A. Phillip West

Just wrapped our @Fusion_Conf on Inter-organelle Communication in Inflammation and Disease. 4 days of outstanding science! Thanks to all speakers, poster presenters, and other attendees for making it a great meeting. (Photo of some of us on excursion to Marsaxlokk village).

About two months to go until the Fusion Inter-Organelle Communication in Inflammation and Disease Conference in Malta. Short talk slots and travel scholarships still available. We'd love to see you at #IOSCD25 so please apply!
@fusionconf.bsky.social

A Membrane-Disruptive Action of VBIT-4 Challenges Its Role as a Widely Used VDAC Oligomerization Inhibitor https://www.biorxiv.org/content/10.1101/2025.06.30.661942v1

Why patients with mitochondrial disease more susceptible to infections A discovery at The Jackson Laboratory reveals how dysfunctional mitochondria put the immune system on overdrive, leading to severe infections.

Also a link to a summary of our findings written by the communications team of @jacksonlab.bsky.social www.jax.org/news-and-ins...

Caspase-11 drives macrophage hyperinflammation in models of Polg-related mitochondrial disease - Nature Communications Mitochondrial diseases lead to chronic health impairment, aggravated by infections and other environmental exposures. Here authors show, in a mouse model of polymerase gamma (Polg)-related mitochondri...

Delighted to share our paper describing how type I interferon promotes caspase-11 hyperactivity in models of PolG-related mitochondrial disease. Thanks to all co-authors and the POLG Foundation for for their support. www.nature.com/articles/s41...

⏰Register & Submit by 02 June 2025⏰
Join discussions around organelle stress communication mechanisms in homeostatic & pathological settings including cancer, metabolic & neurologic diseases, & aging at #IOSCD25!
Find out more: bit.ly/42VGAmD
@westlabmito.bsky.social

If you are interested in mito-nuclear communication and organelle crosstalk, stress responses, and inflammatory signaling, the #IOSCD25 Fusion Conference is for you!
Short talk and early-bird deadline is June 2nd. Travel awards available.
Check it out: www.fusion-conferences.com/conference/182

Inter-organelle Stress Communication in Inflammation & Disease Conference | Fusion Conferences Our scientific research conferences support the development of physical, medical and life sciences, providing a powerful platform that encourages discussion and collaboration in luxury locations acros...

Excited to call your attention to a new Fusion Conference this October in Malta. #IOSCD25 will cover:
• Organelle Crosstalk
• DNA Damage Responses & Inflammation
• Organelles in Innate Immune Signaling
• Organelle Communication in Disease and Aging
More here: bit.ly/4jI458f
@fusionconf.bsky.social

📢1 WEEK TO GO📢
Have you registered for #IOSCD25 yet? Early bird & talk submission close next week!
📄Programme now live
💰Grants available
📆Application deadline: 01 May 2025
Find out more: bit.ly/4jI458f

Structures of ATP-binding cassette transporter ABCC1 reveal the molecular basis of cyclic dinucleotide cGAMP export Cyclic nucleotide GMP-AMP (cGAMP) plays a critical role in mediating the innate immune response through the cyclic GMP-AMP synthase (cGAS)-stimulator …

Congrats to Omkar Shinde and Pingwei Li for resolving the cryo-EM structures of free and cGAMP-bound ABCC1. This paper follows on the great work from Dan Stetson's lab revealing ABCC1 as a cGAMP exporter. www.sciencedirect.com/science/arti...