WargoLab

New in JB: Hartzler, Metskas et al. review recent information about α-carboxysome structure, mechanism, and assembly through the lens of cryo EM and tomography. A really exciting topic - one of my favorite areas to include in my grad course!
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology

Please join us tomorrow for an excellent installment of the CMB seminars, where we will discuss focal adhesions and HIV in action! @wargolab.bsky.social @uvmcmb.bsky.social @msymeonides.bsky.social @devdoot.bsky.social @uvmvermont.bsky.social

Fig. 1. Fundamental elements of DNA structure and topology.

Bacterial DNA supercoiling. Published in Microbiology as part of the Microbial Primers collection: https://doi.org/10.1099/mic.0.001667
#MicrobioJ

Excited about a recent paper from Bassam el Hafi, a recently graduated PhD student, & Fabrice Jean Pierre leveraging 4,200 respiratory microbiomes from CF (pre- and post-ETI), and testing one of the hypotheses that arose from this analysis.
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology

New in JB: Adams & El-Halfawy review how various chemicals produced at the site of infections, including those made by the host & bacteria, impact Abx responsiveness. Learning about such mechanisms could help develop new Abx strategies.
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology

I was liking it because I owed you one 😄

JB Editor's Choice: As part of our History of Microbial Model Systems series, Snow, Hatzios & Salama discuss the first bacteria designated a class I carcinogen, Helicobacter pylori.
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology

A fabulous undergraduate researcher I mentor is graduating this spring and is looking for a job as a lab technician! She's interested in bacterial pathogenesis and is planning to go to grad school after getting more research experience. Please let me know if you or anyone you know is hiring!

I had the fun opportunity to write a Commentary for a JB paper by Bhattarai, Harshey et al. describing their Texas Two-Step model of cdG-mediated motility control.
Commentary: pubmed.ncbi.nlm.nih.gov/41705806/
Paper: journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology

JB Biofilms Collection
journals.asm.org/journal/jb/b...
@asm.org #JBacteriology

JB Table of Contents Volume 208, Issue 2 Journal of Bacteriology: Table of Contents Volume 208, Issue 2

The newest issue of JB is out! Topics include carboxysomes, Helicobacter & cancer, Tad pili, sulfite stress, norepinephrine & Fur, & more.
journals.asm.org/toc/jb/208/2
@asm.org #JBacteriology

Please join us on February 24th for our next installment of the graduate students' CMB seminar! There will be excellent talks and discussions!! @devdoot.bsky.social @uvmcmb.bsky.social @msymeonides.bsky.social @karenglasslab.bsky.social @wargolab.bsky.social @osamaharraz.bsky.social

Our new study combines experiments with bioinformatics to examine amino acid metabolism in Pseudomonas strains co-isolated from pond and soil communities
by Simon Maréchal, Beni Heiniger, @swagatika.bsky.social, Shaohua Gu, Christian Ahrens
www.biorxiv.org/content/10.6...

Four graphs, showing the response of PA14 and an isogenic pel mutant, and PAO1 and an isogenic pel psl double mutant, to meropenem and colistin. There is no difference between the response of mutants and WTs.

During her PhD, Jenny found something unexpected: biofilm-deficient P. aeruginosa mutants were just as tolerant to antibiotics as the WT when grown in our cystic fibrosis lung model. But why? #MicroSky 1/n

🧵 New preprint! Our 4-lab team evolved Streptococcus pneumoniae in antibiotic-treated mice of varying immune states and discovered something surprising: bacteria rarely evolved resistance. Instead, they found a different way to survive — by rewiring RNA turnover.
🔗 www.biorxiv.org/content/10.6...

We're finishing up our 30th M2P2 retreat, with Salvador Almagro-Moreno - our keynote for the Ron Taylor Keynote lecture, a poster session, two career development workshops and ~120 attendees from across northern New England. We also had some open time to network - plus skating & skiing. m2p2.org

Exciting seminars due next week here at the University of Vermont! Hosted by the CMB Graduate Program! Welcome to fun science and great conversations!! @wargolab.bsky.social @msymeonides.bsky.social @uvmcmb.bsky.social @devdoot.bsky.social @karenglasslab.bsky.social

www.pnas.org/doi/10.1073/...

Excited to share that PNAS published our research article focused on "Why are Ralstonia goofy?"

🧠🆕Review article: "Brain Capillary Ion Channels: Physiology and Channelopathies."

Osama F. Harraz and Ahmed M. Hashad
https://ow.ly/MUCH50YbM0p.
#BrainCapillaries #CerebralBloodFlow

JB Editor's Pick: Gallo, Jung et al. show that E. coli can sense acid stress via the protonation of two His residues of the arginine-dependent acid resistance protein AdiY. They propose that protonation drives tetramer formation & DNA binding.
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology

New in JB: Jorgenson reviews recent advances in cell envelope assembly via the lens of the essential lipid carrier undecaprenyl phosphate and with an eye on targets of novel Abx development.
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology

Please join us next week for our next installment of the CMB seminar, presented by Venessa Lopez and Zachary Miller at Davis Auditorium. See you then!
@wargolab.bsky.social @devdoot.bsky.social @uvmcmb.bsky.social @msymeonides.bsky.social @karenglasslab.bsky.social

New in JB: Bange, Dornes, et al. review the molecular basis for flagellar patterns and numbers across bacterial species.
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology

Come and join our editorial team

β-Hairpin Antimicrobial Peptides: Class Diversity and Sequence Analysis Interest in antimicrobial peptides has increased dramatically over the last few decades as researchers continue to explore their potential as alternatives to small molecules, as well as their applicat...

Our lab has a new review on beta-hairpin antimicrobial peptide diversity out in @pubs.acs.org as part of the special issue celebrating Robert E. W. Hancock. Please have a look and share!

pubs.acs.org/doi/10.1021/...

Postdoc position in development of protocols for isolation of microbial strains for sustainable protein production

This 👉🏻 www.jobs.ethz.ch/job/view/112...

Great talk today from @waickmanlab.bsky.social here at UVM on Dengue immunity and neat interactions with other vaccines. I’m not a virologist or immunologist, but he made the whole story very compelling

Please join us for our next installment of CMB seminars presented by Atri Raval and Cory Raymond! We will have excellent science and discussions! Thank you @uvmcmb.bsky.social, @wargolab.bsky.social, @devdoot.bsky.social, Bruno, and Erin for all your organizational support!

JB Editor's Choice: Hritzo, Michalski & Rasko identify a flagellar-related factor that contributes to pathogenesis in Aeromonas.
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology

New lab preprint! Andrew Frando, Bobby Parsek, and Graham Roberts describe how components of the quinolone quorum sensing circuit of P. aeruginosa interact in competition with another Gram-negative bacterium, S. maltophilia -- it's a three-component AND logic gate.

www.biorxiv.org/content/10.6...