Srishti Mishra

The neuronal chromatin landscape in brains from individuals with schizophrenia is linked to early fetal development - Nature Neuroscience This study maps chromatin accessibility in neurons and glia in schizophrenia, revealing fetal-like regulatory patterns in adult neurons enriched for genetic risk variants, linking early brain developm...

Large-scale chromatin accessibility profiling (ATAC-seq) of neurons and non-neurons from 2 human neocortical regions from 469 unique donors, comprising controls and individuals diagnosed with schizophrenia and bipolar disorder

www.nature.com/articles/s41...

Planet’s first catastrophic climate tipping point reached, report says, with coral reefs facing ‘widespread dieback’ Unless global heating is reduced to 1.2C ‘as fast as possible’, warm water coral reefs will not remain ‘at any meaningful scale’, a report by 160 scientists from 23 countries warns

Planet’s first catastrophic climate tipping point reached, with coral reefs facing ‘widespread dieback’

Unless global heating is reduced to 1.2C ‘as fast as possible’, warm water coral reefs will not remain ‘at any meaningful scale.’

www.theguardian.com/environment/...

Great body of work led by @ppiantad.bsky.social

First use of PdCO in the wild to perform closed-loop pre-choice modulation 🤩

www.biorxiv.org/content/10.1...

"Jane Goodall showed us what a life in science could look like: rigorous discovery paired with fierce advocacy for what you study. She gave the world six decades of groundbreaking research on chimpanzees and their habitats, then turned that knowledge into a global movement for conservation." (1/2)

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🚨 New preprint! 🚨

Excited and proud (& a little nervous 😅) to share our latest work on the importance of #theta-timescale spiking during #locomotion in #learning. If you care about how organisms learn, buckle up. 🧵👇

📄 www.biorxiv.org/content/10.1...
💻 code + data 🔗 below 🤩

#neuroskyence

Do inhibitory interneurons encode information or just keep the rhythm? Inhibitory interneurons may help encode the brain’s internal representation of space

Do inhibitory interneurons encode information or just keep the rhythm?
www.science.org/doi/10.1126/...

“Top-down and bottom-up neuroscience: overcoming the clash of research cultures”
doi.org/10.1038/s415...
Small contribution in this piece by @frosas.bsky.social and colleagues on how we need both types of research culture in neuroscience.
#neuroskyence

Criticality: A high point in the computational fitness landscape

Is criticality a unified setpoint of brain function?: www.cell.com/neuron/fullt...

"We perform a meta-analysis of 140 datasets published between 2003 and 2024. We find that a long-standing controversy is the product of a methodological choice with no bearing on underlying dynamics."

Neuroscientist Gerry Fischbach, in his own words In 2023, Ivan Oransky sat down with Gerry Fischbach to hear—and record for posterity—the story of Fischbach’s life and career.

In 2023, Ivan Oransky, @thetransmitter.bsky.social’s editor-in-chief, sat down with Gerry Fischbach over several days to listen to—and record for posterity—the story of Fischbach’s life and career.

www.thetransmitter.org/neuroscience...

The evolving neurobiology of early-life stress This review explores the effects of early-life stress on brain development and cognitive function, highlighting gaps in understanding perceived stress, vulnerable developmental stages, underlying mole...

Excellent review by @talliezee.bsky.social and Matthew T. Birnie on the neurobiological mechanisms underlying the consequences of early life adversity. Highly recommended! www.cell.com/neuron/fullt...

The catastrophic risks of AI — and a safer path Yoshua Bengio — the world's most-cited computer scientist and a "godfather" of artificial intelligence — is deadly concerned about the current trajectory of the technology. As AI models race toward fu...

When I realized how dangerous the current agency-driven AI trajectory could be for future generations, I knew I had to do all I could to make AI safer. I recently shared this personal experience, and outlined the scientific solution I envision @TEDTalks⤵️
www.ted.com/talks/yoshua...

Integrating reproductive states and social cues in the control of sociosexual behaviors A subset of neurons in the medial prefrontal cortex is shown to exert top-down regulation of adaptive innate reproductive behaviors by integrating social cues with estrous states to orchestrate socios...

Integrating reproductive states and social cues in the control of sociosexual behaviors
www.cell.com/cell/fulltex...

A very special 150th episode - I got to interview the one-and-only Eve Marder! Check it out to learn more about her life and science, and highly recommend listening to the interview to hear her many fabulous stories and her words of wisdom, my personal favorite being about how she found her ‘voice’

Today’s editorial in @thehindu.com about academic freedom in India

The Molecular Bond That Helps Secure Your Memories | Quanta Magazine How do memories last a lifetime when the molecules that form them turn over within days, weeks or months? An interaction between two proteins points to a molecular basis for memory.

