Manuel

Many people are indeed saying this 🤔

Table 1. Clinical trials of mRNA cancer therapeutics initiated in the years from 2019 to August 2024

Researchers have registered more than 120 clinical trials to date evaluating the potential of mRNA-based approaches for treating many types of cancer, including lung, breast, and prostate, pancreatic, and brain tumors.

Dr. Katalin Karikó who won a Nobel Prize for developing mRNA vaccines responds to RFK Jr:

"When you are sick, you wouldn't ask for advice from a lawyer like Kennedy. You ask experts, your physician, for advice."

Our brain-immune system axis has recently has some fascinating new reports
Here is one summarized
www.nature.com/articles/s41...
More here erictopol.substack.com/p/our-braini...

No, it's not only the US who will suffer from RFK Jr cancelling vaccine research.

1️⃣ You can't just instantly teleport research projects. Cancelling US projects slows global progress.

2️⃣ Preventing pandemics will always be a group project. The US is letting the team down & putting the world at risk.

"The Trump administration is no longer allowing the NIH to function as an agency that can handle a $47 billion budget."

Cardboard box on a rock in a garden that says free plums & propaganda. Inside the box are French plums and postcards by Marc Fischer that say Losers Attack Our Libraries, Fight for Librarians

Free plums and propaganda.

pixel art landscape - in front a first lake, another one in the middle of the piece. right and left side some trees. background some mountains and a castle on the left side on one of the mountains. behind the castle is a huge planet and a big shining star surrounded by a blue sky full of shining stars. On the lake I the middle is a small boat.

Pixel art landscape - front: plants, flowers, a lot of grass and a guy with his dog (left in the middle). Middle: Waves of the ocean. Background: Dark sky full of shining stars and some planets.

P e aC e f UL w 0r L ds E xi sT

#pixelart

The evidence for nearly all of the injectable peptides that are now getting heavily promoted and widely used is summarized by the slide below.
And here is the text that goes with it
erictopol.substack.com/p/the-peptid...

People walk, cycle, sit, and dine along a temporarily car-free stretch of Meent in Rotterdam, which is lined with retail shopfronts, planter boxes filled with trees and flowers, terraces, bike parking, and benches.

People walk, cycle, sit, and dine along a temporarily car-free stretch of Meent in Rotterdam, which is lined with retail shopfronts, planter boxes filled with trees and flowers, terraces, bike parking, and benches.

People walk, cycle, sit, and dine along a temporarily car-free stretch of Meent in Rotterdam, which is lined with retail shopfronts, planter boxes filled with trees and flowers, terraces, bike parking, and benches.

People walk, cycle, sit, and dine along a temporarily car-free stretch of Meent in Rotterdam, which is lined with retail shopfronts, planter boxes filled with trees and flowers, terraces, bike parking, and benches.

This week, the City of Rotterdam began a car-free pilot along a section of Meent—the busy shopping and nightlife street—which will be closed to all motorised traffic for the rest of the summer. Only emergency services, cyclists, mopeds, delivery vehicles before 10:30, and pedestrians can access it.🧵

Brightly labelled pyramidal cells in the mouse retrosplenial cortex. Blood vessels are visible of various thicknesses in darker colours.

#neuroskyence folks: as my postdoc grant is running out soon, I am looking for new opportunities in systems neuroscience!

Keywords: patch clamp ephys, opto, mouse behavior, (in vivo) voltage imaging. Would love to return to the Basal Ganglia.

Sharing appreciated, and happy #FluorescenceFriday !

Science’s big problem is a loss of influence, not a loss of trust Evidence shows that science and scientists remain highly trusted. But genuine scientific voices are not shouting loud enough over the noise to hold sway.

this is an important thing to remind people: Trust in science remains high but scientists must now COMPETE with other influences, including untrustworthy ones 🧪

"we share data on...strategies to help scientists compete with non-credentialed sources for influence"

www.nature.com/articles/d41...

Beautiful cover from our work isn't it ?
The work is about hematopoietic stem cells in Zebrafish better characterized with photoconversion followed by scRNAseq.
🧪
doi.org/10.1242/dev....

Clearly you are accomplished, but you also present as being rather lazy - University Affairs Why it’s important to provide analysis and context for your experience, credentials and successes in an application.

Are you on the Tenure-track job hunt?

#HigherEd 🧪

Here's something to consider:
universityaffairs.ca/career-advic...

Mitochondrial origins of the pressure to sleep - Nature Research on Drosophila neurons shows links between the need to sleep and aerobic metabolism, indicating that the pressure to sleep may have a mitochondrial origin.

—Why did you go to sleep?
—My mitochondria made me do it.
www.nature.com/articles/s41...

8 Books to Read This Summer—and the Bags in Which to Carry Them In the dog days of summer, does one need much more than a great read and a chic purse? Here's what to bring on planes and trains, to beaches and pools.

You have not lived until you’ve seen your anti capitalist book featured in a $3K basket!! www.vanityfair.com/style/photos...

Enhancer adoption by an LTR retrotransposon generates viral-like particles, causing developmental limb phenotypes - Nature Genetics Activation of an LTR retrotransposon inserted upstream of the Fgf8 gene produces viral-like particles in the mouse developing limb, triggering apoptosis and causing limb malformation. This phenotype c...

Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5

BREAKING: Scientists are staging a “science fair” in the lobby of a Congressional building to tell elected officials about the critical knowledge the US will lose because their research grants have been canceled.

Clear and actionable points by my brilliant friend and colleague Dr. @jncherabiemd.bsky.social on ways to keep standing up against the attacks on health and science. Seems especially relevant today.
"Silence = Death Is Real Now More Than Ever, but Words Aren’t Enough—Action Is Needed!"

I don't want to say I am able to "handle" the ongoing deluge of bad things, but I have had a lot of trauma therapy, and let me tell you, shoving your finger in a wound and just digging around in there to remind yourself the wound exists doesn't really help anybody most of the time.

Confocal Images of the fruit fly Proventriculus

Confocal Images of the fruit fly Proventriculus

🔬New paper! This has been my personal favorite project I’ve ever done - also, the only one that the President has been relentlessly trying to destroy by 100% defunding our lab & institution. Please enjoy:

www.biorxiv.org/content/10.1...

A thread about ongoing erasing and ignoring science... 🧵

-Can we have safe streets?
-No, a driver might get mad.

The entirety of the discussion since the beginning of time.

IF ONLY WE PROVIDED AS MUCH HOUSING FOR HUMANS AS WE PROVIDE FOR CARS. HOUSING MINIMUMS NOT PARKING MINIMUMS

Minimums.

Transit delivers the freedom that auto ads promise.

Check out the latest review article from #TeamKhanna superstars Eduardo Bernier and recent alumni Dr. Eric Bartnicki.

Macrophages: sentinels, warriors, and healers
Free Link:
academic.oup.com/hmg/advance-...

@khannakm.bsky.social

WORLD’S FIRST EVER DUAL BUS-TRAIN BANNER BREAK-THROUGH!!!!!

LAX/Metro Transit Center opens 5pm!

one image with kid biking next to a truck, second image kid is not there We can either design out the conflict or we can design out our kids.

youth mobility and independence is what got me involved in this space and it is what continues to motivate me. shocking to see how we've completely designed out our children from our world.

The Expense.

Gritty Pride
#pride