Guim Aguadé-Gorgorió's Avatar

Guim Aguadé-Gorgorió

@guimaguade.bsky.social

Marie Skłodowska-Curie fellow at ISEM Montpellier. Physicist studying complex biological systems - ecosystems, cancer, immune networks and microbial communities.

841 Followers  |  2,420 Following  |  9 Posts  |  Joined: 23.12.2024  |  1.871

Latest posts by guimaguade.bsky.social on Bluesky

Post image

Immunotherapy fails at curing heterogeneous cancers. Why? Modeling and clinical data suggest a limit to tumor heterogeneity, beyond which T cells fail at controlling highly-diverse tumors. Can we take advantage of this limit? @ricardsole.bsky.social royalsocietypublishing.org/doi/full/10....

02.06.2025 14:59 — 👍 8    🔁 0    💬 0    📌 0
Post image

Our work is based on two great recent articles that strongly impacted the way I think about complexity in ecology. Inspiring! @changyuchang.bsky.social @asanchezlab.bsky.social

22.05.2025 05:42 — 👍 6    🔁 2    💬 0    📌 0
Post image

Microbial communities can harbor many species that do not coexist in pairs, yet can coexist in the full community. Here we provide the mathematical foundations of emergent coexistence, and explain why it can't be predicted from pairwise tests www.biorxiv.org/content/10.1...

20.05.2025 13:16 — 👍 89    🔁 31    💬 2    📌 1

Congrats Lisa!!!

11.03.2025 13:08 — 👍 1    🔁 0    💬 0    📌 0

I've used this paper quite a lot and we've discussed with @ricardsole.bsky.social and @vmaull.bsky.social often. Great and useful work!

31.01.2025 08:20 — 👍 2    🔁 0    💬 0    📌 0
Preview
High burden and pervasive positive selection of somatic mutations in normal human skin Sun-exposed but physiologically normal human skin harbors an unexpectedly high number of cancer-causing mutations. [Also see Perspective by Brash]

Super interesting! reminds me of the work by I. Martincorena, finding that epidermic cells can remain healthy even when carrying hundreds of cancer mutations www.science.org/doi/abs/10.1...
Maybe genome alterations are not enough and other ecological dynamics play a role?

27.01.2025 09:27 — 👍 2    🔁 0    💬 1    📌 0

Thanks! In the paper we mention some ongoing efforts in that direction, but it does still feel a bit futuristic. On my side, I am very interested on the cancer-immune-microbiome ecosystem that you work in! Would love to chat about it at some point :D

22.01.2025 10:11 — 👍 2    🔁 0    💬 0    📌 0
Preview
Modeling tumors as complex ecosystems Ecology; Mathematical biosciences; Cancer systems biology; Cancer

www.cell.com/iscience/ful...

13.01.2025 11:07 — 👍 9    🔁 2    💬 1    📌 0
Post image

Tumors harbor hundreds of different cell types that compete and cooperate, mirroring a natural ecosystem. Can we model cancer as a complex ecosystem of many interacting species?
An honor to work w/ @ricardsole.bsky.social and Sandy Anderson while bringing in recent work in ecology with Sonia Kéfi!

13.01.2025 11:06 — 👍 29    🔁 6    💬 1    📌 1

@guimaguade is following 20 prominent accounts