Roychoudhuri Lab

Wonderful to see the seminal discoveries of Shimon Sakaguchi, Mary E. Brunkow & Fred Ramsdell recognised with the Nobel Prize. From Sakaguchi’s discovery of Treg cells to the identification of Foxp3, their research opened a new chapter in immunology, viewed from the prism of dominant tolerance.

Nuclear polarization to the immune synapse facilitates an early transcriptional burst Cytotoxic T lymphocyte target recognition triggers rapid nuclear polarization to the immune synapse and an early transcriptional burst of cytokines.

Now in #Science #Immunology: @griffithslab.bsky.social report that when #CD8 #TCells encounter their targets, #nucleus localizes to the #ImmuneSynapse (IS) & facilitates delivery of newly synthesized cytokines to the IS. They find nuclear polarization represents key step in #CTL -mediated killing!

The new #ALASCCA RCT shows that low-dose aspirin prevents metastatic recurrence by ~50% in patients with PI3K altered colorectal cancer #aspirin #metastasis #prevention

CAR T Day International Symposium on CAR T Cells

A fantastic 2 days in Lille thinking T cell therapy at CAR T Day - the 9th international symposium on CAR T cells cartday.org. Thanks to Suman Mitra for the invitation to share our new data

Our total energy (electricity) bill for heating and the all other used was £1700 last year! We have described our experience with it here: sites.google.com/view/becomin...

Put in a heatpump this summer! You’ll not look back!

Cool to see so many #heatpumps being installed this year. We’ve had our heatpump at home now for 3 years and it’s been saving us money while providing more comfortable heating and reducing our estimated CO2e by 75-80%.

Petition: Review all trade ties with Israel, suspend 2030 roadmap & impose trade sanctions We call on the Government to review existing trade ties with Israel, suspend the 2030 Roadmap for UK-Israel bilateral relations and impose trade sanctions upon Israel.

Please sign: petition.parliament.uk/petitions/72...

Petition: Review all trade ties with Israel, suspend 2030 roadmap & impose trade sanctions We call on the Government to review existing trade ties with Israel, suspend the 2030 Roadmap for UK-Israel bilateral relations and impose trade sanctions upon Israel.

Please sign this Parliamentary petition calling for comprehensive trade sanctions on Israel - the limited sanctions on specific members of the Israeli Government by the UK do not go far enough: petition.parliament.uk/petitions/72...

www.thelancet.com/journals/lan...

Sign the Petition #StopIsraelNow: Urgent Call for Economic Sanctions and Arms Embargo on Israel by the UK

The limited set of sanctions the UK has placed on specific individuals in Israel is not enough. Comprehensive sanctions needed to pressure the Israeli govt to reverse course in #Gaza. Please sign this petition to Parliament: #StopIsraelNow: chng.it/tsH8ZSJfRH via
@UKChange

Sign the Petition #StopIsraelNow: Urgent Call for Economic Sanctions and Arms Embargo on Israel by the UK

Please sign this urgent petition to Parliament: #StopIsraelNow: Urgent Call for Economic Sanctions and Arms Embargo on Israel by the UK chng.it/tsH8ZSJfRH via
@ukchange.bsky.social

Sign the Petition #StopIsraelNow: Urgent Call for Economic Sanctions and Arms Embargo on Israel by the UK

Please sign this urgent petition to Parliament: #StopIsraelNow: Urgent Call for Economic Sanctions and Arms Embargo on Israel by the UK chng.it/tsH8ZSJfRH via
@ukchange.bsky.social

Many wonders of aspirin 👍

T-cell-derived IFN-γ suppresses T follicular helper cell differentiation and antibody responses
www.embopress.org/doi/full/10....
@iannaconelab.bsky.social

Can Aspirin Prevent Cancer Metastasis? | Rahul Roychoudhuri | 216 Download, watch, read, or listen to this podcast conversation.

Really enjoyed discussing our recent findings and thoughts on cancer immunity with Nick Jikomes of the Mind and Matter podcast mindandmatter.substack.com/p/can-aspiri...
@campathology.bsky.social @crukcamcentre.bsky.social

Can Aspirin Prevent Cancer Metastasis? | Rahul Roychoudhuri | 216 Download, watch, read, or listen to this podcast conversation.

