Gemma Noviello

Yesterday I gave a talk titled "Dividi et impera: Flow-Cytometry for FACS-based CRISPR screens and beyond" during the Flow Cytometry course organised by @embl.org & EMBLRome facilities. It was nice connecting w/ other users & the specialists from the facilities to hear the latest. FC & #FACS rock 🌈

For the record, Melissa's main targets of Jamaica, Haiti, Cuba, and the Bahamas account for, respectively, 0.016%, 0.0089%, 0.064%, and 0.0038% of the global annual total of CO2 emissions.

Great interactions and scientific discussions, incl. over the dinner table w/ @santiagorompani.bsky.social @cornhelix.bsky.social F. Zemmouri & C. Carisi. Thanks to co-organizers F.Zemmouri, P.Micheli and @steliostsagkris.bsky.social 💪🏽 and thanks @graeffjohannes.bsky.social for coming!

Pre-doctoral fellows P. Micheli and F. Zemmouri showing to J. Gräff a microscopy equipment built by the Rompani lab at EMBL Rome.

Yesterday we hosted @graeffjohannes.bsky.social , first speaker of the seminar series organised by and for @embl.org Rome fellows. It was a fantastic #neuro #epigenetics talk (our 2 favourite things). #EMBL #EMBLRome

The Most Efficient Traveler Isn’t a Bird or a Fish—It’s You on a Bike A famous graphic, now updated, compares locomotion in the animal kingdom

Remember this one? “Humans aren’t very efficient movers—until you put us on a bicycle, when we become some of the most energy-efficient land travelers in the animal kingdom.” Via Scientific American @sciam.bsky.social #CityMakingMath

🧬 New study from the Kinkley Lab! 🧬 In collaboration with the Vingron and Hnisz labs at the MPIMG the team has gained new insights how the epigenetic reader PHF13 regulates it´s affinity to bind to chromatin.
Read more: www.molgen.mpg.de/2025-07-28-o...
Congrats to first author Francesca Rossi!

Happy to see this insightful and rigorous work published in its final form! Congrats to all authors and in particular to super hard-working first author @tschwammle.bsky.social and to @eddaschulz.bsky.social for the brilliant guidance.

Embryonic signatures of intergenerational epigenetic inheritance across paternal environments and genetic backgrounds | The EMBO Journal imageimagePaternal environmental exposures have been linked with modulation of phenotype and disease risk in offspring via largely unclear mechanisms. This study employs in vitro fertilization and sin...

❓Can a father’s environmental exposures before conception influence their offspring?

We systematically tackled this - identifying effects of paternal age, environment and genetics on early embryos - as well as confounding influences

www.embopress.org/doi/full/10....

Pizza al taglio senza glutine. 😋 #Roma ci ama. #glutenfree #pizza

What if NIH had been 40% smaller? Replaying history with less NIH funding shows widespread impacts on drug-linked research

This may be the most important paper ever published about NIH funded research.

www.science.org/doi/10.1126/...

Really excited to share our latest work led by @mattiaubertini.bsky.social and @nesslfy.bsky.social: we report that cohesin loop extrusion creates rare but long-lived encounters between genomic sequences which underlie efficient enhancer-promoter communication.
www.biorxiv.org/content/10.1...
A🧵👇

Congrats to all authors! Will dive in the details soon as now I'm very curious.

A quick guide on "How to fall downstairs":

Step 1

Step 6

Step 8, 9, 10, 11.

Nobel laureate Jennifer Doudna tells Jeffrey Goldberg that vaccinations have been so successful that "there's been a collective forgetting that measles, and mumps, and rubella—these used to be diseases that would kill people in fairly large numbers." #TAF25 bit.ly/46a5DUE

Matthew McConaughey says he wants a private LLM, fed only with his books, notes, journals, and aspirations, so he can ask it questions and get answers based solely on that information, without any outside influence.

this exists it is called thinking

Congrats!

Beautiful story about chromatin modifiers orchestrating cell states by fine-tuning gene expression from @jzylicz.bsky.social lab. Congrats to all, especially 1st author Nikos Stamidis !

A Bronx Tale, 1993

One of my kids thought I was making like a bad @theonion.com joke when I told him that their slogan used to be “don’t be evil” but then they got rid of it.

Congrats Juliane! You rock! 🎉🔥💪🏽

Congrats to all winners! A quick consideration as 🇮🇹 researcher. Italians get 11,5% of all StG (55/478, 2nd top after DE): Italian scientists are top level! Italy itself gets 6.2% of all grants (30/378, jumping to 7th after DE, UK, NL, FR, CH, BE). Italy, why do you like to seed but not to harvest?

📢 Recruitment for the EMBL International PhD Programme is officially open!

At EMBL, we train young scientists to become skilled and creative future leaders in academia and other sectors. Join us and get a head start on your career in life sciences!

bit.ly/47mmiFF

Paris said au revoir to cars. Air pollution maps reveal a dramatic change. Air pollution fell substantially as the city restricted car traffic and made way for parks and bike lanes.

“Over the past 20 years, Paris has undergone a major physical transformation, trading automotive arteries for bike lanes, adding green spaces and eliminating 50,000 parking spaces.

Part of the payoff has been invisible — in the air itself.”

Leadership, strategy, real action, common sense. #Paris

Final year PhD students, I know you’re desperately trying to finish experiments/revisions/submissions/write a thesis & just survive - but please spare a few minutes to apply to your dream postdoc labs.

It easily takes A YEAR from first contact, even if everything goes to plan on both sides.

Congrats Julia! That's fantastic news 🎉

NIPBL dosage shapes genome folding by tuning the rate of cohesin loop extrusion Cohesin loop extrusion is a major driver of chromosome folding, but how its dynamics are controlled to shape the genome remains elusive. Here we disentangle the contributions of the cohesin cofactors ...

New preprint with @gfudenberg.bsky.social

We find the rate of cohesin loop extrusion in cells is set by NIPBL dosage and tunes many aspects of chromosome folding.

This provides a molecular basis for NIPBL haploinsufficiency in humans. 🧵👇

www.biorxiv.org/content/10.1...

I mean, it's nice to have a Wikipedia page. Even nicer to have a Wikipedia page devoted to something named after you. But it's hard to beat a Wikipedia page devoted to simply *listing* things that are named after you.

en.wikipedia.org/wiki/List_of...

I just got the notice that all the FlyBase people at Harvard, including me, will be laid off on October 12. I'm devastated.

NSD2 inhibitors rewire chromatin to treat lung and pancreatic cancers - Nature A highly potent and selective small-molecule catalytic inhibitor of the protein lysine methyltransferase NSD2 shows therapeutic efficacy in preclinical models of KRAS-driven pancreatic cancer and...

new out in Nature www.nature.com/articles/s41...

Thanks! Looking forward to hear opinions. I tried to be as simple as possible. I hope it didn't became too banal.