Daniel Stover, MD, FASCO

Utility of plasma circulating DNA tumor fraction in bone-only metastatic breast cancer: a real-world outcomes study - Breast Cancer Research and Treatment Purpose Bone metastases develop in 50–70% of patients with metastatic breast cancer (MBC), with around one-third having bone as only site of distant disease (bone-only [BO]). Standard imaging is frequ...

Is liquid biopsy useful in bone-only metastatic #breastcancer?

Surprise!
✅Pts w bone-only disease are just as likely to have detectable ctDNA
✅ctDNA tumor fraction remains prognostic in bone-only setting

link.springer.com/article/10.1...

@osucccjames.bsky.social

Could not be more thankful for and proud of my parents today ❤️💯

An open letter to graduate students and other procrastinators: it’s time to write Nature Biotechnology - An open letter to graduate students and other procrastinators: it’s time to write

Think of scientific writing as eating a whale: it must be done one forkful at a time!

rdcu.be/egxhh

Thank you to @stolaney1.bsky.social @dfcibreastonc.bsky.social for inviting me to give the J. Dirk Iglehart, M.D. Visiting Scholar Lecture at the DF/HCC Breast & Gynecologic Cancer Symposium.

Incredible science, great friends & connections - what an honor!

www.dfhcc.harvard.edu/events/dfhcc...

Using Epic Signal data for 15.7K oncologists (2019->22): Mean overall EHR inbox messages ⬆️ 19%, mean overall patient-initiated messages ⬆️ 34%, & total InBasket time ⬆️ 25.4%. Total weekly EHR time by subspecialty: med onc>>gyn onc>>surg onc>>rad onc>>ped onc #burnout academic.oup.com/jnci/advance...

New #JITC article: T-cell immune checkpoint inhibition plus hypomethylation for locally advanced HER2-negative breast cancer: a phase 2 neoadjuvant window trial of decitabine and pembrolizumab followed by standard neoadjuvant chemotherapy

jitc.bmj.com/content/13/2...

Did you register for THE conference that covers breast cancer AND normal mammary gland development yet? The GRC Mammary Gland Biology and Neoplasia abstracts will be evaluated for short talks from trainees soon, so get your abstract in!
www.grc.org/mammary-glan...

Critical to keep shining light on the crucial issue of #financialToxicity & cancer care.

& celebrating Women in Science - from my mentors to colleagues to those who have brought so much to Stover Lab!

Promoting Reasonable Career Expectations and Maximizing Professional Fulfillment for Academic Oncologists: ASCO Recommendations for Academic Medical Centers In this statement, ASCO encourages academic medical centers to change their policies and expectations to enhance and promote the professional fulfillment of academic medical oncologists. The statement...

Publication by @ascocancer.bsky.social on academic medical oncology. Makes me wonder- how do we encourage more transparency among institutions to set these standards ? ascopubs.org/doi/10.1200/...

Annual @stoverlab.bsky.social cookie baking!

The team is 💯 and the cookies are even better 🍪

NIH In Your State - United For Medical Research Select a state on the map to see the impact of NIH funding across America.

In Ohio during FY23 (2022-2023) this was the impact of NIH funding:

$1.01 Billion in grants and contracts
$2.05 Billion in economic support
13,061 jobs supported

This reduction in NIH indirect will decimate research and limit health care advances

www.unitedformedicalresearch.org/nih-in-your-...

🤞

NIH eases freeze on grant reviews imposed after Trump communications pause Meetings of study sections and closed portion of councils back on track as agency also deals with diversity-related executive orders

I thought things were supposed to be opening up….

www.science.org/content/arti...

State of Professional Well-Being, Satisfaction, and Career Plans Among US Oncologists in 2023 | JCO Oncology Advances PURPOSERecent data suggest that the rate of burnout among oncologists has risen over time. In addition to the negative effect of burnout on individuals, widespread burnout may prevent the oncology wor...

Oncologist burnout ⬆️14% over past 10yrs.
➡️Emotional exhaustion: 38% (2013) to 57% (2023)
➡️Top stressors: Staffing, EHR, payers
➡️Top fixes: ⬆️support, ⬇️workload
➡️What sparks joy? Talking w patients, helping pt QOL

Oncologists just want time to help patients feel better.

ascopubs.org/doi/pdf/10.1...

Evaluating risk factors for Trastuzumab-Deruxtecan Pneumonitis in patients with metastatic breast cancer - Breast Cancer Research Background Trastuzumab deruxtecan (T-DXd) is FDA-approved for treatment of patients with HER2 positive and HER2-low metastatic breast cancer. Currently, there is limited understanding of pre-treatment...

