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John C. Simon

@simjoblu.bsky.social

Dad - Intensivist - Nephrologist - Human . . .

262 Followers  |  257 Following  |  13 Posts  |  Joined: 16.11.2024  |  2.1067

Latest posts by simjoblu.bsky.social on Bluesky

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Estimating GFR with Vancomycin, the measured GFR that’s sitting right in front of us Vancomycin clearance can approximate GFR offering an alternative to eGFR formulas for estimating kidney function

Estimating GFR from Vancomycin clearance, the mGFR that’s hiding in plane sight

pbfluids.com/2025/08/esti...

03.08.2025 15:05 β€” πŸ‘ 25    πŸ” 9    πŸ’¬ 2    πŸ“Œ 0
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πŸ“‰ GDP: lower than expected
πŸ“ˆ Inflation: higher than expected

The Trump effect in action

02.08.2025 17:05 β€” πŸ‘ 2910    πŸ” 1102    πŸ’¬ 148    πŸ“Œ 59
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"Donald Trump wants this visual list of women who accused him of sexual misconduct removed. You know what to do!"

25.07.2025 21:07 β€” πŸ‘ 1    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
Post image 17.07.2025 23:20 β€” πŸ‘ 16089    πŸ” 3830    πŸ’¬ 412    πŸ“Œ 213

72% of people swept up in Trump’s immigration raids have no criminal record.

That includes at least 250 people detained in deplorable conditions in his β€œAlligator Alcatraz” in Florida.

This was never about targeting criminals. It was always about terrorizing immigrants.

14.07.2025 23:15 β€” πŸ‘ 3910    πŸ” 1268    πŸ’¬ 157    πŸ“Œ 47

In the mess of #SCOTUS decisions, let's not lose sight of the LGBTQ books decision. What's next? Parents exempting their kids from science books that don't cover creationism. Parents exempting their kids from reading about causes of climate change. Fill in the rest; there's no end to this mess.

28.06.2025 17:11 β€” πŸ‘ 8    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0

A federal judgeΒ has ordered the National Institutes of Health to reinstate hundreds of millions of dollars in grants canceled by the Trump admin, saying the terminations were illegal and discriminatory.

16.06.2025 22:15 β€” πŸ‘ 1218    πŸ” 258    πŸ’¬ 16    πŸ“Œ 6
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Rilmenidine extends lifespan and healthspan in Caenorhabditis elegans via a nischarin I1‐imidazoline receptor Rilmenidine has prolongevity and health preserving effects in C. elegans, increased stress resistance and increased autophagy. The stress-resilience, healthspan, and lifespan benefits of rilmenidine ...

Rilmenidine extends lifespan and healthspan in Caenorhabditis elegans via a nischarin I1‐imidazoline receptor - Bennett - 2023 - Aging Cell - Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/... ...

12.06.2025 15:09 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Dual therapy with finerenone + empagliflozin cut albuminuria by ~30% more than either drug alone in CKD + T2Dβ€”with no added safety concerns.
A promising step for combo treatment in DKD.
#CKD #T2D #SGLT2i #Finerenone #CONFIDENCE #Nephrology #BlueskyMD

05.06.2025 15:52 β€” πŸ‘ 5    πŸ” 3    πŸ’¬ 1    πŸ“Œ 0
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We know. They gave you immunity.

16.05.2025 21:33 β€” πŸ‘ 22971    πŸ” 4606    πŸ’¬ 707    πŸ“Œ 310
The push for slower and slower correction was predicated on the idea that there was no consequence to slow correction. The idea that there was something on the other side of that scale is revolutionary in hyponatremia.

The push for slower and slower correction was predicated on the idea that there was no consequence to slow correction. The idea that there was something on the other side of that scale is revolutionary in hyponatremia.

Can we upload animated gifs yet?

02.05.2025 01:02 β€” πŸ‘ 3    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0
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New #UrinarySediment and #UrineMicroscopy case studies in @akdhjournal

Use the link below but be sure to view as a pdf - the online version is not formatted correctly

kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...

01.04.2025 00:02 β€” πŸ‘ 11    πŸ” 5    πŸ’¬ 1    πŸ“Œ 0

Carter added $25 billion to the deficit

Reagan added $74 billion

G.H.W. Bush added $102 billion

Clinton reduced it by $383 billion (leaving a surplus)

G.W. Bush added $1.54 trillion

Obama got it to $585 billion, a reduction of $825B

Trump added $2.1 trillion

Biden reduced it by $942 billion

09.03.2025 20:02 β€” πŸ‘ 370    πŸ” 201    πŸ’¬ 9    πŸ“Œ 13

This actually tells you a lot.

