Physiological Reports

Find out about the most-read papers published in Physiological Reports in 2025.
With congratulations to the authors!
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Real‐life application of respiratory oscillometry in pediatric asthma outpatient care: Feasibility and methodological aspects Asthma diagnosis can be challenging in children. Spirometry is highly effort-dependent and often normal in early disease. Forced oscillation technique (FOT) is an alternative to spirometry and is…

Investigation of the feasibility of forced #oscillation technique for diagnosing childhood #asthma reports feasibility even in young children for whom #spirometry cannot be performed.
#Respiratory #Pediatric

A new #Bayesian approach to estimate minute #ventilation from #heart rate during #exercise shows improved accuracy for assessing environmental exposures for females performing incremental running tests.
doi.org/10.14814/phy...
#Respiratory #AirQuality

#Metabolomics study of plasma from elite male #endurance #athletes after dietary interventions reports greater perturbations of #lipid-based metabolites after low-CHO, high fat food intake.
doi.org/10.14814/phy... Object Identifier (DOI)
#Diet #Exercise

Close-up of a dictionary page showing the word 'cancer' in blue with its medical definition about malignant growths.

This #WorldCancerDay, check out #ISpyPhysiology blog posts that explain some of the basics about this scary disease: 🧪
• Cellular-level understanding https://ow.ly/12cR50Y8cSJ
• Cancer and heart health https://ow.ly/pbSB50Y8cSK
• Metastasis https://ow.ly/mV7x50Y8cSI
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February is #HeartMonth! Raise awareness of #cardiovascular #disease and take care of your heart #health.
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#Renal focal global #glomerulosclerosis relates to #aging and #hypertension and begins with tuft contraction of #glomeruli. This report shows associated #biomarkers of #podocyte depletion, cell #senescence, and activation of #parietal #epithelia #cells.
doi.org/10.14814/phy...
#Kidney #Physiology

High-fat # diet is shown to cause greater #perivascular #adipose tissue-induced impairment in mesenteric artery #vasodilation in female rats compared to male rats.
doi.org/10.14814/phy...
#Obesity #Cardiovascular #FemalePhysiology

🎉 Celebrate 150 years with us!

This year marks the Society’s 150th anniversary, celebrated through our largest programme of meetings and conferences to date.

📆 Browse our 2026 events calendar 🔗 buff.ly/K56YHYq

The physiology of thoracic duct pressure and flow: A review of the literature The thoracic duct (TD) is the largest vessel of the lymphatic system, transporting interstitial fluid, macromolecules, and immune cells into the venous circulation via the lymphovenous junction.…

This systematic #review on the effects of #respiration and #circulation on #thoracic duct #lymph flow and pressure in #humans and non-human #mammals highlights needs for modern #imaging and standardised physiological #protocols.
doi.org/10.14814/phy...
#Lymphatics

Physiological Reports <em>Physiological Reports</em> is a peer-reviewed, open access journal that publishes papers across all areas of basic and translational physiology and allied disciplines.

Physiological Reports is pleased to announce new Editorial Board Members! Check out physoc.onlinelibrary.wiley.com/hub/journal/...
for the current Editorial Board.
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The editors are pleased to announce the appointment of Jacqueline K. Limberg, Ph.D.,
University of Missouri, USA, as a new Associate Editor at PhysReports!
Dr. Limberg brings expertise in #autonomic #physiology, #cardiovascular regulation and sex differences, in health and #obesity.

Renalase deficiency suppresses hepatic triglyceride accumulation in the progression to MASLD/MASH by GAN diet in male mice Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing public health concern characterized by hepatic triglyceride (TG) accumulation, inflammation, and fibrosis. Renalase is…

Analysis of #renalase KO mice for hepatic #lipid #metabolism shows suppression of hepatic #triglyceride accumulation in diet-induced progression to Metabolic dysfunction-associated #steatotic #liver disease.

