Physiological Reports

129S2/SvPas mice are susceptible to #hypertension from dietary #electrolyte manipulation. In a #doxorubicin-induced #proteinuria model, 129S2/SvPas mice proved resistant to proteinuria compared to 129S1/SvImJ mice, and proteolytic processing of #renal #ENaC was not increased
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Your story matters. Tell us what publishing your first article meant to you.

For every story shared, $50 will be donated to Scholars at Risk.

Share now: https://ow.ly/kOeE50XC4xv

#MyFirstArticle #MyResearchJourney

Black and white portraits of Gerald Shulman and Anna Stanhewicz, each framed in a circular gradient border, announcing their 2026 award lectures.

Congrats to Gerald Shulman and Anna Stanhewicz, the 2026 Cannon and Bowditch awardees! These prestigious lectureships recognize lifetime achievement and physiological research excellence in an early-career scientist. They'll speak at #APS2026. Read more: https://ow.ly/24aQ50XFKVA 🧪

Speaker addressing a large audience at the American Physiology Summit in a spacious, well-lit conference hall.

Our webinar program is on a brief hiatus, but new content is coming in January. In the meantime, take a look at the #APS2026 pre-conference events happening on April 23 in Minneapolis. Hope to see you there: https://ow.ly/BfRH50XCS4R #WeArePhysiology 🧪

Benefits of #ischemic #preconditioning - This Short Report provides new data that a single session of IC can increase blood pressure in older adults with knee #osteoarthritis, but did not affect other measures of #cardiovascular function.
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#Ageing #Physiology

The role of bioactive lipids and eicosanoid metabolites in acute exercise in adults: Insights into human cardiorespiratory fitness The molecular mechanisms underlying the salutary effects of exercise remain incompletely understood. Exerkines are signaling molecules with autocrine, paracrine, or endocrine effects released in…

Biosignature of #exercise? Mass Spectrometry study of #plasma #eicosanoids and related #metabolites at rest or peak exercise in adults undergoing #cardiopulmonary exercise testing reports on metabolite changes with exercise or #cardiorespiratory fitness.
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#Exerkines

150 voices: Celebrating our members and their personal histories Keep up to date with The Physiological Society’s news. Press releases, job openings, policy developments, conferences and other physiology news.

Today, we kick off our 150th year celebrations 🎉

For our anniversary, we have launched our 150 voices collection - a gallery of engaging member stories and Society heritage gems.

🗞️ Read our news story to find out more ⬇️ buff.ly/sYaWsDJ

Sex‐specific adaptations to exercise training: Focus on autonomic modulation and oxidative stress in normotensive rats Sex-related physiological differences influence health, disease, and responses to preventive interventions. We aimed to compare the effects of exercise training on cardiovascular autonomic…

Comparison of effects of #exercise training on #cardiovascular #autonomic modulation and #oxidativestress in target organs, in a Wistar rat model finds sex-specific differences in improvements after exercise.
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#Physiology

The effect of a ketone monoester drink on blood glucose and substrate oxidation in adults with metabolic syndrome and matched controls This study aimed to evaluate the acute metabolic effects of oral ketone esters (KE) in individuals with and without metabolic syndrome (MetS) on resting energy expenditure (REE), respiratory…

Testing of oral #ketone esters for metabolic effects in adults without or with #metabolic #syndrome using #respiratory gas exchange reports shift of substrate use to greater #carbohydrate #oxidation and decreased fat Oxid., independent of MetS status.
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#Metabolism #Ketosis

Microvasculature as a Key Regulator of Health and Disease in the Brain and Beyond Microvasculature as a Key Regulator of Health and Disease in the Brain and Beyond, will take place on 16-17 April 2026. Find out more.

⏰ Submit your abstract today to share your insights on vascular risk factors and brain health.

Showcase your research at our Microvasculature meeting, taking place:

📍 Sainsbury Wellcome Centre, UK
📆 16-17 April 2026

Submit now ⬇️

Prenatal fructose exposure independently impacts placental phenotype and female offspring kidney function and liver composition in rats Archaeological and anthropological evidence suggests that human ancestors' diets were rich in fiber, potassium, and complex carbohydrates, while low in sodium, refined sugars, and energy density.…

Inter-generational #physiology: Study of effects of excessive #maternal #fructose intake on the #placenta and offspring in a rat model reports effects on placental anatomy and sex-specific effects on #kidney and #liver function in adult offspring.
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#Metabolism

UK Glia 2026 UK Glia 2026 meeting will highlight the pivotal role of glia in brain physiology, offering invaluable insights for those investigating glia function in both health and disease. Find out more about…

💡 Join us in advancing glial physiology

Submit your abstract to showcase your research at our meeting, UK Glia 2026, taking place on 8 – 9 June 2026 at University of Bristol, UK.

Abstract submission closes on 16 January 2026. Find out more ⬇️

⏰ Last chance to submit your research for our Dietary Manipulations meeting. Abstract submission closes on 30 November 2025!

