I am so happy to report my first co-corresponding authored article that was chosen as an exceptional work by the JBC.
@asbmbjournals.bsky.social
@asbmb.bsky.social
Skin-derived αSyn PD, DLB, MSA strains are bioactive, pathologic and induce neurodegeneration.
www.sciencedirect.com/science/arti...
Extremely proud of Rebecca Wallings & Team in #TanseyLab3.0 for these high-impact findings in @sciencetranslationalmedicine www.science.org/doi/10.1126/...
Researchers examine post-mortem brain tissue & spinal cords from 20 individuals diagnosed with REM sleep behaviour disorder by polysomnography, & find strong neuropathological evidence that it's an early stage of α-synuclein-related neurodegen. disease
www.thelancet.com/journals/lan...
IPS cell-derived midbrain organoids from patients with GBA1-related #Parkinsons develop α-synuclein deposits; Retention of mutant GCase in the ER & the increase of GlcCer are key drivers of this pathology; Ambroxol & GZ667161 reduce the α-syn deposits
academic.oup.com/brain/advanc...
In a new study, researchers report that expression of granulins (using AAV) corrects lysosome defects, inflammation, & lipofuscin in GRN-/- mice; These "findings have important implications for therapeutic development to treat FTD-GRN, #Alzheimers, & #Parkinsons"
www.cell.com/cell-reports...
A new review explores the emerging role of disease-associated microglia in #Parkinsons; "Investigating the spatiotemporal properties of DAM in PD could provide a strong baseline for comparison" across neurodegenerative diseases
www.frontiersin.org/journals/cel...
