Graham Dellaire

Varicella-zoster virus reactivation and the risk of dementia - Nature Medicine Large-scale longitudinal health records reveal consistent association of varicella-zoster virus reactivation with dementia.

A new Nature Medicine study analyzing health records from >100 million people in the US offers compelling evidence that reactivation of varicella-zoster virus (VZV) ,the same virus that causes chickenpox and shingles may contribute to dementia risk.
www.nature.com/articles/s41...

It is kind of crazy that in the US, at least, gym bros would rather inject steriods or non-FDA regulated peptides but are afraid of a vaccine.

Can't Be Censored Society & Culture Podcast · Updated Biweekly · Tired of spin? Fed up with political correctness? So are we. Can’t Be Censored is a bold new show hosted by two seasoned journalists who’ve broken free...

IF you want some insight into the shenanigans going on, try listening to the other, other CBC - Can't Be Censored, started by Travis Dhanraj after his debacle with trying to resign and being told, er... you can't 🫠 2/2 podcasts.apple.com/ca/podcast/c...

Would be hilarious to keep dunking on PP, if he wasn't of right and that the CBC would quit gaslighting people about what has actually been accomplished. When the parliamentary budget officer raised alarm bells, the CBC dug out the old budget officer to chide him. Something is off 1/2

This is going to bring a whole new level of Type A behaviour among men... like the body dysmorphia and looks and gym maxing wasn't enough.

Boo - more deck chair arranging on the good ship SNAFU. They are stalling to prevent a confidence vote. Thing is nobody wants an election right away. I think the Libs are betting on this, and they will keep the meter running on spending while sneaking in service cuts and reallocation of funds.

To provide context... headers can be "broken" on purpose to prevent easy re-analysis using standard tools. Anyone who understands the various analysis pipelines can spend time to "repair" the headers and load software.

A huge number have messed up headers and need to be edited to allow analysis. Some of this is just versioning of software and propoagating errors, and sometimes its malicious.

The hip thrusts - chef’s 😘

Estrogen receptor α-mediated transcription induces cell cycle-dependent DNA double-strand breaks - PubMed Prolonged exposure to estrogen increases breast cancer risk. Estrogen is known to induce chromosomal aberrations, yet the mechanisms by which estrogen promotes genomic instability are not fully unders...

Likely a feature and not a bug… check out estrogen regulated genes and DMA damage. pubmed.ncbi.nlm.nih.gov/21112959/

First “spit take” of the week was just inspired by that! Brilliant.

Noooooo! Barfing cat is my least favorite sound.

Reason #75767 why you should stay away from this publisher.

Not sure doubling down on lithium ion battery investment for EVs make any sense though. Very hard to compete with Asia, especially starting at zero and being shut out of the US market.

Interesting! Napthalene is a major lu g irritant and can cause hemolytic anemia - so be careful.

AI migrant can be a line in your CV now.

Cell cycle matters - and epigenetic/transcriptional state of the locus. HDR is restricted to S and G2 of the cell cycle for example. Heterochromatin is differentially accessible to both Cas9 and repair machinery. #itscomplicated

Nice resource with a web portal for searching for genes involved in Cas9-induced double-strand break (DSB) repair. Web portal here: repairome.bioinfo.cnio.es

A South American lungfish against a black background, with text: This odd fish has 30 times as much DNA as humans—a new record for animals.

A species of lungfish found in South America has claimed the title of the animal with the biggest genome sequenced so far.

Learn more on #WorldAnimalDay: https://scim.ag/46OMl6v

On the left - western blot of B16F10 cells wt and KO for CDK8. Our in house produced antibodies give a lot of unspecific bands. On the right same probes with antibodies preincubated with fixed CDK8 KO cells - there is a specific band and faint unspecific bands, which can be probably eliminated with increase of amount of KO cells.

Neat trick if you polycolonal ab's suck. Incubate them with fixed cells with a KO of your protein of interest, then spin. Protocol here: www.med.upenn.edu/markslab/ass...
I was amazed how well it worked on first try (I'm sure that I can completely eliminate unspecific bands)
#WesternBlot #cellsky

Classic Yeast trick - for westerns, I incubate with a membrane with the KO for 30 min - pour off onto the new membrane with the WT cell line and BINGO! clean blots!

#FACTS - this is why top down science funding mechanisms do not create innovation - you need the freedom to create and funding mechanisms that support investigator-driven research are often more innovative.

Subcellular distribution of endogenous malectin under rest and stress conditions is regulated by ribophorin I Abstract. Malectin is a newly discovered endoplasmic reticulum (ER)-resident lectin, which specifically recognizes Glc2Man9GlcNAc2 on newly synthesized gly

"we found that endogenous malectin mainly localizes in the ER, which is disrupted upon suppression of ribophorin I, leading to its movement from ER to Golgi. In contrast, under ER-stress conditions, malectin mainly localizes in the Golgi" 😀 BOTH RIGHT! academic.oup.com/glycob/artic...

Pepper harvest continues - Jalapeños and Banana Peppers! 🌶️

Cool! Anyone else think - endoplasmic reticulum (ER) as soon as they saw this protein’s localization 🙂🙋‍♂️

We have a new PhD studentship in the lab on the immunogenic roles of transposable elements in paediatric acute myeloid leukaemia! Come and work with us! www.colcc.ac.uk/2026-cyp-phd...

a man wearing glasses is sitting in front of a bookshelf filled with books ALT: a man wearing glasses is sitting in front of a bookshelf filled with books

L OV E THIS!

The boys are back!

Image depicting the napari viewer in grid mode with scale bars and color bars enabled

napari 0.6.5 is out! 🚀

Rapid-fire highlights are: colorbar overlay, custom startup script, and better and prettier documentation! Check out the full release notes here: https://napari.org/dev/release/release_0_6_5.html

Morag is well overdue! Give my congrats if you see here with TFRI stuff.