Wolfram Pönisch

Excited to share this new work from Ana Raffaelli, in collaboration with Ewa Paluch's lab and involving several of my colleagues at Cyclana Bio. In this paper, we show that basement membrane mechanics instructs developmental signalling and fate patterning.
www.biorxiv.org/content/10.6...

🚨 New Preprint from the Paluch & Chalut Labs 🚨
Ana Raffaelli et al show that the stiffness of substrate (in vitro) / basal membrane (in vivo) determine how cells interpret biochemical signals (BMP4) and which fates they acquire
#mechanobiology #hESCs #substratemechanics
doi.org/10.64898/202...

Next Monday, 16th Feb at 2:30 pm, we are excited to welcome Alexander Mietke from the University of Oxford! This will be an online session. Please join our mailing list to get the details of the talk! Hope to see many of you there :)

Excited to share Alison's @alisonkickuth.bsky.social paper from the lab out in @nature.com this week! We uncovered how a mechanical ratchet mechanism drives cytokinesis in early #zebrafish embryos. Read more in this thread 🧵 and at www.nature.com/articles/s41... 🤩
@poldresden.bsky.social @mpi-cbg.de

Thank you!

New preprint out! We use optogenetics, AFM, and active surface modelling to link signalling ⚡ → mechanics ⚙️ → cell shape 🔵

Thank you!

Thank you Caren. I am very optimistic that I will visit Cambridge from time to time.

Thank you Daniele!

Thank you so much

Thank you!

My group will investigate the stochastic morphodynamics of living systems at the interface of biophysical modelling and computational biology.

I will announce positions for PhD students and postdocs in the coming months! Feel free to DM me if you are interested!

Image of the Human Technopole https://it.wikipedia.org/wiki/Human_Technopole#/media/File:Human_Technopole_Milano.jpg

I'm super excited to announce that I will join the Human Technopole @humantechnopole.bsky.social in Milan in April 2026 as a Research Group Leader.

Good news in rough times:
Our work on generalising Lifshitz-Slyosov-Wagner (LSW) theory to active systems, led by the all-mighty Jonathan Bauermann, is out on PRL!! Special thanks to Christoph Weber @m-pol.bsky.social and Frank Jülicher.

doi-org.sire.ub.edu/10.1103/f5x9...

Join us next week (Wednesday!) for the next VGZT morning/eastern session ☀️ ☕️ seminar!

We are looking forward to exciting 🪰🪲 talks by:

Juan Manuel Gómez @gomezjm-devmech.bsky.social

and

Wolfram Pönisch @wolframponisch.bsky.social

🗓️ Wednesday, Feb 12
⏰ 18:00 JST / 10:00 CET / 9:00 UTC

Transport kinetics across interfaces between coexisting liquid phases We investigate the kinetics of material transport across interfaces in phase-separated mixtures. Using non-equilibrium thermodynamics we derive the interfacial kinetics, describing the movement of the...

1/6 🧪 Preprint-Alert!
We looked at how molecules move across phase boundaries, e.g., in liquid droplets, taking into account that chemical potentials inside and outside the boundary can be different!

This unites recent work with stuff from the 60s and has cool consequences 👇
shorturl.at/j0U6i