Guigó Lab

Avui hem obert les portes de la nostra recerca als visitants de l’ #OpenPRBB 🔬🪰🧬 Sempre amb molta il·lusió! @crg.eu @prbb.org

Happy to share the Biodiversity Cell Atlas white paper, out today in @nature.com. We look at the possibilities, challenges, and potential impacts of molecularly mapping cells across the tree of life.
www.nature.com/articles/s41...

🌍✨ Master’s project in our Lab @crg.eu
🌱🧬 Help build the Biodiversity Long-Read Transcriptomic Catalogue @ebpgenome.bsky.social with @pacbio.bsky.social & @nanoporetech.com

💻 Python/R, Linux, seq data
💶 600€/mo + travel
📩 fabio.zanarello@crg.eu / roderic.guigo@crg.eu
ℹ️ www.crg.eu/en/content/t...

🚨 We are hiring a Postdoc @crg.eu! 🧬

Within the EU-funded #PrecisionTox project. We are developing computational methods to predict toxicity by integrating RNA-seq data from humans and model species 🪱🪰🐸🐠. The project will help replace animal testing.

🔗 Apply now: recruitment.crg.eu/content/jobs...

🎉 We’ve earned Bronze LEAF Accreditation for our efforts to make lab work more sustainable @crg.eu! By joining @ucl.ac.uk Laboratory Efficiency Assessment Framework, we are committed to improving efficiency and reducing our environmental impact. 🌱🔬

🎓 Huge congrats to our two @bist.eu Master’s students, Igor Trujnara and @rebeccawallis.bsky.social who successfully defended their theses this week!

🧬💻Igor explored Large Language Models for genome annotation, while Rebecca investigated microbial biodiversity in Pyrenean lakes🏔️.

@crg.eu @upf.edu

🚴🏻🚴🏻‍♀️🚴🏻‍♂️ Read about Ana, Fabio & Nadja’s journey to the LongTREC Summer School in Norwich!
#LongTREC #ScienceOnTheMove #SustainableScience #Bioinformatics #ScienceLife

Great to see our PhD student Fabio Zanarello sharing his work yesterday at LongTREC summer school!
#LongReadsTranscriptomics #LongTREC #GenomeAnnotation #Bioinformatics #EarthBioGenomeProject
@crg.eu

We made it!!!! València-London by train. London-Norwich by bike!!!

First journey done! 🌟 Our amazing cyclists arrived safely in Cambridge — still smiling! 😄🚴‍♀️ More than the ride: sustainability, team spirit & pushing limits. They’re recharging now… and ready for the next leg! #LongCyclingForScience #TeamSpirit
@anaconesa.bsky.social #LeadingByExample

Not everyone can or wants to cycle for 2–3 days, but we can all take a moment to ask ourselves:

💡 “How much am I impacting the planet with this trip?”
💡 “What can I do to reduce that impact?”

@anaconesa.bsky.social

#LongCyclingForScience #SustainableScience #LongReadsTranscriptomics

🚴 From @crg.eu to the roads of Europe, our PhD student Fabio and the #LongTREC team are combining cutting-edge science with sustainable travel.

Now in London, and heading next to Cambridge! #LongCyclingForScience

🚴‍♂️🌍 Excited to see our PhD student Fabio Zanarello featured in the #LongTREC video series! 👏

Don’t miss the video and learn more about #LongTREC #LongReadsTranscriptomics and #LongCyclingForScience.

#SustainableScience #Bioinformatics #PhDLife

@crg.eu

This is going to be so much fun!!! Do not miss our #LongCyclingForSciene adventure! from Valencia to Norwich by train & bike, posting about science and bcsustainability @pacbio.bsky.social @nanoporetech.com @iscb.bsky.social @csic.es @hitseq.bsky.social @bcbhubcsic.bsky.social @sebibc.bsky.social

Studying relative RNA localization from nucleus to the cytosol Abstract. The precise coordination of important biological processes, such as differentiation and development, relies heavily on the regulation of gene exp

📊 RNA localization matters for gene regulation. We present a method to estimate transcript distributions between nucleus & cytosol using nuclear, cytosolic and whole-cell RNAseq.

🔵🧬 doi.org/10.1093/narg...

@crg.eu @rodericguigo.bsky.social

I am so happy to learn that I won the Early Career Award for an outstanding presentation at the ESHG!!
Thanks to @melelab.bsky.social, @guigolab.bsky.social and to my awesome colleagues that also attended the conference for their support @rubenchazarra.bsky.social @ramirezjmiguel.bsky.social

Our lab had dual presence at #BoG25 @cshlmeetings.bsky.social!
🧬 Silvia González-López spoke on chromatin dynamics & transcriptional regulation.
🌍 @fairlie.bsky.social presented ancestry-aware gene annotations — a @guigolab.bsky.social × @melelab.bsky.social collab:
www.biorxiv.org/content/10.1...

Exciting day in the lab, congratulations to Dr. Ntasis on successfully defending! 🎓🥳

Had a great time at the Computational Symposium- such a valuable opportunity to connect with colleagues, hear about exciting projects, and share progress on my master’s research! Presenting my work on the Pyrenean Lake microbiome has been invaluable for gathering feedback and ideas for my analysis 🙂

This week, we had a great time attending the 19th Computational Genomics Symposium at @prbb.org, a very nice opportunity to catch up with colleagues 💻🧬☀️
@crg.eu

A new hub has been added to the Public Hubs listing, EPIration - an atlas of candidate enhancer-gene interactions in human tissues and cell lines.

View this hub using the following URL:
genome.ucsc.edu/cgi-...

We want to thank the @guigolab.bsky.social for making this data available.

The BioGenome Portal: a web-based platform for biodiversity genomics data management Abstract. Biodiversity genomics projects are underway with the aim of sequencing the genomes of all eukaryotic species on Earth. Here we describe the BioGe

🚀 Our new paper is out! The BioGenome Portal: an open-source customizable platform for managing biodiversity genomics data 🧬🌍

doi.org/10.1093/narg...

@crg.eu @rodericguigo.bsky.social

#genomics #biodiversity

This has been a fantastic collaboration with @guigolab.bsky.social and led by @pclavell.bsky.social & @fairlie.bsky.social where we show something we suspected for some time: human gene annotations are European-biased, read this thread to know more about this work @bsc-cns.bsky.social @crg.eu

I never thought that I would wear again the lab coat 🥼 but I did it to sequence RNA with @nanoporetech.com at @guigolab.bsky.social . Thanks to @scarbonells.bsky.social , Carme and Zighi for their great teachings and patience in the wetlab. They definitely have solutions for everything!

Long-read transcriptomics of a diverse human cohort reveals widespread ancestry bias in gene annotation Accurate gene annotations are fundamental for interpreting genetic variation, cellular function, and disease mechanisms. However, current human gene annotations are largely derived from transcriptomic...

Do you work in 💫human genetics💫?
Have you ever worried about what’s inside your gene annotation GTF⁉️

WELL, YOU SHOULD! 😱
Especially when studying a genetically diverse 🌍 cohort!

🔴We discover that gene annotations are European-biased 👉 impacting downstream analyses!

Don't miss this thread🧵⬇️
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I am SO EXCITED about this! An incredible amount of work from two brilliant people. I believe a bluetorial is on the way, stay tuned! 💜 @fairlie.bsky.social @pclavell.bsky.social @melelab.bsky.social @guigolab.bsky.social

Hi Bluesky! Excited to be here! Last week we had our yearly retreat in the mountains, enjoying nature, games, and discussions 🏔️🧬😊