New paper published today in
@bmj.com open from our group describing trajectory of 3590 patients with #longcovid Important insights into inpatient and outpatient treated cohorts, impact of vaccine before illness, recovery and health economics @dremmacbw.bsky.social @nisreenalwan.bsky.social
Annals of Medicine: Mitochondrial function is impaired in long COVID patients
A study comparing Long COVID patients with controls found altered mitochondrial activity in immune cells, including abnormal ATP synthase behaviour.
Read more: https://meassociation.org.uk/icpw
#LongCovid #MECFS
Evidence that Long Covid is fundamentally a disease of mitochondrial dysfunction is becoming overwhelming. Exciting b/c this points toward both potential diagnostics and future therapeutics. I wish my wife could have lived to see this hopeful progress.
www.tandfonline.com/doi/full/10....
Only 5% of the included outcomes were considered to be of high quality for comparison purposes. The inclusion criteria are not clear. There is, however, a brief mention of PEM and need for personalised approach. I don’t think their data justify the headline conclusion.
NL Times: 'Growing number of long covid patients declared unfit for work'
'The number of people in the Netherlands declared partially or fully unfit for work due to long Covid has risen sharply in recent years...more than 12,000 people..'
nltimes.nl/2025/03/03/g...
This is important data. I couldn't see what severity of index infection there was though, (hospitalised, ICU, community managed) which can be important in clinical phenotype. Has anyone found it in the supplementary data (I couldn't on a quick look)? Text says they collected this info
This is an excellent thread that reflects a LOT of what we are dealing with academically and clinically and socially in our service. Damned if you do, damned if you don't, and damned if you think it or say it - or don't. Not an easy space to work in.
Long COVID is a heterogenous disease that has not been well described yet, and research is still required to be able to quickly phenotype patients and guide them towards appropriate management (drug and non-drug) strategies
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We're looking again at the Chief Medical Officer's 2022 #AirPollution report and noting how much diesel contributes to the nitrogen oxides we are breathing across England. Diesel needs to go. #DitchDiesel https://buff.ly/4hY9erU
Population-health impact of new drugs recommended by the National Institute for Health and Care Excellence in England during 2000–20: a retrospective analysis - The Lancet www.thelancet.com/journals/lan... > v thought provoking paper on the opportunity costs of ever more advanced (£) treatments
No clear differentiation of those who were fully vaccinated (two doses) cf single dose - which may be a significant confounder...
Indeed - I don’t doubt that- it was more for anyone who saw the headline in a re-post - no comment on your take at all 👍
And please don’t anyone put the cart before the horse interpreting this paper. There is NOTHING about causation - only that those suffering with LC need support for both body and mind. Holistic care doesn’t ignore psychology- bad care often does
Conclusion about hire the health system needs to change to take account of post-infection illness absolutely spot on… the next pandemic is only a matter of time - we must prepare not just to cope with the acute phase- but also the aftermath.
'Long COVID and sleep: an urgent call to action' by Dr. Elizabeth Benge, Harvard
'Long COVID underscores the urgent need for a multidisciplinary approach to post-viral care. Patients deserve a medical system that validates their experiences, invests in research...
kevinmd.com/2024/12/long...
I need to read it in more detail really - but kids / Christmas etc. Will get to it v soon though.
I found that discrepancy odd too. The improvement from baseline in the intervention group was larger than the specified 10 MCID but it was the difference between groups that was 9.2. The intervention is also interesting (supplement 3) as lots of the CBT could be considered good clinical comms.
'2024 Science Highlights from the NIH Director’s Blog'
Featured on the Top 6: 'Many People with Long COVID Have Signs of Persistent SARS-CoV-2 Proteins, New Findings Show'
directorsblog.nih.gov/2024/12/20/2...
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Random geography facts as we head towards the end of the year:
Glasgow is north of the southern tip of Alaska
Edinburgh is west of Bristol
Denver, Colorado is south of Rome
France's longest land border is with Brazil
The town of Vardø in Norway is nearer to China than to Portugal
Calcific aortic stenosis is a prevalent, progressive disorder in older adults, diagnosed via echocardiography. This narrative review describes the clinical presentation, diagnostic evaluation, and management of calcific aortic stenosis.
ja.ma/3OWLMyN #CardioSky #MedSky
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Another great paper for day 16 of #RespMas! #RespEd #RespIsBest #lungsky #pulmsky
@therestpolitics.bsky.social hey - any explanation for the inability to play on Amazon music? Has there been a falling out?
I thought I saw a link somewhere on here recently about very much simplified approach to anticoagulation choices in AF. Did I dream it? #help #medsky #cardiosky
