oZgun Gokce

"Immigrants, we get the job done"

www.economist.com/graphic-deta...

Immune signatures link myelin oligodendrocyte glycoprotein antibody–associated disease to other autoantibody-mediated conditions Single-cell immunoprofiling uncovered systemic immune cell signatures of neurological MOG antibody–associated disease.

MOG antibody-associated disease (MOGAD) affects the central nervous system, but our new immunophenotyping data show that it also profoundly alters circulating immune cells.
www.science.org/doi/10.1126/...
#Immunology #MOGAD #Autoimmunity #Neurology

Three portraits of men – the 2025 Nobel Prize winners in Chemistry

✨🥳🎉 Heartfelt congratulations to Humboldtians Susumu Kitagawa and Omar M. Yaghi on winning the #NobelPrize in Chemistry 2025 which they share with Richard Robson for the development of "metal-organic frameworks"!

We are truly honoured to have supported a step in their exceptional journey! 💚

Joint Professorship for Susanne Wegmann at DZNE and Charité Boost for Brain Research in Berlin.

🎉 Congratulations to Dr. Susanne Wegmann on her joint professorship at DZNE and Charité!
Her research focuses on the Tau protein in neurodegenerative diseases - a strong boost for brain research in Berlin!

👉 www.dzne.de/en/news/pres...

We present multi-immersion Oblique Plane microscope (miOPM), a light-sheet platform that can be adapted to a wide range of applications, from sensitive live cell imaging to imaging organs and cleared tissues.
www.biorxiv.org/content/10.1...

A photo of a Nobel medal

BREAKING: The Nobel Prize in Physiology or Medicine has been awarded jointly to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi "for their discoveries concerning peripheral immune tolerance"

Stay tuned for more.
#NobelPrize

Standing by Our Colleagues in Gaza — A Plea to the U.S. Medical Community | NEJM In the face of Israel’s ongoing assault on Gaza’s health system and the catastrophic famine caused by the devastation, U.S. physicians have an ethical obligation to respond and support immediate ch...

My friend Naftali Kaminski is an Israeli physician, a professor at Yale, and the child of Holocaust survivors. For me he is a model of absorbing his parents' stories intensely, looking the horror of the 20th century in the eyes, and drawing the lesson of radical empathy for the suffering of others.

We have a new PhD studentship in the lab on the immunogenic roles of transposable elements in paediatric acute myeloid leukaemia! Come and work with us! www.colcc.ac.uk/2026-cyp-phd...

Gestational psychedelic exposure disrupts brain development and offspring behavior in mice Despite increasing non-medical use and clinical investigation of psychedelics, the consequences of prenatal exposure remain unknown. In mice, maternal lysergic acid diethylamide (LSD; 0.3 mg/kg) cross...

🚨 Psychedelics in pregnancy - can a single dose reach the embryo and matter? Yes. In mice they hit embryonic CSF within minutes, activate choroid plexus→CSF axis, & shift cortical development with adult behavioral signatures. @lehtinenlab.bsky.social Preprint:

www.biorxiv.org/content/10.1...

1/13

Big congratulations, this is super exciting!

YouTube video by TUM School of Life Sciences Prof. Dr. Alexander Bartelt | Translational Nutritional Medicine

2 min on our reseach @tum.de youtu.be/1xpXOeDSX_o

📢 New webinar coming soon 📢 
Ozgun Gokce @gokcegroup.bsky.social from German Center for Neurodegenerative Diseases will be our next speaker on October 7th. Check all the information in the flyer and add it to your calendar!

which one? cool looking

Very excited and proud to share my postdoctoral research with @neurrriot.bsky.social looking at the context-specific encoding of social behavior 💃🕺 in hormone-sensitive, large-scale brain networks in mice!

www.biorxiv.org/content/10.1...

#neuroskyence #compneurosky 🧪
1/12

Now I know to whom to be super nice

Erdinc Sezgin to Receive 2026 Early Independent Career Award
www.biophysics.org/news-room/er...

