Sorry Alice, what is Roon? Am I missing out on the Next Big Thing?
I goes off you use Rezafungin ever you’re sort of using Anidula?
YOU’LL JUST HAVE TO LISTEN SHARE THE EPISODE* TELL ALL YOUR MATES* AND DONATE SOME DOSH* TO FIND OUT
*optional
New episode!
Alyssa and Jame are joined by Tihana Bicanic, to discuss the second great antifungal drug class, Echinocandins.
Part 1 of 2! (this episode we discuss the old stuff, next episode we discuss Rezafungin)
#idsky #microsky #fungi
podcasts.apple.com/gb/podcast/i...
Consider this our post advertising the latest episode, ‘Biocide Bashing’, available now!
Hold on to your Phallusocks ®️, this topic’s as scary as it gets! (That’ll make more sense after you listen)
#IDsky #microsky #biocides #microbiotoxicity
podcasts.apple.com/gb/podcast/i...
“Always start with oral for a satisfying resolution”?
“Use the mouth before things go south”?
Everything I think of sounds naughty.
I’ll work on it. Great poster, @drrossanarosa.bsky.social !
I’ll go back to X if you don’t.
OI
YOU
… Podcast on Azole Antifungals.
Would be a shame if you reposted it to AAAAAAALLL your followers, and liked it and commented on what you thought of it below
PLEASE DON’T DO THAT we hate popularity!!
#IDsky #microsky #fungi
podcasts.apple.com/gb/podcast/i...
I count that as gram negative infection (serious), would treat the same way I would for pyelo/GN BSI.
Beta-lac (Ceftriaxone, Piptaz)
FQ (Cipro, Levo)
Cotrim
Aminoglycoside (maybe, +/- amoxicillin)
Depending on previous ABx exposure, micro etc.
In UK it’s Amox/Gent or CRO, depending on location
Incidentally: only oral 3rd gen we have in the UK is cefixime: it’s got low bioavailability, so I wouldn’t consider it equivalent to Ceftriaxone.
I’ve never used it, actually… the UK has a weird attitude to oral cephalosporin in general…
Is this going to be a podcast series?
It should be. At the back of my mind I’ve had an idea for a “Microbe Maestros” mini series where we’d explore famous figures in micro/ID: Pasteur, Koch, Lancefield, Spellberg, etc.
Starting with the GOAT, Fleming, obviously…
First 10 days: leave it the fuck alone. IV Ceftriaxone 2g BD, with IV Amox.
D11 onwards: I forget about all that synergistic Ceftriaxone/gentamicin crap and go with what POET showed worked (maybe even better than IV Rx): one of the oral regimens.
I wonder if @bradspellberg.bsky.social would recommend any mono-Rx regimens from the #wikiguidelines #endocarditis guidance?
(Honoured to be @‘d in the same tweet, naturally. Unless he comes and poopoos my argument in which case I never liked him)
…They’d be on high dose IV Amox/Cef, so wouldn’t switch to PO Amox before as I can’t get to 12g/d with oral admin. Does that make a difference? Who knows; but with 12g/d you’ll be getting T>MIC of almost 100%, even if they’ve got 6 kidneys and a dialysis machine up their backside.
2/3
I advocate for it whenever I can.
POET regimens that made it into ESC 2023 guidance:
-Linez + 1 of Amox, Moxi, Rif
-Amox + 1 of Moxi, Rif
So once I get to D10 I try to switch to 1 of those (the Moxi regimens only if the others can’t be done), and sometimes I’m successful.
Before D10…
1/3
Yeah yeah we all know what to do with Penicillin Allergy BUT: what about cephalosporin allergy? Bet you don’t know what to do about that!
Well this week’s episode can help! Listen below, or on your podcast app…
#IDsky #Microsky #infection #allergy
podcasts.apple.com/gb/podcast/i...
From a UK PoV, we’d use Fluclox as a default: Cefazolin is becoming more widespread post-SNAP and the recent papers re: Cefazolin CNS Penetration, but we’ve the most experience with ASP.
I tried to get Cotrim in S but Callum tier-blocked me.
Can’t disagree with that. It’s probably the next drug episode we’re doing. Thinking of titling it “why vancomycin isn’t crap even though everyone thinks it is”.
Also wonder when Dalba’s off patent if we’ll all start ‘stat Dalba’-ing everyone we need to cover for MRSA and forget about the rest of it
I SAID IF YOU WERE AMERICAN TO SUB AZITHRO FOR CLARI GOD JONATHAN WHAT DID YOUR LAST PODCAST SLAVE DIE OF??!!
#IDsky #microsky #tierlist #Doxynorris #antibiotics
And here it is, Listeners Dearest
The ID:IOTS Antibiotics Tier List
Want to argue? Curse our names to God?
Go right ahead; but sub to Pod
And tell your friends about us, although
It's likely it'll annoy them also
podcasts.apple.com/gb/podcast/i...
Yo ho ho, 4 our listeners dearest
We present an ABx tier list
Ranking drugs from S to D
In a manner so Christmassy
So sit back relax & have a drink
As we discourse in cladist think
And if u rank a different way
We forgive u this Christmas Day
#idsky #microsky
podcasts.apple.com/gb/podcast/i...
Psst. Want to know everything you need to on Capnocytophagia?
Got 15 minutes?
Listen here.
Free pun included! It’s a regular ‘Cap Friday’ deal!
#idsky #microsky
podcasts.apple.com/gb/podcast/i...
We don’t cover IPC, sorry.
Ask Infection Control Matters, those guys will know!
It’s World Antimicrobial Awareness Week! Did u know AMR might kill us all? @bsacandjac.bsky.social do: they partnered up with interested politicians to drive AMR up the UK's political agenda. How is what this episode is all about! Listen on!
#IDsky #microsky #amr
podcasts.apple.com/gb/podcast/i...
I think we’re doing an episode on it?
Maybe. Callum and Alyssa tell me nothing!
Survey on Enterococcus BSI RCT design: an opportunity to give your thoughts!
BRITISH PEOPLE ONLY!!! (not sure why)
They invade hair and nail and skin
The diagnostics not so tough
And if the patient’s has enough
You can try some terbinafin(e)
So come on down and sub to pod
Give ID:IOTS a try tonight
And get an education
On managing Dermatophytes
#idsky #microsky #fungal #mould
It’s the end of Halloween
But for those who want more frights
Allow me to present this show
On the dermatophytes
#idsky #microsky #fungal #mould
podcasts.apple.com/gb/podcast/i...
Ever the salesman