In 1984, Francis Crick described a biological conundrum: Memories last years, while most molecules degrade in days or weeks. “How then is memory stored in the brain so that its trace is relatively immune to molecular turnover?” www.quantamagazine.org/the-molecula... #memory #Crick #philsky

🚀🔬🦠 Releasing 🤖Cellpose-SAM🤖, a cellular segmentation algorithm with superhuman generalization 🦸‍♀️. Try it now on 🤗 huggingface.co/spaces/mouse...

paper: www.biorxiv.org/content/10.1...
w/ @computingnature.bsky.social 1/n

Laborleiter*in (m/w/d) Psychophysiologie und Verha... In der Fakultät für Psychologie und Sportwissenschaft ist zum nächstmöglichen Zeitpunkt die Stelle der*des Laborleiter*in (TV-L E12 bzw. E13) im B...

⚠️Permanent position (E13) as lab manager (psychophysiology, experimental behavioral neuroscience) at University of Bielefeld. Earliest starting date is in July but later is absolutely possible. Please share widely uni-bielefeld.hr4you.org/job/view/427...

NIH cancels its first and largest study centered on women The Women’s Health Initiative has produced numerous influential findings

NIH cancels its first and largest study centered on women

www.science.org/content/arti...

Albert Einstein died on this day, April 18, 1955.

It is incredible to hear Albert Einstein explain his famous formula, E=mc².

Smell studies often use unnaturally high odor concentrations, analysis reveals It’s time to fashion olfactory neuroscience stimuli based on odor concentrations in the wild, say study investigators Elizabeth Hong and Matt Wachowiak.

Olfactory neuroscientists have known for a while that their stimuli stink. A new analysis illuminates the extent of the problem.

By @callimcflurry.bsky.social

#neuroskyence

www.thetransmitter.org/olfaction/sm...

Science’s big problem is a loss of influence, not a loss of trust Evidence shows that science and scientists remain highly trusted. But genuine scientific voices are not shouting loud enough over the noise to hold sway.

"The answer to science’s influence problem is not trust building but rather aiding better-placed confidence and communicating the truth in a more compelling way, one that does not assume a lack of competing sources or that everyone is playing by the same rules of evidence." 🧪

Layer-specific input to medial prefrontal cortex is linked to stress susceptibility - Translational Psychiatry Translational Psychiatry - Layer-specific input to medial prefrontal cortex is linked to stress susceptibility

Layer-specific input to medial prefrontal cortex is linked to stress susceptibility
www.nature.com/articles/s41...

Accepting “bitter lesson” and embracing brain’s complexity To gain insight into complex neural data, we must move toward a data-driven regime, employing large models trained on vast amounts of data. Experts weigh in.

And we need to embrace the likely possibility that brains are more than connectivity patterns and their weightings. That is the start, not the end.
Accepting “the bitter lesson” and embracing the brain’s complexity
www.thetransmitter.org/neuroai/acce...
#neuroscience

Split-Brain: Two Selves in One? | TheCollector The nature of self is a philosophical problem that has truly stood the test of time—split-brain patients are one of the few times something tangible may give us insights into it.

Split-Brain: Two Selves in One?

The nature of self is a philosophical problem that has truly stood the test of time—split-brain patients are one of the few times something tangible may give us insights into it. www.thecollector.com/split-brain-... #self #splitbrain #philsky #science

The new issue of Science Advances (open-access) has multiple papers on women's health. These 2 are related to menopause, hormone replacement and brain health
www.science.org/toc/sciadv/c...

Identification of V0g propriospinal neurons and their role in locomotor control Propriospinal neurons relay sensory and motor information across the spinal cord and are critical components of the circuits coordinating body movements. Their diversity and roles in motor control are...

🥁 Elisa Toscano idenitified a new subtype of propriospinal neurons and found a role in the execution of skilled movements🤸‍♂️. Great job from Elisa and everybody involved 💪. @alesantuz.bsky.social, @lowensteined.bsky.social. Check it out and let us know what you think:
www.biorxiv.org/content/10.1...

‘A gut punch:’ How U.S. neuroscience trainees are grappling with diversity-based funding flux Ten trainees spoke with The Transmitter about how the precarious state of U.S. federal funding is affecting their research and career plans.

Over the past few weeks, science funding in the U.S. has become shrouded in uncertainty. Ten trainees with diversity-based funding share how the changes are affecting their research and career plans.

By @avaskham.bsky.social @claudia-lopez.bsky.social @callimcflurry.bsky.social

bit.ly/42Wifxr

Dr. Malú Tansey — Stories of WiN studies how immune cells and the brain interact in neurodegenerative diseases

Our latest profile is here! Dr. Malú Tansey (@malutansey.bsky.social) studies how immune cells and the brain interact in neurodegenerative diseases. Follow the link below to learn more! #StoriesOfWiN #WomenInNeuroscience

www.storiesofwin.org/profiles/202...

Meet Heinz, a person with a courage none of us living have

Neuroscientists need to do better at explaining basic mental health research The knowledge gap between scientists, health-care professionals, policymakers and people with mental health conditions is growing, slowing the translation of basic science to new treatments.

Neuroscientists need to do better at explaining basic mental health research
www.thetransmitter.org/addiction/ne...