Andreas Schaefer

Nondestructive X-ray tomography of brain tissue ultrastructure - Nature Methods Optimizations of X-ray nanotomography including the choice of resin allows high-resolution imaging of mouse brain tissue, approaching the resolution of volume electron microscopy. Since it does not re...

An optimized X-ray nanotomography method offers an attractive alternative to volume EM for connectomics. @crick.ac.uk @psich.bsky.social psich.bsky.social @adrianawanner.bsky.social @andreas-t-schaefer.bsky.social @ucl.ac.uk @uclnpp.bsky.social
www.nature.com/articles/s41...

By repurposing a radiation-hard epoxy resin from the nuclear/aerospace industry, we made samples withstand >1.15×10¹⁰ Gy and reached sub-40 nm resolution, revealing axons, dendrites, mitochondria and synapses without sectioning.

In a fantastic collaboration co-led by Ana Diaz (@psich.bsky.social), Carles Bosch @carlesbosch.bsky.social) and Andreas Schaefer (@andreas-t-schaefer.bsky.social) from @crick.ac.uk,we tackled a key barrier in X-ray ultrastructural imaging: achieving <40 nm resolution without destroying tissue.

... but also DM if interested in experimental / computational (or mixed) connectomics postdoc positions

Postdoctoral Fellow – X-ray image reconstruction for connectomics Salary for this Role: From £45,500 with benefits, subject to skills &amp; experience Job Title: Postdoctoral Fellow – X-ray image reconstruction for connectomics Reports to: Andreas Schaefer Closing D...

DM me if you are keen to join the team - open positions:
(1) computational imaging postdoc: multislice & beyond DOF reconstructions - crick.wd3.myworkdayjobs.com/External/job...
(2) experimental, permanent senior scientist: X-ray, EM, sample prep… crick.wd3.myworkdayjobs.com/External/job...

X-rays can resolve ultrastructure - milestone for ultrastructure imaging w/o cutting. Thanks to an amazing team -
@carlesbosch.bsky.social
@adrianawanner.bsky.social
Ana Diaz and collaborators
@crick.ac.uk
@psich.bsky.social and
@esrf.fr
and funders
@wellcometrust.bsky.social
@ukri.org

If you are looking for an experimental X-ray connectomics postdoc please DM as well

First two positions:
(1) computational imaging postdoc: multislice & beyond depth of field reconstructions - crick.wd3.myworkdayjobs.com/External/job...
(2) experimental, permanent senior scientist: X-ray tomography, EM, sample prep… crick.wd3.myworkdayjobs.com/External/job...

Enthusiastic about connectomics and X-rays?
Several positions in our group at Crick for postdocs and senior scientists (permanent!).
DM me if interested – and let’s talk if you are at Sfn next days or at the NIH BRAIN CONNECTS meeting today!

Please share!

Join us at Crick - amazing team and great colleagues to collaborate on exciting design and development projects

Bit more than 2 weeks to go...
DM me if you will be in San Diego at SfN and want to talk about it. Please share.

Very excited to continue our amazing collaboration with @apacureanu.bsky.social at @esrf.fr - thank you @wellcometrust.bsky.social and all the collaborators at @crick.ac.uk and @esrf.fr

James DiFrisco

E.g. www.crick.ac.uk/research/lab...

To emphasize: It doesn't matter what aspect of life science you are interested in - we have ancient genomics, computational neuroscience, philosophy of science, cancer biology... anything fits!

The Crick is an absolutely amazing place to work in - please share this opportunity widely with your colleagues and postdocs - and DM me if I can help in any way

Judging by the last ones, this will be amazing - and with all the new developments at next gen synchrotrons, even more timely. Please re-post, join in person if you can travel to London or via zoom

PhD students Our PhD programme attracts the brightest scientific minds and is an opportunity for talented people to embark on their career in biomedical research.

Motivated graduates with backgrounds in biological or biomedical sciences, physics, chemistry, mathematics, engineering and/or computer science are invited to apply to our 4-year fully funded PhD programme.

Apply by 05 November 2025

www.crick.ac.uk/careers-and-...

The Molecular Brain Mapping group at the MRC-LMB is hiring! 🌈🧠

I'm looking for people who are excited about developing multimodal analysis and visualization tools to capture the "hidden connectome," in a highly intersectional environment exploring ideas in meta-science.

mrc.tal.net/vx/mobile-0/...

@uclnpp.bsky.social @crick.ac.uk @uclqsion.bsky.social @hugolayardhorsfall.bsky.social, Mihaly Kollo, Will Muirhead @hanimarcus.bsky.social Tom Mrsic Flogel @sainsburywellcome.bsky.social

Lots of exciting clinical PhD projects at Crick - including the opportunity for neurosurgeons to work with us and record electrical activity in patients with neuropixels probes. Please share widely!

Great opportunity to work with an amazing team on the frontiers of X-ray connectomics www.psi.ch/en/hr/job-op...

Applications are now open for the SWC Systems Neuroscience PhD Programme.

Join us in London!

🧠 World-class neuroscience training
💰 Fully-funded 4-year programme
🖥️ Close links to @gatsbyucl.bsky.social

Apply by 3 Nov: www.sainsburywellcome.org/web/content/...

#preprint:

We optimised the preparation of tissues for #X-ray phase contrast imaging.

Drying tissue samples (instead of embedding them) brings more signal in #X-ray phase contrast images.

The process largely preserves #ultrastructure.

@safekhan.bsky.social @andreas-t-schaefer.bsky.social

Critical point drying of brain tissue for X-ray phase contrast imaging X-ray phase contrast tomography is emerging as a powerful method for imaging large volumes of brain tissue at sub-cellular resolution. However, current sample preparation methods are largely inherited...

Our pre-print is out!
Critical point drying of brain tissue for x-ray phase contrast imaging.
@apeart.bsky.social @yuxinzhang.bsky.social @jkbrmn.bsky.social @apacureanu.bsky.social @andreas-t-schaefer.bsky.social
@carlesbosch.bsky.social
@esrf.fr
@crick.ac.uk
bioarXiv: doi.org/10.1101/2025...

Heidelberg castle by night with reflections of light in the Neckar river

We are looking for an IT engineer with a focus on operations and research data management at the Centre for Organismal Studies at @uniheidelberg in Heidelberg, Germany
#IT #sysadmin #linux #ResearchData
please help to spread this opening […]

[Original post on biologists.social]

We watched mice follow scent trails drawn on an “endless” treadmill. By manipulating trail geometry/statistics, perturbing mouse nose & brain, and modeling behavior with a Bayesian framework, we show that mice use predictive (rather than reactive) strategies.

And we are off - excited that #cns2025florence is under way with record attendance - first keynote starts in 5 minutes.

Scary. Authors building in hidden instructions for presumed LLM peer reviewers (in white text on white background).

Health research in England is grinding to a halt Wes Streeting, the UK health and social care secretary, announced in 2024 that “the NHS is broken” against a background of ballooning waiting lists, delays in disease detection, and reduced staff prod...

Clinical research in England is wild! 3+ years, 20+ meetings, 200+ documents, 500+ emails is what it can take to open a fully funded, observational non-CTIMP study.

Thank you @chrischirp.bsky.social and colleagues for calling attention to this urgent, solvable crisis!

www.bmj.com/content/390/...