Stephane Legriel

Health-Related quality of life after status epilepticus: A cross-sectional study from the ICTAL registry Clinical outcome assessment (COA), particularly health-related quality of life (HRQoL) is an important component of patient-centered outcome assessmen…

Health-Related quality of life after status epilepticus: A cross-sectional study from the ICTAL registry 🧠 🌊⚡️

Congratulations @gwenjacq.bsky.social and @ictalgroup.bsky.social Research Network !

#statusepilepticus #HRQoL #clinicaloutcomeassessments

www.sciencedirect.com/science/arti...

European Resuscitation Council Guidelines 2025 "First Aid" is out now in Resuscitation!

🔗 Read this chapter: www.sciencedirect.com/science/art...

#Resuscitation #RESUS25 #ERCGuidelines #Guidelines2025

European Resuscitation Council Guidelines 2025 "Ethics in Resuscitation" is out now in Resuscitation!

🔗 Read this chapter: www.sciencedirect.com/science/art...

#Resuscitation #RESUS25 #ERCGuidelines #Guidelines2025

The European Resuscitation Council Guidelines 2025 are out now in Resuscitation!

🔗 Read the Executive Summary: www.sciencedirect.com/science/art...

🧵 Explore all the chapters in this thread

#Resuscitation #RESUS25 #ERCGuidelines #Guidelines2025

Acute brain injury care prioritises limiting secondary damage through tiered intracranial pressure strategies and seizure detection with continuous EEG, supported by multimodal monitoring, biomarkers, and imaging. zurl.co/xtUKi

[Epilepsy] Fürbass et al.: "We developed an algorithm for automatic detection of epileptiform EEG discharges, based on a novel deep learning method."

doi.org/10.1016/j.cl...

"Consciousness" - International Insights Help us improve epilepsy care by taking this 5-minute survey about the word “consciousness.”

🗣️ Have YOUR say about consciousness during seizures!! Takes 5 mins! Type in this link! www.surveymonkey.com/r/epilepsytalk

Oxygen and Carbon Dioxide Targets after Cardiac Arrest: An Updated Systematic Review

www.resuscitationjournal.com/article/S03...

#Resuscitation

Figure showing CAR T-cell therapy-associated neurotoxicities. Copyright: Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.

Neurological problems are a significant concern for patients receiving CAR T-cell therapy, yet there are no best practice guidelines.

In @thelancetoncol.bsky.social, a Review provides guidance on managing neurological issues associated with CAR T-cell therapy: tinyurl.com/3fxd5vtt

Cardiac arrest from neurological causes: for whom the brain tolls Cardiac arrest of neurological cause (CA-NC) is an entity whose incidence is unknown. The main reason for this is that the medical literature is mainly concerned with cardiac arrest due to cardiac cau...

#Cardiacarrest from neurological causes: for whom the brain tolls - Resuscitation www.resuscitationjournal.com/article/S030... @resuscitation.bsky.social @stlegriel.bsky.social #marinepaul

Neurologic etiologies of cardiac arrest are associated with early withdrawal of life-sustaining therapy

www.resuscitationjournal.com/article/S03...

#Resuscitation

Letter to the Editor
doi.org/10.1111/epi....

Read the original article - onlinelibrary.wiley.com/doi/10.1111/...

#epilepsy #epilepsia #ILAE #statusepilepticus #acuteseizures #classification #Treatment #Polytherapy

A large-scale, deidentified EEG database with >100 000 unique patients is presented.
doi.org/10.1111/epi....

#epilepsy #epilepsia #ILAE #AI #DatadrivenEEGanalysis #Deidentifiedclinicaldata #EEGdataplatform #EEGlargescaledatabase

Neurological complications of CAR T cell therapy for cancers Nature Reviews Neurology, Published online: 25 June 2025; doi:10.1038/s41582-025-01112-8Chimeric antigen receptor (CAR) T cells provide an effective treatment option for advanced haematological malignancies, but neurological adverse effects of CAR T cell therapies are common. This article reviews current knowledge regarding the mechanisms that contribute to neurological toxicities following CAR T cell therapy and highlights current and emerging management strategies.

New online! Neurological complications of CAR T cell therapy for cancers

If interested in ketamine for status, great debate emcrit.org/emcrit/ketam...
@first10em.bsky.social vs @emcrit.bsky.social #EMIMCC

Histopathological patterns of hypoxic-ischemic encephalopathy after cardiac arrest: A retrospective brain autopsy study of 319 patients Understanding the pathophysiology of hypoxic-ischemic encephalopathy (HIE) provides important knowledge for the interpretation of neuroprognostic inve…

Brain injury after cardiac arrest is not as homogeneous and global as previously thought ❗️

We identified different histopathological phenotypes in 319 (!) patients with postmortem brain autopsies 🧠 🔬

@resuscitation.bsky.social
@neurocritical.bsky.social

www.sciencedirect.com/science/arti...