05.03.2025 16:06 β€” πŸ‘ 17976    πŸ” 5330    πŸ’¬ 465    πŸ“Œ 165

Sadly, loved by cardiologists worldwide 🀦 ...

04.03.2025 05:10 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Both ...

03.03.2025 02:18 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Check out the latest Channel Your Enthusiasm Podcast 🎧 covering Chapter 17: Introduction to Simple and Mixed Acid Base Disorders
#Nephpearls

This discussion brings back memories of the Davenport Diagram πŸ§ͺ

πŸ‘‰πŸΌ www.rosebook.club/episodes/202...

22.02.2025 15:53 β€” πŸ‘ 19    πŸ” 10    πŸ’¬ 3    πŸ“Œ 0
Don't Believe Him | The Ezra Klein Show
YouTube video by The Ezra Klein Show Don't Believe Him | The Ezra Klein Show

This is worth hearing.
#lieslieslies
www.youtube.com/watch?v=K8QL...

08.02.2025 02:48 β€” πŸ‘ 7    πŸ” 5    πŸ’¬ 1    πŸ“Œ 0
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It's a tragedy.

01.02.2025 02:52 β€” πŸ‘ 26784    πŸ” 7798    πŸ’¬ 1116    πŸ“Œ 471
Updates to the KDIGO Guidelines for the treatment of IgA nephropathy, with Prof Jonathan Barratt
YouTube video by Ottawa Nephrology Updates to the KDIGO Guidelines for the treatment of IgA nephropathy, with Prof Jonathan Barratt

The excellent overview of IgA management and the upcoming @kdigo.org guidelines from Prof IgA himself, Dr Barratt

youtu.be/OChs5BcTEGE?...

#NephGR #NephSky

24.01.2025 11:54 β€” πŸ‘ 29    πŸ” 13    πŸ’¬ 0    πŸ“Œ 1
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Increased amounts of fat in skeletal muscle, a marker of inflammation, is associated with higher risk of major cardiovascular events.
From an observational study of >600 participants with PET scans, followed for 6 years (a first)
academic.oup.com/eurheartj/ad...

20.01.2025 00:13 β€” πŸ‘ 192    πŸ” 41    πŸ’¬ 4    πŸ“Œ 2
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Key figure referenced in the post on red meat and other foods for health and environmental impact

20.01.2025 15:25 β€” πŸ‘ 71    πŸ” 16    πŸ’¬ 8    πŸ“Œ 3
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Two new studies provide some insights on red meat intake, with respect to both potential risks and how they can be mitigated.
erictopol.substack.com/p/the-update...

19.01.2025 17:16 β€” πŸ‘ 259    πŸ” 56    πŸ’¬ 18    πŸ“Œ 9
We need leaders not in love with money but in love with justice.  Not in love with publicity but in love with humanity.
MLK Jr.

We need leaders not in love with money but in love with justice. Not in love with publicity but in love with humanity. MLK Jr.

19.01.2025 22:26 β€” πŸ‘ 1030    πŸ” 260    πŸ’¬ 10    πŸ“Œ 12

?!

19.01.2025 23:25 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Spot on Editorial - CONGRATULATIONS to the Lancet www.thelancet.com/action/showPdf?pii=S0140-6736%2825%2900094-7

17.01.2025 20:49 β€” πŸ‘ 8    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0
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Our Sleep, Brain Aging, and Waste Clearance How sleep prevents "dirty" brains that age faster

Publications in the past week built substantially on our knowledge of the brain's waste disposal systemβ€”glymphaticsβ€”and the implications on sleep and brain aging.
Featuring exceptional work by Nedergaard Lab and @jonykipnis.bsky.social
erictopol.substack.com/p/our-sleep-... open-access

12.01.2025 16:20 β€” πŸ‘ 1364    πŸ” 310    πŸ’¬ 46    πŸ“Œ 41
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MicroRNAs
From their role in cancer
jci.org/articles/vie...
to
Rejuvenating aged mice, w/ enhanced physical and cognitive function, and longevity
sciencedirect.com/science/arti...
+ explainer
nature.com/articles/d41...

17.01.2025 21:08 β€” πŸ‘ 148    πŸ” 26    πŸ’¬ 3    πŸ“Œ 0
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I fear there is deep truth here.

11.01.2025 20:47 β€” πŸ‘ 55832    πŸ” 13816    πŸ’¬ 1461    πŸ“Œ 848

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