Eric Topol

"Excising RNA vaccine research from the NIH research portfolio is antithetical to current goals of making America healthy"
jamanetwork.com/journals/jam...
Here's what was funded in 2005 for mRNA vaccines vs pathogens and cancer
jamanetwork.com/journals/jam...

That's right. Worse than Pointless
www.nytimes.com/2026/02/23/o...

And the Lancet's editorial that goes with it
www.thelancet.com/journals/lan...

This week's cover @thelancet.com

And an infographic @notebooklm.bsky.social made from our essay

Decoding the language of sleep with artificial intelligence Sleep is one of medicine's underused data streams. Clinically, disturbed sleep has often been treated as a symptom of a disorder, but sleep is also a physiological state in which brain, cardiac, respi...

The data from sleep is incredibly rich, a window into health and risk of many diseases, decoded by AI.
Our new essay today
@jameszou.bsky.social @thelancet.com
thelancet.com/journals/lan...

For free access t.co/ymJY2l0eGP

What accounts for the progression from healthy aging to Alzheimer's disease over an extended period of time?
The critical role of the immune system, particularly T cells and microglia.
A new, excellent review
www.cell.com/immunity/abs...

CNN News Central - Dr. Eric Topol Powered by SnapStream Cloud Sharing

My @cnn.com clip on this study and Super Agers
video.snapstream.net/Play/3zsATgR...

Just what we don't need
www.wsj.com/opinion/case...

Human hippocampal neurogenesis in adulthood, ageing and Alzheimer’s disease - Nature Mapping of neurogenesis in human hippocampi across ages and different cognitive abilities using multiomic single-cell sequencing reveals distinct signatures between cognitive preservation and decline.

New @nature.com
The brains of Super Agers produce more neurons than people some 50 years younger, a neurogenesis resilient signature linked to exceptional cognitive health and memory skills
nature.com/articles/s41...

Frontiers | Characterization of subchronic lung and brain consequences caused by mouse-adapted SARS-CoV-2 and influenza A infection of C57BL6 mice IntroductionSARS-CoV-2 and, to a lesser extent, influenza A can lead to long-term complications in the respiratory and nervous systems. However, the mechanis...

Comparison of Covid vs flu in the experimental model:
Only Covid showed persistent brain inflammation
Repair of lung tissue impaired with Covid vs flu
www.frontiersin.org/journals/imm...

The imperiled peer review system
@carlbergstrom.com @plosbiology.org
journals.plos.org/plosbiology/... open-access

On negative social ties.
The number of "hasslers" in your life—people who create problems or make life difficult, especially family members (not spouse)—and the link to promoting accelerated aging, inflammation, and adverse health outcomes
@pnas.org
pnas.org/doi/full/10....

FALSE:
"V02 max is the single greatest predictor of your lifespan."

Our AI times :-)

🆕 at @naturemedicine.bsky.social
How does ChatGPT Health do for appropriately triaging a person as to whether to go to the emergency room or stay home? www.nature.com/articles/s41...
Not very well. Under-triaged 52% of case vignettes that are considered gold-standard emergencies

The Flawed V02 Max Craze Conflation With Cardiorespiratory Fitness

The V02 max craze has serious flaws. I reviewed the problems erictopol.substack.com/p/the-flawed...

Progress!

You gotta be kidding me
gift link
www.wsj.com/tech/persona...

On the huge randomized GRAIL trial
Front page NYT today

"The study’s goal was to show a 20 percent reduction in advanced cancers among those who got the test. That did not happen."
gift link
www.nytimes.com/2026/02/20/h...

A potential late sequelae of measles after normal recovery.
Occurs in ~ 2/10,000. Fatal.
www.nejm.org/doi/full/10.... @nejm.org today

Thanks! And true

what was >$1 billion for the 1st human genome

The $100 whole human genome sequence finally reached!
www.sandiegouniontribune.com/2026/02/19/s...

Monocyte-derived IL-10 drives sex differences in pain duration Peripheral monocytes and IL-10 are associated with shorter pain duration in males in both mice and humans.

Sex differences in pain duration
Finding interleukin-10 from monocytes as an/the explanation (in the experimental model and people
www.science.org/doi/10.1126/...

yes. High polygenic risk scores for common cancers, strong family history, genome sequence showing pathogen mutations of known predisposition risk variants, etc.

142,000 participants!
The largest randomized trial of a multi-cancer early detection (MCED) test failed its primary endpoint
genomeweb.com/cancer/grail...
Had the enrollment been risk-based instead of age 50, it would likely have been very positive.

How to get a universal vaccine vs respiratory threats?
Block via the nasal mucosa
@science.org
www.science.org/doi/10.1126/...
@natrevimmunol.nature.com
www.nature.com/articles/s41...