eLife

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Transgenerational Epigenetic Inheritance: Twists and turns in the story of learned avoidance

Evidence that learned avoidance of a pathogenic bacterium can be transmitted to future generations in C. elegans is growing.

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This ‘fundamental’ study uncovers how directing pyruvate into mitochondria can shrink cells by shifting their metabolism away from building amino acids and proteins.
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Sciety is exploring how we can use online social networks for scientific discourse using infrastructure from Bonfire. Help them reach their funding goal! 👇

When cancer adapts to new organs The three-dimensional arrangement of DNA within a cell might influence the ability of a tumor to metastasize to specific locations.

The 3D arrangement of DNA within a cell might influence the ability of a tumour to metastasise to specific locations.
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The pathogenic bacteria Shigella avoids detection inside host cells by degrading RNF213, the protein responsible for sensing the presence of intracellular pathogens.

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Jumping spiders can recognise one another. This ability to learn, remember and represent images is quite surprising for such a tiny-brained animal!
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eLife Latest: Promoting equity, diversity and inclusion – December 2025 update We highlight recent developments in eLife’s equity, diversity and inclusion framework and what steps we plan to take next

Want to know how we're advancing equity, diversity & inclusion in science?

🌍 Check out our latest report!
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Hi Christopher, thanks for reaching out. You can reach out to our Editorial team at editorial@elifesciences.org.

Now published as version of record at @elife.bsky.social !

Layers of Immunity: Deconstructing the Drosophila effector response. The tools are now deposited in the VDRC (link ⬇️)

elifesciences.org/articles/107...
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#Drosophila #IDsky #SymbioSky #Infection #Immunology

Are peer reviewers influenced by their work being cited? Version of record at
@elife.bsky.social. Thorough and useful peer review - who needs and impact factor?!

Links to paper and code/data ⬇️

📄https://elifesciences.org/reviewed-preprints/108748
💻https://github.com/agbarnett/cited_reviewers

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The double life of brown algae Brown algae show life-cycle-related patterns of gene expression, which may be – at least partially – conserved between different species.

Brown algae are incredibly useful, in part for their potential to feed us, but also because they are one of a few lineages that evolved multicellularity. Research into the genes behind their lifecycles could hold secrets to evolution.

Transgenerational Epigenetic Inheritance Please enable JavaScript to proceed.

Transgenerational Epigenetic Inheritance: Twists and turns in the story of learned avoidance

Evidence that learned avoidance of a pathogenic bacterium can be transmitted to future generations in C. elegans is growing.

🔗

When cancer adapts to new organs The three-dimensional arrangement of DNA within a cell might influence the ability of a tumor to metastasize to specific locations.

The 3D arrangement of DNA within a cell might influence the ability of a tumour to metastasise to specific locations.
buff.ly/KbO9jwD

Jumping spiders can recognise one another. This ability to learn, remember and represent images is quite surprising for such a tiny-brained animal!
buff.ly/dCkwPr0

New work reveals Gyc76C as the receptor for the anti-diuretic hormone ITPa in flies, uncovering how it helps control hydration and metabolic balance.
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eLife assessments are a new evaluation tool for research. They are designed to provide readers with richer and more nuanced assessments of articles than binary publishing decisions.

Learn how we write them: buff.ly/10CDKWp

This study presents new tools for measuring the intracellular calcium concentration close to transmitter release sites, which may be relevant for synaptic vesicle fusion and replenishment.
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Two rainforest butterflies have evolved to look more alike, likely to confuse shared predators. But why don’t they get confused themselves?

To avoid mating with the wrong species, they’ve cleverly evolved distinct scents.
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Viral mutations The continuous evolution of HIV shows strong parallels in macaques and humans.

The continuous evolution of HIV shows strong parallels in macaques and humans.
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Peer review is often criticised for being slow, biased and quashing revolutionary ideas.

With our consultative review process, reviewers discuss their reviews with each other before reaching a decision and limit suggestions for extra work. buff.ly/AnqASqz

About eLife · eLife eLife is a non-profit organization committed to making peer review and publishing better for science. In particular, using the publish-review-curate (PRC) approach, we are working to reform the way…

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We're on a mission to make publishing more transparent. Take a look at the #PeerReview tabs of our latest articles or learn about what we're doing for research communication:

This ‘fundamental’ study uncovers how directing pyruvate into mitochondria can shrink cells by shifting their metabolism away from building amino acids and proteins.
buff.ly/hFHjKy9

Using an elegant single-cell RNA-seq analysis approach, researchers show that the gene Eed is essential for guiding facial bone formation and early tissue growth.
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A deep learning approach for the analysis of birdsong An open-source deep learning toolkit performs accurate annotation and similarity scoring of zebra finch song, along with comprehensive feature extraction, enabling consistent, interpretable comparison...

Congrats to @robertslab.bsky.social, the version of record of this paper is now published in @elife.bsky.social

Nice use of optimal transport methods to measure acoustic distance, if you're into that sort of thing 😉

elifesciences.org/articles/101...

#prattle 💬
#bioacoustics

Focus Issue: Trained Immunity Our latest Focus Issue looks at what we’ve learnt over the past decade and what’s next for the field of trained immunity.

2/ Our brand new Focus Issue brings together some of the latest research in trained immunity.

Explore it all today 👇
elifesciences.org/collections/...

Triggers of trained immunity across all tissues.

1/ This Review Article from our new Focus Issue outlines how #epigenetic and metabolic rewiring enables innate immune cells to ‘remember’ past challenges, shaping protection, pathology, and new therapeutic strategies.
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Community | eLife Community Voices · eLife Hear from researchers across the globe about what matters to them in relation to research culture.

Catch up with the Community Voices podcast.

Our interviews with inspiring academics cover topics spanning citizenship as a privilege, how postdoc training needs to change, the intersection of queerness, religion, and science, and plenty more.

Hi Hannah, please send any questions to hr@elifesciences.org where we'll be happy to help.