooo familiar

So, maybe, "The next time we hear a crazy/bitch narrative about a senior woman, let's ask ourselves: How much first-hand evidence do we personally have to back it up -- does it resonate with our own direct observations and interactions with her?"

#Cellpose 3 paper now out. Not all images are perfect. Restore your images with Cellpose3 to get better segmentations, w/ @marius10p.bsky.social www.nature.com/articles/s41...

Congrats Marisol, you rock!

Amid NIH upheaval, how to keep sex as a biological variable Even in the absence of formal instruction to do so, we should continue to hold our colleagues accountable for SABV practices.

Even in the absence of formal instruction to do so, we should continue to hold ourselves and our neuroscience colleagues accountable for “Sex as a Biological Variable” practices, writes @docbecca.bsky.social.

#neuroskyence

www.thetransmitter.org/sex-differen...

My heart is with my fellow american scientists... Politics interfering with science at this level is something I could have never expected

Fantastic defense by the ever amazing @martapiglesias.bsky.social! Watch out for more great things to come from her!

Thank you Carles!

Francis Collins, the NIH Director for 12 years, led the Human Genome Project and other NIH efforts for 32 years, resigned today. Key words from his resignation letter
www.nytimes.com/2025/03/01/u...

Of course, the field has been focused on pruning for too long, disregarding other roles. It's not good for discovery!

🗣️ℹ️How do we prevent misinformation? By talking about it, without reservations and full openness.

🧫🐁It is the same with science communication and #AnimalResearch specifically.

💉💡Even if you somehow oppose it… know why it is still needed.

Thanks for reaching out! The distinction between hunters or gatherers (culling or scavening) is mechanistic and needs to be experimentally determined. Pruning and gardening are poetic terms but not accurate enough in my opinion. They do not help understanding how microglia actually remove synapses

This is today. No recording, so it won't be available in our website.
Don't miss it!

Thinking like a scientist: not that trivial

I would love to hear your views on this article. I discuss some hurdles I faced when thinking about experiments and projects design. This is something no one formally teaches you.

network.febs.org/posts/thinki...

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Interested in pursuing a PhD in neuroimmunology and metabolism? Apply to this call to work on a collaborative project between my group and @cmadore.bsky.social !

"Note, for all the seemingly sophisticated thought and language, the moral indifference born of unintelligence. Here, ChatGPT exhibits something like the banality of evil: plagiarism and apathy and obviation".

"On the contrary, the human mind is a surprisingly efficient and even elegant system that operates with small amounts of information; it seeks not to infer brute correlations among data points but to create explanations".

Opinion | Noam Chomsky: The False Promise of ChatGPT (Published 2023) The most prominent strain of A.I. encodes a flawed conception of language and knowledge.

"The human mind is not, like ChatGPT a lumbering statistical engine for pattern matching, gorging on terabytes of data and extrapolating the most likely conversational response, most probable answer to a scientific question"

Noam Chomsky: The False Promise of ChatGPT www.nytimes.com/2023/03/08/o...

📢New webinar coming soon📢 
Dr. Gilbert Di Paolo from Denali Therapeutics will be our next speaker on February 4th. Check all the information in the flyer and add it to your calendar!

Contact me if you are interested in pursuing an independent position in Neuroscience 🧪🧠 at Achucarro @achucarro.bsky.social

calls.ikerbasque.net

Any #SpatialTranscriptomics people out there interested in studying #microglial development?
We need a collaborator based in the Americas or Asia to apply for a #HSPF grant

www.hfsp.org/funding/hfsp...

Gorgeous!

The floor is open for discussion!