Really enjoyed discussing our recent findings and thoughts on cancer immunity with Nick Jikomes of the Mind and Matter podcast mindandmatter.substack.com/p/can-aspiri...
@campathology.bsky.social @crukcamcentre.bsky.social

Soluble CTLA-4 regulates immune homeostasis and promotes resolution of inflammation by suppressing type 1 but allowing type 2 immunity @cp-immunity.bsky.social
www.cell.com/immunity/ful...

Aspirin helps T cells to stop cancer spread - Nature Reviews Immunology Drugs like aspirin can enhance the anti-metastatic activity of T cells by blocking a platelet-mediated pathway of suppression.

Research Highlight of our recent paper by @jieyang437.bsky.social on Aspirin and cancer metastasis in Nature Reviews Immunology. Thanks to Yvonne Bordon for a crystal clear account of the experimental findings www.nature.com/articles/s41...

Low-dose aspirin to reduce recurrence rate in colorectal cancer patients with PI3K pathway alterations: 3-year results from a randomized placebo-controlled trial. LBA125Background: Colorectal cancer (CRC) affects 1.9 million individuals globally each year. Among patients with stage II-III CRC, 20-40% develop metastatic disease. Aspirin lowers the incidence of a...

New results from the ALASCCA prospective randomised controlled trial showing daily #aspirin reduces colorectal cancer recurrence by ~50% in patients with PIK3CA or related mutations. Findings extend benefits of aspirin beyond Lynch syndrome cancers to nearly 40% of CRCs ascopubs.org/doi/10.1200/...

Reactivation of CTLA4-expressing T cells Accelerates Resolution of Lung Fibrosis in a Humanized Mouse Model @jclinical-invest.bsky.social
www.jci.org/articles/vie...

Imagine if all those who are silent about the terrible evil being committed in Gaza spoke up | Owen Jones No crime in history has been so well documented by its victims. And yet inaction and censorship reign, says Guardian columnist Owen Jones

Imagine if all those who are silent about the terrible evil being committed in Gaza spoke up

www.theguardian.com/commentisfre...

Thank you Jae!

Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity - Nature Inhibition of cyclooxygenase 1 releases T cells from immunosuppression by platelet-derived thromboxane A2, thereby enhancing the immune response against metastasis.

Huge study in @nature.com by the @roychoudhurilab.bsky.social group
#Aspirin prevents metastasis by releasing T cells from immune suppression by platelet TXA2. This could potentially revolutionize cancer treatment and make it so much more accessible!

Thanks for all your ideas and support with this work Klaus!

Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity @nature.com @roychoudhurilab.bsky.social
www.nature.com/articles/s41...

Thrilled to share new work led by @jieyang437.bsky.social in the lab published today in @Nature. We find that Aspirin prevents metastasis by releasing T cells from immune suppression by platelet TXA2. @Cambridge_Uni @CRUKCamCentre rdcu.be/eci1U

Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity - Nature Inhibition of cyclooxygenase 1 releases T cells from immunosuppression by platelet-derived thromboxane A2, thereby enhancing the immune response against metastasis.

‘Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity’ @roychoudhurilab.bsky.social

www.nature.com/articles/s41...

Genome duplication in a long-term multicellularity evolution experiment - Nature In the Multicellularity Long Term Evolution Experiment, diploid yeast evolve to be tetraploid under selection for larger multicellular size, revealing how whole-genome duplication can arise due to its...

1/46 Hey folks, we have a new paper out on the MuLTEE. Strap in and I’ll tell you the story of how this “little paper on polyploidy” turned into the most data rich paper our lab has produced, largely thanks to the leadership and work ethic of @kaitong25.bsky.social.

www.nature.com/articles/s41...

To celebrate with the @keystonesymposia.bsky.social #myeloid cell meeting happening now in Hannover, we have released a free collection of 6 recent #Science #Immunology papers focused on myeloid cells!

Check 'em out! They will be available until the end of April!

bit.ly/SciImm_free

#KSmyeloid25

An oral norovirus vaccine tablet was safe and elicited mucosal immunity in older adults in a phase 1b clinical trial An oral norovirus vaccine tablet is safe and induces strong mucosal and systemic immune responses in adults aged 55 to 80 years.

In the US alone, each year, norovirus causes ~20 million acute gastroenteritis cases, 70,000 hospitalizations, up to 800 deaths, at a cost of ~$10.6 billion annually.
An pill vaccine shows considerable promise in a clinical trial, establishing mucosal immunity
www.science.org/doi/10.1126/...