Gorkiewicz Lab @ Med Uni Graz

🏰 Kicking off the 2nd Annual Meeting of our @fwf-at.bsky.social Cluster of Excellence @microbesplanet.bsky.social at beautiful Castle Schlaining! 🌍

Excited to share ideas 🔬, spark collaborations 🤝, and explore how microbiomes shape the health of our planet 🌱

#Microbiome #PlanetaryHealth #MicroSky

What an inspiring few days! The 2nd CoE Microplanet Annual Meeting at Castle Schlaining hosted 95 scientists to discuss the latest in microbiome research and how these microbial communities can help build a more sustainable future. Thanks to everyone who contributed!
@fwf-at.bsky.social

#EESMicrobiome

Our lab is pleased to be invited to @events.embl.org today, where a conference on the human microbiome starts. @patrickschimmel.bsky.social will be featured in Thursday morning's sessions and will present on FMT for Ulcerative Colitis and mechanism of efficacy beyond bacterial engraftment.

Also thanks to members of the lab that were included in the poster sessions. @patrickschimmel.bsky.social , @kl-fil.bsky.social and Marija Durdevic!

Our PI Gregor Gorkiewicz presented our work at bageco.org 2025 in Graz. Showing the complexity of Fecal Microbiota Transplantation for IBD patients and how we are hunting for mechanisms behind remission. Thanks for the invitation, @gabrieleberg.bsky.social #humanmicrobiome #ibd #fmt

Congrats to our close collaborator @chmoei.bsky.social !!

Congrats from our Lab, Christine. Very curious to hear what the plans will be!

We are also looking for students in this regard! Come join our fascinating science on host-microbiome interactions, IBD treatments and the tumor microbiome! #microbiome #IBD #guthealth #cancerprevention

Fusobacterium nucleatum is enriched in invasive biofilms in colorectal cancer Fusobacterium nucleatum is an oral bacterium known to colonize colorectal tumors, where it is thought to play an important role in cancer progression. Recent advances in sequencing and phenotyping of F. nucleatum have revealed important differences at the subspecies level, but whether these differences impact the overall tumor ecology, and tumorigenesis itself, remain poorly understood. In this study, we sought to characterize Fusobacteria in the tumor microbiome of a cohort of individuals with CRC through a combination of molecular, spatial, and microbiologic analyses. We assessed for relative abundance of F. nucleatum in tumors compared to paired normal tissue, and correlated abundance with clinical and pathological features. We demonstrate striking enrichment of F. nucleatum and the recently discovered subspecies animalis clade 2 (Fna C2) specifically in colon tumors that have biofilms, highlighting the importance of complex community partnerships in the pathogenesis of this important organism. ### Competing Interest Statement C.L.S. has received research funding to Johns Hopkins University from Bristol-Myers Squibb and Janssen, and royalties from Up to Date outside the submitted work. J.R.W. reports equity ownership of Resphera Biosciences.

Our latest selection for our Journal Club: The role of Fusobacterium in Colorectal Cancer is a focus of gut microbiome research. Interesting work by Queen et al.! www.biorxiv.org/content/10.1...
Next Journal Club: 13th of May 13:00. Students of @medunigraz.at, message this channel if interested.

Congrats to Himadri Thapa et al.

Enrichment of human IgA-coated bacterial vesicles in ulcerative colitis as a driver of inflammation - Nature Communications Gut microbiota contribute to the pathogenesis of ulcerative colitis (UC), but the molecular mechanisms are still unclear. Here the authors show that colonic fluid from patients with UC is enriched for...

Vesicles & inflammations in IBD! Our group (@medunigraz.at)has worked together with the group of Stefan Schild (@uni-graz.at) to characterize bacterial vesicles in our clinical cohorts. Published in @natcomms.nature.com doi.org/10.1038/s414...

The Gut Health Benefits of Sauerkraut From the College of Agricultural and Environmental SciencesIs sauerkraut more than just a tangy topping? A new University of California, Davis, study published in Applied and Environmental Microbiolog...

rmi.ucdavis.edu/blog/gut-hea... Yes, #fermentation #fermented foods are great for your #microbiome so I make my own and also pickles

Other permanent members & students: from left to right: Gregor Gorkiewicz (PI), Martin Zacharias, Silvia Schauer, Marija Durdevic, Sophie Steinkögler

Meet our Lab! and follow some of its members on Bsky! @patrickschimmel.bsky.social, @kl-fil.bsky.social.

#KSHostMicrobe25

Last week, our lab was invited to talk at @keystonesymposia.bsky.social, where we talked about FMT & IBD and investigations on triggers towards healing. #gutmicrobiome #mucosalimmunity #fmt #ibd We would like to thank the organizers for a great meeting. Speaker: @patrickschimmel.bsky.social

Just started with the Keystone Symposia at #KSHostMicrobe25 in a breathtaking environment. This afternoon I will be giving a short talk about microbiome transplantation efficacy in IBD, looking beyond bacterial engraftment: work from the @gorkiewiczlab.bsky.social. Hope to see you there.

Happy to join @keystonesymposia.bsky.social for the first time for the Q8 Host-Microbe Co-Evolution in Human Health in a few weeks. Our lab @gorkiewiczlab.bsky.social will be talking about the effects of fecal microbiome transplantation at the mucosa. Lifting the veil beyond microbial engraftment.

Ten species comprise half of the bacteriology literature, leaving most species unstudied Microbiology research has historically focused on a few species of model organisms. Our bibliographic analysis finds extreme bias in the distribution of bacteriology research across species, with half...

Some part of key interactions with the host and metabolism are missing, to understand the microbiome in health and disease.

Ten species comprise half of the bacteriology literature, leaving most species unstudied | bioRxiv doi: doi.org/10.1101/2025...

1st anniversary of our #FWF Cluster of Excellence "Microbiomes Drive Planetary Health"! Inspiring meeting with groundbreaking ideas, especially from our diverse group of international early career researchers. Exciting research is on the horizon - stay tuned for more updates!