Comparison of #skeletal #muscle mitochondrial respiration during off-season and racing season of Siberian huskies and Alaskan #huskies implicates more efficient #mitochondria with minimized energy loss in raced dogs

doi.org/10.14814/phy...
#Metabolism

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This week at APS:
• W/VO2 Master: Dynamic Metabolic Testing Insights in Elite Athletes & Tactical Performance 1/21
• W/Emulate: Organ Chips in Translational Physiology Res. 1/22

Next:
• W/Fauna Bio: Physiological Resilience & Insights in Animal Models 2/17
https://ow.ly/WEWs50WuRYU 🧪
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Analysis of whether #BMI influences an adult's ability to adapt during #heat #acclimation, tested by treadmill walking over 8d at 40C, reports individuals with BMI >25 may have attenuated core #temperature adaptations.
doi.org/10.14814/phy...
#Exercise #ThermalPhysiology

Wiley's Bluesky Network Join the conversation

Keep up with the latest cutting-edge discoveries and research breakthroughs. 💡

Explore our collection of Wiley research pages. ⬇️

https://ow.ly/xzI850XMIWL

#Publishing #Innovation #Discovery

Comparison of #exercise sweating and #pilocarpine induced #sweat testing (a lab-based method to assess sweat composition) reports best match at moderate exercise intensity in trained #athletes.
doi.org/10.14814/phy... Object Identifier (DOI)
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Study of effects of at-risk drinking on central #hemodynamics and #aorta stiffness in midlife adults indicates elevated central #BloodPressure associated with at-risk drinking does not relate to enhanced aortic wave reflection or stiffening.
doi.org/10.14814/phy...
#Cardiovascular #Alcohol

Lactate increases oxygen unloading of preconditioned blood from male elite breath‐hold divers Physical performance can be improved in aerobic athletes and breath-hold divers (BHD) by limb exposure to repetitive ischemia: remote ischemic conditioning (RIC). RIC protects against cardiac ischemi...

Evidence that #erythrocyte and #cardiac lactate dehydrogenase a is higher in breath-holding #divers (BHD) compared to matched controls, and that #lactate facilitates #oxygen-unloading in blood from BHD after remote #ischemia conditioning, similar to diving mammals.
doi.org/10.14814/phy...

Analysis of fecal #microbiomes of newly diagnosed, #pediatric Crohns #disease patients compared to matched controls with other functional #gastrointestinal disorders finds enrichment of #pro-inflammatory bacteria in CD patients.

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Coming up at APS:
• With VO2 Master: Dynamic Metabolic Testing Insights in Elite Athletes and Tactical Performance 1/21
• With Emulate: Organ Chips in Translational Physiology Research 1/22

Learn more on our webinars page: https://ow.ly/WEWs50WuRYU 🧪
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January 2026 – New Call for Papers is open!
“#Ageing, #HealthSpan and #Lifespan: Physiological Aspects”
Find out more and submit at
physoc.onlinelibrary.wiley.com/hub/journal/...

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#Physiology

The Editors Thank all Authors, Reviewers, Readers, Editorial Board members and Staff for their support of the success of Physiological Reports in 2025!

Best wishes for a Happy festive season and a productive 2026.
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2/2 Paper of the Year CONGRATULATIONS TO
Post-doc:
Christopher K. Kargl, Univ. of Pittsburgh
“Circulating extracellular vesicle characteristics differ between men and women following 12 weeks of concurrent exercise training” doi.org/10.14814/phy...
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The Editors are delighted to Announce Paper of the Year 2024 winners!
1/2CONGRATULATIONS
Pre-doc:
Jonathan J. Herrera, Univ. of Michigan
“High-intensity exercise training using a rotarod instrument (RotaHIIT) significantly improves exercise capacity in mice” doi.org/10.14814/phy...
#Physiology

Acute effects of resistance exercise on skeletal muscle glycogen depletion: A systematic review and meta‐analysis To compile and statistically summarize quantitative evidence on the acute effects of resistance training sessions on muscle glycogen concentration, a systematic search was conducted on Pubmed, Web of...

Acute effects of resistance exercise on skeletal muscle glycogen depletion: A systematic review and meta-analysis
physoc.onlinelibrary.wiley.com/doi/10.14814...

In celebration of our 150th anniversary, we are extending the opportunity to submit your abstract for our 2026 Dietary Manipulations meeting.

Submit your abstract by 7 January 2026 ➡️ buff.ly/ae0Yupi

#Nutrition #KetoDiet #BrainHealth #MetabolicHealth

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There’s still plenty of time to register for #APS2026 before the early reg. deadline of Jan. 30. You'll want to be in Minneapolis for the top science and networking opportunities everyone will be talking about. Lock in your spot now: https://ow.ly/MEcZ50XKux9 #WeArePhysiology 🧪

#Postprandial #gastrointestinal #hormones GLP-2 and GIP, alone or in combination, are shown to stimulate superior mesenteric #artery #bloodflow in anesthetized rats, independent of #NitricOxide signaling.