Luke Pilling

View of the River Exe running through the Quay in sunny Exeter.

Post-doc opportunity in Exeter 🌟 studying genetic modifiers of haemochromatosis 🩸

Closing date 30 Oct!

Come and work with a interdisciplinary team of epidemiologists, clinicians, and statistical geneticists, in a beautiful city in the South West of England ❤️

jobs.exeter.ac.uk/hrpr_webrecr...

Yeah... at the least could use {renv} to make the same package versions available etc

But my code doesn't try to emulate the real data structures particularly - just col names and variable types, so that at least the initial test can be done there, then tested properly online

This is really cool Michel. I have been making something for Our Future Health, because of their "airlock" it's much more tedious to test code. Whereas UK Biobank it is very easy (and pretty cheap) to test code on the real data (for most cases anyway - no doubt there are cases where this isn't true)

EMBL-EBI and Google DeepMind renew partnership and release update to AlphaFold Database Deeper collaboration between EMBL-EBI and Google DeepMind brings updates to the AlphaFold Database.

@ewanbirney.bsky.social on the new version of Alphafold at the @emblebi.bsky.social
www.ebi.ac.uk/about/news/t...
AlphaFold has been a transformation not just in structural biology but also - due to its ability to be applied to all proteins - to molecular biology as a whole.

Can be very effective in talks/slides, but for papers the default "white" background is ubiquitous, even in online-only publications!

Indeed! I am not a climber, so hadn't thought of that. More frequent commits required to prevent breaks/fractures? 🤕

Cartoon by the excellent Allison Horst (https://allisonhorst.com/git-github). Includes a quote from Hadley Wickham and Jenny Bryan that says “Using a Git commit is like using anchors and other protection when climbing…if you make a mistake you can’t fall past the previous commit. Commits are also helpful to others, because they show your journey, not just the destination.” On the right, two little monsters climb a cliff face. Their ropes are secured by several anchors, each labeled “Commit”. Three monsters on the ground support the climbers.

One of the biggest increases in my analysis/coding productivity in recent years is completely embracing git repos 🐧

Coupled with GitHub it is *so easy* to be open, reproducible, efficient, and accountable to myself and colleagues 👨‍💻

No more chaotic servers wondering which script led to what! 😵‍💫

What an amazing place to present GEMINI research on steroid pharmacogenomics and osteoporosis by @denizturkmen.bsky.social @lcpilling.bsky.social and the GEMINI #MLTC team @universityofexeter.bsky.social #EUGMS2025

View of the River Exe running through the Quay in sunny Exeter.

Post-doc opportunity in Exeter 🌟 studying genetic modifiers of haemochromatosis 🩸

Closing date 30 Oct!

Come and work with a interdisciplinary team of epidemiologists, clinicians, and statistical geneticists, in a beautiful city in the South West of England ❤️

jobs.exeter.ac.uk/hrpr_webrecr...

a man with long hair and a beard is sitting in the driver 's seat of a car . ALT: a man with long hair and a beard is sitting in the driver 's seat of a car .

Number 1 way journals make me happy at the moment:

"YOU DO NOT NEED TO SPECIFICALLY FORMAT YOUR MANUSCRIPT FOR FIRST SUBMISSION"

#AcademicLife #AcademicChat

Cumulative incidence of haemochromatosis-associated clinical outcomes in males HFE C282Y homozygotes in UK Biobank, stratified into two groups based on transferrin saturation polygenic score (highest vs. lowest quintile). This shows clearly that even within the high-risk C282Y group, likelihood of adverse consequences is influenced by non-HFE genetic variants that also impact iron

Latest preprint by PhD student Mitch Lucas on the genetic iron overload disease #haemochromatosis doi.org/10.1101/2025...

Massive study of factors affecting clinical outcomes in HFE carriers, including genetic predisposition to higher transferrin saturation

@janicelatkins.bsky.social
@exeter.ac.uk

Our Future Health: a unique global resource for discovery and translational research - Nature Medicine Our Future Health has recruited more than 1 million participants in the UK, with biobanked bloods, making it the largest consented cohort of its type in the world.

Very exciting to have access to "Our Future Health" data and begin understanding what is available and how to access it

Many thanks to the volunteers so far. Still a long way to go - consider signing up if you haven't already!

This is a greater primer on the aims www.nature.com/articles/s41...

Study of 230,000 people finds many examples where the effect of a genetic variant differs depending on the parent of origin, especially for growth and metabolism - fascinating!

Amazing study, congrats @rjhfmstr.bsky.social, @zkutalik.bsky.social and team 👏

Lots of instrumental music in my most listened artists... I cannot work if there is singing!

My latest data hobby: my Spotify listening history!

Had no idea until recently that you could download a history over ever song you've ever listened to. Cue some fun R hours!

Some surprising trends and top picks. Dominated by my work listening rather than "favourites"

lcpilling.github.io/spotify

Takes a while to get used to doesn't it! Glad the package helped. Any feedback/bugs/suggestions let me know!

Love a good DAG ❤️

Professor Jane Masoli introducing how secondary care electronic healthcare records data (Epic) can be used for research

Exciting session on using the (appropriately named) "Epic" secondary care electronic healthcare records data for research by Prof Jane Masoli (pictured), Dr Nick kennedy and Michelle Ledbetter at the @swaih.bsky.social 2025 meeting

@janemasoli.bsky.social
@drnickkennedy.bsky.social

A very inspiring talk! So many challenges to overcome... especially with the age demographic and rural challenges in the South West. Looking forward to the SDE sessions Jane

Inspiring talk by @jessrmorley.bsky.social‬ at the @swaih.bsky.social annual meeting

Really important issues to consider. Especially liked the "data availability law" (availability of high quality health data inverse to the health/care needs of the individual)

Lausanne Comp Bio Symposium 2025 (cbiosymposium.unil.ch)

🗓 Abstract deadline 30 June (𝟑 𝐝𝐚𝐲𝐬 𝐭𝐨 𝐠𝐨!!!)
🎤 Oral presentation notifications: 7 July
✅ Early Bird registration deadline: 11 July
💰 Registration fee for non-PI: 150 CHF

Is there anything as grossly unappealing yet probably quite important as mandatory H&S training?

My new fidget spinner. I am holding it in the auditorium

At the UK Human Functional Genomics Initiative @uk-fgx.bsky.social symposium @exeter.ac.uk, currently listening to intro from @jonathanmill.bsky.social

Picked up my first fidget spinner from BioFAIR @biofair.bsky.social which sounds a really cool initiative for open data and methods 🌟

So nice to be able to return a postive review. Great work authors, absolutely loved it ❤️

Just submitted responses to reviews on a grant we have in submission. Not sure how I will get anything done in the next few weeks with all my fingers crossed 🤞

Thanks Dominic! Glad it's helpful. Any comments, suggestions, bugs, just let me know 🤩

Wonderful paper. Congratulations

Exciting! Looking forward to the outputs

Google maps showing the route from Exeter to Swindon via Bristol

First time my donated blood has made it to Swindon! 🤩

Love getting these e-mails of where my blood was used 🩸

Easiest way to save a life. Give blood! 🌟

www.blood.co.uk