Emmottlab

Congrats to Dr @stephenholmes.bsky.social on passing his PhD viva today! Thanks to examiners Al Darby and @mtrost.bsky.social!

For those who missed the British science festival in September, the recordings and mini documentary for antiviral roller skating are now out!

Mitophagy-related prohibitin 2 is an orthoflavivirus restriction factor targeted for degradation during infection Mitophagy selectively removes depolarised and damaged mitochondria, promoting cell viability. Some members of the Orthoflavivirus genus activate mitophagy to allow extended replication times in a surv...

Another new preprint! This time looking at flavivirus NS5 interactions with our collaborator Armando Arias - www.biorxiv.org/content/10.6...

Markella introduces the preprint in her thread here: bsky.app/profile/biom...

Single-cell phenotypic analysis and multiplet detection through incorporation of microscopy data into cellenONE-based single-cell proteomic data analysis The reliability of single-cell proteomics (SCP) is intrinsically linked to the fidelity of cell isolation; however, the identification of co-isolated cells (doublets or multiplets) remains a persisten...

New preprint from the lab, and joint first authors @biomarkella.bsky.social and @stephenholmes.bsky.social!

Single-cell phenotypic analysis and multiplet detection through incorporation of microscopy data into cellenONE-based single-cell proteomic data analysis

www.biorxiv.org/content/10.6...

Viral protease-mediated polyprotein processing in human astroviruses Positive-sense RNA viruses often encode large polyproteins that are proteolytically processed by viral and host proteases into functional replication proteins. Astroviruses infect intestinal and neuro...

New preprint: Viral protease-mediated polyprotein processing in human astroviruses

Great collaboration with Lulla lab. And the first of @leandroxneves.bsky.social proteolysis stories. More coming soon!

www.biorxiv.org/content/10.1...

New preprint: IFIT3 controls IFIT1 accumulation and specificity preventing self mRNA targeting during the innate immune response.

www.biorxiv.org/content/10.1...

Led by Renata Fleith from the Sweeney lab.

MRC DiMeN Doctoral Training Partnership: Molecular Regulation of Proteolysis by Hepatitis E Virus as a Basis for Therapeutic Intervention at University of Leeds on FindAPhD.com PhD Project - MRC DiMeN Doctoral Training Partnership: Molecular Regulation of Proteolysis by Hepatitis E Virus as a Basis for Therapeutic Intervention at University of Leeds, listed on FindAPhD.com

Funded PhD opportunity through the DiMeN DTP: studying HEV proteolysis. You’ll be primarily based in the Herod lab at Leeds, and work with us on the use of MS-based proteomics to study proteolysis! www.findaphd.com/phds/project...

We are still buzzing from our show! Here’s some snaps of what you missed… in case you were wondering….

Huge thank you to the whole production team and the people who made this happen!

@microbiologysociety.org @britsciassoc.bsky.social @emmottlab.bsky.social @livuninews.bsky.social
#BSF25

The lab is being represented at the IX International Calicivirus Conference in Banff by @tartanvirus.bsky.social! Catch Frazer to talk protease substrates and proteomics.

Led by @idb-virology.bsky.social, the lab is contributing to #BSF25 with a performance of antiviral roller skating!

Working with Liverpool roller birds, and supported by the BSF and @microbiologysociety.org

Photo of Dr Max Erdmann overlaid with text reading "Scientific Advisors Dr. Max Erdmann and Dr Ed Emmott" with the Emmott Lab logo beneath the text.

Graphic with a greyscale background that reads "inspired by Bus Regulation: The Musical created by Ellie Harrison. Funding sources: Microbiology Society and British Science Association

👨‍🔬Scientific Advisors Drs. Max Edrmann & Ed Emmott @edemmott.bsky.social

🎭 Inspiration: "Bus Regulation: The Musical" by Ellie Harrison @ellieharrison.bsky.social

💷 Funded by @microbiologysociety.org & @britishscienceassociation.bsky.social

#bsf25 #scicomm #sciencecommunication
#skating #sciart

A photo of I'ah Donovan-Banfield presenting introductory slides to the cast, with text above reading: "written, Directed and Produced by I'ah Donovan-Banfield"

A photo of Ani Bosco, with her back to the camera, leading the choreography of the first rehearsal with five skaters in the background with joined hands. Text overlaid reads "Choreographed by Ani Bosco"

Photos of [left to right] Director of Photography Dr Rebee Penrice-Randal and Videographer Jon Stonehouse of Paroketh Films.

🤝 A collaboration between @liverpooluni.bsky.social & Liverpool Roller Birds

✍️🎬 Written, Directed & Produced by Dr. I'ah Donovan-Banfield @idb-virology.bsky.social

👯‍♀️Choreographed by Ani Bosco

📸 Director of Photography Dr. Rebee Penrice-Randal @rebee.bsky.social

📹 Videography by Paroketh Films

Encephalomyocarditis virus protein 2B* interacts with 14-3-3 proteins through a phosphorylated C-terminal binding motif | mBio Encephalomyocarditis virus (EMCV) infects a range of species, causing economically important reproductive disorders in pigs and encephalitis and myocarditis in rodents. Due to its wide host range, it ...

