@atranscendedman.bsky.social
Transparent to the transcendent. Wrote a book on Long Covid. - https://jondouglas.dev/longhaul/ Extraordinary claims require extraordinary evidence. - Sagan
Stellenbosch University researchers warn that persistent spike protein exposure after COVID-19 or vaccination may disrupt cancer immunity.
Chronic inflammation in Long COVID could awaken dormant tumor cells and reduce immunotherapy effectiveness.
www.sciencedirect.com/science/arti...
From Amsterdam UMC, 297 Dutch household members were studied.
At 6 months, 15% of SARS-CoV-2-positive adults reported lasting respiratory symptoms versus 3% of negatives.
Children rarely had symptoms.
Long COVID linked to lower quality of life
onlinelibrary.wiley.com/doi/10.1002/...
LSU Health Shreveport reported a fatal H5N1 case in a 71-year-old man whose blood carried autoantibodies that blocked type I interferons.
These antibodies likely disabled his early antiviral defenses and may raise the risk of human transmission.
rupress.org/jem/article/...
Karolinska researchers studied 713 MS patients and found that CD4+ T cells activated by the Epstein-Barr virus also attack a brain protein called ANO2, linking viral infection to autoimmune damage in multiple sclerosis.
www.biorxiv.org/content/10.6...
University of Manchester researchers interviewed 20 people with Long COVID in the UK and found that inconsistent workplace support often worsened symptoms.
Unrealistic return-to-work plans and ignored medical advice left many feeling unsupported.
link.springer.com/article/10.1...
University College of Northern Denmark studied 30 people with Long COVID in rehab.
Nearly all reported needing extra time or effort for daily tasks.
Fatigue was the only factor moderately linked to reduced daily function.
www.tandfonline.com/doi/full/10....
Imperial College London scientists studied over 21,000 human lung endothelial cells and found they are not directly infected by SARS-CoV-2.
COVID-19 vascular damage is likely caused by inflammation from nearby infected cells, not the virus itself.
journals.asm.org/doi/10.1128/...
The FDA launched TEMPO, a first-of-its-kind pilot to speed development of digital tools for chronic diseases and aiming to simplify evaluation, support innovation, and improve patient access while keeping strong safety and evidence standards.
www.fda.gov/news-events/...
Oklahoma Medical Research Foundation studied 17 people who recovered from mild COVID.
Those with prolonged symptoms had CD4+ T cells that were less responsive and showed signs of immune exhaustion, even months after infection.
www.biorxiv.org/content/10.6...
National University Hospital Singapore studied 189 people and found stroke patients with prior COVID-19 had 73% worse recovery at 3 months.
Their blood showed lingering immune and protein-synthesis disruptions that may impair brain healing.
www.sciencedirect.com/science/arti...
Griffith University researchers studied 47 people and found long COVID and recovered patients show altered brain structure and chemistry.
These changes were tied to physical limits and cognitive problems.
www.sciencedirect.com/science/arti...
Hong Kongβs Queen Mary Hospital followed 717 COVID survivors and found at least 10% had long COVID, mostly breathlessness, fatigue and forgetfulness.
Those who received at least 3 booster doses had lower odds of these symptoms.
www.sciencedirect.com/science/arti...
Researchers at Kumamoto University found that treating SARS-CoV-2 and Japanese encephalitis virus with a lipid-targeting compound called DMA-Ξ²-CyD drastically reduced their infectivity by disrupting viral envelopes without harming host cells.
journals.asm.org/doi/10.1128/...
Karolinska University Hospital followed 931 patients and found that nearly 66% still had moderate to severe mental and physical impairments long after COVID-19.
Surprisingly, non-hospitalised patients often reported worse fatigue and depression.
www.nature.com/articles/s43...
Teikyo University doctors reported that an 18-year-old with Klinefelter syndrome developed a sudden psychotic episode after COVID-19.
Symptoms resolved in 2 months with aripiprazole, suggesting the virus may trigger psychosis in vulnerable individuals.
onlinelibrary.wiley.com/doi/10.1002/...
From EPI-PHARE in France, a 4-year study of 28 million adults aged 18 to 59 found no increased risk of all-cause mortality after mRNA COVID vaccination and a 74% lower risk of death from severe COVID-19.
jamanetwork.com/journals/jam...
Long COVID gave me anti-ganglioside antibodies.
Charming.
IVIG here we come.
www.medrxiv.org/content/10.1...
The Department of Health and Human Services plans to boost AI use across all its agencies to cut red tape, speed up research, modernize care, and give workers AI tools.
In 2024 alone, it tracked 271 active or planned AI projects.
www.hhs.gov/programs/top...
Yale scientists reviewed 100 years of records and found that Long COVID is part of a larger pattern.
Viruses like polio, SARS, and EBV have long caused lasting illness in some people, often through immune dysfunction
www.cell.com/trends/immun...
Ancillary studies are open. Weβre working hard to get these samples into your hands.
Please apply.
recovercovid.org/ancillary
The RECOVER Initiative has collected over 1.4 million biosamples from nearly 30,000 people to help uncover how Long COVID affects the body and guide future diagnostics and treatments.
recovercovid.org/news/over-14...
Harvard researchers highlight that activating the immune checkpoints PD-1, BTLA and TIGIT can restore immune tolerance in autoimmunity.
Early trials show promise for treating rheumatic disease by flipping these brakes on, not off.
www.nature.com/articles/s41...
Yogi Vemana University analyzed 1,845 samples and found that COVID-19 accelerates immune-related epigenetic aging, especially in older and female patients.
Non-Europeans showed even greater signs of aging in key immune-related clocks like PCPhenoAge.
link.springer.com/article/10.1...
Emory researchers followed 10 rhesus macaques and found that even mild COVID-19 caused months of neuroinflammation and behavioral changes, including impaired memory, taste, and sleep, mimicking long COVID in humans.
www.researchsquare.com/article/rs-8...
University of South Australia researchers analyzed data from over 1,000 individuals and identified 32 genes likely to cause Long COVID.
They uncovered 3 biological subtypes and linked the condition to immune, metabolic, and connective tissue disorders.
journals.plos.org/ploscompbiol...
At Emory University and UTMB, scientists found that SARS-CoV-2 recombines RNA more than other coronaviruses.
A mutated NSP15 enzyme increased defective genomes and inflammation, despite lowering viral load.
www.nature.com/articles/s41...
Tsinghua University scientists report that a low affinity antibody can still neutralize JN.1 because weak spike contacts cause spikes to clump together.
This aggregation blocks infection even when binding is poor.
www.biorxiv.org/content/10.1...
At the Federal University of Alfenas, scientists found that peptides from the SARS-CoV-2 spike protein can cause pain in mice by activating spinal TLR4 receptors and microglia, revealing a new link between COVID-19 and pain.
www.biorxiv.org/content/10.1...
Scientists mourn David Baltimore, who showed that cancer-causing RNA viruses use an enzyme to turn RNA into DNA.
This reverse transcriptase changed how we understand cancer, HIV, and the central flow of genetic information.
www.nature.com/articles/d41...
At CTAD 2025, Merck shared early data on two Alzheimerβs drug candidates. MK-2214, which targets tau buildup in the brain, received FDA Fast Track status and is now in Phase 2 trials for early Alzheimerβs.
www.merck.com/news/merck-s...
