Typas Lab

Group Leader - Genome Biology Unit Are you ready to lead groundbreaking research in Genome Biology? Join us at EMBL! We are seeking a motivated scientist to lead an independent research group addressing exciting and original biological...

To all post-docs: The Genome Biology dept ‪@embl.org
has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

Group Leader – Molecular Systems Biology Unit Are you ready to lead groundbreaking research in Molecular Systems Biology? Join us at EMBL! We are seeking a motivated scientist to lead an independent research group, addressing original biological ...

Pitch your visionary research plan and shape the future of molecular systems biology with us!

Apply by 22 Sep 2025.
embl.wd103.myworkdayjobs.com/en-US/EMBL/d...

@embl.org, @EMBLHeidelberg
#systemsbiology #groupLeader #research #molecularBiology

EMBL offers:
Generous core funding & resources
International, interdisciplinary and highly collaborative environment
Global excellence, visibility and a broad scientific hub
Leadership opportunities & mentoring

We welcome scientists with bold, original ideas—whether your expertise is in integrative structural biology, computational/AI-driven systems, protein design, synthetic biology, high-throughput & data-driven approaches, or innovative genome engineering.

Join a vibrant, interdisciplinary department to build your independent research group, tackling big questions at the molecular, cellular or systems level.

Group Leader – Molecular Systems Biology Unit Are you ready to lead groundbreaking research in Molecular Systems Biology? Join us at EMBL! We are seeking a motivated scientist to lead an independent research group, addressing original biological ...

Ready to lead pioneering research that bridges systems-level investigations of biological systems to molecular mechanism? The EMBL Molecular Systems Biology Unit in Heidelberg is hiring a Group Leader!

Controlled colonization of the human gut with a genetically engineered microbial therapeutic Precision microbiome programming for therapeutic applications is limited by challenges in achieving reproducible colonic colonization. Previously, we created an exclusive niche that we used to engraft...

This work shows a controllable method for colonizing the human gut with engineered bacteria, enabling precise and reversible microbiome therapies and bringing synthetic-biotics closer to clinical reality

www.science.org/doi/10.1126/...

Planetary microbiome structure and generalist-driven gene flow across disparate habitats Microbes are ubiquitous on Earth, forming microbiomes that sustain macroscopic life and biogeochemical cycles. Microbial dispersion, driven by natural processes and human activities, interconnects mic...

Our new preprint is out!
www.biorxiv.org/content/10.1...
In this study, we present the largest systematic analysis of microbiome structure and function, integrating 85K uniformly processed metagenomes from diverse habitats worldwide.
@podlesny.bsky.social @jonas-bio.bsky.social @borklab.bsky.social

Non-antibiotics disrupt colonization resistance against enteropathogens Nature - Non-antibiotic drugs from a wide range of therapeutic classes can alter the ability of gut commensals to resist invasion by enteropathogens, a previously underappreciated side effect of...

Finally online!
Our latest research is out @nature.com: We show that non-antibiotic drugs can disrupt colonization resistance, raising the risk of enteric infections.
rdcu.be/ewwrG

Some gut microbes can absorb and help expel ‘forever chemicals’ from the body, research shows Previously, the only way to reduce levels of Pfas was by bloodletting or a drug with unpleasant side effects

www.theguardian.com/environment/...

@skamrad.bsky.social @kiranrpatil.bsky.social show xenobiotics impact growth of gut bacteria and their metabolic homeostasis by affecting amine metabolism ➡️ www.embopress.org/doi/full/10....

Max Planck Transatlantic Program With its new Transatlantic Program, the Max Planck Society aims to strengthen collaboration and partnerships between its Institutes and leading U.S. institutions. At the same time, it seeks to counter...

The Max Planck Society @maxplanck.de today launched its Transatlantic Program, aimed at strengthening scientific collaboration with US partners, while at same time creating new opportunities for talented researchers at multiple career stages, from PhD through to group-heads & directors. More info 👇🧪

Emmy Noether Programme: in English Friday, 18. July 2025, 10-11:30 a.m. CET

#Prospects PhDs & postdocs of all disciplines note: Would you like to lead an independent junior research group? In our online talk you will get first-hand information about the aims and requirements of the DFG Emmy Noether Programme and more. Link to the meeting will be published here: fcld.ly/enp

Human gut bacteria bioaccumulate PFAS

Excited to share some key details on our latest research in @natmicrobiol.nature.com reporting intra-cellular accumulation of #PFAS (aka forever chemicals) by certain human gut bacteria. #microsky #mevosky #microbiomesky
www.nature.com/articles/s41...

A flooded residential area with water submerging houses and trees. Overlaid text reads: 'EVERYONE is affected by climate change,' with the word 'MILLIONS' crossed out and replaced by 'EVERYONE.' The logo of the European Commission appears in the bottom right corner.

📣 Today, we are proposing to reduce the EU's emissions by 90% by 2040.

This is a significant milestone on our road to net zero by 2050. ⬇️

A visual for European life sciences. Left side displays the logo of 'Choose Europe' with the EU flag, followed by 'FOR LIFE SCIENCES' and 'A Strategy for European Life Sciences' text. Background features a blurred lab setting with science and technology icons such as a laptop, brain, microscope, gear, and DNA helix on the right.

The new EU Life Sciences Strategy is here! 🔬

With over €10 bn invested yearly, the EU is set to make Europe the top hub for breakthrough science by 2030.

