Eric Topol

Aging, stress inside cells, and promoting cancer metastasis
www.nature.com/articles/s41...
AT4 is the effector of the integrated stress response, enriched in patients of advanced age with cancer and correlated with poor survival (Figure)

Human touch
www.alphaomegaalpha.org/wp-content/u...

Want to hack your body with peptides? If only the science agreed Performance-enhancing peptides are increasingly popular among fitness enthusiasts and biohackers, despite limited human testing and potential health risks.

RFK Jr is trying to get 14 peptides licensed without data on safety or efficacy. His favorite is BPC-157.
"Only three small human studies of BPC-157 exist, the largest of which is a telephone survey of 16 people who received an injection of the drug for knee pain"
www.economist.com/science-and-...

Exactly. Challenging dogma

What a study - nearly 15,000 people followed up 4-8 years after a *sole* antibiotic treatment and some *still* had disrupted gut microbiome diversity. Pretty incredible. We’ve always been taught that such disruptions are ephemeral.

#IDSky #MicroSky

A single course of antibiotics can have lasting effects on your gut microbiome, with changes that last well beyond 4 years. Three types of antibiotics stood out for their long term disruptive impact (3 at left, Figure)
nature.com/articles/s41...

Respiratory viral infections prime accelerated lung cancer growth Severe COVID-19 is associated with an increased subsequent risk of lung cancer. Viral pneumonia induces durable lung epigenetic imprinting that promotes tumor-supportive neutrophils and impairs T cell...

A causal link between severe Covid or flu and lung cancer risk by impairing immunity and promoting inflammation, as shown in multiple murine models www.cell.com/cell/fulltex...

There are Lots of Longevity Regimens. One Stands out for Me Amid an explosion of aging research, there are plenty of “biohackers” out there jumping the gun without waiting for proof of efficacy.

www.acsh.org/news/2026/03...

Plasma Phosphorylated Tau 217 and Incident MCI and Dementia in Older Women This cohort study examines associations of baseline plasma phosphorylated tau 217 with incident mild cognitive impairment (MCI) or dementia and whether associations vary by age, race, APOE ε4 carrier ...

Predicting Alzheimer's disease up to 25 years in advance of any symptoms with the p-tau217 biomarker blood test, among 2,766 women mean age 70
jamanetwork.com/journals/jam...

5 million deaths a year globally are attributed to lack of physical activity. Many countries have set policies to promote physical activity but never implemented them.
No improvement in >20 years!
3 new papers
nature.com/articles/s41...
nature.com/articles/s44...
nature.com/articles/s44...

A daily multivitamin (MVM) slowed epigenetic aging in a randomized trial after 2 years; effect was small (~2 months) and not seen with cocoa extract supplement (vitamin was Centrum Silver) nature.com/articles/s41...

Opinion | Should AI prescribe your meds? The evidence is lacking. In health care, unchecked risk at scale is a public health crisis.

Appropriate critique of Utah going with AI for prescriptions based on a Doctronic preprint written by the company, by
@josephsakran.bsky.social

gift link wapo.st/46O8TFh

good timing with this weekend!

A Master Class on Sleep Professor Yo-El Ju, With plenty of practical tips

The latest on sleep science and getting better quality sleep
erictopol.substack.com/p/a-master-c...

On sabotage of our young scientists, by @holdenthorp.bsky.social @science.org
www.science.org/doi/10.1126/...

Glucagon-like peptide-1 receptor agonists and risk of substance use disorders among US veterans with type 2 diabetes: cohort study Objectives To investigate whether initiation of glucagon-like peptide-1 (GLP-1) receptor agonists is associated with both reduced risks of incident alcohol, cannabis, cocaine, nicotine, opioid, and ot...

New in the BMJ: Our study of 600,000 people found GLP-1 drugs associated with 50% fewer substance-related deaths, 39% fewer overdoses, and reduced addiction risk across alcohol, opioids, cocaine, cannabis, and nicotine.
www.bmj.com/content/392/...

Best evidence yet that GLP-1 drugs reduce the risk of substance abuse, from >600,000 US Veterans with T2 diabetes across alcohol, nicotine, opioid, cocaine, cannabis @zalaly.bsky.social
@bmj.com
www.bmj.com/content/392/...

Cell-free DNA fragmentomes for noninvasive detection of liver cirrhosis and other diseases Genome-wide cfDNA fragmentomes are altered in liver disease and other morbidities and enable noninvasive detection of liver fibrosis and cirrhosis.

We've used a blood test—cell free DNA—for detecting cancer or prenatal fetal abnormalities. It turns out it can be used to detect liver diseases and all-cause mortality from other conditions!

science.org/doi/10.1126/...

The proteome (>7,000 circulating proteins) in people with ME/CFS exhibits immune system, vascular and metabolic dysregulation compared with controls
(and likely homologous in #LongCovid)
www.cell.com/cell-reports...

RFK Jr. Tells Joe Rogan He’s About to Unleash 14 Banned Peptides RFK Jr. plans to reverse a sweeping compounding ban of certain peptides issued by the FDA in late 2023.

Add the banned peptides for the anti-MAHA campaign
The latest anti-MAHA
gizmodo.com/rfk-jr-tells...

Estropausal gut microbiota transplant improves measures of ovarian function in adult mice - Nature Aging To investigate the link between the gut microbiome and ovarian health, here the authors transplant gut microbiota from estropausal female mice to young adult female mice. Microbial transplantation imp...

Surprising and notable if it holds up in humans: Extending ovary function and fertility via gut microbiome (fecal) transplant from young mice to old. estropausal mice

"a direct link between the gut microbiota and ovarian health"

www.nature.com/articles/s43...

"Excising RNA vaccine research from the NIH research portfolio is antithetical to current goals of making America healthy"
jamanetwork.com/journals/jam...
Here's what was funded in 2005 for mRNA vaccines vs pathogens and cancer
jamanetwork.com/journals/jam...

That's right. Worse than Pointless
www.nytimes.com/2026/02/23/o...

And the Lancet's editorial that goes with it
www.thelancet.com/journals/lan...

This week's cover @thelancet.com

And an infographic @notebooklm.bsky.social made from our essay

Decoding the language of sleep with artificial intelligence Sleep is one of medicine's underused data streams. Clinically, disturbed sleep has often been treated as a symptom of a disorder, but sleep is also a physiological state in which brain, cardiac, respi...

The data from sleep is incredibly rich, a window into health and risk of many diseases, decoded by AI.
Our new essay today
@jameszou.bsky.social @thelancet.com
thelancet.com/journals/lan...

For free access t.co/ymJY2l0eGP

What accounts for the progression from healthy aging to Alzheimer's disease over an extended period of time?
The critical role of the immune system, particularly T cells and microglia.
A new, excellent review
www.cell.com/immunity/abs...

CNN News Central - Dr. Eric Topol Powered by SnapStream Cloud Sharing

My @cnn.com clip on this study and Super Agers
video.snapstream.net/Play/3zsATgR...