Anurag Das

PEX39 facilitates the peroxisomal import of PTS2-containing proteins - Nature Cell Biology Chen et al. show that PEX39 cooperates with PEX7 in the peroxisomal import of proteins containing a PTS2 site and uncover an (R/K)PWE motif in PEX39 and PEX13 that binds to PEX7 and facilitates the im...

1/New paper on peroxisome assembly, reporting the detailed mechanism of PEX39, a new peroxin involved in PTS2 protein transport. Fantastic work by ‪@walterwchen.bsky.social‬ and a dream team of collaborators, as explained below. www.nature.com/articles/s41...

Congrats @rafsarnataro.bsky.social !! 🎉 Brilliant work from Gero Meisenbock’s group in Oxford.

Congratulations Shefali!

New alleles of D-2-hydroxyglutarate dehydrogenase enable studies of oncometabolite function in Drosophila melanogaster Abstract. D-2-hydroxyglutarate (D-2HG) is a potent oncometabolite capable of disrupting chromatin architecture, altering metabolism, and promoting cellular

Check out our work in @genetics-gsa.bsky.social #G3journal on new #Drosophila tools for studying D-2HG #oncometabolite in a context dependent manner during development and disease.
#devbio #genetics #metabolism

@tennessenlab.bsky.social
@superflymr.bsky.social
@iubiology.bsky.social

Thank you Dr. Sha Liu! :)

Thank you Shefali! 😇 Appreciate it.

Peroxisomal import is circadian in glia and regulates sleep and lipid metabolism https://www.biorxiv.org/content/10.1101/2025.06.23.661129v1

Preprint for my PhD. Thanks to Dr. Bai for letting me merge my interests in neuroscience with lab focus on peroxisome. We discover unexpectedly cell type specific peroxisomal import in subset of glia under autonomous circadian regulations. Gratitude to Dr. John Vaughen for his support. Thread soon.

Congratulations Yvette! Brilliant news!🎉🎊

Very useful overview, especially for the Drosophila-curious.

It’s easy to bring the power of fly genetics to your neurobiology questions.

Congratulations 🎉

Congratulations!

Thanks to my peers who attended today’s departmental seminar where I talked about my PhD research.
Also, excited & elated to have gotten the travel award from UC Irvine & the Centre for Neural Circuit Mapping organising team for the Changing Brain conference later this summer. Happy to be selected!

Sleep pressure accumulates in a voltage-gated lipid peroxidation memory - Nature Sleep-inducing neurons in Drosophila rely on Hyperkinetic, the β-subunit of the KV1 channel Shaker, to monitor sleep need by translating lipid peroxidation events into changes in the oxidation state of a stably bound NADPH cofactor.

Nature research paper: Sleep pressure accumulates in a voltage-gated lipid peroxidation memory

https://go.nature.com/4bG20He

It was great to have the fabulous @SchaferLabUMass Dr. Dori Schafer visiting & enlighten us on the awesome microglia-immune interactions in the brain in context of aging, neurodegeneration. One of the best talks I have heard in the recent times with really exciting science.

GDCB Iowa State University Seminar - MemBrain Lab www.membrainlab.com/1/post/2024/...
Late post - but grateful and had fun hosting my friend and scientific collaborator Dr.John Vaughen who is a freshly minted PI at UCSF, department of Anatomy, UCSF, Parnassus campus. Circa ~ November 2024

Connectome-driven neural inventory of a complete visual system - Nature A connectome of the right optic lobe from a male fruitfly is presented together with an extensive collection of genetic drivers matched to a comprehensive neuron-type catalogue.

I know there's a 𝒍𝒐𝒕 going on right now, but I couldn’t be prouder to share this long-incubated labor of love: the complete connectome of the male 𝐷𝑟𝑜𝑠𝑜𝑝ℎ𝑖𝑙𝑎 optic lobe 🧠🪰
🔗 www.nature.com/articles/s41...

1st citations are always special! Makes me extra happy when one of the leaders in the glial field like Christian Klambt are acknowledging of the work! 🎊😁

Stunning pics, great captures!

Yes, all well here :)

Enjoy! And have a great meeting!

BIG NEWS! The Mosquito Cell Atlas preprint is live! 🦟🧬 My first senior author paper! Massive and accessible snRNA-seq dataset and a lot of cool mosquito biology. A true collaborative achievement! #MCA
biorxiv.org/content/10.1...
See @oliviagoldman.net thread here

I am super excited to share our article addressing a longstanding question in neurobiology: how Ca²⁺ signaling cascades initiated at dendritic spines operate at a distance. Check it out here: authors.elsevier.com/sd/article/S... @cp-cell.bsky.social.

If anyone is attending CellBio2024. Feel free to reach out prior or after my microsymposium (details below - at 10:40am; Room30C). Also, presenting my poster tomorrow at 1:30Pm (Board No B454) during Neuronal Biomechanics & Activity poster session.

Great thread of your awesome work! 👌🏻

Glial peroxisome dysfunction induces axonal swelling and neuroinflammation in Drosophila Abstract. Glial cells are known to influence neuronal functions through glia–neuron communication. The present study aims to elucidate the mechanism behind

academic.oup.com/g3journal/ad... Available in final print form now! 🎉