New paper: collaboration with Cambridge on EMCV 2B* now published journals.asm.org/doi/10.1128/...

@biomarkella.bsky.social

Congratulations to Markella Loi from the @emmottlab.bsky.social on winning the Early Career Award for #BSPR2025 and congratulations to @hannahmayging.bsky.social on being the runner

Certificate for a LEAF gold award for the centre for proteome research

The lab got a nice bit of news yesterday! LEAF gold!

MSCA opens €404.3 million call for Postdoctoral Fellowships Postdoctoral Fellowships offer researchers holding a PhD the opportunity to acquire new skills through advanced training and international, interdisciplinary, and inter-sectoral mobility.

We have projects available on single-cell proteomics, including methods development, and applications to antiviral development and resistance. If you have a strong background in proteomics and are considering an MSCA, get in touch! marie-sklodowska-curie-actions.ec.europa.eu/news/msca-op...

Nikolai and his group are based at Northeastern University and have been pioneers in the field of single cell proteomics.

He will talk about the methods his lab has worked on for multiplexed approaches in SCP, including plexDIA

As we get ready for the British Society for Proteome Research annual meeting in Liverpool (July 7-9th), we will start highlighting our amazing speakers.

First is @slavov-n.bsky.social who will talk to us about Biological and technological frontiers for single-cell proteomics.

Rebee and Max selfie in front of microsoc poster

Max looking happy with his microsoc poster presentation

First poster as @emmottlab.bsky.social PDRAs 🥳

#Microsoc25

Emergence of SARS-CoV-2 subgenomic RNAs that enhance viral fitness and immune evasion Coronaviruses can evolve novel transcription regulatory sequences, generating new RNA transcripts during human infection. This study identifies a prevalent subgenomic RNA in SARS-CoV-2, which produces...

First 2025 paper: delighted to have contributed to this paper on the emergence of a new subgenomic mRNA in SARS-CoV-2 from the Bauer lab

journals.plos.org/plosbiology/...

Investigation of Novel Accessory Proteins in the Replication of Infectious Bronchitis Virus at The Pirbright Institute on FindAPhD.com PhD Project - Investigation of Novel Accessory Proteins in the Replication of Infectious Bronchitis Virus at The Pirbright Institute, listed on FindAPhD.com

Another PhD studentship is available for Oct 2025 start! In a collaboration between the @pirbrightinst.bsky.social and us, you will be investigating the role of novel avian coronavirus accessory genes. See here for more details! www.findaphd.com/phds/project...

Deadline 17 Feb, funded for UK only.

BBSRC NWD CASE: Expanding single-cell proteomics into single-cell multi-Omics at University of Liverpool on FindAPhD.com PhD Project - BBSRC NWD CASE: Expanding single-cell proteomics into single-cell multi-Omics at University of Liverpool, listed on FindAPhD.com

The deadlines for our MRC-funded studentships have now passed, but a funded studentship through the BBSRC NWD DLA is now available for Oct 2025 start in single cell mass spectrometry. See findaphd for more details or drop Ed an email.

www.findaphd.com/phds/project...

Reminder - if you are a new PI in UK virology and you aren’t yet registered for RIVR2025 on Jan9-10th in Liverpool, registration closes on December 5th!

If you are a new group leader in virology in the UK and aren’t yet on the RIVR mailing list, get in touch to be added.

Single cell proteomics! 🙋‍♂️

Loading a mass spec and a nanopore in the same day! Thrilled to be learning another omics method in the @emmottlab.bsky.social 🧬

🙋🏻‍♂️

MRC DiMeN Doctoral Training Partnership: Widening the ‘NET’ to identify new treatments for bronchiectasis at University of Liverpool on FindAPhD.com PhD Project - MRC DiMeN Doctoral Training Partnership: Widening the ‘NET’ to identify new treatments for bronchiectasis at University of Liverpool, listed on FindAPhD.com

The second is primarily based with Dr Helen Wright, and alongside Dr Freddy Frost to study neutrophil NETs and bronchiectasis. We provide training in proteomics and this builds on some of the clinical proteomics we have done to study CF.

More details here: www.findaphd.com/phds/project...

MRC DiMeN Doctoral Training Partnership: Understanding the mechanisms of norovirus replication at University of Liverpool on FindAPhD.com PhD Project - MRC DiMeN Doctoral Training Partnership: Understanding the mechanisms of norovirus replication at University of Liverpool, listed on FindAPhD.com

The first is based primarily in our lab and builds on our work on coronavirus and norovirus replication in collaboration with Prof Al Darby and Dr Dom Byrne.

More details here: www.findaphd.com/phds/project...