@gbeeghly.bsky.social
Postdoc in the Radisic Lab at the University of Toronto and University Health Network. Engineering tissues to understand health and disease. Baker, hiker, cat dad. He/him. 🏳️🌈 https://gbeeghly.github.io/
A Review in Nature Reviews Cardiology highlights the use of heart-on-a-chip and vasculature-on-a-chip platforms consisting of 3D structures that incorporate relevant cell populations to model cardiovascular disease phenotypes and contribute to the development of novel therapeutics.
Tumour heterogeneity comes at different length scales.This article classifies regulators of cancer into tumour-cell-intrinsic, tissue-microenvironment and organism-level sources, describing engineering strategies to measure and analyse these factors:
Unfortunately, I think it is for desktop only but maybe you can find something equivalent for mobile 😬
I found a custom ublock origin filter that gets rid of most of the ads on YouTube! I can’t imagine actually sitting through the number of them on most videos
On a quest to make my own yogurt and cottage cheese… and all I can think is how useful it would be to have a hot plate and stir bar to prevent milk from burning. Why doesn’t this exist? #ScientistsWhoCook
Congrats Jenn!
It was not an easy process getting back to Toronto this weekend and I ended up getting a last minute flight with Flair... Hope you can get it sorted out!
Yes, looking forward to seeing your future work too!
Thank you, Adeel! 🙌
Excited to start my postdoctoral training @utoronto.ca and @uhn.ca this week! I will work with Dr. Milica Radisic who is a leader in developing organ-on-a-chip technologies and engineering functional microtissues. Glad to be in a new environment committed to funding the future of science 🇨🇦🔬
Congrats Ya’el! So happy for you!
Congrats! Amazing news 🥳
Congrats, Pilar! So great to see some good news!
Cali approves of this important breakthrough in science! #catsky #catsofbluesky #calico #scisky
The funding situation is rough! Hopefully things will turn around (this is what I’m telling myself)
Congrats, Johanna! Well deserved!
Had a great visit to Stanford last week and managed to squeeze in a visit to Half Moon Bay! Glad to have soaked up a little extra California sun ☀️ #blueskyartshow #nature #photography
I am incredibly excited to share that I will be starting as an Assistant Professor of Biomedical Engineering in the CBE Department at FAMU-FSU College of Engineering this fall! Ready for some Florida sunshine 😁
Congrats, Nate! This is amazing news! I'm so happy for you! ☀️
I am THRILLED to officially announce that I have accepted a position as an Assistant Professor of Biomedical Engineering at the University of Wisconsin-Madison starting January 2026! My lab will use expertise in polymer science, biomaterials, and ECM engineering study osteochondral disease! 🦡 🔬🧪🧫 🦴
Science Magazine gets it wrong. 🧵
Congrats Jason!
Had a great time working with @natrevbioeng.nature.com to put this review together! Biophysical cues integrate across length scales (molecular, cellular, tissue level, organismal) to drive cancer outcomes. Bioengineers have the tools to measure and model these factors in isolation 🛠️🔬
Overdue debut of my cat Cali on Bluesky for this spring #caturday
#BabysFirstConfocal
Ultimately, our findings suggest that larger adipocytes constitute a distinct cell population within mammary adipose tissue and increase lipid transfer to invading cancer cells. As a result, we propose that adipocyte size could serve as a prognostic biomarker for breast cancer patients. 5/5
In a published cohort of mastectomy patients, we also found that average adipocyte size predicted dyslipidemia and circulating triglycerides more than body mass index. These results suggest that altered lipid release by larger adipocytes may have broader implications for whole body metabolism. 4/5
Functionally, larger adipocytes increase a non-canonical, vesicle-mediated mode of lipid release versus lipolysis. This shift promotes lipid transfer to nearby breast cancer cells, increasing their migration and proliferation in a manner dependent on fatty acid metabolism. 3/5
Here, we developed methods to sort and culture primary adipocytes isolated from the same adipose tissue samples. We determined larger adipocytes are transcriptionally distinct from smaller donor-matched adipocytes and are enriched for gene sets related to altered lipid processing. 2/5
Preprint alert! Excited to share this manuscript from my PhD which aims to answer an age-old question. Does size matter? For fat cells, or adipocytes, the answer seems to be yes. We found that larger adipocytes promote aggressive behavior in breast cancer cells. 1/5 www.biorxiv.org/content/10.1...