Sachin Gadani

Totally agree! Comparative biology is 🔥

Reactivation of mammalian regeneration by turning on an evolutionarily disabled genetic switch 🧪

www.science.org/doi/full/10....

Peripheral infection wires T cells in the brain - Nature Immunology Research shows that previous peripheral microbial encounters can prime the entry of memory T cells into the brain, reshaping neuroimmune surveillance and altering seizure severity through microorganis...

www.nature.com/articles/s41...
Peripheral infection wires T cells in the brain 🧪

STAMP: Single-cell transcriptomics analysis and multimodal profiling through imaging Single-cell transcriptomics analysis and multimodal profiling (STAMP) by imaging enables single-cell analysis of cells in suspension without the need for sequencing. The markedly reduced costs and fle...

www.cell.com/cell/abstrac...
STAMP: Single-cell transcriptomics analysis and multimodal profiling through imaging 🧪

We are looking for a research technician to join our neuroimmunology group at the University of Pittsburgh. Please share to anyone who may be interested!

Posting: cfopitt.taleo.net/careersectio...

A route for cerebrospinal fluid flow through leptomeningeal arterial–venous overlaps enables macromolecule and fluid shunting - Nature Neuroscience The authors describe a mechanism for the clearance of macromolecules from cerebrospinal fluid in which macromolecules traverse from periarterial to perivenous spaces, at sites where intersecting lepto...

www.nature.com/articles/s41... 🧪

A route for cerebrospinal fluid flow through leptomeningeal arterial–venous overlaps enables macromolecule and fluid shunting

New Horizons for Multiple Sclerosis Therapy: 2025 and Beyond The advances achieved against multiple sclerosis (MS) represent one of the great success stories of modern molecular medicine. The development of therapies with increasing selectivity and safety, gui....

Very pleased to co-write this review with Bruce Cree and Steve Hauser on the future of #multiplesclerosis treatment

onlinelibrary.wiley.com/doi/10.1002/...

Prognostic Factors for Multiple Sclerosis Symptoms in Radiologically Isolated Syndrome This study attempts to identify prognostic factors at radiologically isolated syndrome diagnosis associated with the development of multiple sclerosis symptoms.

Prognostic Factors for Multiple Sclerosis Symptoms in Radiologically Isolated Syndrome

jamanetwork.com/journals/jam...

Increased CSF drainage by non-invasive manipulation of cervical lymphatics - Nature The outflow pathway of cerebrospinal fluid into lymph nodes in the neck and how non-invasive mechanical stimulation can enhance drainage and restore impaired outflow in aged mice are explored.

Increased CSF drainage by non-invasive manipulation of cervical lymphatics 🧪

www.nature.com/articles/s41...

"If the proposal is enacted, Americans today and tomorrow will be sicker, poorer, and die younger”
an $18 Billion cut
Only 3 NIH Institutes will remain in place, and even they will have their funds markedly reduced
www.statnews.com/2025/05/30/n...

Choroid plexus apocrine secretion shapes CSF proteome during mouse brain development - Nature Neuroscience The choroid plexus (ChP) provides molecular cues for brain development. However, the underlying mechanisms are unclear. This study identifies an apocrine secretion mechanism in the ChP that modulates ...

Choroid plexus apocrine secretion shapes CSF proteome during mouse brain development 🧪

www.nature.com/articles/s41...

Pathways to Progressive Disability in Multiple Sclerosis: The Role of Glial Cells in Chronic CNS Inflammation Multiple sclerosis (MS) is the most common non-infectious inflammatory CNS disease, characterized by progressive neurodegeneration and focal demyelinated lesions. Traditionally considered an autoimmu....

Nice progressive MS review by Volker Siffrin:

Pathways to Progressive Disability in Multiple Sclerosis: The Role of Glial Cells in Chronic CNS Inflammation

onlinelibrary.wiley.com/doi/10.1002/...

Read our latest review article out in @thelancetneuro.bsky.social if you want to know more about CSF transport across the different compartments of the brain-meningeal border and its importance for neurological diseases with strong neuroimmune components 😉
authors.elsevier.com/a/1l7l75FFzL...

Progress toward Mitigating Disability Progression in Multiple Sclerosis | NEJM Multiple sclerosis is the most common cause of progressive neurologic disability in young adults. There had been no treatments for the disease, except for glucocorticoids, which were used for more ...

Insightful perspective from Dr. Calabresi @pcalabresi.bsky.social on recently published BTKi multiple sclerosis trials.

Progress toward Mitigating Disability Progression in Multiple Sclerosis

www.nejm.org/doi/full/10....

Inflammasome signaling in astrocytes modulates hippocampal plasticity The function of immune pathways in homeostatic neurobiology remains underexplored. Zengeler et al. find that the inflammasome complex, typically associated with immune responses, is involved in memory...

