Eric Topol

5 million deaths a year globally are attributed to lack of physical activity. Many countries have set policies to promote physical activity but never implemented them.
No improvement in >20 years!
3 new papers
nature.com/articles/s41...
nature.com/articles/s44...
nature.com/articles/s44...

A daily multivitamin (MVM) slowed epigenetic aging in a randomized trial after 2 years; effect was small (~2 months) and not seen with cocoa extract supplement (vitamin was Centrum Silver) nature.com/articles/s41...

Opinion | Should AI prescribe your meds? The evidence is lacking. In health care, unchecked risk at scale is a public health crisis.

Appropriate critique of Utah going with AI for prescriptions based on a Doctronic preprint written by the company, by
@josephsakran.bsky.social

gift link wapo.st/46O8TFh

good timing with this weekend!

A Master Class on Sleep Professor Yo-El Ju, With plenty of practical tips

The latest on sleep science and getting better quality sleep
erictopol.substack.com/p/a-master-c...

On sabotage of our young scientists, by @holdenthorp.bsky.social @science.org
www.science.org/doi/10.1126/...

Glucagon-like peptide-1 receptor agonists and risk of substance use disorders among US veterans with type 2 diabetes: cohort study Objectives To investigate whether initiation of glucagon-like peptide-1 (GLP-1) receptor agonists is associated with both reduced risks of incident alcohol, cannabis, cocaine, nicotine, opioid, and ot...

New in the BMJ: Our study of 600,000 people found GLP-1 drugs associated with 50% fewer substance-related deaths, 39% fewer overdoses, and reduced addiction risk across alcohol, opioids, cocaine, cannabis, and nicotine.
www.bmj.com/content/392/...

Best evidence yet that GLP-1 drugs reduce the risk of substance abuse, from >600,000 US Veterans with T2 diabetes across alcohol, nicotine, opioid, cocaine, cannabis @zalaly.bsky.social
@bmj.com
www.bmj.com/content/392/...

Cell-free DNA fragmentomes for noninvasive detection of liver cirrhosis and other diseases Genome-wide cfDNA fragmentomes are altered in liver disease and other morbidities and enable noninvasive detection of liver fibrosis and cirrhosis.

We've used a blood test—cell free DNA—for detecting cancer or prenatal fetal abnormalities. It turns out it can be used to detect liver diseases and all-cause mortality from other conditions!

science.org/doi/10.1126/...

The proteome (>7,000 circulating proteins) in people with ME/CFS exhibits immune system, vascular and metabolic dysregulation compared with controls
(and likely homologous in #LongCovid)
www.cell.com/cell-reports...

RFK Jr. Tells Joe Rogan He’s About to Unleash 14 Banned Peptides RFK Jr. plans to reverse a sweeping compounding ban of certain peptides issued by the FDA in late 2023.

Add the banned peptides for the anti-MAHA campaign
The latest anti-MAHA
gizmodo.com/rfk-jr-tells...

Estropausal gut microbiota transplant improves measures of ovarian function in adult mice - Nature Aging To investigate the link between the gut microbiome and ovarian health, here the authors transplant gut microbiota from estropausal female mice to young adult female mice. Microbial transplantation imp...

Surprising and notable if it holds up in humans: Extending ovary function and fertility via gut microbiome (fecal) transplant from young mice to old. estropausal mice

"a direct link between the gut microbiota and ovarian health"

www.nature.com/articles/s43...

"Excising RNA vaccine research from the NIH research portfolio is antithetical to current goals of making America healthy"
jamanetwork.com/journals/jam...
Here's what was funded in 2005 for mRNA vaccines vs pathogens and cancer
jamanetwork.com/journals/jam...

That's right. Worse than Pointless
www.nytimes.com/2026/02/23/o...

And the Lancet's editorial that goes with it
www.thelancet.com/journals/lan...

This week's cover @thelancet.com

And an infographic @notebooklm.bsky.social made from our essay

Decoding the language of sleep with artificial intelligence Sleep is one of medicine's underused data streams. Clinically, disturbed sleep has often been treated as a symptom of a disorder, but sleep is also a physiological state in which brain, cardiac, respi...

The data from sleep is incredibly rich, a window into health and risk of many diseases, decoded by AI.
Our new essay today
@jameszou.bsky.social @thelancet.com
thelancet.com/journals/lan...

For free access t.co/ymJY2l0eGP

What accounts for the progression from healthy aging to Alzheimer's disease over an extended period of time?
The critical role of the immune system, particularly T cells and microglia.
A new, excellent review
www.cell.com/immunity/abs...

CNN News Central - Dr. Eric Topol Powered by SnapStream Cloud Sharing

My @cnn.com clip on this study and Super Agers
video.snapstream.net/Play/3zsATgR...

Just what we don't need
www.wsj.com/opinion/case...

Human hippocampal neurogenesis in adulthood, ageing and Alzheimer’s disease - Nature Mapping of neurogenesis in human hippocampi across ages and different cognitive abilities using multiomic single-cell sequencing reveals distinct signatures between cognitive preservation and decline.

New @nature.com
The brains of Super Agers produce more neurons than people some 50 years younger, a neurogenesis resilient signature linked to exceptional cognitive health and memory skills
nature.com/articles/s41...

Frontiers | Characterization of subchronic lung and brain consequences caused by mouse-adapted SARS-CoV-2 and influenza A infection of C57BL6 mice IntroductionSARS-CoV-2 and, to a lesser extent, influenza A can lead to long-term complications in the respiratory and nervous systems. However, the mechanis...

Comparison of Covid vs flu in the experimental model:
Only Covid showed persistent brain inflammation
Repair of lung tissue impaired with Covid vs flu
www.frontiersin.org/journals/imm...

The imperiled peer review system
@carlbergstrom.com @plosbiology.org
journals.plos.org/plosbiology/... open-access

On negative social ties.
The number of "hasslers" in your life—people who create problems or make life difficult, especially family members (not spouse)—and the link to promoting accelerated aging, inflammation, and adverse health outcomes
@pnas.org
pnas.org/doi/full/10....

FALSE:
"V02 max is the single greatest predictor of your lifespan."

Our AI times :-)

🆕 at @naturemedicine.bsky.social
How does ChatGPT Health do for appropriately triaging a person as to whether to go to the emergency room or stay home? www.nature.com/articles/s41...
Not very well. Under-triaged 52% of case vignettes that are considered gold-standard emergencies

The Flawed V02 Max Craze Conflation With Cardiorespiratory Fitness

The V02 max craze has serious flaws. I reviewed the problems erictopol.substack.com/p/the-flawed...