Happy to share our retrospective study on #pneumonitis risk in patients with #breastcancer who receive #TDXd #Enhertu @stoverlab.bsky.social @osucccjames.bsky.social #bcsm

ASCO Daily News: Advances in Adjuvant Therapy for High-Risk Early Breast Cancer With Germline Mutations Dr. Jessica Sukumar and Dr. Dionisia Quiroga discuss advances in adjuvant therapy for patients with early breast cancer and BRCA1/2 mutations, including how to identify patients who should receive gen...

🎉Reunion w/ my co-fellow @jasminesukumar.bsky.social @mdanderson.bsky.social to discuss early #breastcancer adj tx w/ path germline muts on the @ascocancer.bsky.social Daily News podcast

👉Who needs testing?
👉OLYMPIA updates
👉Concurrent PARPi use w/ other adj tx

ascodaily.libsyn.com/advances-in-...

Amazing group of medical oncologists that I am privileged to work with every day and call friends @stoverlab.bsky.social @aryaroy.bsky.social @nerealliamd.bsky.social @quirogad.bsky.social @osucccjames.bsky.social

Congratulations to so many fantastic individuals @drdonsdizon.bsky.social @drdawnhershman.bsky.social Susan Domchek, Ian Krop, and many others!

Fantastic USC Keck SOM Breast Cancer Symposium with great faculty, fellow cases, and new collaborations.

Offering my support to all those here in LA impacted by the wildfire devastation.

@drjbhattacharya.bsky.social - Need your leadership to provide clarity & support to re-initiate #NIH #NCI communications, study sections, & meetings. Abrupt stop with no clear path forward causing confusion.

Biomedical research is a critical engine of progress, health, and economic activity.

Annual cancer study shows who could be diagnosed this year Annual cancer study shows who could be diagnosed this year

Great segment on @nbc4i.bsky.social by @stoverlab.bsky.social @osucccjames.bsky.social on the recent #ACS cancer stats www.nbc4i.com/video/annual...

Kim Rathmell to step down as NCI Director January 20. Hope that we can benefit from her leadership at the NCI again in the future.

JCO Oncology Practice: Vol 21, No 1

🚨 The #FinancialToxicity special issue of JCO OP is LIVE today! 🚨

We hope these papers will encourage the next gen of researchers to generate, evaluate, & disseminate patient-centered, high-quality, evidence-based medicine & policy solutions to close the affordability gap!

ascopubs.org/toc/op/21/1

Thank you @ascocancer.bsky.social for devoting an entire issue of JCO OP to the topic of #FinancialToxicity and thank you to @fumikochino.bsky.social @ryannipp.bsky.social for inviting me to 🖊️ a piece for this, on my experience with financial toxicity as someone with privilege and savings.

If physician-scientists were 'in it for the money', we would probably choose different jobs .

🤔Incentives for research are 1) poorly delineated; 2) infrequently implemented; 3) lag clinical incentives many fold.

💰 is not the *only* incentive: research time, space, institutional support are valued

Welcome to Nerea Lopetegui-Lia to the @osuwexmed.bsky.social @osucccjames.bsky.social Breast Medical Oncology Team!

Very excited to have her join us from @clevelandclinic.bsky.social and can't wait to see the impact she has on breast cancer field and individual patients!

Drug Company to Share Revenues With Indigenous People Who Donated Their Genes Variant Bio, a small biotech company based in Seattle, is using genetic information from Indigenous people to develop drugs for obesity and diabetes.

We need to think more about how we engage with patients who donate samples for research studies.

www.nytimes.com/2025/01/07/h...

Divergent paths of mammary gland involution: unveiling the cellular dynamics in abruptly and gradually involuted mouse models - Breast Cancer Research Background Epidemiological studies associate an increase in breast cancer risk, particularly triple-negative breast cancer (TNBC), with lack of breastfeeding. This is more prevalent in African America...

What do we know about how the biology of mammary gland lactation and involution impact breast cancer risk?

Building on work from Dr. Pepper Schedin & many others, new work in #BreastCancerResearch from Ramaswamy Lab @osucccjames.bsky.social

link.springer.com/article/10.1...

Online Reviews: A Growing Threat to Physician Morale and Patient Care One of the naive missteps I took shortly after transitioning from trainee into an attending role was to sign up for Google to alert me whenever one...

Patient satisfaction is important. But medicine involves tough topics & hard decisions.
-Treating provider & restaurant reviews the same is a mistake.
-Obsession over fractions of pct points in satisfaction is unequivocally negatively impacting provider burnout.

www.doximity.com/newsfeed/ab5...