Haering Lab

Congratuations to our PhD Student @gurumoorthya.bsky.social on winning the Poster Award for his work on gene regulation by DNA loop extrusion and phase separation at the CNIO-CaixaResearch Frontiers Meeting on "Machines acting on DNA and RNA, a molecular mechanistic perspective"!

Adding a twist to the loops: the role of DNA superhelicity in the organization of chromosomes by SMC protein complexes Structural maintenance of chromosomes (SMC) protein complexes, including cohesin, condensin, and the Smc5/6 complex, are integral to various processes in chromosome biology. Despite their distinct rol...

In our latest mini review, Toni Valdes and I discuss the potential role(s) of DNA superhelicity in the organization of chromosomes by SMC protein complexes, covering classical biochemistry experiments to recent single-molecule biophysics studies.
doi.org/10.1042/BST2...