Brian Irving, PhD

Sarcopenia and Cachexia in Older Patients with Cancer: Pathophysiology, Diagnosis, Impact on Outcomes, and Management Strategies - Drugs & Aging Sarcopenia and cachexia are two common and overlapping but distinct muscle wasting syndromes that predict adverse outcomes and undermine quality of life among older adults with cancer. Despite their prognostic value and negative effects on older patients’ well-being, sarcopenia and cachexia are not routinely or adequately assessed and managed in clinical oncology practice. However, efforts to recognize and manage sarcopenia and cachexia at diagnosis and during follow-up may have beneficial effects on muscle mass, physical function, and quality of life among older adults with cancer, although evidence on long-term clinical outcomes in response to targeted interventions has yet to be established. This comprehensive review attempts to (i) delineate the differences in the pathophysiology and clinical manifestations between sarcopenia and cachexia, (ii) clarify how sarcopenia and cachexia are defined in the geriatric oncology literature, (iii) describe methods for assessing sarcopenia and cachexia in clinical practice, (iv) review the prognostic value of sarcopenia and cachexia among older patients, particularly those undergoing systemic cancer treatment, and (v) discuss evidence-based strategies aimed at managing sarcopenia and cachexia for older adults with cancer.

In this review, we describe the pathophysiology of sarcopenia and cachexia, explore their definitions in the context of geriatric oncology, and examine assessment methods used in clinical practice. Great job Makis.

link.springer.com/article/10.1...

Exposure of resting #Tcells to physiologically relevant #lactate concentrations is shown to increase #mitochondria #respiration of resting T-cells in culture, suggesting that vigorous #exercise may prime immune cell function.
doi.org/10.14814/phy...
#Physiology #ImmuneSystem

Lactate homeostasis is maintained through regulation of glycolysis and lipolysis Lactate elevations are a hallmark of human disease, but the mechanisms regulating lactate levels remain poorly understood. Here, Lee et al. elucidate the mechanisms of lactate homeostasis. These invol...

Lactate homeostasis is maintained through regulation of glycolysis and lipolysis: Cell Metabolism www.cell.com/cell-metabol...

I recently stumbled upon the gt package for R programming, a real game-changer for anyone looking to elevate their table game!

Developed by Richard Iannone and colleagues, it simplifies table creation.
Package documentation: https://gt.rstudio.com/

More: http://eepurl.com/gH6myT

#data #statistics

Congratulations Brandon

Exercise Therapy Rescues Skeletal Muscle Dysfunction and Exercise Intolerance in Cardiometabolic HFpEF Exercise intolerance, a hallmark of heart failure with preserved ejection fraction (HFpEF) exacerbated by obesity, involves unclear mechanisms related…

www.sciencedirect.com/science/arti...

Kinesiology Faculty - Madison, Wisconsin, United States Job Summary: The Department of Kinesiology at the University of Wisconsin-Madison is seeking outstanding candidates for an open rank tenure-track faculty position. Desirable candidates should be abl...

Open-rank faculty position with focus on healthy aging/lifespan available in the Department of Kinesiology @UWMadison!!!

jobs.wisc.edu/jobs/kinesio...

Exercise Immunology | James Turner, Guillaume Spielmann, John Campbell Exercise immunology is a discipline at the nexus of exercise physiology and immunology that aims to characterise the effects of exercise on the immune system in

Guillaume, James, and John did a great job putting this together. I am glad to have helped.

www.taylorfrancis.com/books/edit/1...

Super excited to have installed the Technavance Bilateral Knee Extension Ergometer. Bengt Saltin would be proud. @lsukinesiology.bsky.social

This will enhance our understanding of how exercise improves lipolytic function to bring about beneficial effects, offering new insights into potential therapeutic avenues for promoting health and alleviating diseases.
www.sciencedirect.com/science/arti...

#Lactate #metabolism and histone lactylation in the central nervous system disorders: impacts and molecular mechanisms
jneuroinflammation.biomedcentral.com/articles/10....

A snip of my profile. Banner image incldes Arendt, Durkheim, Fanon and others drawn rouglys on eggs in Black and White. Profile picture is me in front of some autumn leaves. Key descriptive text identifies me as a criminologist working on atrocity crime. At the bottom, highlighted by a big red arrow is my ORCID ID: 0000-0002-7463-1302

A snip from my ORCID profile page - at the left is a list of institutional and other links to social media, including one to Bluesky, highlighted by a big red arrow.

Academics wanting to 'verify' their Bluesky profile as genuine might give an ORCID identifier in their profile and link back to their Bluesky profile from ORCID.

#AcademicSky

Check out our database of 47 POSTDOCTORAL fellowships in cancer/oncology.

For each fellowship, we provide a brief description, link to opportunity, deadline, and eligibility criteria (e.g. citizenship).

Download this database here (Excel file): research.jhu.edu/rdt/funding-...

Good luck!

Nathan can you add me to your starter pack?

Mitochondrial pyruvate transport regulates presynaptic metabolism and neurotransmission The brain uses pyruvate as an energy source, and mitochondrial pyruvate metabolism in nerve terminals controls neurotransmission.

Mitochondrial pyruvate transport regulates presynaptic metabolism and neurotransmission

www.science.org/doi/10.1126/...

Where is the “Mitochondria is the powerhouse of the cell” starter pack

We are recruiting an Assistant Professor with expertise in biotechnology, biosensing, or Ai in the LSU School of Kinesiology.

lsu.wd1.myworkdayjobs.com/LSU/job/H-P-...

If you have any questions please feel free to reach out.

Count me in too.

Summiting Mount Everest in #deuterium depleting nutritional #ketosis without supplemental oxygen

👇
www.sciencedirect.com/science/arti...

Impaired branched chain amino acid (BCAA) catabolism during adipocyte differentiation decreases glycolytic flux
www.sciencedirect.com/science/arti...

We are recruiting an Assistant Professor with expertise in biotechnology, biosensing, or Ai in the LSU School of Kinesiology.

lsu.wd1.myworkdayjobs.com/LSU/job/H-P-...

If you have any questions please feel free to reach out.

New from Cold Spring Harbor Press. Available in December, 2024, just in time for the holidays! -RJD

a bald man in a blue suit is making a funny face and pointing at something . ALT: a bald man in a blue suit is making a funny face and pointing at something .

People working on #cancermetabolism, #mitochondrialbiology, #metabolism, please reach out! Share this so I can follow who is here! I will share paper on cancer metabolism, but anything else related to mitochondria and metabolism.