oZgun Gokce

🖥️🧬🚀 I am excited to share that our #omnideconv study is finally published on Genome Biology: doi.org/10.1186/s130...

Orwell’s prophecy

Who would have known that Orwell would turn out to be a great prophet?

Genome Data Science and AI for Therapeutic Target Discovery - King’s Prize Doctoral Programme | King's College London PhD programme in human genetics, AI and multi-omics to uncover causal biology and accelerate therapeutic target discovery with academic and industry partners.

📣 Exciting PhD opportunities in our new programme in 🧬Genome Data Science at @kingscollegelondon.bsky.social!

Come and work with me and @oliverpain.bsky.social on APOE penetrance and modifiers in #Alzheimer's.

Get in touch to discuss and apply by 28 February.

www.kcl.ac.uk/research/tar...

A super intense and fantastic sunny week in Alicante discussing single cell and spatial omics in the CNS! Thanks all the students for lots of discussions, great flash talks and lots of fun in the social activities, the local organizers, aka @silviadesantis.bsky.social and my co-chair Ana Falcão.

Thank you Gonçalo, @silviadesantis.bsky.social, and Ana Falcão. Amazing city, students, and science. I had a great time!

What a week! Thank you to the organisers and sponsors
Most of all, thanks to the students for their energy and engagement... was a blast!

🔬 pertpy: a unified, scalable framework for single-cell perturbation analysis, now out in Nature Methods

Designed for modern perturbation data - CRISPR, drug screens, patient treatments - scaling to millions of cells and 1000s of conditions.
👉 www.nature.com/articles/s41...

Maybe because anyone supporting the strike really surprising 🙊

It's an old and obvious pattern. An unpopular president - failing on the economy and losing his grip on power at home - decides to launch a war for regime change abroad.

The American people don’t want to “run” a foreign country while our leaders fail to improve life in this one.

The Company of Biologists 100 logo to the left and QR code to the right. Portrait of Christiane Nüsslein-Volhard , to the left, text to the right 100 extraordinary biologists Christiane Nüsslein-Volhard Christiane Nüsslein-Volhard is a Nobel Prize winner and Emeritus Director of the Max Planck Institute for Developmental Biology in Tübingen, Germany. She led efforts to establish zebrafish as a genetic model for vertebrate development, contributing many papers to the famous 1996 zebrafish issue of Development. #100biologists #biologists100

Our next extraordinary biologist is Christiane Nüsslein-Volhard, a Nobel Prize winner and Emeritus Director of the Max Planck Institute for Developmental Biology in Tübingen, Germany. #100biologists

Hybrid can work, but only when the work structure supports it. In my group, data generation and analysis are shared responsibilities, and that overlap is hard to replace remotely. Fairness and regulatory constraints also matter more than people like to acknowledge.

Does it apply to resubmissions?

Had a holiday get-together with the Gokce & Knoferle Lab, all these brilliant people, and the Enki 🐾
Almost 10 years as a PI, and I love every second of this privilege and joy of discovery!

In-person work can add value in some roles. It should not come at the cost of health... When necessary, roles and processes can be redesigned.

😎

Fully remote models can work beautifully for some groups. At the same time, we shouldn’t force one approach on everyone. I can train students remotely, but I find it less engaging and less rewarding than in-person mentoring.

Once trust exists, remote collaboration works great. especially if you already have a name and network. You have established your name. For you that works and I can see that. But I am not convinced it is good for training new comers to field.

Starting collaborations usually requires trust, and our social brains evolved to use all senses decide who to trust. Trust is the most important decision for a social animal and we use all senses for this.

As a mentor, I rely a lot on non-verbal cues, informal moments, and students teaching each other often during coffee breaks or after seminar bubblinggs. In a multidisciplinary lab like ours, a surprising amount of learning and trust-building happens in those unplanned, low-stakes interactions.

I agree that collaboration shouldn’t be forced, and there are many valid reasons people work remotely (visa, family, health). I strongly support finding ways to make remote work effective and inclusive. What I’m pushing back on is the idea that one model should fit everyone.

Magic happens when u dont directly tell people work together but they do… that just doesn’t happen over zoom often

#histopathology #tissueclearing #lightsheetmicroscopy #postdoc #sciencecareers #munich | Ali Maximilian Ertürk Hiring: PostDoc in Tissue Clearing & 3D Histopathology 🧪🖥️ My lab at Helmholtz Munich is seeking a highly motivated PostDoc/Scientist to strengthen our efforts in advanced imaging of cancer tissues. ...

Hiring: PostDoc in Tissue Clearing & 3D Histopathology 🧪🖥️

My lab at Helmholtz Munich is seeking a highly motivated PostDoc/Scientist to strengthen our efforts in advanced imaging of cancer tissues.
More info: www.linkedin.com/posts/ali-ma...

The human P2X4 receptor - (seen here from above) has three parts. If activated, a pore in the receptor opens and allows ions to flow into the cell. PSB-0704 (shown in color) prevents this from happening and blocks, for example, the transmission of pain signals.

The human P2X4 receptor plays an important role in chronic pain and inflammation. Researchers at the University of Bonn discovered a mechanism that can inhibit this receptor and open a pathway for new drugs. More: www.uni-bonn.de/en/news/216-...; DOI: doi.org/10.1038/s414...
© AG Müller/Hagelüken

Cluster of Excellence ImmunoSensation on Instagram: "🎨 Im Science & Art Workshop NeuVa Mandalas konnten sich Wissenschafts- und Kunstinteressierte kreativ austoben. Die Teilnehmenden konnten mithilf... immunosensation2 on December 4, 2025: "🎨 Im Science & Art Workshop NeuVa Mandalas konnten sich Wissenschafts- und Kunstinteressierte kreativ austoben. Die Teilnehmenden konnten mithilfe verschiedene...

The Science & Art Workshop NeuVa Mandala organised by @ruizdealmodovar.bsky.social and @sciart-is-cool.bsky.social allowed #science and #art enthusiasts to create their own art pieces representing the #neurovasculature

Check out our video from the #workshop:
www.instagram.com/reel/DR1l8NO...

Do nerdy posts count?

Anthony A. Hyman will become EMBL’s next Director General.

He joins EMBL from @mpi-cbg.de in Dresden. He is also Professor of Molecular Biology @tudresden.bsky.social, and was a group leader at EMBL Heidelberg from 1993 to 1999.

www.embl.org/news/people-...

Thanks to @gokcegroup.bsky.social for playing “tour guide” despite the weather! Hiked up to a cool castle above the Rhein and checked out the classic Christmas market in Bonn!

MERFISH+, a large-scale, multi-omics spatial technology resolves the molecular holograms of the 3D human developing heart Hybridization-based spatial transcriptomics technologies have advanced our ability to map cellular and subcellular organization in complex tissues. However, existing methods remain constrained in gene...

MERFISH+ by Quan Zhu and colleagues

- new chemistry that allows better signal retention, which increases multiplexability to 1800 RNAs
- combined RNA-DNA MERFISH
-3D spatially-resolved multi-omic atlas
- 13sq cm imaging area

*Quan is in the job market*

www.biorxiv.org/content/10.1...

Such a sweet and inspiring experience. Four decades of Südhof lab science shaping how we understand synapses and brain function. Grateful for the discoveries, the mentorship, and the friendships that keep growing.

Such a sweet and inspiring experience. Four decades of Südhof lab science shaping how we understand synapses and brain function. Grateful for the discoveries, the mentorship, and the friendships that keep growing.