👉EWS::FLI1 modulates R-loop metabolism via DHX9, driving increased vulnerability to TOP1-targeting agents.
👉Targeting TOP1 in EWS cells destabilizes the genome and provokes strong replication stress and cell death in EwS cells and tumors
Grateful to all collaborators who made this work possible!
29.07.2025 08:36 — 👍 1 🔁 0 💬 0 📌 0
Agradecido por poder SER: persona, pareja, padre, médico, patólogo, investigador, profesor, ciudadano
En todo amar y servir/AMDG
Postdoc at Jacqueline Jacobs lab - The Netherlands Cancer Institute (NKI). #genomeinstability #ALT #DNAreplication
Cardiologa clinica,Profesora ASCIS en La facultad de medicina US. Un absoluto honor ser la Directora Gerente de @HospitalUVRocio.
Associate professor @unisevilla.bsky.social All about #hypoxia @ibis-investigacion.bsky.social
Group leader of SENOXIA_Lab
Where small becomes Great
Research and development in Micro and Nanoelectronics
Micro and Nanofabrication Clean Room (ICTS)
🏅 Unit of Excellence "María de Maeztu"
Institut de Microelectrònica de Barcelona (@CSIC.es)
https://www.imb-cnm.csic.es
Cuenta oficial de la Agencia Estatal de Meteorología.
Investigo y enseño Nutrición y Comunicación Científica en el @csic.es y la @pablodeolavide.bsky.social http://javiersperona.carrd.co ORCID:0000-0001-5919-993X
The Max Planck Institute for Molecular Genetics in Berlin. We want to understand how the genome works and how it is regulated, especially during embryonic development & disease. Imprint: https://www.molgen.mpg.de/impressum
Non-profit publisher of @embojournal.org, @emboreports.org, @embomolmed.org, @molsystbiol.org and @lsajournal.org. #OpenScience #Policy
PLOS is a non-profit organization on a mission to drive open science forward with measurable, meaningful change in research publishing, policy and practice.
The funder-researcher collaboration and open-access publisher for research in the life and biomedical sciences.
Follow @eLifeCommunity.bsky.social
How do cells form tissues? Our research program spans the scales from molecules to organisms. News from the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) in Dresden, Germany. Impressum: https://www.mpi-cbg.de/impressum
Organisme public 🇫🇷 de recherche pluridisciplinaire, le Centre national de la recherche scientifique c'est 33 000 personnes qui font avancer la connaissance. #HelloESR
Structure of Macromolecular Assemblies Laboratory at CIB-Margarita Salas (CSIC).
Interested in Cryo-EM, odd RNA polymerases and processes beyond transcription.
https://www.cib.csic.es/research/cellular-and-molecular-biology/structure-macromolecular-assemb
A leading European centre in personalized oncology, VHIO transforms lab discoveries into clinical breakthroughs through multidisciplinary research and global collaboration.
🌐 vhio.net
Científico empeñado en entender el cáncer y en favorecer la ciencia en nuestro país. Trabajo en el Centro de Investigación del Cáncer de Salamanca. RT≠endorsement
La Delegación del CSIC en Castilla y León está conformada por cinco centros de investigación, varias unidades asociadas y una bioincubadora de empresas 👩🔬🧪 Promueve la I+D+i, la transferencia de conocimiento y la cultura científica en la región.
Liquid biopsy & transcriptomics for biomarker discovery in cancer and beyond. Robust science, reproducibility & RNA-based diagnostics. 🌐 https://flomics.com
“LaPa-ciencia” es un podcast donde la gente que hace ciencia se muestra tal y como es. Sin batas, sin deadlines, sin experimentos y sin presión. Un sitio para personas, de ciencia, pero personas como tú y como yo.🎙️🧫🦠🔬
🥖😬👨🎨 (France) - 🍯🍷🌧️ (Dijon) - 🧬🔬🧪 (CNRS)
GATTACA Lab. Chemical biology & genetics. Trying to understand why and how DNA and RNA fold into ωєιя∂ℓу ѕнαρє∂ structures..
https://sites.google.com/site/monchaudchembiolab/
