Typas Lab

Super excited to share our new selection-free CRISPR-Cas9 editing protocol for Dictyostelids, generating 80% KO and 30% KI efficiencies without selection in D. discoideum, and being effective in Dictyostelid species that diverged millions of years ago! www.biorxiv.org/content/10.1...

HT-PELSA, a new proteomics tool by EMBL researchers, processes samples 100x faster and works directly with complex crude cell, tissue, and bacterial lysates – developments which could accelerate drug discovery and basic biological research 💊

🔗 www.embl.org/news/science...

Happy to see our HT-PELSA paper now published in @natsmb.nature.com 🎊 Big thanks for the constructive review process! 📖Read the manuscript here (www.nature.com/articles/s41...) & check the thread for additional information ⬇️

Isolation, engineering and ecology of temperate phages from the human gut - Nature Human host-associated cellular products may act as induction agents for bacteriophages.

Very excited to share the latest work from our lab, which was published today in Nature!
nature.com/articles/s41...

PhD graduate and now post-doc Sofia Dahlman, along with co-senior author Sam Forster from The Hudson and other researchers from our lab and others.

How nutrient starvation impacts the gut microbiome - Nature Microbiology In this Perspective, Estrela and Huang discuss nutrient starvation in the context of the gut microbiome, outlining what is known and highlighting key questions for future research to address knowledge gaps.

#Perspective

Estrela and Huang discuss nutrient starvation in the context of the gut microbiome, outlining what is known and highlighting key questions for future research to address knowledge gaps.

#MicroSky #MicrobiomeSky 🦠

www.nature.com/articles/s41...

Structure of a distinct β-barrel assembly machinery complex in the Bacteroidota - Nature Microbiology Structural and functional characterization of the β-barrel assembly machinery complex in Bacteroidota reveals a distinct, seven-component complex with a large extracellular domain that may enable β-barrel–surface lipoprotein complex assembly.

Our paper on the Bacteroidota BAM complex is out in @natmicrobiol.nature.com! With @madejmar.bsky.social

We found that BAM in Bacteroides and Porphyromonas gingivalis has a distinct architecture from BAM in Proteobacteria.

doi.org/10.1038/s415...

E15 Groups The Helmholtz Institute for RNA-based Infection Researchopens a call for

Looking to start your own lab? 🧬🧪 The Helmholtz Institute Würzburg (HIRI) is offering group leader positions in RNA biology, RNA medicine & RNA technology. Apply by October 31 at www.helmholtz-hiri.de/en/jobs-tale...

Great collaboration inside and outside @embl.org with @kiranrpatil.bsky.social @indraroux.bsky.social @zimmermannlab.bsky.social @zellerlab.bsky.social
@EMBLHeidelberg

We systematically compared essential genes, protein domains & non-coding elements, uncovering toxic modalities & functional redundancy as key aspects of species-specific essentiality.

Excited to share our preprint led by Carlos Voogdt et al

We developed new genetic tools & genome-wide libraries for species of the Bacteroidales order; constructed saturated barcoded transposon libraries in key representatives of three genera.
www.biorxiv.org/content/10.1...

Two group leader positions available in the broader areas of RNA science, RNA technologies, and RNA medicine. Attractive packages and a great environment. Come and join us at Helmholtz RNA Würzburg, Bavaria.

High-accuracy SNV calling for bacterial isolates using deep learning with AccuSNV Accurate detection of mutations within bacterial species is critical for fundamental studies of microbial evolution, reconstructing transmission events, and identifying antimicrobial resistance mutati...

Precisely calling mutations across hundreds of bacterial isolates has been hard, requiring manual filtering and expertise.

Until now, using AccuSNV.

Herui Liao trained an ML model based on our previous meticulously called SNVs.
www.biorxiv.org/content/10.1...

📣The 2026 ERC Consolidator Grant competition is now open! 📣

Already preparing your proposal? Info links ⬇️

Info for applicants 👉 buff.ly/PSbeUxX

Application portal 👉 buff.ly/mauZoqo

Deadline: 13/01/26

General info on #ERCCoG 👉 buff.ly/KCN6GTh

Bildschirmpräsentation mit der Vita von Prof. Dr. Lisa Maier, Mikrobiologin an der Uni Tübingen, zur Verleihung des Hauptpreises der DGHM in Jena.

Mikrobiologin Prof. Dr. Antje Flieger liest die Laudatio für Prof. Dr. Lisa Maier zur Verleihung des Hauptpreises der DGHM in Jena. Preisträgerin Lisa Maier steht links neben ihr.

🏆 Fighting the Gender Award Gap: Microbiologist Prof Dr Lisa Maier from @unituebingen.bsky.social received the main award of the German Association for #Microbiology and Hygiene at the #DGHM meeting in Jena. Congratulations to @lisamaierlab.bsky.social we are proud of you! 💜
📸 Gabriele Pradel

Directors The Max Planck Society offers Directors a unique platform for groundbreaking research and leadership in diverse scientific fields.

