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Scientists studying over 1,000 people found that lingering SARS-CoV-2 in the gut may block peroxisomes, leaving intestinal stem cells unable to repair the lining.
Existing drugs like fenofibrate may help restore healing.
www.cell.com/developmenta...
Vanderbilt University Medical Center, 79 participants, found 58% of workers with Long COVID were still employed about 3 years later, but many struggled.
Leaving work was tied to worse health, more barriers, and more financial strain.
link.springer.com/article/10.1...
Mie University, 1 patient, COVID-19 was followed by rheumatoid arthritis.
Anti CCP antibodies fell with steroids then returned when symptoms came back, suggesting the infection may sometimes push recovery into autoimmunity.
onlinelibrary.wiley.com/doi/10.1155/...
University of Alberta, 20 participants, found Long COVID with ME/CFS reshapes the immune system with more exhausted T cells, weaker NK cells, and fewer MAIT and gamma delta T cells, linked to Galectin 9 and TIM 3.
www.frontiersin.org/journals/imm...
Federal University of Minas Gerais and USP, 2060 compounds screened, found 3 reversible SARS-CoV-2 main protease blockers.
The best hits gave the virus a new weak spot for future drug design.
www.biorxiv.org/content/10.6...
J Craig Venter Institute and Mount Sinai, 13 participants, found SARS-CoV-2 spike lingering in gut biopsies was linked to a local immune imbalance in Long COVID, strongest in the colon.
www.biorxiv.org/content/10.6...
University Medicine Greifswald and Leibniz Institute of Virology, 52 studies found that SARS-CoV-2 models work best with early infection data.
They suggest early treatment matters most, while missing early samples can blur predictions.
www.nature.com/articles/s44...
Montefiore Health System, 789,897 adults, found COVID was linked to a 1.69 mmHg rise in systolic blood pressure that lasted 16 months, with larger increases in Black, Hispanic, and lower income groups.
www.nature.com/articles/s41...
Copenhagen University Hospital, 5.1 million Danes.
Mild COVID did not meaningfully raise long term diagnosed mental or medical illness versus negative tests.
Severe COVID did, but about as much as other serious infections.
www.nature.com/articles/s41...
Zhengzhou University, 103 patients, found GBS hospitalizations rose 54% during China’s Omicron wave.
COVID linked cases were older and often more severe, but 6 month recovery looked similar to other GBS cases.
www.nature.com/articles/s41...
Scientists built a causal model of long COVID that links symptoms over time to possible organ damage and emerging mechanisms, offering a clearer way to study diagnosis and prognosis.
www.nature.com/articles/s43...
Thank you for 2k.
This started as a way to share information.
Now it's distributing biospecimens to labs, prioritizing drugs, designing a GLP-1 trial, interviewing at ARPA-H twice, and building a clinical trial startup.
Grateful the word gets out and the work is recognized.
University of Santo Tomas researchers analyzed 159,000 participants across 35 studies and found at least 28.5% develop long COVID.
Pre Omicron infections showed higher risk than Omicron.
www.ijidonline.com/article/S120...
Harvard Medical School, mice and human intestinal cells, found that a gut microbe bile acid called LCA can slow the gut’s internal clock, linking food, microbes, and circadian timing in the intestine.
www.pnas.org/doi/10.1073/...
Shanghai Ninth People’s Hospital, 1 patient.
A long stable facial vascular lesion became an aggressive composite hemangioendothelioma after SARS-CoV-2 infection, suggesting intense inflammation may help dormant tumor cells turn dangerous.
jamanetwork.com/journals/jam...
Researchers found a way to steer antibody discovery toward a vulnerable spot on SARS-CoV-2, uncovering antibodies that strongly neutralized several Omicron variants and lowered virus levels in mice.
www.nature.com/articles/s41...
Stefan cel Mare University of Suceava, 345 sources reviewed, found that long COVID in kids can last months, affect many body systems, and is best managed with tailored care, rehab, pacing, and symptom relief.
www.tandfonline.com/doi/full/10....
Sunnybrook Research Institute, 40 hamsters, SARS-CoV-2 left lasting lung, heart, and kidney scarring 28 days after infection.
Early B1 and Alpha caused more damage than Beta, suggesting long COVID risk may differ by variant.
www.sciencedirect.com/science/arti...
BRAC University and Qassim University, 202 studies reviewed, find COVID brain effects seem driven mostly by immune and blood vessel damage, not widespread brain infection.
ACE2 and NRP1 may help entry while TLRs fuel inflammation.
link.springer.com/article/10.1...
Amsterdam UMC studied 834 people and found 109 microglia related proteins in cerebrospinal fluid that change across Alzheimer’s stages.
Early disease shows immune activation while dementia shows stronger inflammatory signals.
www.nature.com/articles/s43...
SUNY researchers studied 9,386 people with lupus and type 2 diabetes and found those taking GLP 1 receptor agonists had lower risk of lupus kidney disease flares and death after one year suggesting these diabetes drugs may also calm immune inflammation.
www.amjmed.com/article/S000...
Azalea Therapeutics, 1 rhesus macaque, showed early proof that targeted gene insertion can reprogram T cells and fully wipe out B cells, with striking clearance in blood, lymph node, and bone marrow.
www.youtube.com/watch?v=tBny...
Chicago, 60 participants. Shirley Ryan AbilityLab scientists are testing whether attention training can ease Long Covid brain fog.
This is a study protocol, so there are no results yet, only a planned randomized trial.
www.medrxiv.org/content/10.6...
Starting tirzepatide tomorrow for long COVID.
The dual agonist research is fascinating.
I have belly fat that won't budge no matter what I do.
I think something is living in it. And I think it's inflaming every nerve between my gut and my skull.
$300/month now.
Let's see.
Researchers studying 96 children with untreated childhood lupus found that lower NK cell levels signal more severe disease, risk of kidney damage, and slower remission.
Higher NK cells predicted faster recovery, suggesting a simple blood biomarker.
link.springer.com/article/10.1...
Hangzhou Zhejiang University researchers studying patients with rare immune mutations found that overactive RIPK1 causes CD8 T cells to die early.
The loss of these cells triggers immune cells to release TNF and IFNγ, driving chronic autoinflammation.
www.nature.com/articles/s41...
Washington University School of Medicine In mice, engineered CAR-T cells cleared Alzheimer’s amyloid plaques and reduced other signs of brain damage, suggesting immune cell therapy could one day help treat Alzheimer’s disease.
www.nih.gov/news-events/...
Washington University, 42 participants, found that fat cell vesicles build up in the blood when metabolic health worsens.
These signals tracked insulin resistance more closely than body fat, hinting at a new clue in obesity related disease.
www.cell.com/cell-metabol...
University of Pennsylvania mice study finds that an aging gut microbiome can weaken memory.
One bacterium, Parabacteroides goldsteinii, stirred inflammation, dulled gut brain signaling, and made young mice act older.
www.nature.com/articles/s41...