Showcase your research and be part of the conversation on #MetabolicHealth and #Nutrition at Manchester Metropolitan University, UK on 8-9 April 2026 ➡️ buff.ly/j9hXo8U

Postprandial #exercise is recommended for people with metabolic disease. This study reports reduced postprandial #insulin and #glucose among young and old active exercisers, with association to #cognitive function and #bodywater compartment ratio.
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#Metabolism #Ageing

Investigation of #masseter #muscle in #microphthalmia mice (with Mitf mutation and masticatory dysfunction) shows increased myocyte #apoptosis and #fibrosis, reduced masseter muscle mass and low expression of #microRNAs needed for #skeletal muscle development
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Fibroblast Has2 limits acute heart failure following myocardial infarction in male mice Changes to the extracellular matrix support acute wound healing following myocardial infarction. Fibroblasts regulate the composition of the extracellular matrix, in part, by secreting hyaluronan.…

#Heart Failure and #Sexdifferences: in a mouse model of non-reperfused #myocardial #infarction, male mice with #fibroblast-specific knockout of #hyaluronan synthase 2 (#Has2), had exacerbated heart failure vs. wildtype mice; a difference not apparent in female mice.

A novel #acetaminophen analogue, D-112, has limited effects on #survival and compensatory #cardiorespiratory responses following #hemorrhage and extremity #trauma in a rat model, suggesting it may have potential as an #analgesic after hemorrhage.

Investigation of effects of #heatadaptation, induced with home-based stationary #cycling while overdressing, in trained females finds that maintenance of heat adaptation further developed #thermal #resistance and potentiated hot #exercise performance.
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#Physiology

President’s Lecture and Awards Ceremony 2025: Celebrating 150 years of physiology Join us for the most prestigious event in The Society's calendar - our 2025 President’s Lecture and Awards Ceremony.

Join us at this year's President's Lecture to hear from Dame Sally Davies, who will present ‘Antimicrobial Resistance: The Challenge of Leadership.’

A critical global health issue from one of the world’s leading voices.

📆 4 December
📍 Royal Society of Medicine
www.physoc.org/events/presi...

Sertraline exposure during development may impact post‐myocardial infarction survival in adult mice The impact of developmental sertraline exposure on post-myocardial infarction (MI) outcomes.

Developmental exposure to the #antidepressant #sertraline is shown to
induce sex-specific #cardiac structural and functional changes in a mouse model of #myocardial #infarction.
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#Cardiovascular

#CarbonMonoxide has #antiischemic and #antiinflammatory effects. This study explores the potential of #CORMA1, a molecule that effects controlled CO release, to protect #kidneys from warm #ischemia and #reperfusion injury in rat and swine models.
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Melorheostosis: Clinical, radiological, and histopathological features with a literature review Melorheostosis is a rare sclerosing bone dysplasia that can clinically and radiologically mimic common bone disorders, particularly in atypical presentations. Its heterogeneous manifestations and…

This new Case report presents a case of #melorheostosis, a rare sclerosing #bone #dysplasia for which the #pathophysiology is poorly understood, and discusses its clinical and potential translational significance.
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#TranslationalPhysiology

New data on #mitochondria Aminoacyl-#tRNASynthetase, DARS2, reports secretion by #airway #epithelial cells in response to #TNFα, and a role in #paracrine signaling resulting in M1 #macrophage like phenotype in recipient THP1 cells.
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Deadline approaching!
Call for Papers on “Tissue Fibrosis Through the Life Course and in Transplanted Organs” will close on 31st Dec. 2025!
Including, but not limited to:
Age-related Fibrosis
Organ Fibrosis
Fibrosis in Transplanted Organs
More Info:
physoc.onlinelibrary.wiley.com/hub/journal/...

Overnight deep inspiration patterns in obstructive sleep apnea patients with and without asthma Asthma and obstructive sleep apnea (OSA) often co-occur, exacerbating respiratory difficulties and altering airway physiology during sleep. Respiratory obstructions in OSA usually terminate with…

Study of overnight deep inspiration patterns in #obstructive #sleep #apnea patients with or without #asthma provides insight into the potential role of deep inspirations in mitigating overnight narrowing in lower #airways and asthma–OSA interactions.
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#Breathing #Respiratory

This systematic review examines evidence for #Sexdifferences in human #skeletal #muscle fiber types and the influences of #age, physical activity or muscle group.
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MyoBlue #Exercise #Ageing #Physiology

Global Climate and Health Summit The 2025 Global Climate and Health Summit placed physiology and partnerships at the heart of climate and health. Read more

📢 Launched today, the Global Climate and Health Summit Phase One report!

It sets out the next steps to drive adaptation to protect lives today & the mitigation needed to secure health for generations to come.

Read the full report ⬇️ www.physoc.org/policy/clima...

#ClimateAction #GCHS2025

Close-up of a calendar page with the 7th day circled by a pencil tip, highlighting the date on a weekday grid.

Planning for #APS2026? Stay ahead of the game! Check out key dates and deadlines so you don’t miss a thing: https://www.physiology.org/professional-development/meetings-events/american-physiology-summit/dates-and-deadlines?SSO=Y #WeArePhysiology 🧪
📷: istock

Read this physiological Case study which examined #energy balance in two recreational, #ultra-endurance #cyclists on plant-based diets during a 30-day cycle ride across Canada.
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#ExerciseandDiet #Metabolism #Nutrition

Heart‐focused breathing technique and attitude breathing technique effects on heart rate variability in young healthy subjects Heart rate variability (HRV) is controlled mainly by the autonomic nervous system (ANS). The aim of our prospective study was to investigate whether respiratory control influences changes in ANS…

Study of heart-focused #breathing and attitude breathing techniques on #heartrate variability in young healthy subjects reports improved #HRV parameters and #cardiorespiratory coherence, with significant differences between sexes and individuals with or without #anxiety.