Andrew Oldfield

Amazing work by @charleneboumendil.bsky.social and her team addressing the crucial role of nuclear pores in chromatin organization. A highly recommended read!

Unsplash image of the Earth, mostly the nightside with a tracery of city lights on every continent.

OK, this is wild.

In September 2023, geophysicists across the world started monitoring a very odd signal coming from the ground under them.

It was picked up in the Arctic. And Antarctica. It was detected everywhere, every 90 seconds, as regular as a metronome, for *nine days*.

What the HELL?

1/

Size-dependent temporal decoupling of morphogenesis and transcriptional programs in gastruloids Understanding the interplay between cell fate specification and morphogenetic changes remains a central challenge in developmental biology. Gastruloids, self-organizing stem cell-based models of post-...

Happy to share our collaborative effort showing a temporal decoupling between morphogenesis and transcription during gastruloids self-organization
www.biorxiv.org/content/10.1...

By definition, enhancers can activate from a distance. But with increased distance between enhancer and promoter, the activation drops. To study this systematically, we build a synthetic locus: www.cell.com/molecular-ce... 1/12

Hi Bluesky! I made a 3D chromatin starter pack.
Let me know if you would like to be added.
go.bsky.app/6tTQdqQ

Me please! ☝🏼

In this review @gracebower.bsky.social & I discuss recent evidence showing that, unlike canonical enhancers, long-range enhancers located hundreds of kb from their targets rely on additional mechanisms to ensure robust gene activation during mammal development. www.sciencedirect.com/science/arti...

Schematic overview of the proposed mode of action of the newly discovered REX element. Top: An enhancer can activate a gene at a short distance, but not at at long range. Middle: Presence of (C/T)AATTA motifs within an enhancer enable it to act over long distances. Bottom: Coupling a short-range enhancer to the REX element containing the same motifs turns it into a long-range enhancer.

REX - a mammalian "range extender" element that can turn short-distance enhancers into long-distance enhancers.

New preprint from a collaboration led by Grace Bower and Evgeny Kvon.

doi.org/10.1101/2024...

Hi all, just to say thanks for all the enthusiasm about the #epigenetics, Chromatin and Gene Regulation starter pack. The interface is a bit unreliable so a few people I added got missed off 😬. If you notice this applies to you, just message me and I'll try again. go.bsky.app/TKp9YAn

Putting together packs of transcription and Chromatin people - Nominate others to add! go.bsky.app/5zgpZfg

I'd love to join this list, thanks!

2 great labs having drinks in a bar in sunny Montpellier

Just finished hosting @PengyiYang82 and lab members for an amazing week @IGH_MTP filled with learning about scMultiomics, brainstorming and maybe a drink or 3. So proud to see how far we've come since our postdocs in @Jothi_Lab 🍻

La grande classe! 👏🏼👏🏼👏🏼

Even better with a working link!
emploi.cnrs.fr/Offres/CDD/U...

🚨Job offer alert: looking for a friendly and enthusiastic research assistant (IE) to help us understand how enhancer activity is orchestrated during the EMT.🚨
Location: 🌞 Montpellier, France.
Duration: up to 3 years. Apply here: tinyurl.com/3dn86pmz
Retweets appreciated 🙏🏼