Andrew Oldfield

Pleased to announce launching Institut Cochin Foundation, on Sept. 18 at 6 p.m., upon registration, either in the Rosalind Franklin room, 22 rue Méchain, Paris or via video conference: presentation of @institutcochin.bsky.social, meet researchers and call for donations-thanks for your support!

I am happy, excited and very humbled to have obtained an ERC starting grant to study the interplay betweeen nuclear pores and chromatin organization! Keep posted for job advertisements and pretty microscopy pictures ;-)

Hi Alexis, i'd love to be added as well! Thanks!

“Our findings suggest the existence of tens of thousands of enhancers that remain undiscovered by currently available chromatin data, underscoring the continued need for expanding resources for enhancer discovery.”
Great paper and very important finding - many congrats Axel & team! 👏👏

Amazing work by @charleneboumendil.bsky.social and her team addressing the crucial role of nuclear pores in chromatin organization. A highly recommended read!

Unsplash image of the Earth, mostly the nightside with a tracery of city lights on every continent.

OK, this is wild.

In September 2023, geophysicists across the world started monitoring a very odd signal coming from the ground under them.

It was picked up in the Arctic. And Antarctica. It was detected everywhere, every 90 seconds, as regular as a metronome, for *nine days*.

What the HELL?

1/

Size-dependent temporal decoupling of morphogenesis and transcriptional programs in gastruloids Understanding the interplay between cell fate specification and morphogenetic changes remains a central challenge in developmental biology. Gastruloids, self-organizing stem cell-based models of post-...

Happy to share our collaborative effort showing a temporal decoupling between morphogenesis and transcription during gastruloids self-organization
www.biorxiv.org/content/10.1...

By definition, enhancers can activate from a distance. But with increased distance between enhancer and promoter, the activation drops. To study this systematically, we build a synthetic locus: www.cell.com/molecular-ce... 1/12

Hi Bluesky! I made a 3D chromatin starter pack.
Let me know if you would like to be added.
go.bsky.app/6tTQdqQ

Me please! ☝🏼

In this review @gracebower.bsky.social & I discuss recent evidence showing that, unlike canonical enhancers, long-range enhancers located hundreds of kb from their targets rely on additional mechanisms to ensure robust gene activation during mammal development. www.sciencedirect.com/science/arti...

Schematic overview of the proposed mode of action of the newly discovered REX element. Top: An enhancer can activate a gene at a short distance, but not at at long range. Middle: Presence of (C/T)AATTA motifs within an enhancer enable it to act over long distances. Bottom: Coupling a short-range enhancer to the REX element containing the same motifs turns it into a long-range enhancer.

REX - a mammalian "range extender" element that can turn short-distance enhancers into long-distance enhancers.

New preprint from a collaboration led by Grace Bower and Evgeny Kvon.

doi.org/10.1101/2024...

Hi all, just to say thanks for all the enthusiasm about the #epigenetics, Chromatin and Gene Regulation starter pack. The interface is a bit unreliable so a few people I added got missed off 😬. If you notice this applies to you, just message me and I'll try again. go.bsky.app/TKp9YAn

Putting together packs of transcription and Chromatin people - Nominate others to add! go.bsky.app/5zgpZfg

I'd love to join this list, thanks!

2 great labs having drinks in a bar in sunny Montpellier

Just finished hosting @PengyiYang82 and lab members for an amazing week @IGH_MTP filled with learning about scMultiomics, brainstorming and maybe a drink or 3. So proud to see how far we've come since our postdocs in @Jothi_Lab 🍻

La grande classe! 👏🏼👏🏼👏🏼

Even better with a working link!
emploi.cnrs.fr/Offres/CDD/U...

🚨Job offer alert: looking for a friendly and enthusiastic research assistant (IE) to help us understand how enhancer activity is orchestrated during the EMT.🚨
Location: 🌞 Montpellier, France.
Duration: up to 3 years. Apply here: tinyurl.com/3dn86pmz
Retweets appreciated 🙏🏼