1/3🧵

The pill that might be relieving your heartburn but killing your gut microbes Why drugs commonly used against heartburn harm your gut microbiome

Big thanks to scientific writer Libera Lo Presti for this great little piece on our recent work exploring how proton pump inhibitors (PPIs) and pH affect human gut microbes.
Check it out here: go.nature.com/4lf6jNk

Latest study from the lab is online today (and another will be out tomorrow, stay tuned:)). We profiled effect of >1700 chemicals (drugs, pesticides,...) on secretion of amines (involved in gut-brain and gut-immune axis. ) by human gut bacteria. Brilliant work by @skamrad.bsky.social and Tara Davis

Human gut bacteria bioaccumulate per- and polyfluoroalkyl substances - Nature Microbiology Human gut bacteria bioaccumulate per- and polyfluoroalkyl substances (PFAS), commonly known as forever chemicals, in intracellular aggregates. Colonization of gnotobiotic mice with bioaccumulating bac...

Gut bacteria to the rescue! 🦠✨
They can shield us from harmful chemicals—and the latest study from Kiran Patil's lab (@kiranrpatil.bsky.social)
uncovers how. We’re proud to have contributed to this exciting work!
#Microbiome #Detox
www.nature.com/articles/s41...

Human gut bacteria bioaccumulate per- and polyfluoroalkyl substances - Nature Microbiology Human gut bacteria bioaccumulate per- and polyfluoroalkyl substances (PFAS), commonly known as forever chemicals, in intracellular aggregates. Colonization of gnotobiotic mice with bioaccumulating bac...

Beautiful work from my friend @kiranrpatil.bsky.social . Gut bacteria can accumulate Forever chemicals and help us get rid of them! Happy we could contribute! www.nature.com/articles/s41...

Intraspecies warfare restricts strain coexistence in human skin microbiomes - Nature Microbiology About 15,000 pairwise interactions within S. epidermidis from 18 people in 6 families reveal the antagonism and molecular trade-offs that shape the skin microbiota.

🚨Out now!

About 15,000 pairwise interactions within S. epidermidis from 18 people in 6 families reveal the antagonism and molecular trade-offs that shape the skin microbiota @contaminatedsci.bsky.social @mancusosci.bsky.social #MicrobiomeSky

www.nature.com/articles/s41...

read here: rdcu.be/et7VP

📢 REMINDER ‼️ AMC - Abstract submission deadline: June 30, 2025

The Aging and Microbiome Conference 2025 #AMC2025 will take place from October 28-29, 2025 in #Jena. Join us for the latest developments and exciting discussions on #microbiome & #aging.

📅 amc25.leibniz-fli.de/registration/

Excited for New Approaches and Concepts in Microbiology 2025 with sessions on Bacterial systems biology, Bacterial cell biology & protein machines, Microbiomes, Environment & evolution, Pathogenesis & phage, Antibiotic discovery, mechanisms, and resistance. #EESMicrobiology

Happy to announce the first paper from my PhD at Korbel group at @embl.org has finally been published:
embopress.org/doi/full/10.1038…
Collaborating with @typaslab.bsky.social, @hennig-lab.bsky.social and the EMBL PEPCF, we designed de novo inhibitors to a bacterial phage defense system 1/🧵

Congratulations, Edith Heard, former EMBL Director General!

She was appointed a Companion of the Order of St Michael and St George in the 2025 King’s Birthday Honours List in the UK 👏

#kingshonours

www.embl.org/news/awards-...

Proton-pump inhibitors increase C. difficile infection risk by altering pH rather than by affecting the gut microbiome based on a bioreactor model Clostridioides difficile infections often occur after antibiotic use, but they have also been linked to proton-pump inhibitor (PPI) therapy. The underlying mechanism – whether infection risk is due...

Ever wondered why proton pump inhibitors raise the risk of C. diff infections? Is it due to pH shifts or direct antibacterial effects on the gut microbiome? We think it’s the pH. 🧪💡 Dive into Julia & Patrick’s new paper for the full story! 📖👇 #Microbiome #PPI
doi.org/10.1080/1949...

Low-input RNA-seq suggests metabolic specialization underlying morphological heterogeneity in a gut commensal bacterium Isogenic bacteria can be phenotypically diverse. This heterogeneity is evident in the Bacteroidota, a predominant phylum of the human gut microbiota. …

The study was published in the journal @cp-cellreports.bsky.social‬: www.sciencedirect.com/science/arti...

🧬🧫🦠 It's Day 1 of #EESInfection!

We’re excited to kick off the symposium with a keynote from Julia Mahamid (EMBL Heidelberg, Germany) on illuminating infection by in-cell structural biology 🔬✨

Looking forward to an inspiring and insightful conference ahead! 🚀

📥 You have only until 24 June to submit your abstract for 'The human microbiome'❗

🔬💊 Explore cutting-edge breakthroughs in #microbiome research, from methodological innovations to integrative approaches and personalised therapeutics. Join #EESMicrobiome 🦠🔍

➡️ https://s.embl.org/ees25-08-bl

Antagonism as a foraging strategy in microbial communities In natural habitats, nutrient availability limits bacterial growth. We discovered that bacteria can overcome this limitation by acquiring nutrients by lysing neighboring cells through contact-dependen...

Thrilled to share our new paper in @science.org describing our discovery that bacteria can switch from competitors to bonafide predators when resources run dry—arming nanoscale “spears” (T6SS) to stab & consume neighbours.

www.science.org/doi/10.1126/...

#MicroSKy #Microbiology