Eric Topol

Thanks Erik!

Thanks! I think so, too

Our Brain—Immune Axis Gets A Jolt Facts, data and analytics about biomedical matters

A rundown on the big advances we’re seeing on the brain-immune axis

erictopol.substack.com/p/our-braini...

New book explores the science behind ‘super aging’ and longer, healthier lifespans Imagine a future where the aging process can be delayed and more people live active, healthy and disease-free lives well into their 90s. That reality may be sooner than you think, according to Dr. Eri...

My interview out today with @pbs.org on extending our healthspan www.pbs.org/newshour/sho... @aliroginpbs.bsky.social

Peptides: performance-boosting, anti-ageing drugs or dangerous snake oil? People are injecting compounds we barely understand.

"Until proper human trials are conducted, users are essentially volunteering as test subjects in an uncontrolled experiment with their own bodies."
theconversation.com/peptides-per... @theconversation.com

This hasn't been seen previously with any drug in a randomized trial. Participants in this trial had a BMI ~30. Await potential independent replication and extension in people not overweight.

An outgrowth of decades of research

New Implant Offers Hope for Easing Rheumatoid Arthritis

Controlling the immune system and inflammation through stimulating the vagus nerve. FDA approval of an implant for refractory rheumatoid arthritis that is also being studied for various autoimmune diseases.
Front page NY Times www.nytimes.com/2025/07/31/h...

The CDC has not provided a SARS-CoV-2 genomic surveillance update for 6 weeks. That is unacceptable

In a randomized, placebo-controlled trial, semaglutide (Ozempic) slowed epigenetic aging and the pace of aging across 11 organ and system clocks
medrxiv.org/content/10.1... (preprint)

Low-dose metformin requires brain Rap1 for its antidiabetic action Metformin lowers blood glucose by inhibiting Rap1 in ventromedial hypothalamic neurons that regulate glucose balance.

Metformin, the first line drug for Type 2 diabetes, has been used for 60 years without a clearcut mechanism of action. It turns out it's not just reducing glucose output from the liver. Metformin also works via the brain www.science.org/doi/10.1126/...

Multimodal AI correlates of glucose spikes in people with normal glucose regulation, pre-diabetes and type 2 diabetes - Nature Medicine Multimodal data from 347 deeply phenotyped individuals including healthy, prediabetic individuals and individuals with T2D report remotely acquired patterns of glucose control via continuous glucose m...

Our @naturemedicine.bsky.social paper on glucose spikes (CGM sensor) and their relationship with physical activity, gut microbiome, genomics, food intake, and sleep via multimodal A.I. Helps identify people with prediabetes who have high risk of progression (cf HbA1c)
www.nature.com/articles/s41...

Add a new drug, CETP inhibitor, to the ways beyond lifestyle that we can reduce p-tau 217, the key biomarker for risk of Alzheimer’s disease

ir.newamsterdampharma.com/news-release...

At @thelancet.com today, entitled:
"A crisis of credibility: the global cost of US vaccine misinformation"
www.thelancet.com/journals/lan...

Human exposure to PM10 microplastics in indoor air The ubiquitous presence of airborne microplastics (MPs) in different indoor environments prompts serious concerns about the degree to which we inhale these particles and their potential impact on huma...

"The microplastic (MP) 1–10 μm exposure estimates are 100-fold higher than previous estimates that were extrapolated from larger MP sizes, and suggest that the health impacts of MP inhalation may be more substantial than we realize."
journals.plos.org/plosone/arti...

We've known that Covid increases the risk in survivors of cancer, but today @nature.com a mechanism of reactivation of cancer cells elucidated in the experimental model
www.nature.com/articles/s41...
www.nature.com/articles/d41...

Trump Administration Puts New Chokehold on Billions in Health-Research Funding The National Institutes of Health can’t award grants to outside researchers under a new White House restriction.