Excited to share our new work demonstrating a role for astrocytic inflammasome signaling in modulating hippocampal plasticity. @cp-immunity.bsky.social
All credit to Kristine Zengeler, who was the brains🧠 and muscle💪 behind this project and is a wonderful collaborator. www.cell.com/immunity/ful...

Very cool work--astrocyte inflammasomes are activated in the healthy brain (check out Fig 1a) and impact neurons through IL-33.

Inflammasome signaling in astrocytes modulates hippocampal plasticity The function of immune pathways in homeostatic neurobiology remains underexplored. Zengeler et al. find that the inflammasome complex, typically associated with immune responses, is involved in memory...

Inflammasome signaling in astrocytes modulates hippocampal plasticity 🧪
www.cell.com/immunity/ful...

Redefining CNS immune privilege - Nature Reviews Immunology In this Perspective, Smyth and Kipnis reappraise the concept of immune privilege in the central nervous system. Although immune privilege was originally thought to involve isolation of the central ner...

Redefining CNS immune privilege - Nature Reviews Immunology
www.nature.com/articles/s41...

Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease Hematopoietic stem cell transplant is the gold standard for treatment of globoid cell leukodystrophy, also called Krabbe disease. Aisenberg et al. define the molecular signature of disease-associated macrophages (globoid cells) and demonstrate that brain-specific high-efficiency macrophage replacement in the twitcher model of Krabbe disease improves neuropathology, macrophage dysfunction, and survival.

Online now: Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease

Broad rim lesions are a new pathological and imaging biomarker for rapid disease progression in multiple sclerosis - Nature Medicine This study identifies a unique multiple sclerosis lesion, the broad rim lesion, which is associated with rapid disease progression and marked by a distinct inflammatory profile involving innate inflam...

Broad rim lesions are a new pathological and imaging biomarker for rapid disease progression in multiple sclerosis 🧪
www.nature.com/articles/s41...

T–B cell cooperation in ectopic lymphoid follicles propagates CNS autoimmunity T and B cells cooperate in meningeal eLFs to promote differentiation and clonal expansion of B cells and reactivation of CNS T cells.

T–B cell cooperation in ectopic lymphoid follicles propagates CNS autoimmunity 🧪
www.science.org/doi/abs/10.1...

Oligodendrocyte-derived IL-33 regulates self-reactive CD8+ T cells in CNS autoimmunity. 🧪

rupress.org/jem/article/...

ReThink - The Gene Lay Institute

‼️BIG news ‼️
#ReThinkNeuroimmunology #RTN registration is open and live! The program is amazing!
Hurry up to register while prices are low!
See you in Boston in October!
genelayinstitute.org/rtn/

Multipotent neural stem cells originating from neuroepithelium exist outside the mouse central nervous system - Nature Cell Biology Han et al. report the existence of neural stem cells (NSCs) outside the central nervous system and show that these peripheral NSCs display features similar to brain NSCs, including the ability to diff...

In an attempt to reproduce stimulus-triggered acquisition of pluripotency (STAP) before those papers were retracted, this group stumbled upon a population of neural stem cells in the periphery.

www.nature.com/articles/s41...

Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety Inflammatory and anti-inflammatory cytokines act as neuromodulators to regulate anxiety levels via direct action on the same population of neurons in the amygdala of mice, underscoring the conservatio...

www.cell.com/cell/fulltex...

Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety

Brain-wide mapping of immune receptors uncovers a neuromodulatory role of IL-17E and the receptor IL-17RB Mapping the expression of all five IL-17 receptor subunits in the mouse brain reveals how IL-17 cytokines shape social behaviors by modulating neuronal activity within the somatosensory cortex.

Brain-wide mapping of immune receptors uncovers a neuromodulatory role of IL-17E and the receptor IL-17RB
www.cell.com/cell/fulltex...

mancusolab.bioinf.be/microglia/in...

Microglia heterogeneity, modeling and cell-state annotation in development and neurodegeneration - Nature Neuroscience Microglia have key roles in CNS development and neurodegeneration. Here, the authors provide an overview of microglia heterogeneity, cell-state annotation and model systems.

Microglia heterogeneity, modeling and cell-state annotation in development and neurodegeneration

Nice review on microglia states--figure 1 would be helpful if you ever have to annotate microglia single cell data, and they include a nice tool to automate the process.

www.nature.com/articles/s41...

Brain sensing of metabolic state regulates circulating monocytes Brain-initiated hunger signals control circulating monocyte dynamics.

Brain sensing of metabolic state regulates circulating monocytes
www.science.org/doi/full/10....

A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer’s disease - Nature Medicine The ratio between the levels of two synaptic proteins in cerebrospinal fluid predicts future cognitive resilience versus decline among presymptomatic individuals and individuals with early Alzheimer’s...

A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer’s disease
www.nature.com/articles/s41... 🧪