Physiological Reports

New research on acute intermittent passive stretching (PS) or #ischemic #preconditioning shows each increase #microvascular responsiveness and #muscle oxidative capacity, suggesting PS as a possible intervention for individuals unable to take traditional #exercise.
doi.org/10.14814/phy...
#MyoBlue

Longitudinal comparison over 1 year of #ventilatory efficiency at rest between asthmatic patients vs. healthy subjects reports similar, stable VE over time, despite shorter breath-holding time in #asthma patients.
doi.org/10.14814/phy...
#Respiratory #Physiology #Breathing

#Kidney #disease progression: study of #renal histopathological parameters indicates that increased cortical volume, independent of #nephron number, may contribute to increased glomerular hydrostatic pressure.

Research on distinctions in body composition, #bone health, and #bioelectrical #impedance parameters between women with healthy #menstruation, #dysmenorrhea, or post-menopause implicates edema or lower body cell mass in the #postmenopausal group.
doi.org/10.14814/phy...
#Physiology #WomensHealth

New Invited Review by G. Davison and colleagues discusses the rigorous methodologies needed to address knowledge gaps in #exercise, #nutrition, #immunity and upper #respiratory tract #infection risk research

Exposure of resting #Tcells to physiologically relevant #lactate concentrations is shown to increase #mitochondria #respiration of resting T-cells in culture, suggesting that vigorous #exercise may prime immune cell function.
doi.org/10.14814/phy...
#Physiology #ImmuneSystem

This large study examines age-related #hemodynamics in individuals (age range 30s to 60s) without #cardiovascular disease during passive head-up tilt, reporting alterations in cardiovascular dynamics and #heartrate variability
doi.org/10.14814/phy...
#Ageing #Physiology

This analysis of meal-induced #heartburn in symptomatic #gastroesophageal #reflux disease patients identifies distinct heartburn severity clinical phenotypes, suggesting a need for tailored therapy options for some patients.
doi.org/10.14814/phy...
#Gastrointestinal

Research on Selective #Androgen #Receptor Modulator #RAD140 in a rat model reports hypertrophic effects on #plantaris #muscle mass and cross-sectional area, but no additive effect in combination with functional overloading.
doi.org/10.14814/phy...
#Myopathy #MuscleHypertrophy

Analysis of effects of three modes of #exercise during pregnancy on #blood #lactate, as a marker of metabolic health, reports exercise to blunt and moderate the BMI-associated rise in maternal lactate.
doi.org/10.14814/phy...
#Pregnancy #Metabolism #Obesity

Use of a cell-based #mathematical model of #cardiac #electrophysiology to assess effects of #cardiomyocyte cell variability predicts reduced #gapjunction #cell coupling to amplify cardiomyocyte variability and destabilise the #heartbeat

Study to examined if #menstrual cycle phase affects #mitochondria function in #skeletalmuscle in females reports a limited influence on measures of submaximal #respiration, coupling efficiency, or H2O2 emission.
doi.org/10.14814/phy...
#Metabolism

Exercise and large airway issues The large airways, extending from the trachea to the main bronchi, respond dynamically to exercise-induced ventilatory demands. Large airway collapse (LAC) represents a spectrum of conditions charact...

Read our latest invited Review “Exercise and large airway issues”, which discusses large #airway behavior during different ventilatory challenges, comparing #exercise #hyperpnea with forced #expiratory manoeuvres
doi.org/10.14814/phy...
#Respiratory

Find out more on our Call for Papers on
“Tissue #Fibrosis Through the Life Course & in Transplanted Organs”
Areas of Interest:
Age-related Fibrosis
Organ Fibrosis
Fibrosis in Transplanted Organs
Tissue Injury & Inflammation
Deadline: 31st Dec. 2025.

Research on a large clinical cohort to compare pathophysiological traits of patients with overlap syndrome (coexisting #COPD and obstructive #sleep #apnea (OSA)) versus OSA alone, reports differences in OSA severity and mechanisms in OVS vs. OSA.
doi.org/10.14814/phy...
#Respiratory #Breathing

Cardiac workload and skeletal muscle oxygenation during incremental exercise in healthy subjects We hypothesized that skeletal muscle oxygenation, measured by Near-infrared spectroscopy (mNIRS), is associated with cardiac workload during incremental exercise. Healthy subjects (n = 30, age 27 ± 6...