Cool method! Congratulations

Cryo-mtscATAC-seq for single-cell mitochondrial DNA genotyping and clonal tracing in archived human tissues High-throughput clonal tracing of primary human samples relies on naturally occurring barcodes, such as somatic mitochondrial DNA (mtDNA) mutations detected via single-cell ATAC-seq (mtscATAC-seq). Fr...

🚨 New preprints from our lab!
First, we introduce Cryo-mtscATAC-seq, led by Maren (@ms-maren.bsky.social ), enabling high-throughput clonal tracing from frozen human samples by isolating nuclei with their mitochondria (“CryoCells”).
👉 www.biorxiv.org/content/10.1...

Bioinformatician / Data Scientist (m/f/d) Bioinformatician / Data scientist position in the Aztekin Lab focusing on Structural Regeneration and support the working group together with the other members

🚀 Looking for a Bioinformatician / Data Scientist to join our crew and explore regeneration through single-cell genomics & evolutionary biology! @mpi-bio-fml.bsky.social
📩 Questions? Contact us ✉️
🔗 Apply here: www.mpg.de/25243280/bio...

We are seeking a Postdoctoral Researcher to join our group at the University Hospital Bonn / DZNE. The project will focus on spatial omics approaches to study how lipid transport and the immune system shape neurodegeneration. DM me here

Excited to be part of the amazing NDCN community! proud of our progress and looking forward to translating discoveries to the clinic! chanzuckerberg.com/wp-content/u...

David Baltimore, Nobel-Winning Molecular Biologist, Dies at 87

Co-discoverer of reverse transcriptase at 32, Nobel Prize at 37, played a key role at the 1975 Asilomar comference.

Elegant work from @perothwell.bsky.social lab!

Aberrant splicing exonizes C9orf72 repeat expansion in ALS/FTD - Nature Neuroscience By selectively isolating and sequencing the rare RNA transcripts containing C9orf72 repeat expansion from ALS–FTD neurons, the authors uncover an alternative splicing mechanism that explains the reten...

Aberrant splicing exonizes C9orf72 repeat expansion in ALS/FTD

@junjieguo.bsky.social @yalerna.bsky.social @yaleneuro.bsky.social

www.nature.com/articles/s41...

The last gift: How bodies donated for research may help find a cure for HIV Pioneering project uses “rapid autopsies” to find virus hideouts in infected people

I started research for this story, which came out today, more than a year ago. Thanks to all who stuck with me, and shared their thoughts. www.science.org/content/arti...

Impaired capillary–venous drainage contributes to gliosis and demyelination in mouse white matter during aging - Nature Neuroscience How reduced blood flow plays a role in progressive white matter loss during aging and associated cognitive decline is unclear. Here the authors show that selective constriction and rarefaction of capi...

Impaired capillary–venous drainage contributes to gliosis and demyelination in mouse white matter during aging

www.nature.com/articles/s41...

🎉 scverse conference 2025 Registration & Call for Abstracts NOW OPEN! 🎉
We're excited to announce that registration and the call for abstracts are officially open for the scverse Conference 2025!
Details in thread!
🧵 1/3

Kinase activity of DYRK family members is required for regulating primary cilium length, stability and morphology - Communications Biology DYRK3 kinase interacts with multiple centriolar satellites and ciliary components to regulate axoneme length dynamics in cooperation with DYRK2.

New paper on DYRK kinases and primary cilium!
This project began with our interest in DYRK3’s relationship to centriolar satellites. But what started as a CS-focused story soon evolved into studying DYRK kinase activity during ciliogenesis.
nature.com/articles/s42...

Repost with a group you'd love to hang out with.

BBS8-dependent ciliary Hedgehog signaling governs cell fate in the white adipose tissue | The EMBO Journal imageimageDisruption of ciliogenesis in Bardet-Biedl syndrome (BBS) leads to obesity and disrupted adipogenesis. This study reveals that ciliary dysfunction in a mouse model of BBS induces a a cell fa...

🚨 New in The EMBO Journal!
Loss of BBS8 disrupts ciliary Hedgehog signaling, switching adipocyte precursors into fibrogenic cells—remodeling adipose tissue before obesity begins.
🔬 #BBS #cilia @for5547.bsky.social @sfb1454.bsky.social @batenergy.bsky.social
📄 www.embopress.org/doi/full/10....