Open Call for Expressions of Interest: become a Max Planck Director & redefine what’s possible in science! We offer scientific independence, long-term stable funding & exceptional infrastructure. Lead your own department & open new frontiers of research. Apply by 31 Oct 2025 → www.mpg.de/directors

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Early-career researchers: want to run your own lab? 🌟Max Planck Research Groups offer 6+ years, up to €2.7M in funding, open-topic freedom, team support & tenure-track opportunities. Intrigued? 😃Apply by Oct 14, 2025! www.mpg.de/max-planck-r...

Join EMBL AI!

We have ambitious plans to transform life sciences research through AI.

Interested in using ML/AI to solve complex interdisciplinary challenges?

We’re looking for two senior leaders based at EMBL Heidelberg👇

Description Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...

New academic faculty posts available at Imperial College London! Assistant/Associate Professors in Life Sciences. Please apply and/or circulate details!

www.imperial.ac.uk/jobs/search-...

Looking for a new approach to studying or eliminating phages? Check out our study introducing anti-phage ASOs (antisense oligos) out in @Nature today. nature.com/articles/s4158…

YouTube video by Oxford Biology Oxford Biology in the LaMB

🚨 We’re hiring! Oxford Biology is recruiting 3 new Associate Professors in:

🌱 Plant Sciences
🦉 Animal Behaviour
🔬 Molecular Cell Biology

Join us as we move into our new building with world-class research & teaching facilities.

Vacancies 👉 bit.ly/488CNW3

View our video here: youtu.be/TZa1x0oyqA0

Call for Applications / Ausschreibung

Springboard for an international scientific career! 🧬🧪🔭⚛️🧠🌱 Call for #MaxPlanckResearchGroups launched; applications are possible until October 14, 2025 www.mpg.de/max-planck-r... #ScienceCareer

Dissecting microbial communities with single-cell transcriptome analysis Revealing insights into the function of microbial communities requires moving beyond measuring bulk taxonomic composition to detecting interactions between subpopulations. Following the transformative...

In a new #ScienceReview, researchers investigate how the recent application of single-cell RNA sequencing technology has helped to evaluate function in microbial populations. https://scim.ag/3V2kc6l

W 3 professorship in Molecular and Evolutionary Zoology - Kiel, Schleswig-Holstein (DE) job with Christian-Albrechts-Universität zu Kiel | 12844416 Kiel University aims to attract more qualified women to professorship positions. The Institute of Zoology at the Faculty of Mathematics and Natural...

A call for W 3 (full) professorship in Molecular and Evolutionary Zoology is now open at our department. Join our community of evolutionary biologists! Excellent facilities and scientific environment!
www.nature.com/naturecareer...

Bacterial cell widening alters periplasmic size and activates envelope stress responses
Kerwyn Huang, @typaslab.bsky.social et al find that E. coli outer-membrane protein RcsF senses reduced periplasm thickness due to increased cell width, & activates Rcs signaling
www.embopress.org/doi/full/10....

Predicting natural variation in the yeast phenotypic landscape with machine learning | Molecular Systems Biology imageimageAn ensemble of phenotypes measured in the genome-sequenced 1,011 S. cerevisiae collection were coupled with genomics and molecular-level data to benchmark machine learning models for quantitative phenotypic predictions at scale. Large-...

Delighted to see @sakshikhaiwal.bsky.social work in print www.embopress.org/doi/full/10....
Huge thank to @univcotedazur.bsky.social for providing extensive support on this project, @pedrobeltrao.bsky.social and Jonas groups for huge help, @cnrs.fr @ircan.bsky.social

Career opportunities at the Baker Heart and Diabetes Institute The Baker Heart and Diabetes Institute is an independent, internationally renowned medical research facility. We have a long and distinguished history, spanning more than 97 years with our work critic...

Come join the Baker Heart and Diabetes Institute @bakerresearchau.bsky.social as a Lab Head in Biomedical Data Science 📣 www.baker.edu.au/career/head-...

There's never been a more exciting time to lead a research program in this area... and have work-life balance to boot!

credit: EMBL

Time to accelerate! ⏱️4 weeks left to apply for EMBL ARISE2 fellowship programme.

Are you interested in developing or improving technologies for life science research? #ARISE2 trains you to become a future research infrastructure leader. 🧪

Apply now! www.embl.org/training/ari...
#careers

Faculty recruitment - Our Scientists Applications for faculty positions are currently being accepted. Application deadline is October 6, 2025.

Applications for faculty positions at Rockefeller are now open! We are seeking exceptional, creative scientists to join our faculty.

Learn more below:

Group Leader Career Development Fellowships - Dunn School Are you an early career researcher interested in the cell or molecular mechanisms underlying disease? Do you have an outstanding record and an innovative research plan?

Are you a postdoc interested in the mechanisms of disease?

Do you have a great record and an exciting vision?

Come and start your own lab @dunnschool.bsky.social by applying for sponsorship for early career fellowships.

Deadline 30th September...pass it on!

www.path.ox.ac.uk/work-with-us...

📢 Recruitment for the EMBL International PhD Programme is officially open!

At EMBL, we train young scientists to become skilled and creative future leaders in academia and other sectors. Join us and get a head start on your career in life sciences!

bit.ly/47mmiFF