The NIH can’t award ANY grants to outside researchers under new WH restriction, reports @wsj.com.

The pause came in the form of a footnote from OMB Director Vought, in a document that doles out federal funds to the NIH.

Prelude to rescissions, especially after his comments over the weekend?

Association between ultra-processed food consumption and lung cancer risk: a population-based cohort study Background The evidence on associations between ultra-processed foods (UPF) and lung cancer risk is limited and inconsistent. Research question Are UPF associated with an increased risk of lung cance...

Ultraprocessed food intake and increased risk of lung cancer thorax.bmj.com/content/earl...

But extreme exercise increases the risk of AF
accompanying editorial
bjsm.bmj.com/content/earl...

Exercise reduces the risk of atrial fibrillation recurrence, severity, symptom severity, and frequency. A systematic review of exercise-based cardiac rehab from 20 RCTs
bjsm.bmj.com/content/earl...

The brain-immune axis at work.
Just photos of people with infections (using VR, avatars) activates the immune system (vs controls)
www.nature.com/articles/d41...
www.nature.com/articles/s41...

Who do you call when you need to design novel, potent nanobodies vs a pathogen?
The virtual lab of A.I. agents @nature.com @jameszou.bsky.social @kylewswanson.bsky.social
www.nature.com/articles/s41...

Daily walking and mortality in racially and socioeconomically diverse US adults While the health benefits of daily walking are well-established, limited research has investigated effects of factors such as walking pace on mortality, particularly in low-income and Black/African-Am...

The pace of walking appears to be important too
www.ajpmonline.org/article/S074...

One of the top peptide influencers, Holtorf, was involved in these cases, who promotes BPC-157, and has claimed peptides prevent and treat Covid
erictopol.substack.com/p/the-peptid...

Healthy Lifestyle Can Help People at Risk for Dementia, Study Finds

www.nytimes.com/2025/07/28/h...

A Las Vegas Festival Promised Ways to Cheat Death. Two Attendees Left Fighting for Their Lives. Authorities are investigating why two women fell ill at the Revolution Against Aging and Death Festival. They both received peptide injections, an alternative therapy promoted by Robert F. Kennedy Jr....

Authorities are investigating why two women fell ill at the Revolution Against Aging and Death Festival. They both received peptide injections, an alternative therapy promoted by Robert F. Kennedy Jr. as a way to fight aging and chronic disease. @anjeanette-damon.bsky.social

Association of ultra-processed food consumption and MRI-based carotid plaque characteristics: results from the Atherosclerosis Risk in Communities study Ultra-processed food and beverage consumption has been linked with adverse cardiovascular events, yet its association with sub-clinical disease remain…

The more ultraprocessed food intake, the more atherosclerotic plaque in the carotid arteries (by MRI)
www.sciencedirect.com/science/arti...

Dietary patterns and accelerated multimorbidity in older adults - Nature Aging In a Swedish cohort, Abbad-Gomez et al. report that diet quality is inversely associated with the rate of accumulation of total, cardiovascular and neuropsychiatric chronic diseases in older adults, s...

A Swedish cohort with long term follow-up once again highlights the link between diet and chronic diseases in older adults
www.nature.com/articles/s43...

Balancing weight and muscle loss in GLP1 receptor agonist therapy - Nature Reviews Endocrinology Rapid weight loss with GLP1 receptor agonists can come at the cost of skeletal muscle, potentially undermining metabolic and functional outcomes. This Comment highlights emerging evidence and advocate...

Preserving muscle mass is a key concern w/ GLP-1 drug treatment. Many ways to help achieve that are being explored, beyond exercise & diet, including myostatin inhibitors, SARMs (selective androgen receptor modulators), and via activin type II receptor pathway (ActRII) www.nature.com/articles/s41...

A randomized trial (N>2,100 participants, multi-center) of structured vs self-guided lifestyle interventions in older adults shows the former improved cognitive function jamanetwork.com/journals/jam...