Woud you like to join us ?

Ictal Registry for StatusEpilepticus 🧠🌊⚡️

@stlegriel.bsky.social @gwenjacq.bsky.social @ilae-epilepsy.bsky.social

www.ilae.org/regions-and-...

Autoimmune encephalitis-associated epilepsy Nature Reviews Neurology, Published online: 02 May 2025; doi:10.1038/s41582-025-01089-4In this Perspective, the authors provide a detailed description of rare autoimmune encephalitic conditions that present with recurrent seizures that are resistant to immunotherapy, grouped under the term autoimmune encephalitis-associated epilepsy. The article considers the clinical characteristics and pathophysiological mechanisms of these conditions, alongside current knowledge of treatment and outcomes.

ICYMI: New online! Autoimmune encephalitis-associated epilepsy

[EEG] Linnavuori et al.: "EEG competence is a multidimensional concept that includes knowledge, skills, attitudes, and values that need to be considered when defining EEG competence and developing tools to measure it." Open access: doi.org/10.1016/j.cn...

New from the ILAE: A streamlined and updated seizure classification system, designed to improve diagnosis, research consistency, and patient communication across care settings.

Read the Epilepsia paper: doi.org/10.1111/epi....

#Epilepsy #SeizureClassification #epilepsia #ILAE

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The value of hypothermia as a neuroprotective and antiepileptic strategy in patients with status epilepticus: an update of the literature Status epilepticus represents a significant neurological emergency, with high morbidity and mortality rates. In addition to standard care, the identification of adjuvant strategies is essential to ...

The value of #hypothermia as a neuroprotective and antiepileptic strategy in patients with #statusepilepticus: an update of the literature
www.tandfonline.com/doi/full/10....
@gwenjacq.bsky.social @stlegriel.bsky.social
@ictalgroup.bsky.social

The value of hypothermia as a neuroprotective and antiepileptic strategy in patients with status epilepticus: an update of the literature Status epilepticus represents a significant neurological emergency, with high morbidity and mortality rates. In addition to standard care, the identification of adjuvant strategies is essential to ...

The value of #hypothermia as a neuroprotective and antiepileptic strategy in patients with #statusepilepticus: an update of the literature
www.tandfonline.com/doi/full/10....
@gwenjacq.bsky.social @stlegriel.bsky.social
@ictalgroup.bsky.social

Patient-Reported Outcomes in Adults after #StatusEpilepticus: A Systematic Review

#EpilepsyAndBehavior @gwenjacq.bsky.social @ictalgroup.bsky.social #PROMS

www.epilepsybehavior.com/article/S152...

Burst Suppression as a Treatment Goal in Refractory Status Epilepticus - Neurocritical Care

#BurstSuppression as a Treatment Goal in Refractory #StatusEpilepticus

link.springer.com/article/10.1...

Clinician-Reported Physical and Cognitive Impairments After Convulsive Status Epilepticus: Post Hoc Study of a Randomized Controlled Trial - Neurocritical Care Background Clinician-reported outcome (ClinRO) measures are emerging as useful contributors to assessments of treatment benefits. The objective of this study was to collect ClinRO measures of physical...

Clinician-Reported Physical and Cognitive Impairments After Convulsive #StatusEpilepticus: Post Hoc Study of a Randomized Controlled Trial @ictalgroup.bsky.social @gwenjacq.bsky.social @stlegriel.bsky.social

link.springer.com/article/10.1...

50 days' free access link www.sciencedirect.com/science/arti...

Health-related quality of life (HRQOL) and mental health were the most extensively studied outcomes, and both were impaired. HRQOL scores ranged from 41.7 ± 11.5 to 48.3 ± 24.5. The prevalence of depression and anxiety varied from 30 % to 36 %, and from 22 % to 62 %.

Patient-Reported Outcomes in Adults after #StatusEpilepticus: A Systematic Review

#EpilepsyAndBehavior @gwenjacq.bsky.social @ictalgroup.bsky.social #PROMS

www.epilepsybehavior.com/article/S152...

Outcomes in Patients With COVID-19 With Acute Encephalopathy and Coma
An International Prospective Study #Neurology

www.neurology.org/doi/10.1212/...