Data on #cardiac workload during submaximal #exercise by healthy subjects provides evidence for association with skeletal muscle tissue saturation index, independent of other variables, implicating regulation by altered skeletal #muscle #oxygenation.
doi.org/10.14814/phy...
#MyoBlue #Metabolism

Effects of reduced #mitochondrial #fusion protein Opa1 are examined in mice with endothelial-specific knockout of #Opa1. Reduced mitochondrial fusion in #endothelial #cells increased mesenteric #vascular #reactivity, and increased oxidative stress in #aging #kidney.

The Role of Insulin in Whole-Body Homeostasis Beyond Glycaemic Control This two-day meeting at University of Aberdeen (UK) will explore the multifaceted role of insulin beyond glucose regulation.

Save with early bird registration and join us to uncover the complex role of insulin.

📆 Secure your place by 14 July. Register now ➡️ buff.ly/O4H2Myh

#InsulinMeeting #BeyondGlycaemicControl

#Inflammation-association effects of #obesity include altered #innate #immune responses in acute #lung injury. Research in a mouse model shows the cytoplasmic receptor #NOD1 to regulates #leukocyte dynamics and #macrophage function in lungs of obese mice.

Using a novel remote occlusion real-time method to image acute #ischemia, this comparison of #Manganese-enhanced & late #gadolinium enhancement #MRI assesses #myocardium damage in a murine ischemia–reperfusion model & reports that LGE MRI may overestimate infarct size

two professionals hold resume at desk with laptop

Looking for a job in #physiology or the #biomedical sciences? Look no further than our job board for current listings: ow.ly/WoiK50Wj9aG #ProfDev 🧪

Maintaining #energy balance under harsh conditions: this study of non-athlete female adults who reached the North Pole by #ski-trekking reports on energy expenditure, metabolic parameters and physical activity
doi.org/10.14814/phy...
#Metabolism #Exercise #Physiology #Arctic

Study on the physiological effects of #breath-holding during high-intensity #exercise in young adults reports that exercise response predominated over #apnea response, yet there were residual effects of breath-holding on #bloodpressure
doi.org/10.14814/phy...
#Respiratory

Research on the response of circulating #IGF1 to an endurance #exercise in non-obese or #obese adults reports reduced IGF1 and #IGFBP3 responses to exercise in obese individuals, yet no change in free serum IGF1 due to the reduced IGFBP3.
doi.org/10.14814/phy...
#Circulation #Biomarkers

This study investigates possible off-target effects of the often-used antibiotic #streptomycin on myoblast cell function. Reduced global #protein #synthesis rate in differentiating #myotubes is reported, while #myoblast proliferation is unaffected.
doi.org/10.14814/phy...
#MyoBlue #CellPhysiology

Closeup of Minneapolis on map with red pushpin.

#APS2026 may be 300 days away, but we know some of you already know you're going. Check out the official conference hotels in Minneapolis as well as the attendee rates. You can even book now: ow.ly/AE3V50WgPO6 🧪

Research on effects of electric pedestal #fan use during daylong exposure of older adults to simulated indoor #overheating reports lack of definite effects on systemic markers of #enterocyte damage, #inflammation or #renal #ischemia.
doi.org/10.14814/phy...
#HeatStress

Investigation on effects of #magnesium nitrate in a rat model of #pulmonary #hypertension shows antispasmodic effects on #pulmonary arteries and activity to limit the progression of pulmonary hypertension.
doi.org/10.14814/phy...
#Cardiovascular

How could we improve human and planetary health? By shifting to a plant-based diet. We’ll discuss how this transition could make an impact, looking at nutrition research and policy interventions at #ClimateHealthSummit25.

Register now ⬇️ buff.ly/jPhEEF0

#ClimateChange #FoodSecurity #Nutrition

New #Methods article presents a #HPLC methodology for simultaneous analysis of #inositol #phosphates and #nucleotides, as exemplified by an analysis of cultured #neuroblastoma cells.
doi.org/10.14814/phy...
#CellSignaling #Metabolism